>AGAP000236-PA

SGD|S000005887 - symbol:PDE2 "High-affinity cyclic AMP phosphodi...    77   6e-014
UNIPROT|P21127 - symbol:CD2L1_HUMAN "CDC2L1, PITSLREA, PK58: PIT...    42   0.002
UNIPROT|P14314 - symbol:GLU2B_HUMAN "PRKCSH, G19P1: Glucosidase ...    40   0.007
TAIR|gene:2201795 - symbol:PDE166 "PIGMENT DEFECTIVE 166" specie...    40   0.011
MGI|MGI:88353 - symbol:Cdc2l1 "cell division cycle 2-like 1" spe...    39   0.015
MGI|MGI:88376 - symbol:Cenpb "centromere protein B" species:1009...    38   0.044
UNIPROT|Q9UQ88 - symbol:CD2L2_HUMAN "CDC2L2, PITSLREB: PITSLRE s...    37   0.057
MGI|MGI:99948 - symbol:Atbf1 "AT motif binding factor 1" species...    37   0.074
SGD|S000004774 - symbol:MSS11 "Transcription factor involved in ...    37   0.097
MGI|MGI:1859515 - symbol:Acrbp "proacrosin binding protein" spec...    37   0.097


==> SGD|S000005887 - symbol:PDE2 "High-affinity cyclic AMP
           phosphodiesterase, component of the cAMP-dependent
           protein kinase signaling system, protects the cell from
           extracellular cAMP, contains readthrough motif
           surrounding termination codon" species:4932
           "Saccharomyces cerevisiae" [GO:0004115 "3',5'-cyclic-AMP
           phosphodiesterase activity" evidence=IDA] [GO:0005634
           "nucleus" evidence=IDA] [GO:0005737 "cytoplasm"
           evidence=IDA] [GO:0019933 "cAMP-mediated signaling"
           evidence=IMP] GenBank:NC_001147.5 Ncbi:NP_015005
          Length = 526

 Score = 77.0 bits (188), Expect = 6e-014
 Identities = 63/233 (27%), Positives = 104/233 (44%), Gaps = 38/233 (16%)

Query: 315 YTVFQDRNIPRTLTIPPTVLLAFVSTVEDHYVADNPFHNSLHAADVTQSTHALLHSPALD 374
           +T+ +  +    + I    LL  + T+E  Y   N FHN  HA DV Q+T  L      D
Sbjct: 228 FTLIKKLSKDAKVLIADNKLLLLLFTLESSYHQVNKFHNFRHAIDVMQATWRLCTYLLKD 287

Query: 375 GVFTPLEVCAALVAACIHDVDHPGLTNQFLINSSSELALMYNDESVLENHHLAVAFKLMQ 434
                L +C A +    HDV HPG  NQ L N  SE+A  + + S+LEN H  + F+ + 
Sbjct: 288 NPVQTLLLCMAAIG---HDVGHPGTNNQLLCNCESEVAQNFKNVSILENFHREL-FQQLL 343

Query: 435 NDDCNILRNLPKKQRATFRKMVIDMVLSTDMSKHMTLLADLKTMVETKKVAISGNQNPGE 494
           ++    L ++ KK+       + + +L+TDM+ H        +  E + +    ++NP  
Sbjct: 344 SEHWPQLLSISKKK----FDFISEAILATDMALH--------SQYEDRLM----HENP-- 385

Query: 495 SRSSGSGVLLRLLDSYTDRIQVLQNLVHCADLSNPTKPLPLYRRWVRRLMEEF 547
                             +I ++  ++  AD+SN T+ L +  RW   +  EF
Sbjct: 386 ----------------MKQITLISLIIKAADISNVTRTLSISARWAYLITLEF 422



