>AGAP001864-PA

FB|FBgn0011576 - symbol:Cyp4d2 "Cytochrome P450-4d2" species:722...   357   3e-098
FB|FBgn0023541 - symbol:Cyp4d14 "Cyp4d14" species:7227 "Drosophi...   355   6e-098
MGI|MGI:2142763 - symbol:Cyp4v3 "cytochrome P450, family 4, subf...   331   1e-090
FB|FBgn0031925 - symbol:Cyp4d21 "Cyp4d21" species:7227 "Drosophi...   329   4e-090
FB|FBgn0035344 - symbol:Cyp4d20 "Cyp4d20" species:7227 "Drosophi...   327   2e-089
FB|FBgn0015032 - symbol:Cyp4c3 "Cytochrome P450-4c3" species:722...   327   3e-089
FB|FBgn0030615 - symbol:Cyp4s3 "Cyp4s3" species:7227 "Drosophila...   322   9e-088
FB|FBgn0015034 - symbol:Cyp4e1 "Cytochrome P450-4e1" species:722...   314   2e-085
FB|FBgn0005670 - symbol:Cyp4d1 "Cytochrome P450-4d1" species:722...   310   2e-084
FB|FBgn0015033 - symbol:Cyp4d8 "Cytochrome P450-4d8" species:722...   308   8e-084
FB|FBgn0015035 - symbol:Cyp4e3 "Cytochrome P450-4e3" species:722...   298   1e-080
FB|FBgn0015036 - symbol:Cyp4ae1 "Cytochrome P450-4ae1" species:7...   295   7e-080
FB|FBgn0014469 - symbol:Cyp4e2 "Cytochrome P450-4e2" species:722...   293   3e-079
FB|FBgn0010019 - symbol:Cyp4g1 "Cytochrome P450-4g1" species:722...   276   3e-074
UNIPROT|P98187 - symbol:CP4F8_HUMAN "CYP4F8: Cytochrome P450 4F8...   273   3e-073
UNIPROT|P78329 - symbol:CP4F2_HUMAN "CYP4F2: Cytochrome P450 4F2...   270   2e-072
FB|FBgn0031693 - symbol:Cyp4ac1 "Cyp4ac1" species:7227 "Drosophi...   270   2e-072
UNIPROT|Q9HBI6 - symbol:CP4FB_HUMAN "CYP4F11: Cytochrome P450 4F...   267   2e-071
MGI|MGI:1919304 - symbol:Cyp4f18 "cytochrome P450, family 4, sub...   260   3e-069
FB|FBgn0030304 - symbol:Cyp4g15 "Cyp4g15" species:7227 "Drosophi...   260   3e-069
UNIPROT|Q08477 - symbol:CP4F3_HUMAN "CYP4F3, LTB4H: Cytochrome P...   259   4e-069
MGI|MGI:1927669 - symbol:Cyp4f14 "cytochrome P450, family 4, sub...   259   7e-069
FB|FBgn0031695 - symbol:Cyp4ac3 "Cyp4ac3" species:7227 "Drosophi...   247   2e-065
FB|FBgn0033397 - symbol:Cyp4p3 "Cyp4p3" species:7227 "Drosophila...   245   8e-065
MGI|MGI:103225 - symbol:Cyp4b1 "cytochrome P450, family 4, subfa...   243   4e-064


==> FB|FBgn0011576 - symbol:Cyp4d2 "Cytochrome P450-4d2" species:7227
           "Drosophila melanogaster" [GO:0009055 "electron carrier
           activity" evidence=ISS;NAS] [GO:0005792 "microsome"
           evidence=NAS] [GO:0016020 "membrane" evidence=NAS]
           InterPro:IPR001128 Pfam:PF00067 InterPro:IPR002401
           EMBL:AE014298 Gene3D:G3DSA:1.10.630.10 PRINTS:PR00463
           PRINTS:PR00385 PROSITE:PS00086 PANTHER:PTHR19383
           HSSP:P14779 EMBL:AL009194 EMBL:X75955 EMBL:Z23005
           EMBL:AY118763 EMBL:AF017006 EMBL:AF017007 EMBL:AF017008
           EMBL:AF017009 EMBL:AF017010 EMBL:AF017011 EMBL:AF017012
           EMBL:AF017013 EMBL:AF017014 EMBL:AF017015 EMBL:AF017016
           EMBL:AF017017 EMBL:AF017018 UniGene:Dm.1696
           Ensembl:CG3466 KEGG:dme:Dmel_CG3466 FlyBase:FBgn0011576
           GermOnline:CG3466 Uniprot:Q27589
          Length = 501

