Bardwell Lab

 

Principal investigator: Lee Bardwell

Department of Developmental and Cell Biology                                                                              

School of Biological Sciences

University of California, Irvine

 

USEFUL LINKS

The Bardwell Lab is in the Department of Developmental and Cell Biology of the School of Biological Sciences at the University of California, Irvine.

Graduate students in the Bardwell lab participate in a multi-departmental Graduate Training Program with academic tracks in

The Bardwell Lab belongs to the

Research Interests

We use molecular biology, biochemistry, genetics, cell biology and math/computation to study fundamental questions of cell signaling and regulation.

Signal transduction networks are a crucial part of the circuitry by which a cell regulates and coordinates its growth and developmental program, and its response to the external environment. Faulty or malfunctioning signaling pathways lie at the heart of the molecular pathology of many diseases, including cancer. The signaling components we study have been highly conserved through evolution, and are thus of great importance to basic biology, as well as medicine.

See our recent publications to get a better idea of what we do.

Selected Recent Publications

  1. AJ Bardwell, E Frankson and L Bardwell (2009)
    Selectivity of docking sites in MAPK kinases.
    Journal of Biological Chemistry 284: 13165-73. Abstract
  2. Z Hilioti, W Sabbagh Jr, S Paliwal, A Bergmann, MD Goncalves, L Bardwell, A Levchenko (2008)
    Oscillatory phosphorylation of yeast Fus3 MAP kinase controls periodic gene expression and morphogenesis.
    Current Biology 18:1700-6. Abstract
  3. L Bardwell (2008)
    Signal transduction: turning a switch into a rheostat.
    Current Biology 18:R910-2. Abstract
  4. L Bardwell,  X Zou, Q Nie and N Komarova (2007)
    Mathematical models of specificity in cell signaling.
    Biochemical Journal     92:3425-41. Abstract
  5. L Bardwell (2006)
    Mechanisms of MAPK signalling specificity.
    Biochemical Society Transactions     34:837-41. Abstract
  6. L Bardwell and K Shah (2006)
    Analysis of mitogen-activated protein kinase activation and interactions with regulators and substrates.
    Methods     40:213-23. Abstract
  7. DT Ho, AJ Bardwell, S Grewal, C Iverson and L Bardwell (2006)
    Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases.
    Journal of Biological Chemistry     281:13169-79. Abstract
  8. S Grewal, DM Molina and L Bardwell (2006)
    Mitogen-activated protein kinase (MAPK)-docking sites in MAPK kinases function as tethers that are crucial for MAPK regulation in vivo.
    Cellular Signalling     18:123-134. Abstract
  9. DM Molina, S Grewal and L Bardwell (2005)
    Characterization of an ERK-binding domain in MITF and differential inhibition of ERK2-mediated substrate phosphorylation.
    Journal of Biological Chemistry     280:42051-60. Abstract
  10. NL Komarova, X Zou, Q Nie and L Bardwell (2005)
    A theoretical framework for specificity in cell signaling.
    Molecular Systems Biology    , doi:10.1038/msb4100031, E1-E5. Online/pdf
  11. LJ Flatauer, S Zadeh and L Bardwell (2005)
    MAP Kinases With Distinct Requirements for Ste5 Scaffolding Influence Signaling Specificity in Yeast.
    Molecular and Cellular Biology     25: 1793-1803. Abstract -- Get pdf
  12. L Bardwell (2005)
    A walk-through of the yeast mating pheromone response pathway.
    Peptides     26 339-350. Abstract -- Download pdf
  13. PJ Cullen, W Sabbagh, M Irick, E Graham, E van Olden, C Neal, J Delrow, L Bardwell and GF Sprague, Jr. (2004)
    Msb2 is a Signaling Mucin at the Head of the Yeast Filamentous Growth MAPK Pathway.
    Genes & Development     18:1695-1708. Abstract
  14. AB Kusari, DM Molina, W Sabbagh Jr., C Lau and L Bardwell (2004)
    A conserved protein interaction network involving the yeast MAP kinases Fus3 and Kss1.
    Journal of Cell Biology     164:267-277. Abstract -- Get pdf
  15. AJ Bardwell, M Abdollahi and L Bardwell (2004)
    Anthrax lethal factor-cleavage products of mitogen-activated protein kinase (MAPK) kinases exhibit reduced binding to their cognate MAPKs.
    Biochemical Journal     378:569-577. Abstract -- Get pdf
  16. DT Ho, AJ Bardwell, M Abdollahi and L Bardwell (2003)
    A docking site in MKK4 mediates high-affinity binding to JNK MAP kinases and competes with similar docking sites in JNK substrates
    Journal of Biological Chemistry     278:32662-72. Abstract
  17. AJ Bardwell, M Abdollahi and L Bardwell (2003)
    Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity
    Biochemical Journal     370:1077-1085. Abstract
  18. W Sabbagh Jr, LJ Flatauer, AJ Bardwell and L Bardwell (2001)
    Specificity of MAPK signaling in yeast differentiation involves transient vs. sustained MAPK activation
    Molecular Cell     8:683-691. Abstract
  19. AJ Bardwell, LJ Flatauer, K Matsukuma, J Thorner and L Bardwell (2001)
    A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission
    Journal of Biological Chemistry     276:10374-10386. Abstract

More Publications

Last modified 2 July 2009. Back to top