==> UNIPROT|P21127 - symbol:CD2L1_HUMAN "CDC2L1, PITSLREA, PK58:
           PITSLRE serine/threonine-protein kinase CDC2L1"
           species:9606 "Homo sapiens" [GO:0004674 "protein
           serine/threonine kinase activity" evidence=IDA]
           [GO:0005515 "protein binding" evidence=IPI] [GO:0005524
           "ATP binding" evidence=IDA] [GO:0000074 "regulation of
           progression through cell cycle" evidence=IEP]
           [GO:0001558 "regulation of cell growth" evidence=IEP]
           [GO:0006355 "regulation of transcription, DNA-dependent"
           evidence=NAS] [GO:0006468 "protein amino acid
           phosphorylation" evidence=IDA] [GO:0006915 "apoptosis"
           evidence=NAS] [GO:0007067 "mitosis" evidence=NAS]
           [GO:0008283 "cell proliferation" evidence=TAS]
           [GO:0050684 "regulation of mRNA processing"
           evidence=IDA] [GO:0005634 "nucleus" evidence=IEP]
           [GO:0005737 "cytoplasm" evidence=TAS] InterPro:IPR000719
           InterPro:IPR002290 InterPro:IPR008271 UniProt:P21127
           Pfam:PF00069 Prosite:PS00108 Prosite:PS00107
           GO:GO:0005515 GO:GO:0005737 GO:GO:0005634 GO:GO:0008283
           GO:GO:0000074 InterPro:IPR011009 ProDom:PD000001
           PROSITE:PS50011 GO:GO:0006915 SMART:SM00220
           GO:GO:0006468 GO:GO:0005524 GO:GO:0006355 GO:GO:0001558
           GO:GO:0007067 GO:GO:0004674 HSSP:P24941 EMBL:M37712
           EMBL:M88563 EMBL:M88553 EMBL:M88554 EMBL:M88555
           EMBL:M88558 EMBL:M88559 EMBL:M88560 EMBL:M88561
           EMBL:M88562 EMBL:U04815 EMBL:U04816 EMBL:U04817
           EMBL:U04818 EMBL:U04824 EMBL:AF067512 EMBL:AF067513
           EMBL:AF067514 EMBL:AF067515 EMBL:AF067516 EMBL:AF067517
           EMBL:AF080683 EMBL:AF080685 EMBL:AF080686 EMBL:AF080687
           EMBL:AF080688 EMBL:AF092429 EMBL:AF092430 EMBL:AF080678
           EMBL:AF080679 EMBL:AF080680 EMBL:AF080681 EMBL:AF080682
           EMBL:AF174497 EMBL:BC033069 PIR:A38282 UniGene:Hs.651228
           DIP:DIP:29015N IntAct:P21127 Ensembl:ENSG00000008128
           KEGG:hsa:984 HGNC:HGNC:1729 MIM:176873 LinkHub:P21127
           ArrayExpress:P21127 GermOnline:ENSG00000008128
           RZPD-ProtExp:T1797 GO:GO:0050684
          Length = 795

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 20/62 (32%), Positives = 35/62 (56%)

Query: 598 DAQDILDRLEENRAYYQALIPPPSPPSHEKDEEEEEEAEEAAKREAKQQQQQQERAEQEA 657
           D QDI D   +  +   +     S    E++EEEEEE E +   E++++++++E  E+E 
Sbjct: 278 DLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEET 337

Query: 658 GS 659
           GS
Sbjct: 338 GS 339



==> UNIPROT|P14314 - symbol:GLU2B_HUMAN "PRKCSH, G19P1: Glucosidase 2
           subunit beta precursor" species:9606 "Homo sapiens"
           [GO:0003674 "molecular_function" evidence=ND]
           [GO:0007243 "protein kinase cascade" evidence=NAS]
           [GO:0005622 "intracellular" evidence=NAS] UniProt:P14314
           Prosite:PS00018 PROSITE:PS50222 GO:GO:0007243
           GO:GO:0005622 PROSITE:PS00014 HSSP:P01130 EMBL:J03075
           EMBL:U50326 EMBL:U50317 EMBL:U50318 EMBL:U50319
           EMBL:U50320 EMBL:U50321 EMBL:U50322 EMBL:U50323
           EMBL:U50324 EMBL:U50325 EMBL:AF144075 EMBL:BT009858
           EMBL:BC013586 EMBL:BC015154 PIR:A32469 UniGene:Hs.610830
           Ensembl:ENSG00000130175 KEGG:hsa:5589 HGNC:HGNC:9411
           MIM:174050 MIM:177060 ArrayExpress:P14314
           GermOnline:ENSG00000130175
          Length = 528

