>AGAP000929-PA MGI|MGI:2386403 - symbol:Csmd3 "CUB and Sushi multiple domains 3... 293 1e-078 MGI|MGI:2137383 - symbol:Csmd1 "CUB and Sushi multiple domains 1... 273 9e-073 UNIPROT|P16109 - symbol:LYAM3_HUMAN "SELP, GMRP: P-selectin prec... 250 8e-066 UNIPROT|P20023 - symbol:CR2_HUMAN "CR2, C3DR: Complement recepto... 246 9e-065 MGI|MGI:88489 - symbol:Cr2 "complement receptor 2" species:10090... 237 5e-062 UNIPROT|P17927 - symbol:CR1_HUMAN "CR1, C3BR: Complement recepto... 229 1e-059 MGI|MGI:98280 - symbol:Selp "selectin, platelet" species:10090 "... 225 2e-058 UNIPROT|P16581 - symbol:LYAM2_HUMAN "SELE, ELAM1: E-selectin pre... 196 2e-049 MGI|MGI:98278 - symbol:Sele "selectin, endothelial cell" species... 181 4e-045 UNIPROT|P04003 - symbol:C4BP_HUMAN "C4BPA, C4BP: C4b-binding pro... 157 7e-038 UNIPROT|P08603 - symbol:CFAH_HUMAN "CFH, HF, HF1: Complement fac... 148 4e-035 MGI|MGI:88229 - symbol:C4bp "complement component 4 binding prot... 140 9e-033 FB|FBgn0010114 - symbol:hig "hikaru genki" species:7227 "Drosoph... 124 7e-028 UNIPROT|P05160 - symbol:F13B_HUMAN "F13B: Coagulation factor XII... 114 5e-025 MGI|MGI:88379 - symbol:F13b "coagulation factor XIII, beta subun... 108 4e-023 MGI|MGI:88513 - symbol:Crry "complement receptor related protein... 108 4e-023 UNIPROT|P15529 - symbol:MCP_HUMAN "CD46, MCP: Membrane cofactor ... 100 2e-020 UNIPROT|Q9BXR6 - symbol:FHR5_HUMAN "CFHR5, CFHL5, FHR5: Compleme... 97 9e-020 UNIPROT|Q9I927 - symbol:FUCL5_ANGJA "Fucolectin-5 precursor" spe... 93 2e-018 UNIPROT|P02749 - symbol:APOH_HUMAN "APOH, B2G1: Beta-2-glycoprot... 92 4e-018 UNIPROT|P00751 - symbol:CFAB_HUMAN "CFB, BF: Complement factor B... 91 6e-018 UNIPROT|P98131 - symbol:LYAM1_BOVIN "SELL: L-selectin precursor"... 91 1e-017 UNIPROT|P20851 - symbol:C4BB_HUMAN "C4BPB: C4b-binding protein b... 88 5e-017 MGI|MGI:104850 - symbol:Cd55 "CD55 antigen" species:10090 "Mus m... 88 7e-017 UNIPROT|Q9I931 - symbol:FUCL1_ANGJA "Fucolectin-1 precursor" spe... 87 1e-016 ==> MGI|MGI:2386403 - symbol:Csmd3 "CUB and Sushi multiple domains 3" species:10090 "Mus musculus" [GO:0005575 "cellular_component" evidence=ND] [GO:0004553 "hydrolase activity, hydrolyzing O-glycosyl compounds" evidence=RCA] [GO:0005975 "carbohydrate metabolic process" evidence=RCA] MGI:MGI:2386403 InterPro:IPR000859 InterPro:IPR000436 Pfam:PF00084 SMART:SM00032 PROSITE:PS50923 Pfam:PF00431 SMART:SM00042 PROSITE:PS01180 EMBL:AK122567 EMBL:AK015672 UniGene:Mm.309363 Ensembl:ENSMUSG00000022311 KEGG:mmu:239420 ArrayExpress:Q80T79 GermOnline:ENSMUSG00000022311 Uniprot:Q80T79 Length = 2796 Score = 293 bits (749), Expect = 1e-078 Identities = 197/667 (29%), Positives = 293/667 (43%), Gaps = 68/667 (10%) Query: 353 LSCGSPEALVNTTIVGRNYTVGANITYQCPVGHSLIGVEMRT--CQQNGVWSG--TPPAC 408 +SCG P+A N I+ +Y VG +TY C G+ L E+ T CQ +G WS P C Sbjct: 1719 ISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTATCQSDGTWSNHNKTPRC 1778 Query: 409 KYVDCGPLPE--IEHGGI-ILSEQRTSFGVQASYTCHENYTLIGNENRTCQASG---WSG 462 V C + ++HG I++ + + ++C Y +G + C +G W Sbjct: 1779 VVVTCPSINSFTLDHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRT 1838 Query: 463 TQPKCLIDWCPE-PPPIQGGRIKVSGRRAGSTALYTCDYGFVLIGEPVLSCGLGGNWTGK 521 +P C I C E P P G +I GSTA++TCD GF+L+G V C G W+G Sbjct: 1839 ERPYCQIISCGELPTPPNGNKIGTQ-TSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSGS 1897 Query: 522 IPVCRYVDCGMPARPDRGNMLLLNDSTTVGSVVRYFCDDDYWLVGPQELYCTKDGKWSGS 581 C CG+P G ++ ++ V Y C+ + L+G C +D WSG Sbjct: 1898 ETRCLAGHCGIPELIVNGQ--VIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQ 1955 Query: 582 APACELITCETPHVPPGSYVIGYDYNIHSSIQYHCDPGHILRGEDTLTCLESGQWSGDAP 641 P+C ++C P P G +N + + + C+ G++++G C + QWS P Sbjct: 1956 LPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPP 2015 Query: 642 DCEYVDCGPLTPIPFGSHRYTQ----NTTFLGSEVVYSCANSHRLAGVNRRLCLDTGLWS 697 C+ V+C IP S R ++ N T+ G+ V Y C + L G + +C G W Sbjct: 2016 VCKVVNCSD-PGIPANSKRESKIEHGNFTY-GTVVFYDCNPGYFLFGSSVLICQPNGQWD 2073 Query: 698 ETAPRCEEIRCTEPTLTPHSFVSVTGNDRMYG----------RTLIRTSDATV------S 741 + P C I C P + P++ +S G +G R+L+ + T S Sbjct: 2074 KPLPECIMIDCGHPGIPPNAVLS--GEKYTFGSTVHYSCTGKRSLLGQASRTCQLNGHWS 2131 Query: 742 GAQ-------------------------TFRVGALAKYRCERGYKIVGEALITCEENGLW 776 G+Q FR + ++ C+ GY + G TC NG W Sbjct: 2132 GSQPHCSGDTTGTCGDPGTPGHGSRQESDFRTKSTVRFACDTGYILYGSEERTCLSNGSW 2191 Query: 777 SGEIPECVYVDCEMPQNVTHGKVTLATNATYYGAAALYECDGNFKLDGVSRRLCLEDGTW 836 +G PEC V C P +GKV + T + ++ +Y C + L G S R C +GTW Sbjct: 2192 TGRQPECKAVQCGNPGTTANGKV-FRIDGTTFSSSVIYSCLEGYILSGPSVRQCTANGTW 2250 Query: 837 SHETPACVEITCNEMNVSDALLVSYGSRRVGVQAEFSCSKGRYMVGNGT--RTCLPTGHW 894 S P C I+C + + L VG + C G + NG+ RTC G W Sbjct: 2251 SGSLPNCTIISCGDPGIPANGLRYGDDFVVGQNVSYMCQPGYTIELNGSRVRTCTTNGTW 2310 Query: 895 SGRNPVCKLIDCGRPADIENGRVIVVNESTVYGGSAEYHCVPHYNRIGPYLRKCMDDGKW 954 SG P C+ + C P I NGR+ N +G S Y C Y P + C+ +G W Sbjct: 2311 SGVMPTCRAVTCSTPPQISNGRLEGTNFD--WGFSISYICSAGYELSFPAVLTCVGNGTW 2368 Query: 955 SGEEPRC 961 SGE P+C Sbjct: 2369 SGEVPQC 2375 Score = 282 bits (722), Expect = 1e-075 Identities = 180/633 (28%), Positives = 274/633 (43%), Gaps = 53/633 (8%) Query: 355 CGSPEALVNTTIVGRNY-TVGANITYQCPVGHSLIGVEMRTCQQNGV----WSGTPPACK 409 C +PE+ + I+ + + + + + C G L+G C+++ W PAC+ Sbjct: 1658 CSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHSWDAPVPACQ 1717 Query: 410 YVDCGPLPEIEHGGIILSEQRTSFGVQASYTCHENYTLIGNE--NRTCQASG-WS--GTQ 464 + CG +GGI+ ++ G + +Y C++ Y L E TCQ+ G WS Sbjct: 1718 AISCGIPKAPTNGGILTTDYLV--GTRVTYFCNDGYRLSSKELTTATCQSDGTWSNHNKT 1775 Query: 465 PKCLIDWCP--EPPPIQGGRIKV---SGRRAGSTALYTCDYGFVLIGEPVLSCGLGGNWT 519 P+C++ CP + GR ++ S + +++CD G+ +G + C G W+ Sbjct: 1776 PRCVVVTCPSINSFTLDHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWS 1835 Query: 520 GKI--PVCRYVDCGMPARPDRGNMLLLNDSTTVGSVVRYFCDDDYWLVGPQELYCTKDGK 577 + P C+ + CG P GN + T+ GS + CD + LVG C G Sbjct: 1836 WRTERPYCQIISCGELPTPPNGNK--IGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGL 1893 Query: 578 WSGSAPACELITCETPHVPPGSYVIGYDYNIHSSIQYHCDPGHILRGEDTLTCLESGQWS 637 WSGS C C P + VIG +Y ++ Y C+PG L G C + WS Sbjct: 1894 WSGSETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWS 1953 Query: 638 GDAPDCEYVDCG-PLTPIPFGSHRYTQNTTFLGSEVVYSCANSHRLAGVNRRLCLDTGLW 696 G P C V CG P +PI +G R + N V +SC + + G + C W Sbjct: 1954 GQLPSCVPVSCGHPGSPI-YG--RTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQW 2010 Query: 697 SETAPRCEEIRCTEPTLTPHSFVSVTGNDRMYGRTLIRTSDATVSGAQTFRVGALAKYRC 756 S P C+ + C++P + +S + G F G + Y C Sbjct: 2011 SHPPPVCKVVNCSDPGIPANS----------------KRESKIEHG--NFTYGTVVFYDC 2052 Query: 757 ERGYKIVGEALITCEENGLWSGEIPECVYVDCEMPQNVTHGKVTLATNATYYGAAALYEC 816 GY + G +++ C+ NG W +PEC+ +DC P L+ +G+ Y C Sbjct: 2053 NPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPG--IPPNAVLSGEKYTFGSTVHYSC 2110 Query: 817 DGNFKLDGVSRRLCLEDGTWSHETPACVEITCNEMNVSDALLVSYGSR-----RVGVQAE 871 G L G + R C +G WS P C T D +GSR R Sbjct: 2111 TGKRSLLGQASRTCQLNGHWSGSQPHCSGDTTG--TCGDPGTPGHGSRQESDFRTKSTVR 2168 Query: 872 FSCSKGRYMVGNGTRTCLPTGHWSGRNPVCKLIDCGRPADIENGRVIVVNESTVYGGSAE 931 F+C G + G+ RTCL G W+GR P CK + CG P NG+V + + T + S Sbjct: 2169 FACDTGYILYGSEERTCLSNGSWTGRQPECKAVQCGNPGTTANGKVFRI-DGTTFSSSVI 2227 Query: 932 YHCVPHYNRIGPYLRKCMDDGKWSGEEPRCELI 964 Y C+ Y GP +R+C +G WSG P C +I Sbjct: 2228 YSCLEGYILSGPSVRQCTANGTWSGSLPNCTII 2260 Score = 278 bits (710), Expect = 4e-074 Identities = 186/662 (28%), Positives = 282/662 (42%), Gaps = 65/662 (9%) Query: 353 LSCGSPEALVNTTIVGRNYTVGANITYQCPVGHSLIGVEMRTCQQNGVWSGTPPACKYVD 412 +SCG N +G + G+ + C +G L+G +R C +G+WSG+ C Sbjct: 1846 ISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSGSETRCLAGH 1905 Query: 413 CGPLPEIEHGGIILSEQRTSFGVQAS--YTCHENYTLIGNENRTCQAS-GWSGTQPKCLI 469 CG +PE+ G ++ E ++G + + Y C+ + LIG+ R CQ WSG P C+ Sbjct: 1906 CG-IPELIVNGQVIGE---NYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVP 1961 Query: 470 DWCPEPPPIQGGRIKVSGRRAGSTALYTCDYGFVLIGEPVLSCGLGGNWTGKIPVCRYVD 529 C P GR +G ++C+ G+++ G C W+ PVC+ V+ Sbjct: 1962 VSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPVCKVVN 2021 Query: 530 C---GMPARPDRGNMLLLNDSTTVGSVVRYFCDDDYWLVGPQELYCTKDGKWSGSAPACE 586 C G+PA R + + + + T G+VV Y C+ Y+L G L C +G+W P C Sbjct: 2022 CSDPGIPANSKRESKIE-HGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI 2080 Query: 587 LITCETPHVPPGSYVIGYDYNIHSSIQYHCDPGHILRGEDTLTCLESGQWSGDAPDCEYV 646 +I C P +PP + + G Y S++ Y C L G+ + TC +G WSG P C Sbjct: 2081 MIDCGHPGIPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQASRTCQLNGHWSGSQPHCSGD 2140 Query: 647 DCGPLTPIPFGSHRYTQNTTF-LGSEVVYSCANSHRLAGVNRRLCLDTGLWSETAPRCEE 705 G H Q + F S V ++C + L G R CL G W+ P C+ Sbjct: 2141 TTGTCGDPGTPGHGSRQESDFRTKSTVRFACDTGYILYGSEERTCLSNGSWTGRQPECKA 2200 Query: 706 IRCTEPTLTPHSFV----------------------------SVTGNDRMYGR----TLI 733 ++C P T + V T N G T+I Sbjct: 2201 VQCGNPGTTANGKVFRIDGTTFSSSVIYSCLEGYILSGPSVRQCTANGTWSGSLPNCTII 2260 Query: 734 RTSDATVSG-----AQTFRVGALAKYRCERGYKIV--GEALITCEENGLWSGEIPECVYV 786 D + F VG Y C+ GY I G + TC NG WSG +P C V Sbjct: 2261 SCGDPGIPANGLRYGDDFVVGQNVSYMCQPGYTIELNGSRVRTCTTNGTWSGVMPTCRAV 2320 Query: 787 DCEMPQNVTHGKVTLATNATYYGAAALYECDGNFKLDGVSRRLCLEDGTWSHETPACVEI 846 C P +++G++ TN +G + Y C ++L + C+ +GTWS E P C+ Sbjct: 2321 TCSTPPQISNGRLE-GTNFD-WGFSISYICSAGYELSFPAVLTCVGNGTWSGEVPQCLPK 2378 Query: 847 TCNEMNVSDALLVSYGSRRVGVQAEFSCSKGRYMVGNGTRTCLPTGHWSGRNPVC---KL 903 C + + S + FSC+ +VG+ TR C G WSG +P C Sbjct: 2379 FCGDPGIPSQGKREGKSFIYQSEVSFSCNSPFILVGSSTRLCQTDGTWSGSSPHCIEPTR 2438 Query: 904 IDCGRPADIENGRVIVVNESTVYG---GS-AEYHCVPHYNRIGPYLRKCMDDGKWSGEEP 959 C P +G +++ +G GS ++HC + G R C+ D WSG +P Sbjct: 2439 TSCENPGVPRHG-----SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQP 2493 Query: 960 RC 961 C Sbjct: 2494 EC 2495 Score = 266 bits (679), Expect = 1e-070 Identities = 182/636 (28%), Positives = 261/636 (41%), Gaps = 104/636 (16%) Query: 352 PLSCGSPEALVNTTIVGRNYTVGANITYQCPVGHSLIGVEMRTCQQNGVWSGTPPACKYV 411 P+SCG P + + G + +T+ C +G+ + G CQ N WS PP CK V Sbjct: 1961 PVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPVCKVV 2020 Query: 412 DCG---------------------------------------------------PLPE-- 418 +C PLPE Sbjct: 2021 NCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI 2080 Query: 419 ---IEHGGI----ILSEQRTSFGVQASYTCHENYTLIGNENRTCQASG-WSGTQPKCLID 470 H GI +LS ++ +FG Y+C +L+G +RTCQ +G WSG+QP C D Sbjct: 2081 MIDCGHPGIPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQASRTCQLNGHWSGSQPHCSGD 2140 Query: 471 ---WCPEPPPIQGGRIKVSGRRAGSTALYTCDYGFVLIGEPVLSCGLGGNWTGKIPVCRY 527 C +P G + S R ST + CD G++L G +C G+WTG+ P C+ Sbjct: 2141 TTGTCGDPGTPGHGSRQESDFRTKSTVRFACDTGYILYGSEERTCLSNGSWTGRQPECKA 2200 Query: 528 VDCGMPARPDRGNMLLLNDSTTVGSVVRYFCDDDYWLVGPQELYCTKDGKWSGSAPACEL 587 V CG P G + + D TT S V Y C + Y L GP CT +G WSGS P C + Sbjct: 2201 VQCGNPGTTANGKVFRI-DGTTFSSSVIYSCLEGYILSGPSVRQCTANGTWSGSLPNCTI 2259 Query: 588 ITCETPHVPPGSYVIGYDYNIHSSIQYHCDPGHI--LRGEDTLTCLESGQWSGDAPDCEY 645 I+C P +P G D+ + ++ Y C PG+ L G TC +G WSG P C Sbjct: 2260 ISCGDPGIPANGLRYGDDFVVGQNVSYMCQPGYTIELNGSRVRTCTTNGTWSGVMPTCRA 2319 Query: 646 VDCGPLTPIPFGSHRYTQNTTFLGSEVVYSCANSHRLAGVNRRLCLDTGLWSETAPRCEE 705 V C TP + R G + Y C+ + L+ C+ G WS P+C Sbjct: 2320 VTCS--TPPQISNGRLEGTNFDWGFSISYICSAGYELSFPAVLTCVGNGTWSGEVPQCLP 2377 Query: 706 IRCTEPTLTPHSFVSVTGNDRMYGRTLIRTSDATVSGAQTFRVGALAKYRCERGYKIVGE 765 C +P + + G++ I S+ + S C + +VG Sbjct: 2378 KFCGDP--------GIPSQGKREGKSFIYQSEVSFS--------------CNSPFILVGS 2415 Query: 766 ALITCEENGLWSGEIPECV---YVDCEMPQNVTHGKVTLATNATYYGAAALYECDGNFKL 822 + C+ +G WSG P C+ CE P HG T G+ + C L Sbjct: 2416 STRLCQTDGTWSGSSPHCIEPTRTSCENPGVPRHGSQN-NTFGFQVGSVVQFHCKKGHLL 2474 Query: 823 DGVSRRLCLEDGTWSHETPACVEITCNE-MNVSDALLVSYGSRRVGVQAEFSCSKGRYMV 881 G + R CL D TWS P C+ +C + + + A +V G ++C G ++ Sbjct: 2475 QGSTTRTCLPDLTWSGIQPECIPHSCKQPESPAHANVVGMDLPSHGYTLIYTCQPGFFLA 2534 Query: 882 GNGT--RTCLPTGHWSGRNPVCK-----LIDCGRPA 910 G GT R C W+G+ PVC+ L+ RPA Sbjct: 2535 G-GTEHRVCRSDNTWTGKVPVCEAGSKILVKDPRPA 2569 Score = 85.1 bits (209), Expect = 4e-016 Identities = 164/787 (20%), Positives = 263/787 (33%), Gaps = 177/787 (22%) Query: 302 DTVLKPTWGKDQPNNYNGEQNCVVLDGGRSWLWNDVGCNLDYLNYICQHNPLSCGSPEAL 361 + +LK G P+ + N V + + + G + + + + +C P Sbjct: 638 EMLLKEVSGSLIPDGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVAT----ACRDPGVP 693 Query: 362 VNTTIVGRNYTVGANITYQCPVGHSLIGVEMRTCQQ---NGVWSGTPPACKYVDCG---- 414 +N T G G + +QC G+ L G E TC Q W +PP C CG Sbjct: 694 MNGTRNGDGREPGDTVVFQCDPGYELQGQERITCIQVENRYFWQPSPPVC-IAPCGGNLT 752 Query: 415 -------------PLPEIE--------HGGIILSEQRTSFGVQASYTC-------HENYT 446 P P + ++S SF ++ +Y N Sbjct: 753 GSSGFILSPNFPHPYPHSRDCDWTISVNTDYVISLAFISFSIEPNYDFLYIYDGPDSNSP 812 Query: 447 LIGN----------------------ENRTCQASGWSGTQPKCLIDWCPEPPPIQGGRIK 484 LIG+ + + +G+ L + C +P I G Sbjct: 813 LIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRL 872 Query: 485 VSGRRAGSTALYTCDYGFVLIGEPVLSCGLGGN----WTGKIPVCRYVDCGMPARPDRGN 540 + GST Y CD G+VL G L+C +G + W +P C + CG + G Sbjct: 873 GMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRVLPSC-HAPCGSRSTGSEGT 931 Query: 541 MLLLNDSTTVGSVVRYFCDDDYWLVGPQELYCTKDGKWSGSAPACELITCETPHVPPGSY 600 +L N V + C Y + P+E + P C + P Sbjct: 932 VLSPNYPKNYS--VDHNCV--YSIAVPKEF----------AVPRTSSTQCSSVPEPRFGR 977 Query: 601 VIGYDYNIHSSIQYHCDPGHILRGEDTLTC----LESGQWSGDAPDCEYVDCG------- 649 IG D+ + S + + C+PG+IL G + C QW+ P C V CG Sbjct: 978 RIGNDFAVGSLVLFECNPGYILHGSRAIRCETVPNSLAQWNDSLPTC-IVPCGGILTKRK 1036 Query: 650 -----PLTPIPFGSHR--YTQNTTFLGSEV---VYSCANSHRLAGVNRRLCLDTGLWSET 699 P P P+ ++ + T G+ + V S A H ++ D G Sbjct: 1037 GTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLD---FYDGG--DNN 1091 Query: 700 APRCEEIRCTEPTLTPHSFVSVTGNDRMYGRTLI----------------------RTSD 737 APR + T PH S + N + ++ I +T Sbjct: 1092 APR---LGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPS 1148 Query: 738 ATVSGAQTFRVGALAKYRCERGYKIVGEALITCEENGL--WSGEIPECVYVDCEMPQNVT 795 + + + VG + ++C++GY + G + ITC + W+ IP C+ C Sbjct: 1149 SGIKVGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICL-AQCG------ 1201 Query: 796 HGKVTLATNATYYGAAALYECDGNFKLDGVSRRLCLEDGTWSHETPACVEITCNEMNVSD 855 + + G GN+ D TW+ + P + +N S Sbjct: 1202 ------GAMSDFSGVILSPGFPGNYPSS--------LDCTWTIKLPIGFGVHLQFVNFST 1247 Query: 856 ALLVSYGSRRVGVQAEFSCSKGRYMVGNGTRTCLPTGHWSGR----------------NP 899 + Y R G +E S GR + T H + Sbjct: 1248 ETIHDYLEVRSG-SSEISTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQ 1306 Query: 900 VCKLIDCGRPADIENGRVIVVNESTVYGGSAEYHCVPHYNRIGPYLRKCMD--DGKWSGE 957 +L C P NG ++ N+ TV G + + C P Y IG C+ W+ Sbjct: 1307 AYQLQSCPDPRPFRNG-FVIGNDFTV-GQTISFECFPGYTLIGNSALTCLHGVSRNWNHP 1364 Query: 958 EPRCELI 964 PRCE + Sbjct: 1365 LPRCEAL 1371 Score = 60.8 bits (146), Expect = 9e-009 Identities = 138/649 (21%), Positives = 220/649 (33%), Gaps = 206/649 (31%) Query: 303 TVLKPTWGKDQPNNYNGEQNCVVLDGGRSWLWNDVGCNLDYLNYICQHNPLSCGS-PEAL 361 TVL P + P NY+ + NCV + ++ + + + C S PE Sbjct: 931 TVLSPNY----PKNYSVDHNCVY----------SIAVPKEFA--VPRTSSTQCSSVPEPR 974 Query: 362 VNTTIVGRNYTVGANITYQCPVGHSLIGVEMRTCQQ--NGV--WSGTPPACKYVDCGPLP 417 I G ++ VG+ + ++C G+ L G C+ N + W+ + P C V CG + Sbjct: 975 FGRRI-GNDFAVGSLVLFECNPGYILHGSRAIRCETVPNSLAQWNDSLPTC-IVPCGGIL 1032 Query: 418 EIEHGGII-------------------------LSEQRTSFGVQASYTCHENYTLIGNEN 452 G I+ + Q SF + ++ + Y G +N Sbjct: 1033 TKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYD--GGDN 1090 Query: 453 RTCQASGWSGTQ-PKCL------------------------------IDWCPEPPPIQGG 481 + +SGT P L +D CPEP G Sbjct: 1091 NAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSG 1150 Query: 482 RIKVSGR-RAGSTALYTCDYGFVLIGEP-------------------------------- 508 IKV R G + CD G+ L G Sbjct: 1151 -IKVGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSG 1209 Query: 509 -VLSCGLGGN--------WTGKIPV-----CRYVDCGMPARPDRGNMLLLNDSTTVGSVV 554 +LS G GN WT K+P+ ++V+ D + + + S+ + +V+ Sbjct: 1210 VILSPGFPGNYPSSLDCTWTIKLPIGFGVHLQFVNFSTETIHDY--LEVRSGSSEISTVI 1267 Query: 555 RYFCDDDYWLVGPQ------------ELYCTKDGKWSGSA-----PACELITCETPHVPP 597 L GPQ LY D + A +L +C P Sbjct: 1268 GR-------LSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFR 1320 Query: 598 GSYVIGYDYNIHSSIQYHCDPGHILRGEDTLTCLE--SGQWSGDAPDCE----------- 644 +VIG D+ + +I + C PG+ L G LTCL S W+ P CE Sbjct: 1321 NGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMN 1380 Query: 645 --------------YVDCGPLTPIPFGSHRYTQNTTFLGSEVVYSC--------ANSHRL 682 + DC L +P G+ Y N T L +E +Y NS ++ Sbjct: 1381 GTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYI-NFTVLQTEPIYDFITVWDGPDQNSPQI 1439 Query: 683 AGVNRRLCLDTGLWSETAPRCEEIRCTEPT-----LTPHSF-VSVTGNDRMYGRTLIRTS 736 + L++ ++S + + T L+ H++ + V I T Sbjct: 1440 GQFSGNTALES-VYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQPPPPVPNAEILTE 1498 Query: 737 DATVSGAQTFRVGALAKYRCERGYKIVGEALITCE--ENGLWSGEIPEC 783 D F +G + +Y+C G+ +VG A++TC E G P C Sbjct: 1499 D------DEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVC 1541 Score = 50.8 bits (120), Expect = 9e-006 Identities = 105/475 (22%), Positives = 164/475 (34%), Gaps = 133/475 (28%) Query: 540 NMLLLNDSTTVGSVVRYFCDDDYWLV-GPQELYCT-KDGK--WSGSAPACELITCETPHV 595 N D+ +GS + C++ + G + + C DGK WSG P C C Sbjct: 1 NARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGPIPRCGA-PCGGHFS 59 Query: 596 PPGSYVIG------YDYNIHSSIQYHCDPGHILRGEDTLTCLESGQWSGDAPDCEYVDCG 649 P ++ Y +++ +PGH ++ E Q + E D G Sbjct: 60 APSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIK-----ITFERFQTELNYDVLEVHD-G 113 Query: 650 P--LTPIPFGSHRYTQNTTFLGSE-----VVYSCANSHRLAGVNRRLCLDTGLWSETAPR 702 P L+P+ GS+ TQ FL S ++++ NS G + Sbjct: 114 PNLLSPL-LGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHY---------ESVT 163 Query: 703 CEEIRCTEPTLTPHSFVSVTGNDRMYGRTLIRTSDATVSGAQTFRVGALAKYRCERGYKI 762 C +P + H R YG F +G+ + C+ GY++ Sbjct: 164 VNTYSCLDPGIPVHG--------RRYGHD--------------FSIGSTVSFSCDPGYRL 201 Query: 763 VGEALITCEENGLWSGEIPEC-------------------------VYVDCEMPQNVTHG 797 E + CE+N WS +P C ++C +VTHG Sbjct: 202 SHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHG 261 Query: 798 K-----------------VTLATNATYYGA--------------AALYECDGNFKLDGVS 826 K + + N ++ A LY GNF+ + Sbjct: 262 KGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSELPSTINAGLY---GNFR----A 314 Query: 827 RRLCLEDGTWSHETPACVEITCNEMNV---SDALLVSYGSR-----RVGVQAEFSCSKGR 878 + + D + S+E IT +E N+ D + YGSR VG FSCS G Sbjct: 315 QLRFISDFSISYEG---FNITFSEYNLEPCEDPGIPQYGSRVGFSFGVGDTLTFSCSLGY 371 Query: 879 YMVGNGTRTCLPTGH--WSGRNPVCKLIDCGRPADIENGRVIVVNESTVYGGSAE 931 + G+ CL G WS P C + +CG A G ++ N Y + E Sbjct: 372 RLEGSSEIICLGGGRRVWSAPLPRC-VAECGASATNNEGILLSPNYPLNYENNHE 425 Score = 49.7 bits (117), Expect = 2e-005 Identities = 89/428 (20%), Positives = 145/428 (33%), Gaps = 98/428 (22%) Query: 351 NPLSCGSPEALVNTTIVGRNYTVGANITYQCPVGHSLIGVEMRTCQQNGVWSGTPPACKY 410 N SC P V+ G ++++G+ +++ C G+ L E C++N WS P C Sbjct: 165 NTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDPGYRLSHEEPLLCEKNHWWSHPLPTCDA 224 Query: 411 VDCGPLPEIEHGGIILSEQRTSF-----------------GVQASYTC-----HENYTLI 448 + G + G ILS F GVQ ++ H +Y LI Sbjct: 225 LCGGDVR--GPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLI 282 Query: 449 GNENRTCQA-----------------------------------SGWSGTQPKCLIDWCP 473 Q G++ T + ++ C Sbjct: 283 TENGSFTQPLARLTGSELPSTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCE 342 Query: 474 EPP-PIQGGRIKVSGRRAGSTALYTCDYGFVLIGEPVLSCGLGGN--WTGKIPVCRYVDC 530 +P P G R+ S G T ++C G+ L G + C GG W+ +P C +C Sbjct: 343 DPGIPQYGSRVGFS-FGVGDTLTFSCSLGYRLEGSSEIICLGGGRRVWSAPLPRC-VAEC 400 Query: 531 GMPARPDRGNMLLLNDSTTVGSVVRYFCDDDYWLVGPQELYCTKDGKWSGSAPACELITC 590 G A + G +LL+ + + + C +Y + G I+ Sbjct: 401 GASATNNEG--ILLSPNYPLNYENNHEC-----------IYSLQVQAGKGIN-----ISA 442 Query: 591 ETPHVPPGSYVIGYDYNIHSSIQYHCDPGHILRGEDTLTCLESGQWSGDAPDCEYVDCG- 649 T H+ G + YD ++ G +RG TL+ + W D E D G Sbjct: 443 RTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGL-TLSSTSNQLWLEFNSDSEGTDEGF 501 Query: 650 ------------PLTPIPFGSHRYTQNTTFLGSEVVYSCANSHRLAGVNRRLCL--DTGL 695 IP ++ + F GS ++Y C + L G + C+ + Sbjct: 502 QLVYTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRA 561 Query: 696 WSETAPRC 703 W P C Sbjct: 562 WDYPLPSC 569 Score = 49.3 bits (116), Expect = 3e-005 Identities = 22/58 (37%), Positives = 30/58 (51%) Query: 2 CGPPAVPANARVHTEKATDGSGGLKSARYDCDPGYELFGSETIRCDPVKGWDRELPFC 59 C P +PAN++ ++ YDC+PGY LFGS + C P WD+ LP C Sbjct: 2022 CSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPEC 2079 Score = 40.0 bits (92), Expect = 0.016 Identities = 24/67 (35%), Positives = 31/67 (46%), Gaps = 4/67 (5%) Query: 586 ELITCETPHVPPGSYVIG-YDYNIHSSIQYHCDPGHILRGEDTLTCL--ESGQWSGDAPD 642 EL CE P +P Y I + S+I Y C+PG+ L G L C+ E W P Sbjct: 509 ELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPS 568 Query: 643 CEYVDCG 649 C +CG Sbjct: 569 C-IAECG 574 Score = 38.5 bits (88), Expect = 0.047 Identities = 18/58 (31%), Positives = 26/58 (44%), Gaps = 4/58 (6%) Query: 2 CGPPAVPANARVHTEKATDGSGGLKSARYDCDPGYELFGSETIRCDPVKGWDRELPFC 59 C P +P + R + + GS + + CDPGY L E + C+ W LP C Sbjct: 169 CLDPGIPVHGRRYGHDFSIGS----TVSFSCDPGYRLSHEEPLLCEKNHWWSHPLPTC 222 Score = 38.1 bits (87), Expect = 0.061 Identities = 23/63 (36%), Positives = 31/63 (49%), Gaps = 4/63 (6%) Query: 472 CPEPP-PIQGGRIKVSGRRAGSTALYTCDYGFVLIGEPVLSCGLGGN--WTGKIPVCRYV 528 C +P P G +I G AGST +Y C+ G+ L G +L C G W +P C Sbjct: 513 CEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC-IA 571 Query: 529 DCG 531 +CG Sbjct: 572 ECG 574 ==> MGI|MGI:2137383 - symbol:Csmd1 "CUB and Sushi multiple domains 1" species:10090 "Mus musculus" [GO:0005615 "extracellular space" evidence=RCA] [GO:0016021 "integral to membrane" evidence=RCA] [GO:0003674 "molecular_function" evidence=ND] [GO:0008150 "biological_process" evidence=ND] MGI:MGI:2137383 InterPro:IPR000859 InterPro:IPR000436 Pfam:PF00084 SMART:SM00032 PROSITE:PS50923 Pfam:PF00431 SMART:SM00042 PROSITE:PS01180 HSSP:Q9UCV4 EMBL:AY017475 EMBL:AK038679 EMBL:AK082377 UniGene:Mm.419813 Ensembl:ENSMUSG00000060924 ArrayExpress:Q923L3 GermOnline:ENSMUSG00000060924 Uniprot:Q923L3 Length = 3564 Score = 273 bits (698), Expect = 9e-073 Identities = 181/627 (28%), Positives = 264/627 (42%), Gaps = 46/627 (7%) Query: 352 PLSCGSPEALVNTTIVGRNYTVGANITYQCPVGHSLIGVEMRTCQQNGVWSGTPPACKYV 411 P++CG P + G + + + + C G+ L G C+ NG WS P C+ V Sbjct: 2735 PITCGHPGNPAHGLTNGTEFNLNDLVNFTCHTGYRLQGASRAQCRSNGQWSSPLPICRVV 2794 Query: 412 DCGPLPEIE----HGGIILSEQRTSFGVQASYTCHENYTLIGNENRTCQASG-WSGTQPK 466 +C +E HG E +G Y C + L+G+ TC ASG W + PK Sbjct: 2795 NCSDPGSVENAVRHGQQNFPES-FEYGTSVMYHCKTGFYLLGSSALTCMASGLWDRSLPK 2853 Query: 467 CLIDWCPEPPPIQGGRIKVSGRRAGSTALYTCDYGFVLIGEPVLSCGLGGNWTGKIPVCR 526 CL C P + G+T Y+C G +L G C +W+G +P C Sbjct: 2854 CLAISCGHPGVPANAVLTGELFTYGATVQYSCKGGQILTGNSTRVCQEDSHWSGSLPHCS 2913 Query: 527 YVD---CGMPARPDRGNMLLLNDSTTVGSVVRYFCDDDYWLVGPQELYCTKDGKWSGSAP 583 CG P P G+ L D S++R+ C+ + L G E C +G WSG P Sbjct: 2914 GNSPGFCGDPGTPAHGSR--LGDEFKTKSLLRFSCEMGHQLRGFAERTCLVNGSWSGVQP 2971 Query: 584 ACELITCETPHVPPGSYVIGYD-YNIHSSIQYHCDPGHILRGEDTLTCLESGQWSGDAPD 642 CE ++C P P ++ D SS+ Y C G+ G T C +G W+G APD Sbjct: 2972 VCEAVSCGNPGTPTNGMILSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPD 3031 Query: 643 CEYVDCGPLTPIPFGSHRYTQNTTFLGSEVVYSCANSHRLAGVNRRL--CLDTGLWSETA 700 C + CG +P G T T V Y C + + C G W+++ Sbjct: 3032 CTIISCGDPGTLPNGIQFGTDFT--FNKTVSYQCNPGYLMEPPTSPTIRCTKDGTWNQSR 3089 Query: 701 PRCEEIRCTEPTLTPHSFVSVTGNDRMYGRTLIRTSDATVSGAQTFRVGALAKYRCERGY 760 P C+ + C +P P+ V G+D FR GA Y C GY Sbjct: 3090 PLCKAVLCNQPPPVPNG--KVEGSD--------------------FRWGASISYSCVDGY 3127 Query: 761 KIVGEALITCEENGLWSGEIPECVYVDCEMPQNVTHGKVTLATNATYYGAAALYECDGNF 820 ++ A+++CE G+W GE+P+C+ V C P G+ L+ + + + +C F Sbjct: 3128 QLSHSAILSCEGRGVWKGEVPQCLPVFCGDPGTPAEGR--LSGKSFTFKSEVFIQCKPPF 3185 Query: 821 KLDGVSRRLCLEDGTWSHETPACVE---ITCNEMNVSD-ALLVSYGSRRVGVQAEFSCSK 876 L G SRR C DG WS P C++ C + + S VG F C K Sbjct: 3186 VLVGSSRRTCQADGIWSGIQPTCIDPAHTACPDPGTPHFGIQNSSKGYEVGSTVFFRCRK 3245 Query: 877 GRYMVGNGTRTCLPTGHWSGRNPVCKLIDCGRPADIENGRVIVVNESTVYGGSAEYHCVP 936 G ++ G+ TRTCL WSG C C +P + V + + +G + Y C P Sbjct: 3246 GYHIQGSTTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAI-DLPAFGYTLVYTCHP 3304 Query: 937 HYNRI-GPYLRKCMDDGKWSGEEPRCE 962 + G R C D KW+G+ P C+ Sbjct: 3305 GFFLAGGSEHRTCKADMKWTGKSPVCK 3331 Score = 270 bits (690), Expect = 7e-072 Identities = 190/682 (27%), Positives = 290/682 (42%), Gaps = 77/682 (11%) Query: 342 DYLNYICQHNPLSCGSPEALVNTTIVGRNYTVGANITYQCPVGHSLIGVEMRT--CQQNG 399 D + +CQ +SCG PEA N + G +T+ + +TY+C G L + T CQ++G Sbjct: 2484 DSMAPLCQ--AVSCGIPEAPGNGSFTGNEFTLDSKVTYECNEGFKLDASQEATTVCQEDG 2541 Query: 400 VWS--GTPPACKYVDCGPLPEIEHGGI-------ILSEQRTSFGVQASYTCHENYTLIGN 450 +WS G PP CK V C P IE G + ++S +G Q +C Y L G Sbjct: 2542 LWSNRGKPPTCKPVPC---PSIE-GQLSEHVLWRLVSGSLNEYGAQVLLSCSPGYFLQGQ 2597 Query: 451 ENRTCQASG-WSGTQ--PKCLIDWCPEPP-PIQGGRIKVSGRRAGSTALYTCDYGFVLIG 506 CQA+G WS + P+C + C P G +I G+TA++TC+ G+ L+G Sbjct: 2598 RLLQCQANGTWSTEEDRPRCKVISCGSLSFPPNGNKIGTL-TIYGATAIFTCNTGYTLVG 2656 Query: 507 EPVLSCGLGGNWTGKIPVCRYVDCGMPARPDRGNMLLLNDSTTVGSVVRYFCDDDYWLVG 566 V C G W+G C CG P G+ + D + V Y C+ + LVG Sbjct: 2657 SHVRECLANGLWSGSETRCLAGHCGSPDPIVNGH--ISGDGFSYRDTVVYQCNPGFRLVG 2714 Query: 567 PQELYCTKDGKWSGSAPACELITCETPHVPPGSYVIGYDYNIHSSIQYHCDPGHILRGED 626 C + G C ITC P P G ++N++ + + C G+ L+G Sbjct: 2715 TSVRICCRTTSGRGRLTVCVPITCGHPGNPAHGLTNGTEFNLNDLVNFTCHTGYRLQGAS 2774 Query: 627 TLTCLESGQWSGDAPDCEYVDCGP----LTPIPFGSHRYTQNTTFLGSEVVYSCANSHRL 682 C +GQWS P C V+C + G + ++ + G+ V+Y C L Sbjct: 2775 RAQCRSNGQWSSPLPICRVVNCSDPGSVENAVRHGQQNFPESFEY-GTSVMYHCKTGFYL 2833 Query: 683 AGVNRRLCLDTGLWSETAPRCEEIRCTEPTLTPHSFVSVTGNDRMYGRTL--------IR 734 G + C+ +GLW + P+C I C P + ++ +TG YG T+ I Sbjct: 2834 LGSSALTCMASGLWDRSLPKCLAISCGHPGVPANAV--LTGELFTYGATVQYSCKGGQIL 2891 Query: 735 TSDAT---------------VSG------------------AQTFRVGALAKYRCERGYK 761 T ++T SG F+ +L ++ CE G++ Sbjct: 2892 TGNSTRVCQEDSHWSGSLPHCSGNSPGFCGDPGTPAHGSRLGDEFKTKSLLRFSCEMGHQ 2951 Query: 762 IVGEALITCEENGLWSGEIPECVYVDCEMPQNVTHGKVTLATNATYYGAAALYECDGNFK 821 + G A TC NG WSG P C V C P T+G + L+++ + ++ +Y C +K Sbjct: 2952 LRGFAERTCLVNGSWSGVQPVCEAVSCGNPGTPTNGMI-LSSDGILFSSSVIYACWEGYK 3010 Query: 822 LDGVSRRLCLEDGTWSHETPACVEITCNEMNVSDALLVSYGSRRVGVQAEFSCSKGRYM- 880 G+ R C +GTW+ P C I+C + + + C+ G M Sbjct: 3011 TSGLMTRHCTANGTWTGTAPDCTIISCGDPGTLPNGIQFGTDFTFNKTVSYQCNPGYLME 3070 Query: 881 -VGNGTRTCLPTGHWSGRNPVCKLIDCGRPADIENGRVIVVNESTVYGGSAEYHCVPHYN 939 + T C G W+ P+CK + C +P + NG+ V +G S Y CV Y Sbjct: 3071 PPTSPTIRCTKDGTWNQSRPLCKAVLCNQPPPVPNGK--VEGSDFRWGASISYSCVDGYQ 3128 Query: 940 RIGPYLRKCMDDGKWSGEEPRC 961 + C G W GE P+C Sbjct: 3129 LSHSAILSCEGRGVWKGEVPQC 3150 Score = 269 bits (687), Expect = 2e-071 Identities = 189/656 (28%), Positives = 274/656 (41%), Gaps = 66/656 (10%) Query: 355 CGSPEALVNTTIVGRNY-TVGANITYQCPVGHSLIGVEMRTCQQNGV----WSGTPPACK 409 C L N I+ + VG+ + Y C G+ +IG TC++N V W P C+ Sbjct: 2432 CSLTSTLRNGGILNKTAGAVGSKVHYFCKPGYRMIGHSNATCRRNPVGVYQWDSMAPLCQ 2491 Query: 410 YVDCGPLPEIEHGGIILSEQRTSFGVQASYTCHENYTLIGNENRT--CQASG-WS--GTQ 464 V CG +PE G + T + +Y C+E + L ++ T CQ G WS G Sbjct: 2492 AVSCG-IPEAPGNGSFTGNEFT-LDSKVTYECNEGFKLDASQEATTVCQEDGLWSNRGKP 2549 Query: 465 PKCLIDWCPEPPPIQGGRIK-------VSG--RRAGSTALYTCDYGFVLIGEPVLSCGLG 515 P C P P P G++ VSG G+ L +C G+ L G+ +L C Sbjct: 2550 PTCK----PVPCPSIEGQLSEHVLWRLVSGSLNEYGAQVLLSCSPGYFLQGQRLLQCQAN 2605 Query: 516 GNWTGK--IPVCRYVDCGMPARPDRGNMLLLNDSTTVGSVVRYFCDDDYWLVGPQELYCT 573 G W+ + P C+ + CG + P GN + T G+ + C+ Y LVG C Sbjct: 2606 GTWSTEEDRPRCKVISCGSLSFPPNGNK--IGTLTIYGATAIFTCNTGYTLVGSHVRECL 2663 Query: 574 KDGKWSGSAPACELITCETPHVPPGSYVIGYDYNIHSSIQYHCDPGHILRGEDTLTCLES 633 +G WSGS C C +P ++ G ++ ++ Y C+PG L G C + Sbjct: 2664 ANGLWSGSETRCLAGHCGSPDPIVNGHISGDGFSYRDTVVYQCNPGFRLVGTSVRICCRT 2723 Query: 634 GQWSGDAPDCEYVDCG-PLTPIPFGSHRYTQNTTF-LGSEVVYSCANSHRLAGVNRRLCL 691 G C + CG P P +H T T F L V ++C +RL