 Score =  357 bits (915), Expect = 3e-098
 Identities = 204/491 (41%), Positives = 301/491 (61%), Gaps = 31/491 (6%)

Query: 48  IPVLGSAYLFKDPTPEGIFQTFTGFHRQFGRNLITQSLFNFPSMQVCDPKVIEQIMQART 107
           +P LG+  +++   PE I        R++GR L    + +  ++   DP+ IE ++ ++ 
Sbjct: 37  LPFLGNLLMYRGLDPEQIMDFVKKNQRKYGR-LYRVWILHQLAVFSTDPRDIEFVLSSQQ 95

Query: 108 -IEKTIIYDFMVPWLGTGLVVSTGTKWAQRRKIITPTFHFKILEDFLVIMNHQTDVLIEK 166
            I K  +Y  +  WLG GL++STG KW  RRKIITPTFHFKILE F+ I + Q+ V++E+
Sbjct: 96  HITKNNLYKLLNCWLGDGLLMSTGRKWHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQ 155

Query: 167 LKQNANS-TDFDIYEHVTYCALDIISESAMGVKLNTQQQPNSEYVMAVKEISDIILKRLF 225
           L+  A+  T  +I+  +   ALDII+E+AMG K+N Q+ PN  YV AV ++++I++KR  
Sbjct: 156 LQSRADGKTPINIFPVICLTALDIIAETAMGTKINAQKNPNLPYVQAVNDVTNILIKRFI 215

Query: 226 SFLREYKWAFQFTK--SHRRQEELVKIVHDFAHNVISERKKQLQDEREQQLTQEKLEEED 283
              +   W F+ T+    +RQ++ +K++HDF  N+I ER++ L +  ++   +E   E +
Sbjct: 216 HAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRERRETLVNNSKETTPEE---EVN 272

Query: 284 VYGKRRMTLLDLLLNLEEEDVYGKRRMTLLDLLLNVTIDGKPLSDSDIREEVDTFMFAGH 343
             G+                   KRRM LLD+LL  TIDG PLSD DIREEVDTFMF GH
Sbjct: 273 FLGQ-------------------KRRMALLDVLLQSTIDGAPLSDEDIREEVDTFMFEGH 313

Query: 344 DTTTSCISFAAYYLSRDATVQQRVYDEILAIVGPDAKTQELTYGTLQELKYLDMVIKETL 403
           DTTTS ISF  Y +SR   VQQR+  EI  ++G D K+  +T   L ELK+++ VIKE+L
Sbjct: 314 DTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKS-PVTLRDLGELKFMENVIKESL 372

Query: 404 RINPSVPIIGRRSAGDMLIDGVTIPKGMDFGILIYALHNDPELYPEPARFDPERFSEEAS 463
           R++P VP+IGR  A D+ I G  IP G +F + I+ L  DPE +  P  F PERF  +  
Sbjct: 373 RLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVP 432

Query: 464 EKRQPYSYIPFSVGARNCIGQRYAMLEIKTMLVKLVANYQLLPCDERNKLRIKTDMTLKP 523
           +   PY+YIPFS G RNCIGQ++AMLE+K+ + KL+ +++LLP     + R   ++ L+ 
Sbjct: 433 Q-IHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGP--EPRHSMNIVLRS 489

Query: 524 VDGAFIKIVPR 534
            +G  + + PR
Sbjct: 490 ANGVHLGLKPR 500



==> FB|FBgn0023541 - symbol:Cyp4d14 "Cyp4d14" species:7227 "Drosophila
           melanogaster" [GO:0009055 "electron carrier activity"
           evidence=ISS;NAS] [GO:0005792 "microsome" evidence=NAS]
           [GO:0016020 "membrane" evidence=NAS] InterPro:IPR001128
           Pfam:PF00067 InterPro:IPR002401 EMBL:AE014298
           Gene3D:G3DSA:1.10.630.10 PRINTS:PR00463 PRINTS:PR00385
           PROSITE:PS00086 PANTHER:PTHR19383 HSSP:P14779
           EMBL:AL009194 UniGene:Dm.12710 Ensembl:CG3540
           KEGG:dme:Dmel_CG3540 FlyBase:FBgn0023541
           BioCyc:DMEL-XXX-02:DMEL-XXX-02-000319-MONOMER
           GermOnline:CG3540 Uniprot:O46051
          Length = 507

 Score =  355 bits (912), Expect = 6e-098
 Identities = 203/465 (43%), Positives = 288/465 (61%), Gaps = 26/465 (5%)