 Score = 40.4 bits (93), Expect = 0.007
 Identities = 21/57 (36%), Positives = 32/57 (56%), Gaps = 7/57 (12%)

Query: 593 ELVRPDAQDILDRLEENRAYYQALIPPPSPPSHEKDEEEEEEAEEAAKREAKQQQQQ 649
           +L  P A D+ +  EE         P PS P+ E++EEEEEE EEA + E ++  ++
Sbjct: 288 DLPAPSAPDLTEPKEEQP-------PVPSSPTEEEEEEEEEEEEEAEEEEEEEDSEE 337



==> TAIR|gene:2201795 - symbol:PDE166 "PIGMENT DEFECTIVE 166"
           species:3702 "Arabidopsis thaliana" [GO:0010007
           "magnesium chelatase complex" evidence=TAS] [GO:0015995
           "chlorophyll biosynthetic process" evidence=TAS]
           GenBank:NM_100725.3 Ncbi:NP_563821
          Length = 760

 Score = 39.7 bits (91), Expect = 0.011
 Identities = 21/57 (36%), Positives = 30/57 (52%), Gaps = 6/57 (10%)

Query: 606 LEENRAYYQALIPPPSPP------SHEKDEEEEEEAEEAAKREAKQQQQQQERAEQE 656
           L+E     Q   PPP PP        E++EEE+EE EE    E  + +QQQ++  +E
Sbjct: 400 LDETPPEQQNQPPPPPPPPQNSESGEEENEEEQEEEEEDESNEENENEQQQDQIPEE 456



==> MGI|MGI:88353 - symbol:Cdc2l1 "cell division cycle 2-like 1"
           species:10090 "Mus musculus" [GO:0001824 "blastocyst
           development" evidence=IMP] [GO:0005634 "nucleus"
           evidence=IDA] [GO:0007088 "regulation of mitosis"
           evidence=IMP] [GO:0006915 "apoptosis" evidence=IMP]
           InterPro:IPR000719 InterPro:IPR002290 InterPro:IPR008271
           Pfam:PF00069 Prosite:PS00108 MGI:MGI:88353
           Prosite:PS00107 GO:GO:0005634 GO:GO:0007088
           InterPro:IPR011009 ProDom:PD000001 PROSITE:PS50011
           GO:GO:0006915 SMART:SM00220 HSSP:P24941 EMBL:M58633
           EMBL:L37092 EMBL:AK077668 EMBL:AK147133 EMBL:BC052920
           PIR:A55817 UniGene:Mm.267410 Ensembl:ENSMUSG00000029062
           KEGG:mmu:12537 ArrayExpress:P24788
           GermOnline:ENSMUSG00000029062 GO:GO:0001824
           Uniprot:P24788
          Length = 784

 Score = 39.3 bits (90), Expect = 0.015
 Identities = 19/59 (32%), Positives = 32/59 (54%)

Query: 598 DAQDILDRLEENRAYYQALIPPPSPPSHEKDEEEEEEAEEAAKREAKQQQQQQERAEQE 656
           D QDI D   +  +   +     S    E++EEEEEE EE +  E  ++++++E  E+E
Sbjct: 265 DLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEE 323



==> MGI|MGI:88376 - symbol:Cenpb "centromere protein B" species:10090
           "Mus musculus" [GO:0000775 "chromosome, pericentric
           region" evidence=ISS] InterPro:IPR004875
           InterPro:IPR012287 Interpro:IPR009057 InterPro:IPR011526
           InterPro:IPR006695 MGI:MGI:88376 Gene3D:G3DSA:1.10.10.60
           InterPro:IPR006600 Pfam:PF03184 SMART:SM00674
           PROSITE:PS51253 PROSITE:PS50960 HSSP:P07199 Pfam:PF04218
           EMBL:X55038 UniGene:Mm.252722 SMR:P27790
           Ensembl:ENSMUSG00000068267 KEGG:mmu:12616
           ArrayExpress:P27790 GermOnline:ENSMUSG00000068267
           Uniprot:P27790
          Length = 599

 Score = 37.7 bits (86), Expect = 0.044
 Identities = 15/38 (39%), Positives = 26/38 (68%)