G +R C Sbjct: 2724 TSGRGRLTVCVPITCGHPGNP----AHGLTNGTEFNLNDLVNFTCHTGYRLQGASRAQCR 2779 Query: 692 DTGLWSETAPRCEEIRCTEPTLTPHSFVSVTGNDRMYGRTLIRTSDATVSGAQTFRVGAL 751 G WS P C + C++P G + ++F G Sbjct: 2780 SNGQWSSPLPICRVVNCSDP-----------------GSVENAVRHGQQNFPESFEYGTS 2822 Query: 752 AKYRCERGYKIVGEALITCEENGLWSGEIPECVYVDCEMPQNVTHGKVTLATNATYYGAA 811 Y C+ G+ ++G + +TC +GLW +P+C+ + C P L YGA Sbjct: 2823 VMYHCKTGFYLLGSSALTCMASGLWDRSLPKCLAISCGHPG--VPANAVLTGELFTYGAT 2880 Query: 812 ALYECDGNFKLDGVSRRLCLEDGTWSHETPACVEITCNEMN-VSDALLVSYGSR-----R 865 Y C G L G S R+C ED WS P C + N D ++GSR + Sbjct: 2881 VQYSCKGGQILTGNSTRVCQEDSHWSGSLPHC---SGNSPGFCGDPGTPAHGSRLGDEFK 2937 Query: 866 VGVQAEFSCSKGRYMVGNGTRTCLPTGHWSGRNPVCKLIDCGRPADIENGRVIVVNESTV 925 FSC G + G RTCL G WSG PVC+ + CG P NG +I+ ++ + Sbjct: 2938 TKSLLRFSCEMGHQLRGFAERTCLVNGSWSGVQPVCEAVSCGNPGTPTNG-MILSSDGIL 2996 Query: 926 YGGSAEYHCVPHYNRIGPYLRKCMDDGKWSGEEPRCELIVNDAQETNSLGTGIAIG 981 + S Y C Y G R C +G W+G P C +I + +L GI G Sbjct: 2997 FSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTII--SCGDPGTLPNGIQFG 3050 Score = 266 bits (679), Expect = 1e-070 Identities = 175/619 (28%), Positives = 255/619 (41%), Gaps = 40/619 (6%) Query: 353 LSCGSPEALVNTTIVGRNYTVGANITYQCPVGHSLIGVEMRTCQQNGVWSGTPPACKYVD 412 +SCGS N +G GA + C G++L+G +R C NG+WSG+ C Sbjct: 2620 ISCGSLSFPPNGNKIGTLTIYGATAIFTCNTGYTLVGSHVRECLANGLWSGSETRCLAGH 2679 Query: 413 CGPLPEIEHGGIILSEQRTSFGVQASYTCHENYTLIGNENRTC-QASGWSGTQPKCLIDW 471 CG I +G I S S+ Y C+ + L+G R C + + G C+ Sbjct: 2680 CGSPDPIVNGHI--SGDGFSYRDTVVYQCNPGFRLVGTSVRICCRTTSGRGRLTVCVPIT 2737 Query: 472 CPEPPPIQGGRIKVSGRRAGSTALYTCDYGFVLIGEPVLSCGLGGNWTGKIPVCRYVDCG 531 C P G + +TC G+ L G C G W+ +P+CR V+C Sbjct: 2738 CGHPGNPAHGLTNGTEFNLNDLVNFTCHTGYRLQGASRAQCRSNGQWSSPLPICRVVNCS 2797 Query: 532 MPARPD---RGNMLLLNDSTTVGSVVRYFCDDDYWLVGPQELYCTKDGKWSGSAPACELI 588 P + R +S G+ V Y C ++L+G L C G W S P C I Sbjct: 2798 DPGSVENAVRHGQQNFPESFEYGTSVMYHCKTGFYLLGSSALTCMASGLWDRSLPKCLAI 2857 Query: 589 TCETPHVPPGSYVIGYDYNIHSSIQYHCDPGHILRGEDTLTCLESGQWSGDAPDCEYVD- 647 +C P VP + + G + +++QY C G IL G T C E WSG P C Sbjct: 2858 SCGHPGVPANAVLTGELFTYGATVQYSCKGGQILTGNSTRVCQEDSHWSGSLPHCSGNSP 2917 Query: 648 --CG-PLTPIPFGSHRYTQNTTFLGSEVVYSCANSHRLAGVNRRLCLDTGLWSETAPRCE 704 CG P TP GS + T S + +SC H+L G R CL G WS P CE Sbjct: 2918 GFCGDPGTP-AHGSRLGDEFKT--KSLLRFSCEMGHQLRGFAERTCLVNGSWSGVQPVCE 2974 Query: 705 EIRCTEPTLTPHSFVSVTGNDRMYGRTLIRTSDATVSGAQTFRVGALAKYRCERGYKIVG 764 + C P TP + + ++ + ++ ++I Y C GYK G Sbjct: 2975 AVSCGNPG-TPTNGMILSSDGILFSSSVI--------------------YACWEGYKTSG 3013 Query: 765 EALITCEENGLWSGEIPECVYVDCEMPQNVTHGKVTLATNATYYGAAALYECDGNFKLDG 824 C NG W+G P+C + C P + +G + T+ T + Y+C+ + ++ Sbjct: 3014 LMTRHCTANGTWTGTAPDCTIISCGDPGTLPNG-IQFGTDFT-FNKTVSYQCNPGYLMEP 3071 Query: 825 VSRRL--CLEDGTWSHETPACVEITCNEMNVSDALLVSYGSRRVGVQAEFSCSKGRYMVG 882 + C +DGTW+ P C + CN+ V R G +SC G + Sbjct: 3072 PTSPTIRCTKDGTWNQSRPLCKAVLCNQPPPVPNGKVEGSDFRWGASISYSCVDGYQLSH 3131 Query: 883 NGTRTCLPTGHWSGRNPVCKLIDCGRPADIENGRVIVVNESTVYGGSAEYHCVPHYNRIG 942 + +C G W G P C + CG P GR + +S + C P + +G Sbjct: 3132 SAILSCEGRGVWKGEVPQCLPVFCGDPGTPAEGR--LSGKSFTFKSEVFIQCKPPFVLVG 3189 Query: 943 PYLRKCMDDGKWSGEEPRC 961 R C DG WSG +P C Sbjct: 3190 SSRRTCQADGIWSGIQPTC 3208 Score = 184 bits (466), Expect = 7e-046 Identities = 126/442 (28%), Positives = 176/442 (39%), Gaps = 34/442 (7%) Query: 350 HNPLSCGSPEALVNTTIVGRNYTVGANITYQCPVGHSLIGVEMRTCQQNGVWSGTPPACK 409 ++P CG P + + +G + + + + C +GH L G RTC NG WSG P C+ Sbjct: 2915 NSPGFCGDPGTPAHGSRLGDEFKTKSLLRFSCEMGHQLRGFAERTCLVNGSWSGVQPVCE 2974 Query: 410 YVDCGPLPEIEHGGIILSEQRTSFGVQASYTCHENYTLIGNENRTCQASG-WSGTQPKCL 468 V CG P G+ILS F Y C E Y G R C A+G W+GT P C Sbjct: 2975 AVSCGN-PGTPTNGMILSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCT 3033 Query: 469 IDWCPEPPPIQGGRIKVSGRRAGSTALYTCDYGFVL--IGEPVLSCGLGGNWTGKIPVCR 526 I C +P + G + T Y C+ G+++ P + C G W P+C+ Sbjct: 3034 IISCGDPGTLPNGIQFGTDFTFNKTVSYQCNPGYLMEPPTSPTIRCTKDGTWNQSRPLCK 3093 Query: 527 YVDCGMPARPDRGNMLLLNDSTTVGSVVRYFCDDDYWLVGPQELYCTKDGKWSGSAPACE 586 V C P P N + G+ + Y C D Y L L C G W G P C Sbjct: 3094 AVLCNQP--PPVPNGKVEGSDFRWGASISYSCVDGYQLSHSAILSCEGRGVWKGEVPQCL 3151 Query: 587 LITCETPHVPPGSYVIGYDYNIHSSIQYHCDPGHILRGEDTLTCLESGQWSGDAPDCEYV 646 + C P P + G + S + C P +L G TC G WSG P C + Sbjct: 3152 PVFCGDPGTPAEGRLSGKSFTFKSEVFIQCKPPFVLVGSSRRTCQADGIWSGIQPTC--I 3209 Query: 647 D-CGPLTPIPFGSHRYTQNTT---FLGSEVVYSCANSHRLAGVNRRLCLDTGLWSETAPR 702 D P P H QN++ +GS V + C + + G R CL WS Sbjct: 3210 DPAHTACPDPGTPHFGIQNSSKGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTE 3269 Query: 703 CEEIRCTEPTLTPHSFVSVTGNDRMYGRTLIRTSDATVSGAQTFRVGALAKYRCERGYKI 762 C C +P H+ V + +G TL+ Y C G+ + Sbjct: 3270 CIPHACRQPETPAHADVRAI-DLPAFGYTLV--------------------YTCHPGFFL 3308 Query: 763 V-GEALITCEENGLWSGEIPEC 783 G TC+ + W+G+ P C Sbjct: 3309 AGGSEHRTCKADMKWTGKSPVC 3330 Score = 154 bits (390), Expect = 4e-037 Identities = 171/665 (25%), Positives = 260/665 (39%), Gaps = 98/665 (14%) Query: 335 NDVGCNLDYLNYICQHNPLSCGSPEALVNTTIVGRNYTVGANITYQCPVGHSLIGVEMRT 394 N G L Y Y Q+ C P A N ++ +Y+VG +I+++C G+ L+G + T Sbjct: 2071 NRQGFKLSYQAYELQN----CPDPPAFQNGFMINSDYSVGQSISFECYPGYILLGHPVLT 2126 Query: 395 CQQ--NGVWSGTPPACKYVDCGPLPEIEHGGI----------ILSEQRTSFGVQASYTCH 442 CQ + W+ P C CG ++G I IL + V + + Sbjct: 2127 CQHGTDRNWNYPFPRCD-APCGYNVTSQNGTIYSPGFPDEYPILKDCLWLVTVPPGHGVY 2185 Query: 443 ENYTLIGNENRTCQASGWSGTQPKCLIDWCPEPPPIQGGRIKVSGRRAGSTALYTCDYGF 502 N+TL+ E + W G P+ Q G SG A TA + + Sbjct: 2186 INFTLLQTEAVNDYIAVWDG----------PDQNSPQLG--VFSGNTAPETAYSSTNQVL 2233 Query: 503 VLIGEPVLSCGLGGNWTGKIPVCRYVDCGMPARPDRGNMLLLNDSTTVGSVVRYFCDDDY 562 + + GG + + C P + ++L ++ +G V+Y C Y Sbjct: 2234 LKFHSDFSN---GGFFVLNFHAFQLKRCPPPPAVPQADLLTEDEDFEIGDFVKYQCHPGY 2290 Query: 563 WLVGPQELYCTKDGK--WSGSAPACELITCETPHVPPGSYVI----GYDYNIHSSIQYHC 616 L+G L C + + GS P CE C V S + GY N +S C Sbjct: 2291 TLLGSDTLTCKLSSQLLFQGSPPTCE-AQCPANEVRTESSGVILSPGYPGNYFNS--QTC 2347 Query: 617 DPGHILRGEDTLTCLESGQWSGDAPDCEYVDCG-----PLTPIPFGSHRYTQNTTFLGSE 671 ++ +T S D V G PL + G+H N T + Sbjct: 2348 AWSIKVKPNFNITLFVDTFQSEKQFDALEVFDGSSGRSPLLVVLSGNHTEQSNFTSRSNH 2407 Query: 672 VVYSCANSHRLAGVNRRLCLDTGLWSETAPRCEEIRCTEPTLTPHSFVSVTGNDRMYGRT 731 + + H T+ + +IR P + S+T R G Sbjct: 2408 LYLRWSTDH-----------------ATSKKGFKIRYAAP------YCSLTSTLR-NGGI 2443 Query: 732 LIRTSDATVSGAQTFRVGALAKYRCERGYKIVGEALITCEENGL----WSGEIPECVYVD 787 L +T+ A VG+ Y C+ GY+++G + TC N + W P C V Sbjct: 2444 LNKTAGA---------VGSKVHYFCKPGYRMIGHSNATCRRNPVGVYQWDSMAPLCQAVS 2494 Query: 788 CEMPQNVTHGKVTLATNATYYGAAALYECDGNFKLDG--VSRRLCLEDGTWSH--ETPAC 843 C +P+ +G T N + YEC+ FKLD + +C EDG WS+ + P C Sbjct: 2495 CGIPEAPGNGSFT--GNEFTLDSKVTYECNEGFKLDASQEATTVCQEDGLWSNRGKPPTC 2552 Query: 844 VEITCN--EMNVSDAL---LVSYGSRRVGVQAEFSCSKGRYMVGNGTRTCLPTGHWSGR- 897 + C E +S+ + LVS G Q SCS G ++ G C G WS Sbjct: 2553 KPVPCPSIEGQLSEHVLWRLVSGSLNEYGAQVLLSCSPGYFLQGQRLLQCQANGTWSTEE 2612 Query: 898 -NPVCKLIDCGRPADIENGRVIVVNESTVYGGSAEYHCVPHYNRIGPYLRKCMDDGKWSG 956 P CK+I CG + NG I T+YG +A + C Y +G ++R+C+ +G WSG Sbjct: 2613 DRPRCKVISCGSLSFPPNGNKI--GTLTIYGATAIFTCNTGYTLVGSHVRECLANGLWSG 2670 Query: 957 EEPRC 961 E RC Sbjct: 2671 SETRC 2675 Score = 66.2 bits (160), Expect = 2e-010 Identities = 66/281 (23%), Positives = 106/281 (37%), Gaps = 72/281 (25%) Query: 530 CGMPARPDRGNMLLLNDSTTVGSVVRYFCDDDYWLVGPQELYCTKD----GKWSGSAPAC 585 C P PD G VG+ V++ C+D+Y L G + + C + W+ P C Sbjct: 349 CPDPGIPDNGRRA--GSDFRVGANVQFSCEDNYVLQGAKGITCQRVTETLAAWNDHRPIC 406 Query: 586 ELITCETPHVPPGSYVIGYDYNIHSSIQYHC-------DPGHIL----------RGEDTL 628 TC + P + +Y + HC DP ++ RG DTL Sbjct: 407 RARTCGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTL 466 Query: 629 TCLESGQWSGDAPDCEYVDCGPLTPIPFGSHRYTQNTTFLGSEVVYSCANSHRLAGVNRR 688 T ++G+ GD YV G P +++ S +N L Sbjct: 467 TVGDAGK-VGDTRSVLYVLTGSSVP-----------------DLIVSMSNQMWL-----H 503 Query: 689 LCLDTGLWS----ETAPRCEEIRCTEPTLTPHSFVSVTGNDRMYGRTLIRTSDATVSGAQ 744 L D + S E+ C +P + ++ TG+ ++G TL Sbjct: 504 LQSDDSIGSPGFKAVYQEIEKGGCGDPGIP--AYGKRTGSSFLHGDTL------------ 549 Query: 745 TFRVGALAKYRCERGYKIVGEALITCEENGLWSGEIPECVY 785 + C+ +++VGE +ITC++N WSG P CV+ Sbjct: 550 --------TFECQAAFELVGERVITCQKNNQWSGNKPSCVF 582 Score = 58.5 bits (140), Expect = 4e-008 Identities = 143/664 (21%), Positives = 218/664 (32%), Gaps = 137/664 (20%) Query: 354 SCGSPEALVNTTIVGRNYTVGANITYQCPVGHSLIGVEMRTCQQNGV--WSGTPPACKYV 411 +C P N +G Y V +++QC G++L G +C V W+ P C Sbjct: 1914 ACQEPALPSNGIKIGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCIAT 1973 Query: 412 DCGPLPEIEHGGIILSEQRTSFGVQASYTCHENYTLIGNENRTCQASGWSGTQPKCL-ID 470 G L + G+ILS G+ G+ P L Sbjct: 1974 CGGTLTSMS--GVILSP------------------------------GFPGSYPNNLDCT 2001 Query: 471 WCPEPPPIQGGRIKVSGRRAGSTALYTCDYGFVLIGEPVLSCGLGGNWTGKIPVCRYVDC 530 W P G I+ + DY + G P S + G ++G Sbjct: 2002 WKISLPIGYGAHIQFLNFSTEANH----DYLEIQNG-PYHSSPMMGQFSG---------- 2046 Query: 531 GMPARPDRGNMLLLNDSTTVGSVVRYFCDDDYWLVGPQELYCTKDGKWSGSAPACELITC 590 PD LL STT +++R++ D G + Y A EL C Sbjct: 2047 -----PDLPTSLL---STTHETLIRFYSDHSQNRQGFKLSY-----------QAYELQNC 2087 Query: 591 ETPHVPPGSYVIGYDYNIHSSIQYHCDPGHILRGEDTLTCLE--SGQWSGDAPDCE---- 644 P ++I DY++ SI + C PG+IL G LTC W+ P C+ Sbjct: 2088 PDPPAFQNGFMINSDYSVGQSISFECYPGYILLGHPVLTCQHGTDRNWNYPFPRCDAPCG 2147 Query: 645 ---------------------YVDCGPLTPIPFGSHRYTQNTTFLGSEVVYSCANSHRLA 683 DC L +P G H N T L +E V Sbjct: 2148 YNVTSQNGTIYSPGFPDEYPILKDCLWLVTVPPG-HGVYINFTLLQTEAVNDYIAVWDGP 2206 Query: 684 GVNRRLCLDTGLWS-ETAPRCEEIRCTEPTLTPHSFVSVTG----NDRMYGRTLIRTSDA 738 N G++S TAP + L HS S G N + A Sbjct: 2207 DQNSP---QLGVFSGNTAPETAYSSTNQVLLKFHSDFSNGGFFVLNFHAFQLKRCPPPPA 2263 Query: 739 T-----VSGAQTFRVGALAKYRCERGYKIVGEALITCEENG--LWSGEIPECVYVDCEMP 791 ++ + F +G KY+C GY ++G +TC+ + L+ G P C + + P Sbjct: 2264 VPQADLLTEDEDFEIGDFVKYQCHPGYTLLGSDTLTCKLSSQLLFQGSPPTC---EAQCP 2320 Query: 792 QNVTHGK---VTLATN--ATYYGAAALYECDGNFKLDGVSRRLCLEDGTWSHETPACVEI 846 N + V L+ Y+ + C + K+ D S + +E+ Sbjct: 2321 ANEVRTESSGVILSPGYPGNYFNSQT---CAWSIKVKPNFNITLFVDTFQSEKQFDALEV 2377 Query: 847 TCNEMNVSDALLVSYGSRRVGVQAEFSCSKGRYMVGNGTRTCLPTGHWSGR--NPVCKLI 904 S L+V G+ Q+ F+ + T + R P C L Sbjct: 2378 FDGSSGRSPLLVVLSGNHT--EQSNFTSRSNHLYLRWSTDHATSKKGFKIRYAAPYCSL- 2434 Query: 905 DCGRPADIENGRVIVVNESTVYGGSAEYHCVPHYNRIGPYLRKCMDDG----KWSGEEPR 960 + + NG ++ V G Y C P Y IG C + +W P Sbjct: 2435 ----TSTLRNGGILNKTAGAV-GSKVHYFCKPGYRMIGHSNATCRRNPVGVYQWDSMAPL 2489 Query: 961 CELI 964 C+ + Sbjct: 2490 CQAV 2493 Score = 57.4 bits (137), Expect = 1e-007 Identities = 112/530 (21%), Positives = 178/530 (33%), Gaps = 125/530 (23%) Query: 303 TVLKPTWGKDQPNNYNGEQNCVVLDGGRSWLWNDVGCNLDYLNYICQHNPLSCGSPEALV 362 TVL G + P + V L+ G N+ Y + C P V Sbjct: 649 TVLGTFSGNEVPAQLASSGHIVRLEFQSDHSTTGRGFNITYTTF----GQNECHDPGIPV 704 Query: 363 NTTIVGRNYTVGANITYQCPVGH-SLIGVEMRTC---QQNGVWSGTPPACKYVDCGPLPE 418 N G + +G+++++ C G G E TC N VWS T P C+ G L Sbjct: 705 NGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEAPCGGHLTA 764 Query: 419 IEHGGIILSEQRTSFGVQASYTCHENYTLIGNENRTCQASGWSGTQPKCL-IDWCPEPPP 477 G+IL GW G L +W E P Sbjct: 765 --SSGVILPP------------------------------GWPGYYKDSLNCEWVIEAKP 792 Query: 478 IQGGRIKVSGRRAGSTALYTCDYGFVLIGEPVLSCGLGGNWTGKIPVCRYVDCGMPARPD 537 G IK++ R + Y + P S L G + G + G + Sbjct: 793 --GHSIKITFDRFQTEVNYDT---LEVRDGPTSSSPLIGEYHGTQAPQFLISTG-----N 842 Query: 538 RGNMLLLNDST--TVGSVVRYFCDDDYWLVGPQELYCTKDGKWSGSAPACELITCETPHV 595 +L DS+ +VG ++ Y + E +C P + Sbjct: 843 YMYLLFTTDSSRASVGFLIHY------------------------ESVTLESDSCLDPGI 878 Query: 596 PPGSYVIGYDYNIHSSIQYHCDPGHILRGEDTLTCLESGQWSGDAPDCEYVDCG------ 649 P G ++ I S++ + CDPG+ L ++ L C ++ QW+ P C+ + CG Sbjct: 879 PVNGQRHGSNFGIRSTVTFSCDPGYTLSDDEPLVCEKNHQWNHALPSCDAL-CGGYIHGK 937 Query: 650 ---PLTPIPFGSHRYTQNTTFL-----GSEVVYSCANSHRLAGVNRRLCLDTGLWSETAP 701 L+P + + N T+ G V + H + + L + G +SE Sbjct: 938 SGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMNFHTFHLESSHDYLLITEDGSFSEPVA 997 Query: 702 RCEEIRCTEPTLTPHS-----FVSVTGNDRMYGRTLIRTSDATVSGAQ------------ 744 R ++ PH+ F + T R I ++ A+ Sbjct: 998 R------LTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITFAEYDLEPCDDPGVP 1051 Query: 745 --------TFRVGALAKYRCERGYKIVGEALITCEENG--LWSGEIPECV 784 F VG + C +GY++ G +TC G +WS +P CV Sbjct: 1052 AFSRRIGFQFGVGDTLAFTCFQGYRLEGATKLTCLGGGRRVWSAPLPRCV 1101 Score = 53.9 bits (128), Expect = 1e-006 Identities = 103/482 (21%), Positives = 163/482 (33%), Gaps = 129/482 (26%) Query: 355 CGSPEALVNTTIVGRNYTVGANITYQCPVGHSLIGVEMRTCQQN----GVWSGTPPACKY 410 C P N G ++ VGAN+ + C + L G + TCQ+ W+ P C+ Sbjct: 349 CPDPGIPDNGRRAGSDFRVGANVQFSCEDNYVLQGAKGITCQRVTETLAAWNDHRPICRA 408 Query: 411 VDCGPLPEIEHGGIILSEQRTSFGVQASYTCHENYTLIGNENRTCQASGW--SGTQPKCL 468 CG S R GV S NY + +N C W + T P + Sbjct: 409 RTCG------------SNLRGPSGVITS----PNYPVQYEDNAHCV---WVITTTDPDKV 449 Query: 469 IDWCPEPPPIQGGRIKVSGRRAGSTALYTCDYGFVLIGE--PVLSCGLGGN-WT------ 519 I E ++ G ++ AG T +VL G P L + W Sbjct: 450 IKLAFEEFELERGYDTLTVGDAGKVG-DTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDD 508 Query: 520 -----GKIPVCRYVD---CGMPARPDRGNMLLLNDSTTVGSVVRYFCDDDYWLVGPQELY 571 G V + ++ CG P P G S G + + C + LVG + + Sbjct: 509 SIGSPGFKAVYQEIEKGGCGDPGIPAYGKRT--GSSFLHGDTLTFECQAAFELVGERVIT 566 Query: 572 CTKDGKWSGSAPACELITCETPHVPPGSYVIGYDYNIHSSIQYHC------DPG---HIL 622 C K+ +WSG+ P+C + +C P ++ +Y +C +PG H++ Sbjct: 567 CQKNNQWSGNKPSC-VFSCFFNFTAPSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLI 625 Query: 623 -----------------RGEDTLTCLESGQWSGDAPDCEYVDCGPLTPIPFGSHRYTQNT 665 G +T L G +SG+ + G + + F S +T Sbjct: 626 FKDFDVEPQFDFLAVKDDGISDITVL--GTFSGNEVPAQLASSGHIVRLEFQS---DHST 680 Query: 666 TFLGSEVVYSCANSHRLAGVNRRLCLDTGLWSETAPRCEEIRCTEPTLTPHSFVSVTGND 725 T G + Y+ + C D G + N Sbjct: 681 TGRGFNITYTTFGQNE--------CHDPG--------------------------IPVNG 706 Query: 726 RMYGRTLIRTSDATVSGAQTFRVGALAKYRCERGY-KIVGEALITC---EENGLWSGEIP 781 R +G F +G+ + C+ G+ K G ITC + N +WS +P Sbjct: 707 RRFG--------------DRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVP 