Cell Biology 231B/D154

University of California, Irvine

This is an intensive, one-quarter course on fundamental and advanced topics in cell biology for graduate students and highly advanced undergraduates.

Selected topics may include: The cell cycle, membranes and organelles, protein sorting and vesicular transport, apoptosis, the cytoskeleton & cell motility, differentiation, cell adhesion & extracellular matrix, signal transduction, the cellular basis of development, and the cell biology of cancer.

Course coordinator: Lee Bardwell

Instructor Web pages and e-mails

• Lee Bardwell   Lab   E-mail: bardwell@uci.edu
• Steve Gross   Lab  E-mail: sgross@uci.edu
• Christine Suetterlin   E-mail: suetterc@uci.edu
• Aimee Edinger  Lab  E-mail: aedinger@uci.edu
• Rahul Warrior   Lab  E-mail: rwarrior@uci.edu

Key documents and links

• 2006 Syllabus (PDF). Updated 2/17/06.
• Grading Policy (click here)
• 231B Course mailing list archive (2006)
• D154 Course mailing list archive (2006)

Sample Exams, Study Questions, Answer Keys, etc

• Cell cycle study questions
• Answer Key to cell cycle study questions
• 2006 Midterm on Cell Cycle
• 2006 Midterm on Cell Cycle Answer Key
• Study Questions/Homework for She et al. Cancer Cell paper (Dr. Edinger)
• Sample Final Exam Questions (Dr. Warrior)

Reading (2006) (pdf downloads)

• Bardwell
  1. Murray & Kirschner 1989 "Cyclin synthesis drives the early embyonic cell cycle"
  2. Xiong & Ferrell 2003 "A positive-feedback based bistable 'memory module' that governs a cell fate decision"
  3. Imposing Specificity Review by Ptashne and Gann
  4. Evolvability Review by Kirschner & Gerhart
• Gross
  1. Block et al. 1990 - Kinesin bead movement
  2. Rodionov et al. 2003 - transport switching
• Suetterlin
  1. Recommend reading list last updated 2/6/06
• Edinger
  1. Hallmarks Of Cancer Review by Hannahan & Weinberg
  2. Hahn & Weinberg Cancer Review 2002
  3. She et al., Cancer Cell 2005 - Bad phosphorylation
  4. Study Questions/Homework for She et al. Cancer Cell paper
• Warrior
  1. Espinosa et al. 2005 - New Bicoid targets
  2. Ephrussi & St. Johston 2004 - Bicoid review
  3. Markstein & Levine 2002 - computational identification of enhancers review

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Lecture Downloads (2006)

• Bardwell 2006
  1. Cell Cycle I
  2. Cell Cycle II
  3. Cell Design Principles
  4. Differentiation
• Gross 2006
  1. Lecture I
  2. Lecture II
• Suetterlin 2006
  1. Lecture I PowerPoint PDF
  2. Lecture II PowerPoint PDF
  3. Lecture III PowerPoint PDF
  4. Lecture IV PowerPoint PDF
  5. Lecture V PowerPoint PDF
• Edinger 2006
  1. Lecture 1 PowerPoint PDF
  2. Lecture 2 PowerPoint PDF
  3. Lecture 3 PowerPoint PDF
  4. Lecture 4 PowerPoint PDF
  5. Lecture 5 PowerPoint PDF
  6. Lecture 6 PowerPoint PDF
• Warrior 2006
  1. Combined Lecture File PowerPoint

Lecture Downloads (2005)

• Warrior 2005
  1. Development 1 & 2 & 3. Three lectures in one pdf file!
  2. Development 4
  3. Development References

Interesting/useful links:

General

• Advanced Medline Search
• NCBI, find sequences, structures, BLAST, etc.
• Nobel Prizes
• Bioscience Virtual Library:
  • Research Tools

Genome Databases

• Human
  • Human Genome Resources from NCBI.
  • Mendelian Inheritance In Man online database.
  • Genecards, a database of human genes, their products and their involvement in disease.
  • Human Gene Mutation Database at Cardiff.
    • Mutations in CDK4 or p16/INK4/CDKN2 in familial melanoma.
    • p57KIP2/CDKN1C mutations in Beckwith-Wiedemann syndrome.
    • RB1 mutations in Retinoblastoma.
    • p53 mutations in Li-Fraumeni syndrome and various cancers.
  • Cancer-related Genes listed alphabetically and by chromosomal locus. Note that a small proportion of these have been shown to be mutated or rearranged in human cancers.
  • Cancer information from the National Cancer Institute.
• Mouse
  • The Transgenic/Targeted Mutation Database, Jackson Laboratory.
  • Mouse gene knock-outs listed alphabetically, not searchable.
  • Other transgenic databases.
• Fly (Drosophila)
  • Flybase
• Worm (C. elegans)
  • Wormbase
• Yeast (S. cerevisiae)
  • Saccharomyces Genome Database

General Tutorial

• Genetics
  • BBC's Gene Stories. An excellent series, aimed at the layperson.
• Cell Cycle
  • Genes...the Cell Cycle...and Clocks. Emphasis on cancer relevance.
  • 2001 Nobel Prize in Medicine (for cell cycle research).
  • Online review article about E2F transcription factors.
• Signaling
  • Protein kinase resource. From our friends at UCSD.
  • Mammalian MAPK signalling pathways Map of pathway; click on a component to get a description. Somewhat out of date. From Jim Woodgett at U Toronto.
  • Tutorials from the THCME Medical Biochemistry Page:
    • Signal transduction
    • Glycogen metabolism, including regulation by signaling pathways
    • Growth factors and cytokines
    • Peptide hormones and receptors
    • Wnt and BMP signaling
    • Oncogenes and cancer
    • Tumor suppressors
  • Breaking the code of color About human color vision, from HHMI.
  • Finding the odorant receptors These are 7-transmembrane, G-protein coupled receptors as well.
• Development
  • The Interactive Fly, a web guide to Drosophila genes and their roles in development.
• Cancer
  • Tutorials from the THCME Medical Biochemistry Page:
    • Oncogenes and cancer
    • Tumor suppressors

Last modified 21 March 2006. Back to top