Query: 621 SPPSHEKDEEEEEEAEEAAKREAKQQQQQQERAEQEAG 658
           S    E++EEEEEE EE  + E +++++++E  E+E G
Sbjct: 403 SEGEEEEEEEEEEEEEEEEEGEGEEEEEEEEEGEEEGG 440



==> UNIPROT|Q9UQ88 - symbol:CD2L2_HUMAN "CDC2L2, PITSLREB: PITSLRE
           serine/threonine-protein kinase CDC2L2" species:9606
           "Homo sapiens" [GO:0004674 "protein serine/threonine
           kinase activity" evidence=IDA] [GO:0005515 "protein
           binding" evidence=IPI] [GO:0005524 "ATP binding"
           evidence=IDA] [GO:0000074 "regulation of progression
           through cell cycle" evidence=IEP] [GO:0001558
           "regulation of cell growth" evidence=IEP] [GO:0006355
           "regulation of transcription, DNA-dependent"
           evidence=NAS] [GO:0006468 "protein amino acid
           phosphorylation" evidence=IDA] [GO:0006915 "apoptosis"
           evidence=NAS] [GO:0007067 "mitosis" evidence=NAS]
           [GO:0050684 "regulation of mRNA processing"
           evidence=IDA] [GO:0005634 "nucleus" evidence=IEP]
           InterPro:IPR000719 InterPro:IPR002290 InterPro:IPR008271
           Pfam:PF00069 Prosite:PS00108 UniProt:Q9UQ88
           Prosite:PS00107 GO:GO:0005515 GO:GO:0005634
           GO:GO:0000074 InterPro:IPR011009 ProDom:PD000001
           PROSITE:PS50011 GO:GO:0006915 SMART:SM00220
           GO:GO:0006468 GO:GO:0005524 GO:GO:0006355 GO:GO:0001558
           GO:GO:0007067 GO:GO:0004674 HSSP:P24941
           UniGene:Hs.651228 Ensembl:ENSG00000008128
           GermOnline:ENSG00000008128 RZPD-ProtExp:T1797
           GO:GO:0050684 EMBL:U04819 EMBL:U07704 EMBL:U07705
           EMBL:AF067518 EMBL:AF067519 EMBL:AF067520 EMBL:AF067521
           EMBL:AF067522 EMBL:AF067523 EMBL:AF067524 EMBL:AF067525
           EMBL:AF067526 EMBL:AF067527 EMBL:AF067528 EMBL:AF067529
           EMBL:AF080694 EMBL:AF080695 EMBL:AF105714 EMBL:AF080696
           EMBL:AF080697 EMBL:AF092427 EMBL:AF092428 EMBL:AF080689
           EMBL:AF080690 EMBL:AF080691 EMBL:AF080692 EMBL:AF080693
           EMBL:AL031282 IntAct:Q9UQ88 HGNC:HGNC:1730 MIM:116951
          Length = 780

 Score = 37.4 bits (85), Expect = 0.057
 Identities = 22/62 (35%), Positives = 35/62 (56%), Gaps = 3/62 (4%)

Query: 598 DAQDILDRLEENRAYYQALIPPPSPPSHEKDEEEEEEAEEAAKREAKQQQQQQERAEQEA 657
           D QDI D  E   +  ++        S E++EEEEEE EE +  E  ++++++E  E+E 
Sbjct: 266 DLQDISDS-ERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE--EEET 322

Query: 658 GS 659
           GS
Sbjct: 323 GS 324



==> MGI|MGI:99948 - symbol:Atbf1 "AT motif binding factor 1"
           species:10090 "Mus musculus" [GO:0006355 "regulation of
           transcription, DNA-dependent" evidence=NAS] [GO:0005634
           "nucleus" evidence=NAS] [GO:0005739 "mitochondrion"
           evidence=IDA] [GO:0003700 "transcription factor
           activity" evidence=TAS] [GO:0030182 "neuron
           differentiation" evidence=TAS] InterPro:IPR007087
           InterPro:IPR003604 InterPro:IPR012287 InterPro:IPR001356
           Interpro:IPR009057 Pfam:PF00096 Pfam:PF00046
           Prosite:PS00028 MGI:MGI:99948 GO:GO:0005634
           GO:GO:0005739 Gene3D:G3DSA:1.10.10.60 GO:GO:0003700
           ProDom:PD000010 SMART:SM00389 PROSITE:PS00027
           PROSITE:PS50071 GO:GO:0006355 SMART:SM00355
           PROSITE:PS50157 GO:GO:0030182 HSSP:P50480 SMART:SM00451
           EMBL:D26046 UniGene:Mm.416972 UniGene:Mm.435503
           TRANSFAC:T03881 Ensembl:ENSMUSG00000038872
           KEGG:mmu:11906 ArrayExpress:Q61329
           GermOnline:ENSMUSG00000038872 Uniprot:Q61329
          Length = 3726