752 Query: 782 EC 783 C Sbjct: 753 RC 754 Score = 53.9 bits (128), Expect = 1e-006 Identities = 57/240 (23%), Positives = 95/240 (39%), Gaps = 45/240 (18%) Query: 586 ELITCETPHVPPGSYVIGYDYNIHSSIQ-YHCDPGHILRGEDTLTCLESGQ--WSGDAPD 642 +L+ CE P +P Y I D + ++ Y C+PG+ + G TLTCL + W P Sbjct: 1213 DLVKCEDPGIPNYGYRIRDDGHFTDTVVLYSCNPGYAMHGSSTLTCLSGDRRVWDKPMPS 1272 Query: 643 CEYVDCGPLT-------------PIPFGSHRYTQNT-------TFLGSEVVYSCANSHRL 682 C +CG L P P+ ++ + T T +V+ +H + Sbjct: 1273 C-VAECGGLVHAATSGRILSPGYPAPYDNNLHCTWTIEADPGKTISLHFIVFDTETAHDI 1331 Query: 683 -----AGVNRRLCLDTGLWSETAPRCEEIRCTEPTLT----PHSFVSVTGNDRMYGRTLI 733 V+ + L WS +A E+I T +LT F+S +G + ++ Sbjct: 1332 LKVWDGPVDSNILLKE--WSGSA-LPEDIHSTFNSLTLQFDSDFFISKSGFSIQFSTSIA 1388 Query: 734 RTSDATVSGAQTFRVGALAK------YRCERGYKIVGEALITC---EENGLWSGEIPECV 784 T + R G + ++C+ GY++ G A ITC W + P C+ Sbjct: 1389 STCNDPGMPQNGTRYGDSREPGDTITFQCDPGYQLQGPAKITCVQLNNRFFWQPDPPSCI 1448 Score = 46.6 bits (109), Expect = 2e-004 Identities = 60/263 (22%), Positives = 94/263 (35%), Gaps = 61/263 (23%) Query: 450 NENRTCQASGWSGTQPKCLIDWCPEPP-PIQGGRIKVSGRRAGSTALYTCDYGFVLIGEP 508 N N + A G+ T + C +P P G RI+ G + LY+C+ G+ + G Sbjct: 1195 NTNGSDTAQGFQLTYTSFDLVKCEDPGIPNYGYRIRDDGHFTDTVVLYSCNPGYAMHGSS 1254 Query: 509 VLSCGLGGN--WTGKIPVC--------------RYVDCGMPA------------RPDRGN 540 L+C G W +P C R + G PA D G Sbjct: 1255 TLTCLSGDRRVWDKPMPSCVAECGGLVHAATSGRILSPGYPAPYDNNLHCTWTIEADPGK 1314 Query: 541 MLLLN----DSTTVGSVVRYF---CDDDYWLVG------PQELYCT-------------- 573 + L+ D+ T +++ + D + L P++++ T Sbjct: 1315 TISLHFIVFDTETAHDILKVWDGPVDSNILLKEWSGSALPEDIHSTFNSLTLQFDSDFFI 1374 Query: 574 -KDGKWSGSAPACELITCETPHVPPGSYVIGYDYNIHSSIQYHCDPGHILRGEDTLTCLE 632 K G +S TC P +P G +I + CDPG+ L+G +TC++ Sbjct: 1375 SKSG-FSIQFSTSIASTCNDPGMPQNGTRYGDSREPGDTITFQCDPGYQLQGPAKITCVQ 1433 Query: 633 SGQ---WSGDAPDCEYVDCGPLT 652 W D P C G LT Sbjct: 1434 LNNRFFWQPDPPSCIAACGGNLT 1456 Score = 45.8 bits (107), Expect = 3e-004 Identities = 62/265 (23%), Positives = 96/265 (36%), Gaps = 37/265 (13%) Query: 406 PACKYVDCGPLPEIEHGGIILSEQRTSFGVQASYTCHENYTLIGNENRTCQA-----SGW 460 P C +PE +G I SE S G + C+ Y L G+ CQ+ + W Sbjct: 1734 PRTSDTQCSSVPEPRYGRRIGSE--FSAGSIVRFECNPGYLLQGSTAIRCQSVPNALAQW 1791 Query: 461 SGTQPKCLIDWCPEPPPIQGGRIKVSGRRAGSTALYTCDYGFVL-----IGEPVLSCGLG 515 + T P C++ C + G I G C + ++ I V+S Sbjct: 1792 NDTIPSCVVP-CSGNFTQRRGTILSPGYPEPYGNNLNCVWKIIVSEGSGIQIQVISFATE 1850 Query: 516 GNWTGKIPVCRYVDCGMPARPDRGNM------LLLNDSTTVGSVVRYFCDDDYWLVGPQE 569 NW D G P G+ LLN ST+ + + D G Sbjct: 1851 QNWDS----LEIHDGGDMTAPRLGSFSGTTVPALLN-STSNQLCLHFQSDISVAAAGFHL 1905 Query: 570 LYCTKDGKWSGSAPACELITCETPHVPPGSYVIGYDYNIHSSIQYHCDPGHILRGEDTLT 629 Y T L C+ P +P IG Y ++ + + C+PG+ L+G ++ Sbjct: 1906 EYKTVG-----------LAACQEPALPSNGIKIGDRYMVNDVLSFQCEPGYTLQGRSHIS 1954 Query: 630 CLES--GQWSGDAPDCEYVDCGPLT 652 C+ +W+ +P C G LT Sbjct: 1955 CMPGTVRRWNYPSPLCIATCGGTLT 1979 Score = 45.4 bits (106), Expect = 4e-004 Identities = 81/375 (21%), Positives = 124/375 (33%), Gaps = 96/375 (25%) Query: 239 FDKARAVCKSHGGDLIHDFRGVTTDYIISELERRKTDLRTQLVWIGAQKEPGITS----- 293 +DK C + G L+H T+ I+S D W + +PG T Sbjct: 1266 WDKPMPSCVAECGGLVH---AATSGRILSPGYPAPYDNNLHCTWT-IEADPGKTISLHFI 1321 Query: 294 -----------RTWKW-VNGDTVLKPTWGKDQPNNYNGEQNCVVLDGGRSWLWNDVGCNL 341 + W V+ + +LK G P + + N + L + + G ++ Sbjct: 1322 VFDTETAHDILKVWDGPVDSNILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSI 1381 Query: 342 DYLNYICQHNPLSCGSPEALVNTTIVGRNYTVGANITYQCPVGHSLIGVEMRTCQQ---N 398 + I +C P N T G + G IT+QC G+ L G TC Q Sbjct: 1382 QFSTSIAS----TCNDPGMPQNGTRYGDSREPGDTITFQCDPGYQLQGPAKITCVQLNNR 1437 Query: 399 GVWSGTPPACKYVDCGPLPEIEHGGIILSEQR--------------------------TS 432 W PP+C G L G+ILS S Sbjct: 1438 FFWQPDPPSCIAACGGNL--TGPAGVILSPNYPQPYPPGKECDWRIKVNPDFVIALIFKS 1495 Query: 433 FGVQASYTC-------HENYTLIGNEN-------------------RTCQASGWSG---- 462 F ++ SY N LIG+ R+ + G SG Sbjct: 1496 FSMEPSYDFLHIYEGEDSNSPLIGSFQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIE 1555 Query: 463 --TQPKCLIDWCPEPPPIQGGRIKVSGRRAGSTALYTCDYGFVLIGEPVLSCGLGG---- 516 +P+ + C +P I G + + GST Y CD G+ ++ + C G Sbjct: 1556 FKEKPR---EACFDPGNIMNGTRIGTDFKLGSTVTYQCDSGYKIVDPSSIECVTGADGKP 1612 Query: 517 NWTGKIPVCRYVDCG 531 +W +P C+ CG Sbjct: 1613 SWDRALPACQ-APCG 1626 Score = 45.1 bits (105), Expect = 5e-004 Identities = 23/66 (34%), Positives = 34/66 (51%), Gaps = 3/66 (4%) Query: 586 ELITCETPHVPPGSYVIGYDYNIHSSIQYHCDPGHILRGEDTLTCLESGQ--WSGDAPDC 643 +L C+ P VP S IG+ + + ++ + C G+ L G LTCL G+ WS P C Sbjct: 1041 DLEPCDDPGVPAFSRRIGFQFGVGDTLAFTCFQGYRLEGATKLTCLGGGRRVWSAPLPRC 1100 Query: 644 EYVDCG 649 +CG Sbjct: 1101 -VAECG 1105 Score = 40.8 bits (94), Expect = 0.009 Identities = 23/61 (37%), Positives = 28/61 (45%), Gaps = 4/61 (6%) Query: 2 CGPPAVPANARVHTEKATDGSGGLKSARYDCDPGYELFGSETIRCDPVKGWDRELPFCGT 61 CG P VPANA + E T G+ + +Y C G L G+ T C W LP C Sbjct: 2859 CGHPGVPANAVLTGELFTYGA----TVQYSCKGGQILTGNSTRVCQEDSHWSGSLPHCSG 2914 Query: 62 N 62 N Sbjct: 2915 N 2915 Score = 38.9 bits (89), Expect = 0.036 Identities = 21/60 (35%), Positives = 29/60 (48%), Gaps = 8/60 (13%) Query: 2 CGPPAVPANARVHTEKATDGSG-GLKSA-RYDCDPGYELFGSETIRCDPVKGWDRELPFC 59 C P +P N + H GS G++S + CDPGY L E + C+ W+ LP C Sbjct: 873 CLDPGIPVNGQRH------GSNFGIRSTVTFSCDPGYTLSDDEPLVCEKNHQWNHALPSC 926 Score = 37.7 bits (86), Expect = 0.080 Identities = 25/100 (25%), Positives = 35/100 (35%), Gaps = 16/100 (16%) Query: 2 CGPPAVPANARVHTEKATDGSGGLKSARYDCDPGYELFGSETIRCDPVKG---WDRELPF 58 C P +P N + + G + + CDPGY+L G I C + W + P Sbjct: 1391 CNDPGMPQNGTRYGDSREPGD----TITFQCDPGYQLQGPAKITCVQLNNRFFWQPDPPS 1446 Query: 59 CGTNVAYRKPVNQSSATRAGPAGYANDGKPGNQNPDGQEC 98 C + GPAG P G+EC Sbjct: 1447 C---------IAACGGNLTGPAGVILSPNYPQPYPPGKEC 1477 ==> UNIPROT|P16109 - symbol:LYAM3_HUMAN "SELP, GMRP: P-selectin precursor" species:9606 "Homo sapiens" [GO:0005515 "protein binding" evidence=IPI] [GO:0007155 "cell adhesion" evidence=TAS] [GO:0005624 "membrane fraction" evidence=IDA] [GO:0005625 "soluble fraction" evidence=TAS] [GO:0005886 "plasma membrane" evidence=TAS] [GO:0005887 "integral to plasma membrane" evidence=TAS] [GO:0031092 "platelet alpha granule membrane" evidence=IDA] InterPro:IPR001304 InterPro:IPR002396 UniProt:P16109 InterPro:IPR000742 InterPro:IPR006210 InterPro:IPR006209 GO:GO:0005515 GO:GO:0005887 GO:GO:0005624 Pfam:PF00059 SMART:SM00034 PROSITE:PS00615 PROSITE:PS50041 GO:GO:0005625 Reactome:REACT_604.1 GO:GO:0007155 InterPro:IPR013032 PROSITE:PS00022 PROSITE:PS01186 PROSITE:PS50026 SMART:SM00181 Pfam:PF00008 PDB:1HES InterPro:IPR000436 Pfam:PF00084 SMART:SM00032 PROSITE:PS50923 PRINTS:PR00343 EMBL:M60234 EMBL:M60217 EMBL:M60218 EMBL:M60219 EMBL:M60222 EMBL:M60223 EMBL:M60224 EMBL:M60225 EMBL:M60226 EMBL:M60227 EMBL:M60228 EMBL:M60229 EMBL:M60231 EMBL:M60232 EMBL:M60233 EMBL:AF542391 EMBL:M25322 UniGene:Hs.73800 PDB:1FSB PDB:1G1Q PDB:1G1R PDB:1G1S PDB:1KJD IntAct:P16109 Ensembl:ENSG00000174175 KEGG:hsa:6403 HGNC:HGNC:10721 HPA:CAB002145 HPA:HPA002655 MIM:173610 LinkHub:P16109 ArrayExpress:P16109 GermOnline:ENSG00000174175 RZPD-ProtExp:A0387 GO:GO:0031092 Length = 830 Score = 250 bits (638), Expect = 8e-066 Identities = 208/808 (25%), Positives = 314/808 (38%), Gaps = 125/808 (15%) Query: 210 CASPNLSVETVLTTFAKTCYEFHITRGESFDKARAVCKSHGGDLIHDFRGVTTDYIISEL 269 C S +S T A Y + T+ S++ +R C++ DL+ DY+ L Sbjct: 25 CFSALISELTNQKEVAAWTYHYS-TKAYSWNISRKYCQNRYTDLVAIQNKNEIDYLNKVL 83 Query: 270 ERRKTDLRTQLVWIGAQKEPGITSRTWKWVNGDTVLK---PTWGKDQPNNYNGEQNCV-- 324 + WIG +K ++TW WV L W ++PNN ++CV Sbjct: 84 P-----YYSSYYWIGIRKN----NKTWTWVGTKKALTNEAENWADNEPNNKRNNEDCVEI 134 Query: 325 -VLDGGRSWLWNDVGC--NLDYLNYICQHNPLSCGSPEALVNTTIVGRNYTVGANITYQC 381 + WND C L Y +SC + T N T C Sbjct: 135 YIKSPSAPGKWNDEHCLKKKHALCYTASCQDMSCSKQGECLETI---------GNYTCSC 185 Query: 382 PVGHSLIGVEMRTCQQNGVWSGTPPACKYV-DCGPLPEIEHGGIILSEQ--RTSFGVQAS 438 G P C+YV +CG L +H + S SF Q S Sbjct: 186 YPGFY------------------GPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCS 227 Query: 439 YTCHENYTLIGNENRTCQASG-WSGTQPKCLIDWCPEPP-PIQGGRIKVSGRRA---GST 493 + C + Y + G C ASG W+ P+CL CP P +G I + +A S+ Sbjct: 228 FHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMICLHSAKAFQHQSS 287 Query: 494 ALYTCDYGFVLIGEPVLSCGLGGNWTGKIPVCRYVDCGMPARPDRGNMLLLNDSTTV--G 551 ++C+ GF L+G V+ C G WT PVC+ V C P G M ++ T G Sbjct: 288 CSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYG 347 Query: 552 SVVRYFCDDDYWLVGPQELYCTKDGKWSGSAPACELITCETPHVP--------PGSYVIG 603 S ++ C Y + G L C G WS P CE I+CE P P Sbjct: 348 SSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQ 407 Query: 604 YDYNIHSSIQYHCDPGHILRGEDTLTCLESGQWSGDAPDCEYVDCGPLTPIP-------- 655 YD N + C G +LRG D + C GQW+ AP C+ + C L P+P Sbjct: 408 YDTNC----SFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDL-PVPNEARVNCS 462 Query: 656 --FGSHRYTQNTTFLGSEVVYSCANSHRLAGVNRRLCLDTGLWSETAPRCEEIRCTEPTL 713 FG+ RY +F +C L G + CL TG W+ P C+ I CT P L Sbjct: 463 HPFGAFRYQSVCSF-------TCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCT-PLL 514 Query: 714 TPHSFVSVTGNDRMYGRTLIRTSDATVSGAQTFRVGALAKYRCERGYKIVGEALITCEEN 773 +P N M T ++ G+ +++ + ++ C+ GY + G + C + Sbjct: 515 SPQ-------NGTM---TCVQPL-----GSSSYK--STCQFICDEGYSLSGPERLDCTRS 557 Query: 774 GLWSGEIPECVYVDCEMPQNVTHGKVTLATNATYY--GAAALYECDGNFKLDGVSRRLCL 831 G W+ P C + C G + + + G+ + C+ FKL+G + C Sbjct: 558 GRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCNNGFKLEGPNNVECT 617 Query: 832 EDGTWSHETPACVEIT--------CNEMNVSDALLVSY----GSRRVGVQAEFSCSKGRY 879 G WS P C I C + + G+ F C+ G Sbjct: 618 TSGRWSATPPTCKGIASLPTPGLQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFT 677 Query: 880 MVGNGTRTCLPTGHWSGRNPVCKLIDCGRPADIENGRVIVVNESTV-----YGGSAEYHC 934 ++G+ T +C P+G W+ P C+ + C +++ + I +N S + YG +HC Sbjct: 678 LIGDSTLSCRPSGQWTAVTPACRAVKC---SELHVNKPIAMNCSNLWGNFSYGSICSFHC 734 Query: 935 VPHYNRIGPYLRKCMDDGKWSGEEPRCE 962 + G C ++G WS P C+ Sbjct: 735 LEGQLLNGSAQTACQENGHWSTTVPTCQ 762 Score = 196 bits (498), Expect = 1e-049 Identities = 128/506 (25%), Positives = 204/506 (40%), Gaps = 60/506 (11%) Query: 492 STALYTCDYGFVLIGEPVLSCGLGGNWTGKIPVCRYVDCGMPARPDRGNMLLLNDSTTVG 551 S + C G+ + G L C G WT K P C C P+RGNM+ L+ + Sbjct: 224 SQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMICLHSAKAFQ 283 Query: 552 --SVVRYFCDDDYWLVGPQELYCTKDGKWSGSAPACELITCETPHVPPGSYV------IG 603 S + C++ + LVGP+ + CT G W+ AP C+ + C+ P + Sbjct: 284 HQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTA 343 Query: 604 YDYNIHSSIQYHCDPGHILRGEDTLTCLESGQWSGDAPDCEYVDCGPLTPIPFGS----- 658 + Y SS ++ C PG+ +RG D L C++SG WS P CE + C PL GS Sbjct: 344 FAYG--SSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSP 401 Query: 659 ----HRYTQNTTFLGSEVVYSCANSHRLAGVNRRLCLDTGLWSETAPRCEEIRCTEPTLT 714 +Y N +F CA L G + C + G W+ AP C+ ++C + + Sbjct: 402 SLRAFQYDTNCSF-------RCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVP 454 Query: 715 PHSFVSVTGNDRMYGRTLIRTSDATVSGAQTFRVGALAKYRCERGYKIVGEALITCEENG 774 + V+ + +G FR ++ + C G +VG +++ C G Sbjct: 455 NEARVNCS---HPFG---------------AFRYQSVCSFTCNEGLLLVGASVLQCLATG 496 Query: 775 LWSGEIPECVYVDCEMPQNVTHGKVTLA--TNATYYGAAALYECDGNFKLDGVSRRLCLE 832 W+ PEC + C + +G +T ++ Y + + CD + L G R C Sbjct: 497 NWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTR 556 Query: 833 DGTWSHETPACVEITCNEMNVSDALLV----SYGSRRVGVQAEFSCSKGRYMVGNGTRTC 888 G W+ P C I C E+ + + + G VG FSC+ G + G C Sbjct: 557 SGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCNNGFKLEGPNNVEC 616 Query: 889 LPTGHWSGRNPVCKLIDCGRPADIENGRVIVVNESTVY----------GGSAEYHCVPHY 938 +G WS P CK I ++ + + T+Y + + C + Sbjct: 617 TTSGRWSATPPTCKGIASLPTPGLQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGF 676 Query: 939 NRIGPYLRKCMDDGKWSGEEPRCELI 964 IG C G+W+ P C + Sbjct: 677 TLIGDSTLSCRPSGQWTAVTPACRAV 702 Score = 192 bits (488), Expect = 2e-048 Identities = 123/464 (26%), Positives = 194/464 (41%), Gaps = 52/464 (11%) Query: 371 YTVGANITYQCPVGHSLIGVEMRTCQQNGVWSGTPPACKYVDCGPLPEIEHGGIILSEQR 430 + G++ ++C G+ + G++M C +G WS P C+ + C PL HG + S Sbjct: 344 FAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSL 403 Query: 431 TSF--GVQASYTCHENYTLIGNENRTCQASG-WSGTQPKCLIDWCPEPPPIQGGRIKVS- 486 +F S+ C E + L G + C G W+ P C C + P R+ S Sbjct: 404 RAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSH 463 Query: 487 ---GRRAGSTALYTCDYGFVLIGEPVLSCGLGGNWTGKIPVCRYVDCGMPARPDRGNMLL 543 R S +TC+ G +L+G VL C GNW P C+ + C P G M Sbjct: 464 PFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTC 523 Query: 544 LN--DSTTVGSVVRYFCDDDYWLVGPQELYCTKDGKWSGSAPACELITCETPHVPPGSYV 601 + S++ S ++ CD+ Y L GP+ L CT+ G+W+ S P CE I C P + Sbjct: 524 VQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSL 583 Query: 602 IGYD----YNIHSSIQYHCDPGHILRGEDTLTCLESGQWSGDAPDCEYV--------DCG 649 D +N+ S+ + C+ G L G + + C SG+WS P C+ + C Sbjct: 584 DCSDTRGEFNVGSTCHFSCNNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGLQCP 643 Query: 650 PLTPIPFGSH--RYTQNTTFLGSEVVYSCANSHRLAGVNRRLCLDTGLWSETAPRCEEIR 707 LT G+ R+ T + + C L G + C +G W+ P C ++ Sbjct: 644 ALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVK 703 Query: 708 CTEPTLTPHSFVSVTGNDRMYGRTLIRTSDATVSGAQTFRVGALAKYRCERGYKIVGEAL 767 C+E ++ I + + + G F G++ + C G + G A Sbjct: 704 CSE----------------LHVNKPIAMNCSNLWG--NFSYGSICSFHCLEGQLLNGSAQ 745 Query: 768 ITCEENGLWSGEIPECVYVDCEMPQNVTHGKVTLATNATYYGAA 811 C+ENG WS +P C G +T+ TY+G A Sbjct: 746 TACQENGHWSTTVPTC-----------QAGPLTIQEALTYFGGA 778 Score = 162 bits (411), Expect = 2e-039 Identities = 116/464 (25%), Positives = 180/464 (38%), Gaps = 41/464 (8%) Query: 523 PVCRYV-DCGMPARPDRGNMLLLNDSTTVG-----SVVRYFCDDDYWLVGPQELYCTKDG 576 P C YV +CG P +L+N S +G S + C D Y + GP +L C G Sbjct: 192 PECEYVRECGELELPQH---VLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASG 248 Query: 577 KWSGSAPACELITCETPHVPPGSYVI----GYDYNIHSSIQYHCDPGHILRGEDTLTCLE 632 W+ P C C +P +I + SS + C+ G L G + + C Sbjct: 249 IWTNKPPQCLAAQCPPLKIPERGNMICLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTA 308 Query: 633 SGQWSGDAPDCEYVDCGPLTPIPFGSHRYTQNTTFL--GSEVVYSCANSHRLAGVNRRLC 690 SG W+ AP C+ V C L G+ T GS + C +R+ G++ C Sbjct: 309 SGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRC 368 Query: 691 LDTGLWSETAPRCEEIRCTEPTLTPHSFVSVTGNDRMYGRTLIRTSDATVSGAQTFRVGA 750 +D+G WS P CE I C EP +P + S + F+ Sbjct: 369 IDSGHWSAPLPTCEAISC-EPLESP-----------------VHGSMDCSPSLRAFQYDT 410 Query: 751 LAKYRCERGYKIVGEALITCEENGLWSGEIPECVYVDCEMPQNVTHGKVTLAT--NATYY 808 +RC G+ + G ++ C+ G W+ P C + C+ +V + A Y Sbjct: 411 NCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRY 470 Query: 809 GAAALYECDGNFKLDGVSRRLCLEDGTWSHETPACVEITCNEM----NVSDALLVSYGSR 864 + + C+ L G S CL G W+ P C I C + N + + GS Sbjct: 471 QSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSS 530 Query: 865 RVGVQAEFSCSKGRYMVGNGTRTCLPTGHWSGRNPVCKLIDCGRPADIENGRVIVVNEST 924 +F C +G + G C +G W+ P+C+ I C E G + + Sbjct: 531 SYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRG 590 Query: 925 VY--GGSAEYHCVPHYNRIGPYLRKCMDDGKWSGEEPRCELIVN 966 + G + + C + GP +C G+WS P C+ I + Sbjct: 591 EFNVGSTCHFSCNNGFKLEGPNNVECTTSGRWSATPPTCKGIAS 634 Score = 53.9 bits (128), Expect = 1e-006 Identities = 34/143 (23%), Positives = 59/143 (41%), Gaps = 7/143 (4%) Query: 841 PACVEIT-CNEMNVSDALLVS----YGSRRVGVQAEFSCSKGRYMVGNGTRTCLPTGHWS 895 P C + C E+ + +L++ G+ Q F C+ G + G CL +G W+ Sbjct: 192 PECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWT 251 Query: 896 GRNPVCKLIDCGRPADIENGRVIVVNESTVYG--GSAEYHCVPHYNRIGPYLRKCMDDGK 953 + P C C E G +I ++ + + S + C + +GP + +C G Sbjct: 252 NKPPQCLAAQCPPLKIPERGNMICLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGV 311 Query: 954 WSGEEPRCELIVNDAQETNSLGT 976 W+ P C+ + E S GT Sbjct: 312 WTAPAPVCKAVQCQHLEAPSEGT 334 ==> UNIPROT|P20023 - symbol:CR2_HUMAN "CR2, C3DR: Complement receptor type 2 precursor" species:9606 "Homo sapiens" [GO:0004875 "complement receptor activity" evidence=NAS] [GO:0042803 "protein homodimerization activity" evidence=IDA] [GO:0005886 "plasma membrane" evidence=NAS] [GO:0016021 "integral to membrane" evidence=NAS] UniProt:P20023 GO:GO:0006955 GO:GO:0005886 GO:GO:0016021 GO:GO:0042803 InterPro:IPR000436 Pfam:PF00084 SMART:SM00032 PROSITE:PS50923 PDB:1GHQ PDB:1W2S GO:GO:0004875 EMBL:M26004 EMBL:M26016 EMBL:M24007 EMBL:M24008 EMBL:M24009 EMBL:M24010 EMBL:M24011 EMBL:M26009 EMBL:M26010 EMBL:M26011 EMBL:M26012 EMBL:M26013 EMBL:M26014 EMBL:M26015 EMBL:Y00649 EMBL:J03565 EMBL:S62696 PIR:JL0028 UniGene:Hs.445757 PDB:1LY2 PDB:1W2R Ensembl:ENSG00000117322 KEGG:hsa:1380 HGNC:HGNC:2336 HPA:CAB002659 MIM:120650 LinkHub:P20023 ArrayExpress:P20023 GermOnline:ENSG00000117322 RZPD-ProtExp:O0029 Length = 1033 Score = 246 bits (629), Expect = 9e-065 Identities = 190/661 (28%), Positives = 276/661 (41%), Gaps = 83/661 (12%) Query: 352 PLSCGSPEALVNTTIVGRNY---TVGANITYQCPVGHSLIGVEMRTCQQNGVWSGTPPAC 408 PL C + + N N G ++TY C G+ L+G ++ C +G WS PP C Sbjct: 151 PLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTC 210 Query: 409 KYVDCGPLPEIEHGGIILSEQRTSFGVQASYTCHENYTLIGNENRTCQASG----WSGTQ 464 + C L +G + GV A++ C E Y L G + C +G W+ Sbjct: 211 EEARCKSLGRFPNGK-VKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KM 268 Query: 465 PKCLIDWCPEPPPIQGGR---IKVSGRRAGSTALYTCD------YGFVLIGEPVLSCGLG 515 P C +CP PPPI GR ++ GS YTCD F+LIGE L C + Sbjct: 269 PVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVD 328 Query: 516 ----GNWTGKIPVCRY----VDCGMPARPDRGNMLL-LNDSTTVGSVVRYFCDDDYWLVG 566 G W+G P C V C P + RG M+ D T V + C + L G Sbjct: 329 SQKTGTWSGPAPRCELSTSAVQCPHP-QILRGRMVSGQKDRYTYNDTVIFACMFGFTLKG 387 Query: 567 PQELYCTKDGKWSGSAPACELITCETPHVPPGS----YVIGYDYNIHSSIQYHCDPGHIL 622 +++ C G W SAP CE P++ G +++ +D +SI+Y C+PG++L Sbjct: 388 SKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPG--TSIKYSCNPGYVL 445 Query: 623 RGEDTLTCLESGQWSGDAPDCEYVDCGPLTPIPFGSHRYTQ-NTTFLGSEVVYSCANSHR 681 GE+++ C G W+ P C+ C G T+ F+ +V SC ++ Sbjct: 446 VGEESIQCTSEGVWTPPVPQCKVAACEAT-----GRQLLTKPQHQFVRPDVNSSCGEGYK 500 Query: 682 LAGVNRRLCLDTGLWSETAPRCEEIRCTEPTLTPHSFVSVTGNDRMYGRTLIRTSDATVS 741 L+G + C T W C+EI C P +I T S Sbjct: 501 LSGSVYQECQGTIPWFMEIRLCKEITCPPP-------------------PVIYNGAHTGS 541 Query: 742 GAQTFRVGALAKYRC----ERG--YKIVGEALITC----EENGLWSGEIPEC----VYVD 787 + F G Y C ERG + ++GE+ I C +E G WSG P C + V Sbjct: 542 SLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQ 601 Query: 788 CEMPQNVTHGKVTLATNATYYGAAALYECDGNFKLDGVSRRLCLEDGTWSHETPACVEIT 847 C K++ +Y ++C F L G S+ C D TW E P C + T Sbjct: 602 CSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKET 661 Query: 848 CNEMNVSDALLVSYGSRRVGVQAEFSCSKGRYMVGNGTRTC--LPTGHWSGRNPVCKLID 905 C + S L + GSR V SC G + G+ + C G W + P+CK+I Sbjct: 662 CQHVRQSLQELPA-GSRVELVNT--SCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIH 718 Query: 906 CGRPADIENGR-VIVVNESTVYGGSAEYHCVPHYNRIGPYLRKCMDD----GKWSGEEPR 960 C P I NG+ ++ E+ +YG Y C + +G +C D G WSG P+ Sbjct: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778 Query: 961 C 961 C Sbjct: 779 C 779 Score = 193 bits (490), Expect = 1e-048 Identities = 173/705 (24%), Positives = 278/705 (39%), Gaps = 105/705 (14%) Query: 353 LSCGSPEALVNTTIVGRN--YTVGANITYQCPVGHSLIGVEMRTCQQNGVWSGTPPACKY 410 + C P+ L + G+ YT + + C G +L G + C G W + P C+ Sbjct: 349 VQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK 408 Query: 411 VDCGPLPEIEHGGIILSEQRTSF----GVQASYTCHENYTLIGNENRTCQASG-WSGTQP 465 +C P I +G E R G Y+C+ Y L+G E+ C + G W+ P Sbjct: 409 -ECQAPPNILNGQ---KEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVP 464 Query: 466 KCLIDWCPEPPPIQGGR---IKVSGRRAGSTALYTCDYGFVLIGEPVLSCGLGGNWTGKI 522 +C + C GR K + +C G+ L G C W +I Sbjct: 465 QCKVAACEAT-----GRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEI 519 Query: 523 PVCRYVDCGMPA----RPDRGNMLLLNDSTTVGSVVRYFCDD------DYWLVGPQELYC 572 +C+ + C P G+ L + G+ V Y C+ ++ L+G + C Sbjct: 520 RLCKEITCPPPPVIYNGAHTGSSL---EDFPYGTTVTYTCNPGPERGVEFSLIGESTIRC 576 Query: 573 TKD----GKWSGSAPACEL----ITCETPHVPPGSYVIGYD--YNIHSSIQYHCDPGHIL 622 T + G WSG AP C+L + C H+ G + G + Y + ++ + C G L Sbjct: 577 TSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTL 636 Query: 623 RGEDTLTCLESGQWSGDAPDCEYVDCG----PLTPIPFGSHRYTQNTTFLGSEVVYSCAN 678 +G + C W + P CE C L +P GS NT SC + Sbjct: 637 KGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVELVNT---------SCQD 687 Query: 679 SHRLAGVNRRLCLDT--GLWSETAPRCEEIRCTEPTLTPHSFVSVTGNDRMYGRTLIRTS 736 ++L G ++C D G+W + P C+ I C P V V G Sbjct: 688 GYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPP------VIVNGKH----------- 730 Query: 737 DATVSGAQTFRVGALAKYRCERGYKIVGEALITCEEN----GLWSGEIPECV----YVDC 788 T A+ F G Y C++G+ ++GE + C + G WSG P+C+ C Sbjct: 731 --TGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRC 788 Query: 789 EMPQNVTHGKVTLATNATYYGAAALY-ECDGNFKLDGVSRRLCLEDGTWSHETPACVE-- 845 P+ V HG T++ Y +Y +C+ F ++G C D TW P C++ Sbjct: 789 PNPE-VKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKA 847 Query: 846 -ITCNEM------NVSDALLVSYGSRRVGVQAEFSCSKGRYMVGNGTRTCLPTGHWSGRN 898 I C N + + + G+ +SC +G +VG C G WS Sbjct: 848 FIGCPPPPKTPNGNHTGGNIARFSP---GMSILYSCDQGYLLVGEALLLCTHEGTWSQPA 904 Query: 899 PVCKLIDCGRPADIEN-GRVIVVNESTVYGGSAEYHCVPHYNRIGPYLRKCMDDGKWSGE 957 P CK ++C PAD++ + + + YG C Y G +C D +W+ Sbjct: 905 PHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNP- 963 Query: 958 EPRCELIVNDAQETNSLGTGIAIGAAIIVILLIL-IGVLFLHRNK 1001 L V ++ + GIA G ++ L+++ + V+ HR + Sbjct: 964 ----PLAVCRSRSLAPVLCGIAAGLILLTFLIVITLYVISKHRER 1004 Score = 170 bits (430), Expect = 1e-041 Identities = 163/611 (26%), Positives = 232/611 (37%), Gaps = 84/611 (13%) Query: 406 PACKYVDCGPLPEIEHGGIILSEQRTSFGVQASYTCHENYTLIGNENRTCQASG-----W 460 P + CG P I +G I + G Y+C + LIG ++ C W Sbjct: 16 PGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTW 75 Query: 461 SGTQPKC----LIDWCPEPPPIQGGRIKVSGR---RAGSTALYTCDYGFVLIGEPVLSCG 513 PKC CPE PI G K+ G R G + + C F + G + C Sbjct: 76 DKPAPKCEYFNKYSSCPE--PIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQ 133 Query: 514 LGGNW-TGKIPVCRYV---DCGMPARPDRGNMLLLNDSTTVGSV-----VRYFCDDDYWL 564 W ++P C V +C PA P N + S VGS+ V Y C+ Y L Sbjct: 134 ANNMWGPTRLPTCVSVFPLEC--PALPMIHNG--HHTSENVGSIAPGLSVTYSCESGYLL 189 Query: 565 VGPQELYCTKDGKWSGSAPACELITCET-PHVPPGSYVIGYDYNIHSSIQYHCDPGHILR 623 VG + + C GKWS P CE C++ P G + + + CD G+ L+ Sbjct: 190 VGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQ 249 Query: 624 GEDTLTCLESGQ---WSGDAPDCEYVDCGPLTPIPFGSH--RYTQNTTFLGSEVVYSC-- 676 G + C+ +GQ W+ P CE + C PI G H N ++ GS V Y+C Sbjct: 250 GPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSLANVSY-GSIVTYTCDP 307 Query: 677 -----ANSHRLAGVNRRLCLD---TGLWSETAPRCE----EIRCTEPTLTPHSFVSVTGN 724 N + R +D TG WS APRCE ++C P + VS + Sbjct: 308 DPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKD 367 Query: 725 DRMYGRTLIRTSDATVSGAQTFRVGALAKYRCERGYKIVGEALITCEENGLWSGEIPECV 784 Y T+I + C G+ + G I C G W P C Sbjct: 368 RYTYNDTVI--------------------FACMFGFTLKGSKQIRCNAQGTWEPSAPVC- 406 Query: 785 YVDCEMPQNVTHGKVTLATNATY-YGAAALYECDGNFKLDGVSRRLCLEDGTWSHETPAC 843 +C+ P N+ +G+ + G + Y C+ + L G C +G W+ P C Sbjct: 407 EKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQC 466 Query: 844 VEITCNEMNVSDALLVSYGSRRVGVQAEFSCSKGRYMVGNGTRTCLPTGHWSGRNPVCKL 903 C LL + V SC +G + G+ + C T W +CK Sbjct: 467 KVAACEA--TGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKE 524 Query: 904 IDCGRPADIENGRVIVVN-ESTVYGGSAEYHCVP------HYNRIGPYLRKC----MDDG 952 I C P I NG + E YG + Y C P ++ IG +C + G Sbjct: 525 ITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERG 584 Query: 953 KWSGEEPRCEL 963 WSG P C+L Sbjct: 585 TWSGPAPLCKL 595 Score = 155 bits (391), Expect = 3e-037 Identities = 132/480 (27%), Positives = 193/480 (40%), Gaps = 66/480 (13%) Query: 528 VDCGMPARPDRGNMLLLNDSTTVGSVVRYFCDDDYWLVGPQELYC-TK---DGKWSGSAP 583 + CG P G + + VG+V+RY C + L+G + L C TK DG W AP Sbjct: 21 ISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80 Query: 584 ACELI----TCETPHVPPGSYVIG-YDYNIHSSIQYHCDPGHILRGEDTLTCLESGQWSG 638 CE +C P VP G + G Y S+ + C + G ++ C + W Sbjct: 81 KCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGP 140 Query: 639 D-APDCEYV---DCGPLTPIPFGSHRYTQNTTFL--GSEVVYSCANSHRLAGVNRRLCLD 692 P C V +C P P+ H ++N + G V YSC + + L G CL Sbjct: 141 TRLPTCVSVFPLEC-PALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLS 199 Query: 693 TGLWSETAPRCEEIRCTEPTLTPHSFVSVTGNDRMYGRTLIRTSDATVSGAQTFRVGALA 752 +G WS P CEE RC ++L R + V RVG A Sbjct: 200 SGKWSAVPPTCEEARC---------------------KSLGRFPNGKVKEPPILRVGVTA 238 Query: 753 KYRCERGYKIVGEALITCEENG---LWSGEIPECVYVDCEMPQNVTHGK-VTLATNATYY 808 + C+ GY++ G C G W+ ++P C + C P + +G+ + + Y Sbjct: 239 NFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSLANVSY 297 Query: 809 GAAALYECDG------NFKLDGVSRRLCLED----GTWSHETPAC----VEITCNEMNVS 854 G+ Y CD NF L G S C D GTWS P C + C + Sbjct: 298 GSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQIL 357 Query: 855 DALLVSYGSRRVGVQ--AEFSCSKGRYMVGNGTRTCLPTGHWSGRNPVCKLIDCGRPADI 912 +VS R F+C G + G+ C G W PVC+ +C P +I Sbjct: 358 RGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK-ECQAPPNI 416 Query: 913 ENG----RVIVVNESTVYGGSAEYHCVPHYNRIGPYLRKCMDDGKWSGEEPRCELIVNDA 968 NG R +V + G S +Y C P Y +G +C +G W+ P+C++ +A Sbjct: 417 LNGQKEDRHMVRFDP---GTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEA 473 Score = 144 bits (364), Expect = 5e-034 Identities = 133/533 (24%), Positives = 200/533 (37%), Gaps = 70/533 (13%) Query: 472 CPEPPPIQGGRIKVSGR--RAGSTALYTCDYGFVLIGEPVLSC----GLGGNWTGKIPVC 525 C PPPI GRI G+ Y+C F LIGE L C + G W P C Sbjct: 23 CGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC 82 Query: 526 RYVD----CGMPARPDRGNMLLLNDSTTVGSVVRYFCDDDYWLVGPQELYCTKDGKWSGS 581 Y + C P P G + + G V + C ++ + G + ++C + W + Sbjct: 83 EYFNKYSSCPEPIVPG-GYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPT 141 Query: 582 A-PAC-ELITCETPHVPPGSYVIGYDYNIHS-----SIQYHCDPGHILRGEDTLTCLESG 634 P C + E P +P N+ S S+ Y C+ G++L GE + CL SG Sbjct: 142 RLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSG 201 Query: 635 QWSGDAPDCEYVDCGPLTPIPFGSHRYTQNTTFLGSEVVYSCANSHRLAGVNRRLCLDTG 694 +WS P CE C L P G + +G + C +RL G C+ G Sbjct: 202 KWSAVPPTCEEARCKSLGRFPNGKVK-EPPILRVGVTANFFCDEGYRLQGPPSSRCVIAG 260 Query: 695 ---LWSETAPRCEEIRCTEPTLTPHSFVSVTGNDRMYGRTLIRTSDATVSGAQTFRVGAL 751 W++ P CEEI C P N R G +L S G++ Sbjct: 261 QGVAWTK-MPVCEEIFCPSP--------PPILNGRHIGNSLANVS-----------YGSI 300 Query: 752 AKYRCER------GYKIVGEALITC----EENGLWSGEIPECVY----VDCEMPQNVTHG 797 Y C+ + ++GE+ + C ++ G WSG P C V C PQ + G Sbjct: 301 VTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQ-ILRG 359 Query: 798 KVTLATNATY-YGAAALYECDGNFKLDGVSRRLCLEDGTWSHETPACVEITCNEMNV--- 853 ++ Y Y ++ C F L G + C GTW P C + N+ Sbjct: 360 RMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNG 419 Query: 854 --SDALLVSYGSRRVGVQAEFSCSKGRYMVGNGTRTCLPTGHWSGRNPVCKLIDCGRPAD 911 D +V + G ++SC+ G +VG + C G W+ P CK+ C + Sbjct: 420 QKEDRHMVRFDP---GTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAAC----E 472 Query: 912 IENGRVIVVNESTVYGGSAEYHCVPHYNRIGPYLRKCMDDGKWSGEEPRCELI 964 +++ + C Y G ++C W E C+ I Sbjct: 473 ATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEI 525 Score = 122 bits (305), Expect = 3e-027 Identities = 99/358 (27%), Positives = 144/358 (40%), Gaps = 50/358 (13%) Query: 640 APDCEYVDCGPLTPIPFGSHRYTQNTTFLGSEVVYSCANSHRLAGVNRRLCLD----TGL 695 AP + CG PI G Y +G+ + YSC+ + RL G LC+ G Sbjct: 15 APGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGT 74 Query: 696 WSETAPRCEEIR----CTEPTLTPHSFVSVTGNDRMYGRTLIRTSDATVSGAQTFRVGAL 751 W + AP+CE C EP + P + + G+ +R G Sbjct: 75 WDKPAPKCEYFNKYSSCPEP-IVPGGY--------------------KIRGSTPYRHGDS 113 Query: 752 AKYRCERGYKIVGEALITCEENGLWS-GEIPECVYV---DCEMPQNVTHGKVTLA-TNAT 806 + C+ + + G + C+ N +W +P CV V +C + +G T + Sbjct: 114 VTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSI 173 Query: 807 YYGAAALYECDGNFKLDGVSRRLCLEDGTWSHETPACVEITCNEM-NVSDALLVSYGSRR 865 G + Y C+ + L G CL G WS P C E C + + + R Sbjct: 174 APGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILR 233 Query: 866 VGVQAEFSCSKGRYMVGNGTRTCLPTGH---WSGRNPVCKLIDCGRPADIENGRVIVVNE 922 VGV A F C +G + G + C+ G W+ + PVC+ I C P I NGR I + Sbjct: 234 VGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSL 292 Query: 923 STV-YGGSAEYHCVP------HYNRIGPYLRKCMDD----GKWSGEEPRCELIVNDAQ 969 + V YG Y C P ++ IG +C D G WSG PRCEL + Q Sbjct: 293 ANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQ 350 ==> MGI|MGI:88489 - symbol:Cr2 "complement receptor 2" species:10090 "Mus musculus" [GO:0009897 "external side of plasma membrane" evidence=IDA] [GO:0042803 "protein homodimerization activity" evidence=ISS] [GO:0016021 "integral to membrane" evidence=RCA] [GO:0005515 "protein binding" evidence=IPI] [GO:0004872 "receptor activity" evidence=IDA] [GO:0004875 "complement receptor activity" evidence=IMP] [GO:0042113 "B cell activation" evidence=IMP] UniProt:P19070 MGI:MGI:88489 GO:GO:0009897 InterPro:IPR000436 Pfam:PF00084 SMART:SM00032 PROSITE:PS50923 GO:GO:0004875 EMBL:M81083 EMBL:M35684 EMBL:M61132 EMBL:M35685 EMBL:M29281 PIR:A43526 UniGene:Mm.235387 HSSP:P20023 Ensembl:ENSMUSG00000026616 ArrayExpress:P19070 GermOnline:ENSMUSG00000026616 GO:GO:0042113 Length = 1025 Score = 237 bits (605), Expect = 5e-062 Identities = 187/669 (27%), Positives = 275/669 (41%), Gaps = 90/669 (13%) Query: 347 ICQHN-PLSCGSPEALVNTTIVGRN---YTVGANITYQCPVGHSLIGVEMRTCQQNGVWS 402 +C+ + PL C S + N G++ + G ++TY C G+ L G + C +G W Sbjct: 137 VCESDFPLECPSLPTIHNGHHTGQHVDQFVAGLSVTYSCEPGYLLTGKKTIKCLSSGDWD 196 Query: 403 GTPPACKYVDC---GPLPEIEHGGIILSEQRTSFGVQASYTCHENYTLIGNENRTC---- 455 G P CK C G P G + G ++C+E Y L G + C Sbjct: 197 GVIPTCKEAQCEHPGKFPN----GQVKEPLSLQVGTTVYFSCNEGYQLQGQPSSQCVIVE 252 Query: 456 QASGWSGTQPKCLIDWCPEPPPIQGGRIKVSGRRA---GSTALYTCD------YGFVLIG 506 Q + W+ +P C CP PPP++ G S GST YTCD F LIG Sbjct: 253 QKAIWT-KKPVCKEILCPPPPPVRNGSHTGSFSENVPYGSTVTYTCDPSPEKGVSFTLIG 311 Query: 507 EPVLSCGLG----GNWTGKIPVC----RYVDCGMPARPDRGNML-LLNDSTTVGSVVRYF 557 E ++C G G W+G P C V C P + RG +L +L DS + V + Sbjct: 312 EKTINCTTGSQKTGIWSGPAPYCVLSTSAVLCLQP-KIKRGQILSILKDSYSYNDTVAFS 370 Query: 558 CDDDYWLVGPQELYCTKDGKWSGSAPACELITCETPHVPPG----SYVIGYDYNIHSSIQ 613 C+ + L G + + C G W P CE P + G SY++ +D +SI+ Sbjct: 371 CEPGFTLKGNRSIRCNAHGTWEPPVPVCEKGCQAPPKIINGQKEDSYLLNFDPG--TSIR 428 Query: 614 YHCDPGHILRGEDTLTCLESGQWSGDAPDCEYVDCGPLTPIPFGSHRYTQNTTFLGSEVV 673 Y CDPG++L GEDT+ C G+W+ P C +C P+ P F + QN F+ + V Sbjct: 429 YSCDPGYLLVGEDTIHCTPEGKWTPITPQCTVAECKPVGPHLF---KRPQN-QFIRTAVN 484 Query: 674 YSCANSHRLAGVNRRLCLDTGLWSETAPRCEEIRCTEPTLTPHSFVSVTGNDRMYGRTLI 733 SC +L+ +LC T W C+EI C P +I Sbjct: 485 SSCDEGFQLSESAYQLCQGTIPWFIEIRLCKEITCPPP-------------------PVI 525 Query: 734 RTSDATVSGAQTFRVGALAKYRCERG------YKIVGEALITCEEN----GLWSGEIPEC 783 T S ++ G + Y C G +K++GE I C + G WS P C Sbjct: 526 HNGTHTWSSSEDVPYGTVVTYMCYPGPEEGVKFKLIGEQTIHCTSDSRGRGSWSSPAPLC 585 Query: 784 VY----VDCEMPQNVTHGKVTLATNATYYGAAALYECDGNFKLDGVSRRLCLEDGTWSHE 839 V C K+T +Y + +++CD + L G S+ C + TW E Sbjct: 586 KLSLPAVQCTDVHVENGVKLTDNKAPYFYNDSVMFKCDDGYILSGSSQIRCKANNTWDPE 645 Query: 840 TPACVEITCNEMNVSDALLVSYGSRRVGVQAEFSCSKGRYMVGNGTRTC--LPTGHWSGR 897 P C + C M V S+ + +C G + G C G W + Sbjct: 646 KPLCKKEGCEPMRVHGLPDDSHIK-----LVKRTCQNGYQLTGYTYEKCQNAENGTWFKK 700 Query: 898 NPVCKLIDCGRPADIEN-GRVIVVNESTVYGGSAEYHCVPHYNRIGPYLRKCMDD----G 952 VC +I C P I N G ++ + +YG Y C + +G +C++D G Sbjct: 701 IEVCTVILCQPPPKIANGGHTGMMAKHFLYGNEVSYECDEGFYLLGEKSLQCVNDSKGHG 760 Query: 953 KWSGEEPRC 961 WSG P+C Sbjct: 761 SWSGPPPQC 769 Score = 190 bits (483), Expect = 7e-048 Identities = 172/705 (24%), Positives = 271/705 (38%), Gaps = 99/705 (14%) Query: 365 TIVGRNYTVGANITYQCPVGHSLIGVEMRTCQQNGVWSGTPPACKYVDCGPLPEIEHGGI 424 +I+ +Y+ + + C G +L G C +G W P C+ C P+I +G Sbjct: 355 SILKDSYSYNDTVAFSCEPGFTLKGNRSIRCNAHGTWEPPVPVCEK-GCQAPPKIING-- 411 Query: 425 ILSEQRTSF------GVQASYTCHENYTLIGNENRTCQASG-WSGTQPKCLIDWCPEPPP 477 ++ S+ G Y+C Y L+G + C G W+ P+C + C P Sbjct: 412 ---QKEDSYLLNFDPGTSIRYSCDPGYLLVGEDTIHCTPEGKWTPITPQCTVAECKPVGP 468 Query: 478 IQGGRIKVSGRRAGSTALYTCDYGFVLIGEPVLSCGLGGNWTGKIPVCRYVDCGMPARPD 537 R + R + +CD GF L C W +I +C+ + C P Sbjct: 469 HLFKRPQNQFIRTAVNS--SCDEGFQLSESAYQLCQGTIPWFIEIRLCKEITCPPPPVIH 526 Query: 538 RG-NMLLLNDSTTVGSVVRYFCDDD------YWLVGPQELYCTKD----GKWSGSAPACE 586 G + ++ G+VV Y C + L+G Q ++CT D G WS AP C+ Sbjct: 527 NGTHTWSSSEDVPYGTVVTYMCYPGPEEGVKFKLIGEQTIHCTSDSRGRGSWSSPAPLCK 586 Query: 587 L----ITCETPHVPPGSYVIG----YDYNIHSSIQYHCDPGHILRGEDTLTCLESGQWSG 638 L + C HV G + Y YN S+ + CD G+IL G + C + W Sbjct: 587 LSLPAVQCTDVHVENGVKLTDNKAPYFYN--DSVMFKCDDGYILSGSSQIRCKANNTWDP 644 Query: 639 DAPDCEYVDCGPLTP--IPFGSHRYTQNTTFLGSEVVYSCANSHRLAGVNRRLC--LDTG 694 + P C+ C P+ +P SH T C N ++L G C + G Sbjct: 645 EKPLCKKEGCEPMRVHGLPDDSHIKLVKRT---------CQNGYQLTGYTYEKCQNAENG 695 Query: 695 LWSETAPRCEEIRCTEPTLTPHSFVSVTGNDRMYGRTLIRTSDATVSGAQTFRVGALAKY 754 W + C I C P I T A+ F G Y Sbjct: 696 TWFKKIEVCTVILCQPPPK-------------------IANGGHTGMMAKHFLYGNEVSY 736 Query: 755 RCERGYKIVGEALITC----EENGLWSGEIPECVY----VDCEMPQNVTHG-KVTLATNA 805 C+ G+ ++GE + C + +G WSG P+C+ C P+ V HG K+ +A Sbjct: 737 ECDEGFYLLGEKSLQCVNDSKGHGSWSGPPPQCLQSSPLTHCPDPE-VKHGYKLNKTHSA 795 Query: 806 TYYGAAALYECDGNFKLDGVSRRLCLEDGTWSHETPACVEITCNEMNVSDALLVSYGSRR 865 + + C+ F ++G C + TW P C+ + + G+ Sbjct: 796 FSHNDIVHFVCNQGFIMNGSHLIRCHTNNTWLPGVPTCIRKA--SLGCQSPSTIPNGNHT 853 Query: 866 VGVQAEF--------SCSKGRYMVGNGTRTCLPTGHWSGRNPVCKLIDCGRPADIENG-- 915 G A F SC +G M G C G WS P CK ++C P D NG Sbjct: 854 GGSIARFPPGMSVMYSCYQGFLMAGEARLICTHEGTWSQPPPFCKEVNCSFPED-TNGIQ 912 Query: 916 RVIVVNESTVYGGSAEYHCVPHYNRIGPYLRKCMDDGKWSGEEPRCELIVNDAQETNSLG 975 + ++ +G + C Y G +C DD +W+ P L T L Sbjct: 913 KGFQPGKTYRFGATVTLECEDGYTLEGSPQSQCQDDSQWN---PPLALCKYRRWSTIPLI 969 Query: 976 TGIAIGAAIIVILLILIGVLFLHR-----NKARPVKNTENVQAAE 1015 GI++G+A+I+++ + ++ HR K RP + +++ E Sbjct: 970 CGISVGSALIILMSVGFCMILKHRESNYYTKTRPKEGALHLETRE 1014 Score = 177 bits (450), Expect = 5e-044 Identities = 178/692 (25%), Positives = 258/692 (37%), Gaps = 121/692 (17%) Query: 346 YICQHNPLSCGSPEALVNTTIVGRNYTV--GANITYQCPVGHSLIGVEMRTC----QQNG 399 ++ + +SC P + N + + G + Y C + LIG + C Q + Sbjct: 5 FLFYFSEISCDPPPEVKNARKPYYSLPIVPGTVLRYTCSPSYRLIGEKAIFCISENQVHA 64 Query: 400 VWSGTPPAC----KYVDCGPLPEIEHGGIILSEQRTSF--GVQASYTCHENYTLIGNENR 453 W PP C K + C I GG + + F G ++TC N+T+ G++ Sbjct: 65 TWDKAPPICESVNKTISCSD--PIVPGGFMNKGSKAPFRHGDSVTFTCKANFTMKGSKTV 122 Query: 454 TCQASG-WSGTQ-PKCLIDW---CPEPPPIQGGR---IKVSGRRAGSTALYTCDYGFVLI 505 CQA+ W T P C D+ CP P I G V AG + Y+C+ G++L Sbjct: 123 WCQANEMWGPTALPVCESDFPLECPSLPTIHNGHHTGQHVDQFVAGLSVTYSCEPGYLLT 182 Query: 506 GEPVLSCGLGGNWTGKIPVCRYVDCGMPARPDRGNMLLLNDSTTVGSVVRYFCDDDYWLV 565 G+ + C G+W G IP C+ C P + G + S VG+ V + C++ Y L Sbjct: 183 GKKTIKCLSSGDWDGVIPTCKEAQCEHPGKFPNG-QVKEPLSLQVGTTVYFSCNEGYQLQ 241 Query: 566 GPQELYCT---KDGKWSGSAPACELITCETPHVPP---GSYVIGYDYNI--HSSIQYHCD 617 G C + W+ P C+ I C P PP GS+ + N+ S++ Y CD Sbjct: 242 GQPSSQCVIVEQKAIWT-KKPVCKEILCPPP--PPVRNGSHTGSFSENVPYGSTVTYTCD 298 Query: 618 P------GHILRGEDTLTCL----ESGQWSGDAPDC-----------EYVDCGPLTPIPF 656 P L GE T+ C ++G WSG AP C + G + I Sbjct: 299 PSPEKGVSFTLIGEKTINCTTGSQKTGIWSGPAPYCVLSTSAVLCLQPKIKRGQILSILK 358 Query: 657 GSHRYTQNTTFLGSEVVYSCANSHRLAGVNRRLCLDTGLWSETAPRCEEIRCTEPTLTPH 716 S+ Y V +SC L G C G W P CE+ C P Sbjct: 359 DSYSYNDT-------VAFSCEPGFTLKGNRSIRCNAHGTWEPPVPVCEK-GCQAP----- 405 Query: 717 SFVSVTGNDRMYGRTLIRTSDATVSGAQTFRVGALAKYRCERGYKIVGEALITCEENGLW 776 I S F G +Y C+ GY +VGE I C G W Sbjct: 406 --------------PKIINGQKEDSYLLNFDPGTSIRYSCDPGYLLVGEDTIHCTPEGKW 451 Query: 777 SGEIPECVYVDC--------EMPQNVTHGKVTLATNATYYGAAALYECDGNFKLDGVSRR 828 + P+C +C + PQN + A CD F+L + + Sbjct: 452 TPITPQCTVAECKPVGPHLFKRPQN------------QFIRTAVNSSCDEGFQLSESAYQ 499 Query: 829 LCLEDGTWSHETPACVEITCNEMNVSDALLVSYGSRR---VGVQAEFSCSKGR------Y 879 LC W E C EITC V ++ S G + C G Sbjct: 500 LCQGTIPWFIEIRLCKEITCPPPPVIHNGTHTWSSSEDVPYGTVVTYMCYPGPEEGVKFK 559 Query: 880 MVGNGTRTCLP----TGHWSGRNPVCKL----IDCGRPADIENGRVIVVNEST-VYGGSA 930 ++G T C G WS P+CKL + C +ENG + N++ Y S Sbjct: 560 LIGEQTIHCTSDSRGRGSWSSPAPLCKLSLPAVQC-TDVHVENGVKLTDNKAPYFYNDSV 618 Query: 931 EYHCVPHYNRIGPYLRKCMDDGKWSGEEPRCE 962 + C Y G +C + W E+P C+ Sbjct: 619 MFKCDDGYILSGSSQIRCKANNTWDPEKPLCK 650 Score = 148 bits (374), Expect = 3e-035 Identities = 126/477 (26%), Positives = 188/477 (39%), Gaps = 77/477 (16%) Query: 353 LSCGSPEALVNTTIV---GRNYTVGANITYQCPVG------HSLIGVEMRTCQQN----G 399 ++C P + N T + G +TY C G LIG + C + G Sbjct: 517 ITCPPPPVIHNGTHTWSSSEDVPYGTVVTYMCYPGPEEGVKFKLIGEQTIHCTSDSRGRG 576 Query: 400 VWSGTPPACKYVDCGPLPEIE------HGGIILSEQRTSFGVQAS--YTCHENYTLIGNE 451 WS P CK LP ++ G+ L++ + + S + C + Y L G+ Sbjct: 577 SWSSPAPLCKL----SLPAVQCTDVHVENGVKLTDNKAPYFYNDSVMFKCDDGYILSGSS 632 Query: 452 NRTCQASG-WSGTQPKCLIDWCPEPPPIQG----GRIKVSGRRAGSTALYTCDYGFVLIG 506 C+A+ W +P C + C EP + G IK+ R TC G+ L G Sbjct: 633 QIRCKANNTWDPEKPLCKKEGC-EPMRVHGLPDDSHIKLVKR--------TCQNGYQLTG 683 Query: 507 EPVLSC--GLGGNWTGKIPVCRYVDCGMPAR-PDRGNMLLLNDSTTVGSVVRYFCDDDYW 563 C G W KI VC + C P + + G+ ++ G+ V Y CD+ ++ Sbjct: 684 YTYEKCQNAENGTWFKKIEVCTVILCQPPPKIANGGHTGMMAKHFLYGNEVSYECDEGFY 743 Query: 564 LVGPQELYCTKD----GKWSGSAPACELITCETPHVPPGSYVIGYDYN-IHSSIQYH--- 615 L+G + L C D G WSG P C L + H P GY N HS+ ++ Sbjct: 744 LLGEKSLQCVNDSKGHGSWSGPPPQC-LQSSPLTHCPDPEVKHGYKLNKTHSAFSHNDIV 802 Query: 616 ---CDPGHILRGEDTLTCLESGQWSGDAPDC---EYVDCGPLTPIPFGSHRYTQNTTFL- 668 C+ G I+ G + C + W P C + C + IP G+H F Sbjct: 803 HFVCNQGFIMNGSHLIRCHTNNTWLPGVPTCIRKASLGCQSPSTIPNGNHTGGSIARFPP 862 Query: 669 GSEVVYSCANSHRLAGVNRRLCLDTGLWSETAPRCEEIRCTEPTLTPHSFVSVTGNDRMY 728 G V+YSC +AG R +C G WS+ P C+E+ C+ P T N Sbjct: 863 GMSVMYSCYQGFLMAGEARLICTHEGTWSQPPPFCKEVNCSFPEDT---------NGIQK 913 Query: 729 GRTLIRTSDATVSGAQTFRVGALAKYRCERGYKIVGEALITCEENGLWSGEIPECVY 785 G +T+R GA CE GY + G C+++ W+ + C Y Sbjct: 914 G----------FQPGKTYRFGATVTLECEDGYTLEGSPQSQCQDDSQWNPPLALCKY 960 Score = 42.7 bits (99), Expect = 0.002 Identities = 22/43 (51%), Positives = 23/43 (53%), Gaps = 2/43 (4%) Query: 27 SARYDCDPGYELFGSETIRCDPVKGWDRELPFCGTNVAYRKPV 69 S RY CDPGY L G +TI C P W P C VA KPV Sbjct: 426 SIRYSCDPGYLLVGEDTIHCTPEGKWTPITPQC--TVAECKPV 466 Score = 38.9 bits (89), Expect = 0.036 Identities = 18/46 (39%), Positives = 23/46 (50%) Query: 14 HTEKATDGSGGLKSARYDCDPGYELFGSETIRCDPVKGWDRELPFC 59 HT + D S Y C+PGY L G +TI+C WD +P C Sbjct: 157 HTGQHVDQFVAGLSVTYSCEPGYLLTGKKTIKCLSSGDWDGVIPTC 202 ==> UNIPROT|P17927 - symbol:CR1_HUMAN "CR1, C3BR: Complement receptor type 1 precursor" species:9606 "Homo sapiens" [GO:0004877 "complement component C3b receptor activity" evidence=NR] [GO:0005887 "integral to plasma membrane" evidence=TAS] UniProt:P17927 GO:GO:0005887 InterPro:IPR000436 Pfam:PF00084 SMART:SM00032 PROSITE:PS50923 GO:GO:0006956 EMBL:M11569 EMBL:L17418 EMBL:L17390 EMBL:L17399 EMBL:L17409 EMBL:L17419 EMBL:L17420 EMBL:L17421 EMBL:L17422 EMBL:L17423 EMBL:L17391 EMBL:L17392 EMBL:L17393 EMBL:L17394 EMBL:L17395 EMBL:L17396 EMBL:L17397 EMBL:L17398 EMBL:L17400 EMBL:L17401 EMBL:L17402 EMBL:L17403 EMBL:L17404 EMBL:L17405 EMBL:L17406 EMBL:L17407 EMBL:L17408 EMBL:L17410 EMBL:L17411 EMBL:L17412 EMBL:L17413 EMBL:L17414 EMBL:L17415 EMBL:L17416 EMBL:L17417 EMBL:X14362 EMBL:M11617 EMBL:M11618 EMBL:Y00816 EMBL:X05309 PIR:I73012 UniGene:Hs.334019 PDB:1GKG PDB:1GKN PDB:1GOP PDB:1PPQ SMR:P17927 Ensembl:ENSG00000203710 KEGG:hsa:1378 HGNC:HGNC:2334 MIM:120620 MIM:607486 ArrayExpress:P17927 GermOnline:ENSG00000203710 GO:GO:0004875 Length = 2039 Score = 229 bits (584), Expect = 1e-059 Identities = 175/642 (27%), Positives = 267/642 (41%), Gaps = 73/642 (11%) Query: 371 YTVGANITYQCPVGHSLIGVEMRTCQQNGVWSGTPPACKYVDCGPLPEIEHGGIILSEQR 430 + +G + Y+C G+S + C +N VW+G C+ C P+ G++ + Sbjct: 63 FPIGTYLNYECRPGYSGRPFSI-ICLKNSVWTGAKDRCRRKSCRNPPD-PVNGMVHVIKG 120 Query: 431 TSFGVQASYTCHENYTLIGNENRTCQASG----WSGTQPKCLIDWCPEPPPIQGGRIKVS 486 FG Q Y+C + Y LIG+ + TC SG W P C C PP I G + Sbjct: 121 IQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFIST 180 Query: 487 GR---RAGSTALYTCDYG------FVLIGEPVLSCGLG----GNWTGKIPVCRYVDCGMP 533 R GS Y C+ G F L+GEP + C G W+G P C + P Sbjct: 181 NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP 240 Query: 534 ARPDRGNMLLLNDST-TVGSVVRYFCDDDYWLVGPQELYCTKDGKWSGSAPACELITCET 592 + G ++ N S ++ VV + C + + GP+ + C KW P+C + Sbjct: 241 PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPP 300 Query: 593 PHVPPGSYVIGYDYNIH--SSIQYHCDPGHILRGEDTLTCLESGQWSGDAPDCEYVDCGP 650 P V N + Y C+PG+ LRG ++ C G WS AP CE C Sbjct: 301 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDD 360 Query: 651 LTPIPFGSHRYTQNTTFLGSEVVYSCANSHRLAGVNRRLCLDTG---LWSETAPRCEEIR 707 LG++V + C +L G + C+ G LW+ + P CE+I Sbjct: 361 FMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF 420 Query: 708 CTEPTLTPHSFVSVTGNDRMYGRTLIRTSDATVSGAQTFRVGALAKYRC----ERG--YK 761 C P + P N R G+ L + F G Y C +RG + Sbjct: 421 CPSPPVIP--------NGRHTGKPL-----------EVFPFGKAVNYTCDPHPDRGTSFD 461 Query: 762 IVGEALITC----EENGLWSGEIPEC-VYVDCEMPQNVTHGKVTLATNATYY--GAAALY 814 ++GE+ I C + NG+WS P C + C+ P + K+ TNA+ + G + Y Sbjct: 462 LIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKY 521 Query: 815 ECDGNFKLDGVSRRLCLEDGTWSHETPACVEITC-NEMNVSDALLVSYGSRRVGVQAEFS 873 EC + S CL++ WS C +C + + ++ +VG + +S Sbjct: 522 ECRPEYYGRPFS-ITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYS 580 Query: 874 CSKGRYMVGNGTRTCLPTG---HWSGRNPVCKLIDCGRPADIENGRVIVVN-ESTVYGGS 929 C+ G ++G+ + C+ +G HWS + P+C+ I CG P I NG I N E+ YG Sbjct: 581 CTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSV 640 Query: 930 AEYHCVPH------YNRIGPYLRKCMDD----GKWSGEEPRC 961 Y C P + +G C + G WSG P+C Sbjct: 641 VTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC 682 Score = 217 bits (553), Expect = 6e-056 Identities = 189/708 (26%), Positives = 281/708 (39%), Gaps = 104/708 (14%) Query: 354 SCGSPEALVNTTI-VGRNYTVGANITYQCPVGHSLIGVEMRTCQQNGV---WSGTPPACK 409 SC +P VN + V + VG+ I Y C GH LIG C +G WS