Query: 49  PVLGSAYLFKDPTPEGIFQTFTGFHRQFGRNLITQSLFNFPSMQVCDPKVIEQIMQAR-T 107
           P++G+A L  + +P+ IF        +FG+N+ TQ L     M   D K+IE IM ++ T
Sbjct: 40  PLVGNAPLLINESPKTIFDMQFRLIAEFGKNIKTQMLGESGFM-TADSKMIEAIMSSQQT 98

Query: 108 IEKTIIYDFMVPWLGTGLVVSTGTKWAQRRKIITPTFHFKILEDFLVIMNHQTDVLIEKL 167
           I+K  +Y  +V WLG GL++S G KW +RRKIITP FHFKILEDF+ + + Q+  +++KL
Sbjct: 99  IQKNNLYSLLVNWLGDGLLISQGKKWFRRRKIITPAFHFKILEDFVEVFDQQSATMVQKL 158

Query: 168 KQNANS-TDFDIYEHVTYCALDIISESAMGVKLNTQQQPNSEYVMAVKEISDIILKRLFS 226
              A+  T  +++     CA+DII+E+AMGVK+N Q QP   YV +V   S ++ +R  +
Sbjct: 159 YDRADGKTVINMFPVACLCAMDIIAETAMGVKINAQLQPQFTYVQSVTTASAMLAERFMN 218

Query: 227 FLREYKWAFQ--FTKSHRRQEELVKIVHDFAHNVISERKKQLQDEREQQLTQEKLEEEDV 284
            L+   +  +  + K   +  + VK +HDF ++VI+ER++ LQ                 
Sbjct: 219 PLQRLDFTMKLFYPKLLDKLNDAVKNMHDFTNSVITERRELLQKAIADG----------- 267

Query: 285 YGKRRMTLLDLLLNLEEEDVYGKRRMTLLDLLLNVTIDGKPLSDSDIREEVDTFMFAGHD 344
            G     LL+        DV  KRRM LLD+LL  TIDG PLS+ DIREEVDTFMF GHD
Sbjct: 268 -GDADAALLN--------DVGQKRRMALLDVLLKSTIDGAPLSNDDIREEVDTFMFEGHD 318

Query: 345 TTTSCISFAAYYLSRDATVQQRVYDEILAIVGPDAKTQELTYGTLQELKYLDMVIKETLR 404
           TTTS I+F  Y L+R   VQ RV+ E+  ++G D K+  +T   L ELKYL+ VIKE+LR
Sbjct: 319 TTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDD-KSAPVTMKLLGELKYLECVIKESLR 377

Query: 405 INPSVPIIGRRSAGDMLIDGVTIPKGMDFGILIYALHNDPELYPEPARFDPERFSEEASE 464
           + PSVPIIGR  + D ++DG  IP   +  ILIY    DP+ +P+P +F P+RFS E   
Sbjct: 378 LFPSVPIIGRYISQDTVLDGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKG 437

Query: 465 KRQPYSYIPFSVGARNCIGQRYAMLEIKTMLVKLVANYQLLPCDE 509
           +  P++Y PFS G RNCIGQ++AMLE+K+ + K+V +++LLP  E
Sbjct: 438 EISPFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLPLGE 482



==> MGI|MGI:2142763 - symbol:Cyp4v3 "cytochrome P450, family 4,
           subfamily v, polypeptide 3" species:10090 "Mus musculus"
           [GO:0005575 "cellular_component" evidence=ND]
           [GO:0003674 "molecular_function" evidence=ND]
           [GO:0008150 "biological_process" evidence=ND]
           InterPro:IPR001128 Pfam:PF00067 InterPro:IPR002401
           MGI:MGI:2142763 Gene3D:G3DSA:1.10.630.10 PRINTS:PR00463
           PRINTS:PR00385 PROSITE:PS00086 PANTHER:PTHR19383
           HSSP:P14779 EMBL:AB056457 EMBL:AK004724
           UniGene:Mm.245297 Ensembl:ENSMUSG00000031640
           ArrayExpress:Q9DBW0 GermOnline:ENSMUSG00000031640
           RZPD-ProtExp:IOM20931 Uniprot:Q9DBW0
          Length = 525

 Score =  331 bits (848), Expect = 1e-090
 Identities = 200/536 (37%), Positives = 308/536 (57%), Gaps = 32/536 (5%)