 Score = 37.0 bits (84), Expect = 0.074
 Identities = 16/52 (30%), Positives = 28/52 (53%)

Query: 607 EENRAYYQALIPPPSPPSHEKDEEEEEEAEEAAKREAKQQQQQQERAEQEAG 658
           +E+  +         P   E+ EEEEEE EEA + E +++++++E  E   G
Sbjct: 444 QESGGHQDCFSEKVEPAEEEEAEEEEEEEEEAEEEEEEEEEEEEEEEEASKG 495



==> SGD|S000004774 - symbol:MSS11 "Transcription factor involved in
           regulation of invasive growth and starch degradation"
           species:4932 "Saccharomyces cerevisiae" [GO:0003704
           "specific RNA polymerase II transcription factor
           activity" evidence=IDA] [GO:0005634 "nucleus"
           evidence=IC] [GO:0005983 "starch catabolic process"
           evidence=IMP] [GO:0007124 "pseudohyphal growth"
           evidence=IGI] [GO:0045944 "positive regulation of
           transcription from RNA polymerase II promoter"
           evidence=IDA] GenBank:NC_001145.2 Ncbi:NP_013887
          Length = 758

 Score = 36.6 bits (83), Expect = 0.097
 Identities = 12/56 (21%), Positives = 34/56 (60%)

Query: 601 DILDRLEENRAYYQALIPPPSPPSHEKDEEEEEEAEEAAKREAKQQQQQQERAEQE 656
           D+    +  ++  Q +  P   P H+  ++++++ ++  +++ +QQQQQQ++ +Q+
Sbjct: 267 DLQSPAQPQQSSQQQIQQPQHQPQHQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ 322



==> MGI|MGI:1859515 - symbol:Acrbp "proacrosin binding protein"
           species:10090 "Mus musculus" [GO:0005615 "extracellular
           space" evidence=RCA] [GO:0005634 "nucleus" evidence=RCA]
           [GO:0001669 "acrosome" evidence=ISS] [GO:0005515
           "protein binding" evidence=ISS] [GO:0016504 "protease
           activator activity" evidence=ISS] [GO:0003677 "DNA
           binding" evidence=RCA] [GO:0007286 "spermatid
           development" evidence=ISS] [GO:0048240 "sperm
           capacitation" evidence=ISS] MGI:MGI:1859515
           UniProt:Q3V140 GO:GO:0048240 InterPro:IPR009865
           InterPro:IPR002350 Pfam:PF07222 SMART:SM00280
           EMBL:D17573 EMBL:D17574 EMBL:AK076691 EMBL:AK132705
           EMBL:BC011079 UniGene:Mm.347910
           Ensembl:ENSMUSG00000072770 ArrayExpress:Q3V140
           GermOnline:ENSMUSG00000072770
          Length = 540

 Score = 36.6 bits (83), Expect = 0.097
 Identities = 16/74 (21%), Positives = 39/74 (52%)

Query: 585 HPLWEAWAELVRPDAQDILDRLEENRAYYQALIPPPSPPSHEKDEEEEEEAEEAAKREAK 644
           H  ++ W E +  + +++L          Q     P     ++++ +E + EEA ++E +
Sbjct: 161 HQAFQPWPERLNNNVEELLQSSLSLGGKDQQSSRRPGQEQRKQEQIQEHKLEEAQEQEEQ 220

Query: 645 QQQQQQERAEQEAG 658
           ++++++E A+QE G
Sbjct: 221 EEEEEEEEAKQEEG 234