PP C+ Sbjct: 1003 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQ 1062 Query: 410 YVDCGPLPEIEHGGIILSEQRT-SFGVQASYTCH------ENYTLIGNENRTC-----QA 457 + CG P I +G I + + +G +Y C+ + + L+G + C Q Sbjct: 1063 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQV 1122 Query: 458 SGWSGTQPKCLIDWCPEPPPIQGGRIKVSGRRA----GSTALYTCDYGFVLIGEPVLSCG 513 WSG P+C+I PP ++ G I VS R+ + C GFV+ G + C Sbjct: 1123 GIWSGPAPQCIIPNKCTPPNVENG-ILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ 1181 Query: 514 LGGNWTGKIPVCRYVDCGMPARPDRGNMLLLN-DSTTVGSVVRYFCDDDYWLVGPQELYC 572 W ++P C V C P G + D+ + G V Y C+ Y L G L+C Sbjct: 1182 ALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHC 1240 Query: 573 TKDGKWSGSAPACELITCET--PHVPPGSYVIGYDYNIHSSIQYHCDPGHILRGEDTLTC 630 T G WS AP C + +C+ +P G + + + + + + CD G L+G C Sbjct: 1241 TPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHC 1300 Query: 631 LESGQ---WSGDAPDCEYVDCGPLTPIPFGSHRYTQNTTF-LGSEVVYSC------ANSH 680 + G W+ P CE++ C I G H T + G E+ Y+C + Sbjct: 1301 VLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTF 1360 Query: 681 RLAGVNRRLCLD----TGLWSETAPRCE-EIR---CTEPTLTPHSFVSVTGND------- 725 L G + C G+WS APRCE +R C P P + ++ ND Sbjct: 1361 NLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGT 1420 Query: 726 ------------RMYG----RTLIRTS-----------------DATVSGAQTFRVGALA 752 +M+ L+ +S + V + G+ Sbjct: 1421 SLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTV 1480 Query: 753 KYRCERGYKIVGEALITCEENG---LWSGEIPECVYVDCEMPQNVTHGKVTLATNATYY- 808 Y C G++++G TC +G W + P C + CE P +++G +++ Sbjct: 1481 NYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHN 1540 Query: 809 GAAALYEC----DGN--FKLDGVSRRLCLED----GTWSHETPACVEIT-CNEMNVSDAL 857 G Y+C DG F+L G C G WS P C+ C V +A+ Sbjct: 1541 GTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAI 1600 Query: 858 LVSYGSRRVGVQAE---FSCSKGRYMVGNGTRTCLPTGHWSGRNPVCKLIDCGRPADIEN 914 V G+R E F C G MVG+ T C G W + P C + C P +I + Sbjct: 1601 RVP-GNRSFFSLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV-CQPPPEILH 1658 Query: 915 GRVIVVNESTVYGGSAE-YHCVPHYNRIGPYLRKCMDDGKWSGEEPRC 961 G + ++ G Y C P Y+ G C G WS E PRC Sbjct: 1659 GEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRC 1706 Score = 213 bits (542), Expect = 1e-054 Identities = 204/773 (26%), Positives = 300/773 (38%), Gaps = 100/773 (12%) Query: 325 VLDGGRSWLWNDVGCNLDYLNYICQHNPLSCGSPEALVNTTIVGR---NYTVGANITYQC 381 VL G RS LWN+ +C+H + C +P A++N G + G I+Y C Sbjct: 1301 VLVGMRS-LWNNSVP-------VCEH--IFCPNPPAILNGRHTGTPSGDIPYGKEISYTC 1350 Query: 382 P------VGHSLIGVEMRTCQQ----NGVWSGTPPACKY-VDCGPLPEIEH-----GGII 425 + +LIG C NGVWS P C+ V G E I Sbjct: 1351 DPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIP 1410 Query: 426 LSEQRTSFGVQASYTCHENYTLIGNENRTCQASGWSGTQPKCLIDWCPEPPPIQGGRIKV 485 +++ G +Y C Y + WS + C C PP G + + Sbjct: 1411 INDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHI 1470 Query: 486 S-GRRAGSTALYTCDYGFVLIGEPVLSCGLGGN---WTGKIPVCRYVDCGMPARPDRGNM 541 + + GST Y+C+ GF LIG P +C + GN W K P+C + C P G+ Sbjct: 1471 NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1530 Query: 542 LLLN-DSTTVGSVVRYFC------DDDYWLVGPQELYCT-KD---GKWSGSAPAC-ELIT 589 N S G+VV Y C + + LVG + +YCT KD G WS P C Sbjct: 1531 YSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNK 1590 Query: 590 CETPHVPPGSYVIGYD--YNIHSSIQYHCDPGHILRGEDTLTCLESGQWSGDAPDCEYVD 647 C P V V G +++ I++ C PG ++ G T+ C +G+W P C V Sbjct: 1591 CTAPEVENAIRVPGNRSFFSLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV- 1649 Query: 648 CGPLTPIPFGSHRYTQNTTFL-GSEVVYSCANSHRLAGVNRRLCLDTGLWSETAPRCEEI 706 C P I G H + F G EV YSC S+ L G C G WS APRC Sbjct: 1650 CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVK 1709 Query: 707 RCTEPT-LTPHSFVSVTGNDRMYGRTLIRTSDATVSGAQTFRVGALAKYRCERGYKIVGE 765 C + PH GR L+ + ++GA + C+ G+++ G Sbjct: 1710 SCDDFLGQLPH------------GRVLLPLN---------LQLGAKVSFVCDEGFRLKGR 1748 Query: 766 ALITCEENG---LWSGEIPECVYVDCEMPQNVTHGKVTLATNATY-YGAAALYECDGN-- 819 + C G LW+ +P C + C P + +G+ T YG Y CD + Sbjct: 1749 SASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPD 1808 Query: 820 ----FKLDGVSRRLCLED----GTWSHETPAC---VEITC-NEMNVSDALLVS--YGSRR 865 F L G S C D G WS P C V C + + + + Sbjct: 1809 RGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYL 1868 Query: 866 VGVQAEFSCSKGRYMVGNGTRTCLPTGHWSGRNPVCKLIDCGRPADIEN-GRVIVVNEST 924 G+ ++C G +VG G C G WS + CK ++C P + + + + + Sbjct: 1869 PGMTISYTCDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEMKKVY 1928 Query: 925 VYGGSAEYHCVPHYNRIGPYLRKCMDDGKWSGEEPRCELIVNDAQETNSLGTGIAIGAAI 984 YG C Y G +C D +W +C +DA L G G Sbjct: 1929 HYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKCTSRAHDA-----LIVGTLSGTIF 1983 Query: 985 IVILLILIG-VLFLHRNKARPVKNTENVQAAEHKEDQNAAVMSYSSLENGRHN 1036 ++L+I + ++ HR +N + V A H Q + + +L+ N Sbjct: 1984 FILLIIFLSWIILKHRKGNNAHENPKEV--AIHLHSQGGSSVHPRTLQTNEEN 2034 Score = 207 bits (528), Expect = 4e-053 Identities = 184/672 (27%), Positives = 264/672 (39%), Gaps = 77/672 (11%) Query: 354 SCGSPEALVNTTI-VGRNYTVGANITYQCPVGHSLIGVEMRTCQQNGV---WSGTPPACK 409 SC +P VN + V + VG+ I Y C GH LIG C +G WS PP C+ Sbjct: 553 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 612 Query: 410 YVDCGPLPEIEHGGIILSEQRT-SFGVQASYTCHEN------YTLIGNENRTC-----QA 457 + CG P I +G I + + +G +Y C+ + L+G + C Q Sbjct: 613 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQV 672 Query: 458 SGWSGTQPKCLIDWCPEPPPIQGGRIKVSGRRA----GSTALYTCDYGFVLIGEPVLSCG 513 WSG P+C+I PP ++ G I VS R+ + C GFV+ G + C Sbjct: 673 GIWSGPAPQCIIPNKCTPPNVENG-ILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ 731 Query: 514 LGGNWTGKIPVCRYVDCGMPARPDRGNMLLLNDSTTVGSVVRYFCDDDYWLVGPQELYCT 573 W ++P C V P D+ + G V Y C+ Y L G + CT Sbjct: 732 ALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCT 791 Query: 574 KDGKWSGSAPACELITCE--TPHVPPGSYVIGYDYNIHSSIQYHCDPGHILRGEDTLTCL 631 G WS +AP CE+ +C+ + G + + + + + + CD G L+G C+ Sbjct: 792 PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCV 851 Query: 632 ESGQ---WSGDAPDCEYVDCGPLTPIPFGSHRYTQNTTF-LGSEVVYSC------ANSHR 681 +G W+ P CE + C IP G H F G V Y+C S Sbjct: 852 LAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFD 911 Query: 682 LAGVNRRLCLD----TGLWSETAPRCEEI-RCTEPTLTPHSFVSVTGNDRMYGRTLIRTS 736 L G + C G+WS APRC + C P D L Sbjct: 912 LIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAP-------------DHFLFAKL---- 954 Query: 737 DATVSGAQTFRVGALAKYRCERGYKIVGEAL-ITCEENGLWSGEIPECVYVDCEMPQNVT 795 T + A F +G KY C Y G ITC +N +WS C C+ P + Sbjct: 955 -KTQTNASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPV 1011 Query: 796 HGKVTLATNATYYGAAALYECDGNFKLDGVSRRLCLEDGT---WSHETPACVEITCN--- 849 +G V + T+ G+ Y C +L G S C+ G WS + P C I C Sbjct: 1012 NGMVHVITD-IQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPP 1070 Query: 850 EMNVSDALLVSYGSRRVGVQAEFSC---SKGR---YMVGNGTRTCL----PTGHWSGRNP 899 + D + + + G + C S+GR +VG + C G WSG P Sbjct: 1071 TIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAP 1130 Query: 900 VCKLIDCGRPADIENGRVIVVNESTV-YGGSAEYHCVPHYNRIGPYLRKCMDDGKWSGEE 958 C + + P ++ENG ++ N S E+ C P + GP KC KW E Sbjct: 1131 QCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPEL 1190 Query: 959 PRCELIVNDAQE 970 P C + E Sbjct: 1191 PSCSRVCQPPPE 1202 Score = 202 bits (514), Expect = 2e-051 Identities = 178/666 (26%), Positives = 259/666 (38%), Gaps = 77/666 (11%) Query: 354 SCGSPEALVNTTI-VGRNYTVGANITYQCPVGHSLIGVEMRTCQQNG---VWSGTPPACK 409 SC +P VN + V + G+ I Y C G+ LIG TC +G +W P C Sbjct: 103 SCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICD 162 Query: 410 YVDCGPLPEIEHGGIILSEQRT-SFGVQASYTCHEN------YTLIGNENRTC-----QA 457 + CG P I +G I + + +G +Y C+ + L+G + C Q Sbjct: 163 RIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQV 222 Query: 458 SGWSGTQPKCLIDWCPEPPPIQGGRIKVSGRRA----GSTALYTCDYGFVLIGEPVLSCG 513 WSG P+C+I PP ++ G I VS R+ + C GFV+ G + C Sbjct: 223 GIWSGPAPQCIIPNKCTPPNVENG-ILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ 281 Query: 514 LGGNWTGKIPVCRYVDCGMPARPDRGNMLLLNDSTTVGSVVRYFCDDDYWLVGPQELYCT 573 W ++P C V P D+ + G V Y C+ Y L G + CT Sbjct: 282 ALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCT 341 Query: 574 KDGKWSGSAPACELITCE--TPHVPPGSYVIGYDYNIHSSIQYHCDPGHILRGEDTLTCL 631 G WS +AP CE+ +C+ + G + + + + + + CD G L+G C+ Sbjct: 342 PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCV 401 Query: 632 ESGQ---WSGDAPDCEYVDCGPLTPIPFGSHRYTQNTTF-LGSEVVYSC------ANSHR 681 +G W+ P CE + C IP G H F G V Y+C S Sbjct: 402 LAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFD 461 Query: 682 LAGVNRRLCLD----TGLWSETAPRCEEI-RCTEPTLTPHSFVSVTGNDRMYGRTLIRTS 736 L G + C G+WS APRC + C P D L Sbjct: 462 LIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAP-------------DHFLFAKL---- 504 Query: 737 DATVSGAQTFRVGALAKYRCERGYKIVGEAL-ITCEENGLWSGEIPECVYVDCEMPQNVT 795 T + A F +G KY C Y G ITC +N +WS C C+ P + Sbjct: 505 -KTQTNASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPV 561 Query: 796 HGKVTLATNATYYGAAALYECDGNFKLDGVSRRLCLEDGT---WSHETPACVEITCN--- 849 +G V + T+ G+ Y C +L G S C+ G WS + P C I C Sbjct: 562 NGMVHVITD-IQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPP 620 Query: 850 EMNVSDALLVSYGSRRVGVQAEFSCSKGR------YMVGNGTRTCL----PTGHWSGRNP 899 + D + + + G + C+ G +VG + C G WSG P Sbjct: 621 TIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAP 680 Query: 900 VCKLIDCGRPADIENGRVIVVNESTV-YGGSAEYHCVPHYNRIGPYLRKCMDDGKWSGEE 958 C + + P ++ENG ++ N S E+ C P + GP KC KW E Sbjct: 681 QCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPEL 740 Query: 959 PRCELI 964 P C + Sbjct: 741 PSCSRV 746 Score = 47.0 bits (110), Expect = 1e-004 Identities = 29/102 (28%), Positives = 40/102 (39%), Gaps = 5/102 (4%) Query: 866 VGVQAEFSCSKGRYMVGNGTRTCLPTGHWSGRNPVCKLIDCGRPADIENGRVIVVNESTV 925 +G + C G Y + CL W+G C+ C P D NG V V+ + Sbjct: 65 IGTYLNYECRPG-YSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVI-KGIQ 122 Query: 926 YGGSAEYHCVPHYNRIGPYLRKCMDDGK---WSGEEPRCELI 964 +G +Y C Y IG C+ G W E P C+ I Sbjct: 123 FGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRI 164 Score = 42.4 bits (98), Expect = 0.003 Identities = 20/59 (33%), Positives = 29/59 (49%), Gaps = 1/59 (1%) Query: 1 VCGPPAVPANARVHTEKATDGSGGLKSARYDCDPGYELFGSETIRCDPVKGWDRELPFC 59 VC PP +A T++ D + Y C+PGY+L G+ ++RC P W P C Sbjct: 296 VCQPPPDVLHAE-RTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC 353 Score = 42.4 bits (98), Expect = 0.003 Identities = 20/59 (33%), Positives = 29/59 (49%), Gaps = 1/59 (1%) Query: 1 VCGPPAVPANARVHTEKATDGSGGLKSARYDCDPGYELFGSETIRCDPVKGWDRELPFC 59 VC PP +A T++ D + Y C+PGY+L G+ ++RC P W P C Sbjct: 746 VCQPPPDVLHAE-RTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC 803 Score = 42.4 bits (98), Expect = 0.003 Identities = 20/59 (33%), Positives = 27/59 (45%), Gaps = 1/59 (1%) Query: 1 VCGPPAVPANARVHTEKATDGSGGLKSARYDCDPGYELFGSETIRCDPVKGWDRELPFC 59 VC PP + HT D + Y C+PGY+L G+ ++ C P W E P C Sbjct: 1196 VCQPPPEILHGE-HTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC 1253 Score = 41.6 bits (96), Expect = 0.006 Identities = 24/62 (38%), Positives = 30/62 (48%), Gaps = 8/62 (12%) Query: 2 CGPPAVPANARVHTEKATDGSGGLKSARYDCDPGYELFGSETIRCDPVKG----WDRELP 57 CGPP P N VH TD G + Y C+ G+ L GS + C V G WD++ P Sbjct: 1457 CGPPPEPFNGMVHIN--TDTQFG-STVNYSCNEGFRLIGSPSTTC-LVSGNNVTWDKKAP 1512 Query: 58 FC 59 C Sbjct: 1513 IC 1514 Score = 39.3 bits (90), Expect = 0.028 Identities = 19/59 (32%), Positives = 26/59 (44%), Gaps = 1/59 (1%) Query: 1 VCGPPAVPANARVHTEKATDGSGGLKSARYDCDPGYELFGSETIRCDPVKGWDRELPFC 59 VC PP + HT D + Y C+P Y+L G+ ++ C P W E P C Sbjct: 1649 VCQPPPEILHGE-HTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRC 1706 Score = 37.7 bits (86), Expect = 0.080 Identities = 23/62 (37%), Positives = 25/62 (40%), Gaps = 8/62 (12%) Query: 2 CGPPAVPANARVHTEKATDGSGGLKSARYDCDPGYELFGSETIRC----DPVKGWDRELP 57 C P P N VH K +K Y C GY L GS + C D V WD E P Sbjct: 104 CRNPPDPVNGMVHVIKGIQFGSQIK---YSCTKGYRLIGSSSATCIISGDTVI-WDNETP 159 Query: 58 FC 59 C Sbjct: 160 IC 161 ==> MGI|MGI:98280 - symbol:Selp "selectin, platelet" species:10090 "Mus musculus" [GO:0016020 "membrane" evidence=IDA] [GO:0005624 "membrane fraction" evidence=ISS] [GO:0016021 "integral to membrane" evidence=RCA] [GO:0006954 "inflammatory response" evidence=IMP] [GO:0031092 "platelet alpha granule membrane" evidence=ISS] InterPro:IPR001304 MGI:MGI:98280 InterPro:IPR002396 InterPro:IPR000742 InterPro:IPR006210 InterPro:IPR006209 Pfam:PF00059 SMART:SM00034 PROSITE:PS00615 PROSITE:PS50041 GO:GO:0006954 InterPro:IPR013032 PROSITE:PS00022 PROSITE:PS01186 PROSITE:PS50026 SMART:SM00181 Pfam:PF00008 InterPro:IPR000436 Pfam:PF00084 SMART:SM00032 PROSITE:PS50923 HSSP:P16109 PRINTS:PR00343 EMBL:M87861 EMBL:M72332 PIR:A42755 UniGene:Mm.3337 SMR:Q01102 Ensembl:ENSMUSG00000026580 KEGG:mmu:20344 ArrayExpress:Q01102 GermOnline:ENSMUSG00000026580 Uniprot:Q01102 Length = 768 Score = 225 bits (574), Expect = 2e-058 Identities = 184/713 (25%), Positives = 279/713 (39%), Gaps = 104/713 (14%) Query: 234 TRGESFDKARAVCKSHGGDLIHDFRGVTTDYIISELERRKTDLRTQLVWIGAQKEPGITS 293 T+ S++ +R C+ H DL+ + I+ L WIG +K + Sbjct: 48 TKAYSWNNSRVFCRRHFTDLV----AIQNKNEIAHLND-VIPFFNSYYWIGIRK----IN 98 Query: 294 RTWKWVNGDTVLKP---TWGKDQPNNYNGEQNCV---VLDGGRSWLWNDVGC--NLDYLN 345 W WV + L W ++PNN Q+CV + WND C L Sbjct: 99 NKWTWVGTNKTLTEEAENWADNEPNNKKNNQDCVEIYIKSNSAPGKWNDEPCFKRKRALC 158 Query: 346 YICQHNPLSCGSPEALVNTTIVGRNYTVGANITYQCPVGHSLIGVEMRTCQQNGVWSGTP 405 Y +SC + + T +G+ Y C G Sbjct: 159 YTASCQDMSCSNQGECIET--------IGS---YTCSCYPGFYG---------------- 191 Query: 406 PACKYV-DCGPLPEIEHGGIILSEQ--RTSFGVQASYTCHENYTLIGNENRTCQASG-WS 461 P C+YV +CG + +H + S SF Q +++C E Y L G C ASG W+ Sbjct: 192 PECEYVKECGKVNIPQHVLMNCSHPLGEFSFNSQCTFSCAEGYELDGPGELQCLASGIWT 251 Query: 462 GTQPKCLIDWCP--EPPP--IQGGRIKVSGRRAGSTALYTCDYGFVLIGEPVLSCGLGGN 517 PKC C E PP ++ S+ + C G+ G L C G Sbjct: 252 NNPPKCDAVQCQSLEAPPHGTMACMHPIAAFAYDSSCKFECQPGYRARGSNTLHCTGSGQ 311 Query: 518 