Query: 4   KMFLVLLTTLLGIAVTCMVVTIIRNRATVAKLKKQLHNF-TVIPAIPVLGSAYLFKDPTP 62
           K+ L    + + +A   ++++I     + A+  +Q+ +  +V  A P++G A L+  P  
Sbjct: 12  KLLLWGAASAVSLAGATILISIFPMLVSYARKWQQMRSIPSVARAYPLVGHA-LYMKPNN 70

Query: 63  EGIFQTFTGFHRQFGR-NLITQSLFNFPSMQVCDPKVIEQIM-QARTIEKTIIYDFMVPW 120
              FQ    +  +F    +I   +   P + +   + +E I+  ++ I+K+ +Y F+ PW
Sbjct: 71  AEFFQQLIYYTEEFRHLPIIKLWIGPVPLVALYKAENVEVILTSSKQIDKSFLYKFLQPW 130

Query: 121 LGTGLVVSTGTKWAQRRKIITPTFHFKILEDFLVIMNHQTDVLIEKLKQNANSTDFDIYE 180
           LG GL+ STG+KW  RRK++TPTFHF ILE+FL +MN Q ++L+ KL+++ N   F+ + 
Sbjct: 131 LGLGLLTSTGSKWRTRRKMLTPTFHFTILENFLDVMNEQANILVNKLEKHVNQEAFNCFF 190

Query: 181 HVTYCALDIISESAMGVKLNTQQQPNSEYVMAVKEISDIILKRL-FSFLREYKWAFQFTK 239
           ++T CALDII E+AMG  +  Q   +SEYV  V  +SD+I +R+   +L    W   F K
Sbjct: 191 YITLCALDIICETAMGKNIGAQSNNDSEYVRTVYRMSDMIYRRMKMPWLWFDLWYLVF-K 249

Query: 240 SHRRQEELVKIVHDFAHNVISERKKQLQDEREQQLTQEKLEEEDVYGKRRMTLLDLLLNL 299
             R  +  +K +H F +NVI+ER K            E+  EED  G  R  +       
Sbjct: 250 EGRDHKRGLKCLHTFTNNVIAERVK------------ERKAEEDWTGAGRGPIPSK---- 293

Query: 300 EEEDVYGKRRMTLLDLLLNVTID-GKPLSDSDIREEVDTFMFAGHDTTTSCISFAAYYLS 358
                   +R   LDLLL+VT + G  LS  DIREEVDTFMF GHDTT + I+++ Y L 
Sbjct: 294 -------NKRKAFLDLLLSVTDEEGNRLSQEDIREEVDTFMFEGHDTTAAAINWSLYLLG 346

Query: 359 RDATVQQRVYDEILAIVGPDAKTQELTYGTLQELKYLDMVIKETLRINPSVPIIGRRSAG 418
            +  VQ++V  E+  + G   +   +T   L++LKYLD VIKETLR+ PSVP+  R  + 
Sbjct: 347 TNPEVQRKVDQELDEVFGRSHRP--VTLEDLKKLKYLDCVIKETLRVFPSVPLFARSLSE 404

Query: 419 DMLIDGVTIPKGMDFGILIYALHNDPELYPEPARFDPERFSEEASEKRQPYSYIPFSVGA 478
           D  + G  + KG +  I+ YALH DP  +P+P  F PERF  E S+ R PY+Y+PFS G 
Sbjct: 405 DCEVGGYKVTKGTEAIIIPYALHRDPRYFPDPEEFRPERFFPENSQGRHPYAYVPFSAGP 464

Query: 479 RNCIGQRYAMLEIKTMLVKLVANYQLLPCDERNKLRIKTDMTLKPVDGAFIKIVPR 534
           RNCIGQ++A++E KT+L  ++  + +    +R +L +  D+ L+P +G +IK+  R
Sbjct: 465 RNCIGQKFAVMEEKTILACILRQFWVESNQKREELGLAGDLILRPNNGIWIKLKRR 520



==> FB|FBgn0031925 - symbol:Cyp4d21 "Cyp4d21" species:7227 "Drosophila
           melanogaster" [GO:0009055 "electron carrier activity"
           evidence=ISS;NAS] [GO:0005792 "microsome" evidence=NAS]
           [GO:0016020 "membrane" evidence=NAS] InterPro:IPR001128
           Pfam:PF00067 InterPro:IPR002403 EMBL:AE014134
           Gene3D:G3DSA:1.10.630.10 PRINTS:PR00385 PROSITE:PS00086
           PANTHER:PTHR19383 PRINTS:PR00465 UniGene:Dm.1463
           Ensembl:CG6730 KEGG:dme:Dmel_CG6730 FlyBase:FBgn0031925
           BioCyc:DMEL-XXX-02:DMEL-XXX-02-007849-MONOMER
           GermOnline:CG6730 Uniprot:Q9VLZ7
          Length = 511