WTGKIPVCRYVDCGMPARPDRGNMLLLNDSTTVG--SVVRYFCDDDYWLVGPQELYCTKD 575 W+ +P C + C P P G+M + + T G S + C + + L G + C Sbjct: 312 WSEPLPTCEAIACEPPEIPIHGSMDCVPSTGTFGYNSSCTFLCAEGFVLKGNDAIQCADS 371 Query: 576 GKWSGSAPACELITCETPHVPPGSYVIGYD----YNIHSSIQYHCDPGHILRGEDTLTCL 631 G+W+ AP CE + C VP + V D S + CD G +L G + CL Sbjct: 372 GQWTAPAPFCEALQCPEFPVPSKAQVNCSDPFGTLTYQSVCSFSCDEGSLLVGASVIRCL 431 Query: 632 ESGQWSGDAPDCEYVDCGPLTPIPFGSHRYTQ---NTTFLGSEVVYSCANSHRLAGVNRR 688 +G W+G P+C+ V C P+ GS Q N+T+ S + C L+G R Sbjct: 432 ATGHWNGAPPECQAVSCAPMLSPENGSMTCVQPLGNSTYK-STCQFMCDEGFYLSGPERL 490 Query: 689 LCLDTGLWSETAPRCEEIRCTEPTLTPHSFVSVTGNDRMYGRTLIRTSDATVSGAQTFRV 748 C +G W+ T P CE I+C P F GN + V G F V Sbjct: 491 DCSPSGHWTGTPPTCEAIKC------PGIFAPEQGN----------LDCSHVHGE--FGV 532 Query: 749 GALAKYRCERGYKIVGEALITCEENGLWSGEIPECVYVDC------EMPQNVTHGKVTLA 802 G++ + C ++++G + C +G WS P C + P T G+ T++ Sbjct: 533 GSICHFSCNEDFELLGSENVECTVSGRWSAPPPTCKGITSLPAPAVRCPALTTPGQGTMS 592 Query: 803 T---------NATYYGAAALYECDGNFKLDGVSRRLCLEDGTWSHETPACVEITCNEMNV 853 N T Y + C F L G + C G W+ TP C + C+E+++ Sbjct: 593 CQHHLGSFGPNTTCY-----FGCKTGFTLRGANSLRCRASGQWTAVTPMCRAVKCSELHM 647 Query: 854 SDALLVS----YGSRRVGVQAEFSCSKGRYMVGNGTRTCLPTGHWSGRNPVCK 902 A+ ++ +G+ G F C +G+ + G+ TC GHWS P C+ Sbjct: 648 DTAVAMNCSNPWGNFSYGSTCTFQCPEGQSLNGSVRATCREDGHWSDAMPTCQ 700 Score = 191 bits (486), Expect = 3e-048 Identities = 140/536 (26%), Positives = 215/536 (40%), Gaps = 65/536 (12%) Query: 492 STALYTCDYGFVLIGEPVLSCGLGGNWTGKIPVCRYVDCGMPARPDRGNMLLLNDSTTVG 551 S ++C G+ L G L C G WT P C V C P G M ++ Sbjct: 224 SQCTFSCAEGYELDGPGELQCLASGIWTNNPPKCDAVQCQSLEAPPHGTMACMHPIAAFA 283 Query: 552 --SVVRYFCDDDYWLVGPQELYCTKDGKWSGSAPACELITCETPHVP--------PGSYV 601 S ++ C Y G L+CT G+WS P CE I CE P +P P + Sbjct: 284 YDSSCKFECQPGYRARGSNTLHCTGSGQWSEPLPTCEAIACEPPEIPIHGSMDCVPSTGT 343 Query: 602 IGYDYNIHSSIQYHCDPGHILRGEDTLTCLESGQWSGDAPDCEYVDCGPLTPIPFGSHRY 661 GY+ SS + C G +L+G D + C +SGQW+ AP CE + C P P+P + Sbjct: 344 FGYN----SSCTFLCAEGFVLKGNDAIQCADSGQWTAPAPFCEALQC-PEFPVPSKAQVN 398 Query: 662 TQN---TTFLGSEVVYSCANSHRLAGVNRRLCLDTGLWSETAPRCEEIRCTEPTLTPHSF 718 + T S +SC L G + CL TG W+ P C+ + C P L+P Sbjct: 399 CSDPFGTLTYQSVCSFSCDEGSLLVGASVIRCLATGHWNGAPPECQAVSCA-PMLSPE-- 455 Query: 719 VSVTGNDRMYGRTLIRTSDATVSGAQTFRVGALAKYRCERGYKIVGEALITCEENGLWSG 778 N M T ++ G T++ + ++ C+ G+ + G + C +G W+G Sbjct: 456 -----NGSM---TCVQPL-----GNSTYK--STCQFMCDEGFYLSGPERLDCSPSGHWTG 500 Query: 779 EIPECVYVDCEMPQNVTHGKVTLATNATYYGAAAL--YECDGNFKLDGVSRRLCLEDGTW 836 P C + C G + + +G ++ + C+ +F+L G C G W Sbjct: 501 TPPTCEAIKCPGIFAPEQGNLDCSHVHGEFGVGSICHFSCNEDFELLGSENVECTVSGRW 560 Query: 837 SHETPACVEIT--------CNEMNVSDALLVS----YGSRRVGVQAEFSCSKGRYMVGNG 884 S P C IT C + +S GS F C G + G Sbjct: 561 SAPPPTCKGITSLPAPAVRCPALTTPGQGTMSCQHHLGSFGPNTTCYFGCKTGFTLRGAN 620 Query: 885 TRTCLPTGHWSGRNPVCKLIDCGRPADIENGRVIVVNEST-----VYGGSAEYHCVPHYN 939 + C +G W+ P+C+ + C +++ + +N S YG + + C + Sbjct: 621 SLRCRASGQWTAVTPMCRAVKC---SELHMDTAVAMNCSNPWGNFSYGSTCTFQCPEGQS 677 Query: 940 RIGPYLRKCMDDGKWSGEEPRCELIVNDAQET-NSLG------TGIAIGAAIIVIL 988 G C +DG WS P C+ QE LG TG+A+G ++ +L Sbjct: 678 LNGSVRATCREDGHWSDAMPTCQAGTLTIQEALTYLGGAVASTTGLAVGGTLLALL 733 Score = 173 bits (438), Expect = 1e-042 Identities = 130/474 (27%), Positives = 195/474 (41%), Gaps = 57/474 (12%) Query: 523 PVCRYV-DCGMPARPDRGNMLLLNDSTTVG-----SVVRYFCDDDYWLVGPQELYCTKDG 576 P C YV +CG P +L+N S +G S + C + Y L GP EL C G Sbjct: 192 PECEYVKECGKVNIPQH---VLMNCSHPLGEFSFNSQCTFSCAEGYELDGPGELQCLASG 248 Query: 577 KWSGSAPACELITCETPHVPPGSY------VIGYDYNIHSSIQYHCDPGHILRGEDTLTC 630 W+ + P C+ + C++ PP + + Y+ SS ++ C PG+ RG +TL C Sbjct: 249 IWTNNPPKCDAVQCQSLEAPPHGTMACMHPIAAFAYD--SSCKFECQPGYRARGSNTLHC 306 Query: 631 LESGQWSGDAPDCEYVDCGPLTPIPFGSHRYTQNTTFLG--SEVVYSCANSHRLAGVNRR 688 SGQWS P CE + C P GS +T G S + CA L G + Sbjct: 307 TGSGQWSEPLPTCEAIACEPPEIPIHGSMDCVPSTGTFGYNSSCTFLCAEGFVLKGNDAI 366 Query: 689 LCLDTGLWSETAPRCEEIRCTEPTLTPHSFVSVTGNDRMYGRTLIRTSDATVSGAQTFRV 748 C D+G W+ AP CE ++C E + + + SD G T++ Sbjct: 367 QCADSGQWTAPAPFCEALQCPEFPVP--------------SKAQVNCSDP--FGTLTYQ- 409 Query: 749 GALAKYRCERGYKIVGEALITCEENGLWSGEIPECVYVDCEMPQNVTHGKVTLAT---NA 805 ++ + C+ G +VG ++I C G W+G PEC V C + +G +T N+ Sbjct: 410 -SVCSFSCDEGSLLVGASVIRCLATGHWNGAPPECQAVSCAPMLSPENGSMTCVQPLGNS 468 Query: 806 TYYGAAALYECDGNFKLDGVSRRLCLEDGTWSHETPACVEITC-----NEMNVSDALLVS 860 T Y + + CD F L G R C G W+ P C I C E D V Sbjct: 469 T-YKSTCQFMCDEGFYLSGPERLDCSPSGHWTGTPPTCEAIKCPGIFAPEQGNLDCSHV- 526 Query: 861 YGSRRVGVQAEFSCSKGRYMVGNGTRTCLPTGHWSGRNPVCK--------LIDCGRPADI 912 +G VG FSC++ ++G+ C +G WS P CK + C Sbjct: 527 HGEFGVGSICHFSCNEDFELLGSENVECTVSGRWSAPPPTCKGITSLPAPAVRCPALTTP 586 Query: 913 ENGRVIVVNESTVYGGSAE--YHCVPHYNRIGPYLRKCMDDGKWSGEEPRCELI 964 G + + +G + + C + G +C G+W+ P C + Sbjct: 587 GQGTMSCQHHLGSFGPNTTCYFGCKTGFTLRGANSLRCRASGQWTAVTPMCRAV 640 Score = 60.5 bits (145), Expect = 1e-008 Identities = 36/137 (26%), Positives = 58/137 (42%), Gaps = 7/137 (5%) Query: 841 PACVEIT-CNEMNVSDALLVS----YGSRRVGVQAEFSCSKGRYMVGNGTRTCLPTGHWS 895 P C + C ++N+ +L++ G Q FSC++G + G G CL +G W+ Sbjct: 192 PECEYVKECGKVNIPQHVLMNCSHPLGEFSFNSQCTFSCAEGYELDGPGELQCLASGIWT 251 Query: 896 GRNPVCKLIDCGRPADIENGRVIVVNE--STVYGGSAEYHCVPHYNRIGPYLRKCMDDGK 953 P C + C +G + ++ + Y S ++ C P Y G C G+ Sbjct: 252 NNPPKCDAVQCQSLEAPPHGTMACMHPIAAFAYDSSCKFECQPGYRARGSNTLHCTGSGQ 311 Query: 954 WSGEEPRCELIVNDAQE 970 WS P CE I + E Sbjct: 312 WSEPLPTCEAIACEPPE 328 ==> UNIPROT|P16581 - symbol:LYAM2_HUMAN "SELE, ELAM1: E-selectin precursor" species:9606 "Homo sapiens" [GO:0006954 "inflammatory response" evidence=TAS] [GO:0005886 "plasma membrane" evidence=TAS] InterPro:IPR001304 InterPro:IPR002396 UniProt:P16581 InterPro:IPR000742 InterPro:IPR006210 InterPro:IPR006209 Pfam:PF00059 SMART:SM00034 PROSITE:PS00615 PROSITE:PS50041 GO:GO:0005886 GO:GO:0006954 InterPro:IPR013032 PROSITE:PS00022 PROSITE:PS01186 PROSITE:PS50026 SMART:SM00181 Pfam:PF00008 InterPro:IPR000436 Pfam:PF00084 SMART:SM00032 PROSITE:PS50923 PRINTS:PR00343 EMBL:M30640 EMBL:M61893 EMBL:M61895 EMBL:M61887 EMBL:M61888 EMBL:M61890 EMBL:M61891 EMBL:M61892 EMBL:M24736 EMBL:AF540378 EMBL:AL021940 PIR:A38615 UniGene:Hs.89546 PDB:1ESL PDB:1G1T PDB:1KJA Ensembl:ENSG00000007908 KEGG:hsa:6401 HGNC:HGNC:10718 HPA:CAB002143 MIM:131210 LinkHub:P16581 ArrayExpress:P16581 GermOnline:ENSG00000007908 RZPD-ProtExp:A0249 RZPD-ProtExp:IOH42039 Length = 610 Score = 196 bits (497), Expect = 2e-049 Identities = 141/532 (26%), Positives = 213/532 (40%), Gaps = 72/532 (13%) Query: 234 TRGESFDKARAVCKSHGGDLIHDFRGVTTDYIISELERRKTDLRTQLVWIGAQKEPGITS 293 T ++D+A A C+ L+ +Y+ S L + WIG +K + Sbjct: 28 TEAMTYDEASAYCQQRYTHLVAIQNKEEIEYLNSILSYSPS-----YYWIGIRK----VN 78 Query: 294 RTWKWVNGDTVLKP---TWGKDQPNNYNGEQNCVVLDGGRS---WLWNDVGCNLDYL--- 344 W WV L W +PNN +++CV + R +WND C+ L Sbjct: 79 NVWVWVGTQKPLTEEAKNWAPGEPNNRQKDEDCVEIYIKREKDVGMWNDERCSKKKLALC 138 Query: 345 ---------------------NYICQHNPLSCGSP-EALVNTTIVGR------------- 369 NY C+ +P G E +VN T + Sbjct: 139 YTAACTNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLG 198 Query: 370 NYTVGANITYQCPVGHSLIGVEMRTCQQNGVWSGTPPACKYVDCGPLPEIEHGGIILSEQ 429 N++ ++ + C G+ +E C +G WS PAC V+C + +G + + Sbjct: 199 NFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQN 258 Query: 430 RTSF--GVQASYTCHENYTLIGNENRTCQASG-WSGTQPKCLIDWCPEPPPIQGGRIKVS 486 SF ++ C E + L+G ++ C +SG W +P C C Q G ++ S Sbjct: 259 PGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCS 318 Query: 487 GRRAG-----STALYTCDYGFVLIGEPVLSCGLGGNWTGKIPVCRYVDCGMPARPDRGNM 541 AG S+ +TC+ GF+L G + C G WT +IPVC C + P+RG M Sbjct: 319 HSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYM 378 Query: 542 LLL---NDSTTVGSVVRYFCDDDYWLVGPQELYCTKDGKWSGSAPACELITCETPHVPPG 598 L + S GS + C+ + L G + L C G+W P CE + C+ H PP Sbjct: 379 NCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPK 438 Query: 599 SYV------IGYDYNIHSSIQYHCDPGHILRGEDTLTCLESGQWSGDAPDCEYVDCGPLT 652 V IG ++ SS + C+ G L G L C GQW+ + P C+ V C L Sbjct: 439 GLVRCAHSPIG-EFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLA 497 Query: 653 PIPFGSHRYTQNTTFLGSEVVYSCANSHRLAGVNRRLCLDTGLWSETAPRCE 704 +P + G+ ++C L G R C TG WS P CE Sbjct: 498 -VPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCE 548 Score = 164 bits (414), Expect = 7e-040 Identities = 99/388 (25%), Positives = 168/388 (43%), Gaps = 30/388 (7%) Query: 528 VDCGMPARPDRGNMLLLND--STTVGSVVRYFCDDDYWLVGPQELYCTKDGKWSGSAPAC 585 V+C P+ G+++ + + + S CD Y + + C G+WS PAC Sbjct: 178 VNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPAC 237 Query: 586 ELITCETPHVPPGSYVIGYD----YNIHSSIQYHCDPGHILRGEDTLTCLESGQWSGDAP 641 ++ C+ P +V + + +++ + C+ G L G +L C SG W + P Sbjct: 238 NVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKP 297 Query: 642 DCEYVDCGPLTPIPFGSHRYTQNTT---FLGSEVVYSCANSHRLAGVNRRLCLDTGLWSE 698 C+ V C + GS R + + S ++C L G + C G W++ Sbjct: 298 TCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQ 357 Query: 699 TAPRCEEIRCTEPTLTPHSFVSVTGNDRMYGRTLIRTSDATVSGAQTFRVGALAKYRCER 758 P CE +CT +++ +R Y L S + +FR G+ ++ CE+ Sbjct: 358 QIPVCEAFQCT----------ALSNPERGYMNCL-------PSASGSFRYGSSCEFSCEQ 400 Query: 759 GYKIVGEALITCEENGLWSGEIPECVYVDCEMPQNVTHGKVTLATNAT---YYGAAALYE 815 G+ + G + C G W E P C V C+ G V A + Y ++ + Sbjct: 401 GFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFS 460 Query: 816 CDGNFKLDGVSRRLCLEDGTWSHETPACVEITCNEMNVSDALLVSYGSRRV-GVQAEFSC 874 C+ F+L G ++ C G W+ E P+C + C+ + V + +S V G +F+C Sbjct: 461 CEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFAC 520 Query: 875 SKGRYMVGNGTRTCLPTGHWSGRNPVCK 902 +G + G+ RTC TGHWSG P C+ Sbjct: 521 PEGWTLNGSAARTCGATGHWSGLLPTCE 548 Score = 143 bits (361), Expect = 1e-033 Identities = 110/461 (23%), Positives = 183/461 (39%), Gaps = 42/461 (9%) Query: 572 CTKDGKWSGSAPACE-LITCETPHVPP-GSYVIGY---DYNIHSSIQYHCDPGHILRGED 626 C D +SG CE ++ C P GS V + +++ +SS CD G++ + Sbjct: 163 CKCDPGFSGLK--CEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSME 220 Query: 627 TLTCLESGQWSGDAPDCEYVDCGPLTPIPFGSHRYTQNTTFL--GSEVVYSCANSHRLAG 684 T+ C+ SG+WS P C V+C +T G QN + + C L G Sbjct: 221 TMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMG 280 Query: 685 VNRRLCLDTGLWSETAPRCEEIRCTEPTLTPHSFVSVTGNDRMYGRTLIRTSDATVSGAQ 744 C +G W P C+ + C + V + + +G Sbjct: 281 AQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSP---------------AGEF 325 Query: 745 TFRVGALAKYRCERGYKIVGEALITCEENGLWSGEIPECVYVDCEMPQNVTHGKVTLATN 804 TF+ + + CE G+ + G A + C G W+ +IP C C N G + + Sbjct: 326 TFK--SSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPS 383 Query: 805 AT---YYGAAALYECDGNFKLDGVSRRLCLEDGTWSHETPACVEITCNEMNVSDALLVSY 861 A+ YG++ + C+ F L G R C G W +E P C + C+ ++ LV Sbjct: 384 ASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRC 443 Query: 862 GSRRVGV-----QAEFSCSKGRYMVGNGTRTCLPTGHWSGRNPVCKLIDCGRPADIENGR 916 +G FSC +G + G+ C G W+ P C+++ C A + Sbjct: 444 AHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLA-VPGKI 502 Query: 917 VIVVNESTVYGGSAEYHCVPHYNRIGPYLRKCMDDGKWSGEEPRCELIVNDAQETNSLGT 976 + + V+G ++ C + G R C G WSG P CE A +++ Sbjct: 503 NMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCE-----APTESNIPL 557 Query: 977 GIAIGAAIIVILLILIGVLFLHR--NKARPVKNTENVQAAE 1015 + AA + +L + +L+L + KA+ + Q+ E Sbjct: 558 VAGLSAAGLSLLTLAPFLLWLRKCLRKAKKFVPASSCQSLE 598 Score = 95.5 bits (236), Expect = 3e-019 Identities = 62/228 (27%), Positives = 94/228 (41%), Gaps = 10/228 (4%) Query: 371 YTVGANITYQCPVGHSLIGVEMRTCQQNGVWSGTPPACKYVDCGPLPEIEHGGI-ILSEQ 429 +T ++ + C G L G C G W+ P C+ C L E G + L Sbjct: 325 FTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSA 384 Query: 430 RTSF--GVQASYTCHENYTLIGNENRTCQASG-WSGTQPKCLIDWCPEPPPIQGGRIKVS 486 SF G ++C + + L G++ C +G W +P C C G ++ + Sbjct: 385 SGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCA 444 Query: 487 GRRAG-----STALYTCDYGFVLIGEPVLSCGLGGNWTGKIPVCRYVDCGMPARPDRGNM 541 G S+ ++C+ GF L G L C G WT ++P C+ V C A P + NM Sbjct: 445 HSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINM 504 Query: 542 LLLNDSTTVGSVVRYFCDDDYWLVGPQELYCTKDGKWSGSAPACELIT 589 + G+V ++ C + + L G C G WSG P CE T Sbjct: 505 SCSGEPV-FGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPT 551 Score = 45.4 bits (106), Expect = 4e-004 Identities = 26/82 (31%), Positives = 37/82 (45%), Gaps = 2/82 (2%) Query: 2 CGPPAVPANARVHTEKATDGSGGLKSARYDCDPGYELFGSETIRCDPVKGWDRELPFCG- 60 C PAN V + + +DC+ G+EL G+++++C WD E P C Sbjct: 242 CDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKA 301 Query: 61 -TNVAYRKPVNQSSATRAGPAG 81 T A R+P N S PAG Sbjct: 302 VTCRAVRQPQNGSVRCSHSPAG 323 ==> MGI|MGI:98278 - symbol:Sele "selectin, endothelial cell" species:10090 "Mus musculus" [GO:0005509 "calcium ion binding" evidence=RCA] [GO:0007157 "heterophilic cell adhesion" evidence=RCA] InterPro:IPR001304 InterPro:IPR002396 InterPro:IPR000742 InterPro:IPR006210 InterPro:IPR006209 MGI:MGI:98278 UniProt:Q00690 Pfam:PF00059 SMART:SM00034 PROSITE:PS00615 PROSITE:PS50041 HSSP:P16581 InterPro:IPR013032 PROSITE:PS00022 PROSITE:PS01186 PROSITE:PS50026 SMART:SM00181 Pfam:PF00008 InterPro:IPR000436 Pfam:PF00084 SMART:SM00032 PROSITE:PS50923 PRINTS:PR00343 EMBL:M80778 EMBL:M87862 PIR:S23174 UniGene:Mm.5245 SMR:Q00690 Ensembl:ENSMUSG00000026582 KEGG:mmu:20339 ArrayExpress:Q00690 GermOnline:ENSMUSG00000026582 Length = 612 Score = 181 bits (459), Expect = 4e-045 Identities = 134/528 (25%), Positives = 207/528 (39%), Gaps = 71/528 (13%) Query: 238 SFDKARAVCKSHGGDLIHDFRGVTTDYIISELERRKTDLRTQLVWIGAQKEPGITSRTWK 297 ++D+A A C+ L+ +Y+ S L+ + WIG +K + W Sbjct: 32 TYDEASAYCQRDYTHLVAIQNKEEINYLNSNLKHSPS-----YYWIGIRK----VNNVWI 82 Query: 298 WVNGDTVLKP---TWGKDQPNNYNGEQNCVVLDGGR---SWLWNDVGCNLDYL------- 344 WV L W +PNN ++CV + R S +WND CN L Sbjct: 83 WVGTGKPLTEEAQNWAPGEPNNKQRNEDCVEIYIQRTKDSGMWNDERCNKKKLALCYTAS 142 Query: 345 -----------------NYICQHNP----------LSCGSPE----ALVNTTIVGRNYTV 373 +Y C+ +P ++C E +N + ++ Sbjct: 143 CTNASCSGHGECIETINSYTCKCHPGFLGPNCEQAVTCKPQEHPDYGSLNCSHPFGPFSY 202