 Score =  329 bits (844), Expect = 4e-090
 Identities = 194/503 (38%), Positives = 292/503 (58%), Gaps = 34/503 (6%)

Query: 13  LLGIAVTCMVVTIIRNR----ATVAKLKKQLHNFTVIPAIPVLGSAYLFKDPTPEGIFQT 68
           LLGIAV  M +    +R        +  + L  FT    IP++G+        PE   Q 
Sbjct: 4   LLGIAVLIMTLVWDNSRKQWRVNTFEKSRILGPFT----IPIVGNGLQALTLRPENFIQR 59

Query: 69  FTGFHRQFGRNLITQSLFNFPSMQVCDPKVIEQIMQARTI-EKTIIYDFMVPWLGTGLVV 127
           F  +  ++G+      L     +   D K  E I+ + T+ +K  +Y F+  +LG GL++
Sbjct: 60  FGDYFNKYGKTFRLWILGEC-LIYTKDLKYFESILSSSTLLKKAHLYRFLRDFLGDGLLL 118

Query: 128 STGTKWAQRRKIITPTFHFKILEDFLVIMNHQTDVLIEKLKQNANS-TDFDIYEHVTYCA 186
           STG KW  RRK++ P FHFK LE+F+ IM+  + +++EKLK  A+  T  D+++ V+  A
Sbjct: 119 STGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEA 178

Query: 187 LDIISESAMGVKLNTQQQPNSEYVMAVKEISDIILKRLFSFLREYKWAFQFTKS--HRRQ 244
           LD+ +E+AMGV++N Q +PN  Y  A+K +  I  KRL S    Y W F       +RR 
Sbjct: 179 LDVTTETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLVYRRL 238

Query: 245 EELVKIVHDFAHNVISERKKQLQDEREQQLTQEKLEEEDVYGKRRMTLLDLLLNLEEEDV 304
           ++ + I+ DF   VI ER+  L          E+   +  Y           L + ++D+
Sbjct: 239 QKDIAIMQDFTDKVIRERRAIL----------ERARADGTYKP---------LIMGDDDI 279

Query: 305 YGKRRMTLLDLLLNVTIDGKPLSDSDIREEVDTFMFAGHDTTTSCISFAAYYLSRDATVQ 364
            GK +MTLLD+LL  TID KPLSD DIREEVD F+FAG DTTTS +S A + +SR   VQ
Sbjct: 280 GGKAKMTLLDILLQATIDNKPLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQ 339

Query: 365 QRVYDEILAIVGPDAKTQELTYGTLQELKYLDMVIKETLRINPSVPIIGRRSAGDMLIDG 424
           + +Y+E+++++GPD     +T   L ELKYLD VIKET+R++P VPI+GR    D+ I  
Sbjct: 340 ECIYEELVSVLGPDPDA-SVTQTKLLELKYLDCVIKETMRLHPPVPILGRYIPEDLKIGE 398

Query: 425 VTIPKGMDFGILIYALHNDPELYPEPARFDPERFSE-EASEKRQPYSYIPFSVGARNCIG 483
           +TIP      ++ Y ++ DPE +P+P  F PER+ + + +    P +YIPFS G +NCIG
Sbjct: 399 ITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIG 458

Query: 484 QRYAMLEIKTMLVKLVANYQLLP 506
           Q++A L++K ++ K++ +Y+LLP
Sbjct: 459 QKFANLQMKALISKVIRHYELLP 481



==> FB|FBgn0035344 - symbol:Cyp4d20 "Cyp4d20" species:7227 "Drosophila
           melanogaster" [GO:0009055 "electron carrier activity"
           evidence=ISS;NAS] [GO:0005792 "microsome" evidence=NAS]
           [GO:0016020 "membrane" evidence=NAS] InterPro:IPR001128
           Pfam:PF00067 InterPro:IPR002401 EMBL:AE014296
           Gene3D:G3DSA:1.10.630.10 PRINTS:PR00463 PRINTS:PR00385
           PROSITE:PS00086 PANTHER:PTHR19383 HSSP:P14779
           UniGene:Dm.6104 Ensembl:CG16761 KEGG:dme:Dmel_CG16761
           FlyBase:FBgn0035344
           BioCyc:DMEL-XXX-02:DMEL-XXX-02-014840-MONOMER
           GermOnline:CG16761 Uniprot:Q9W011
          Length = 510

 Score =  327 bits (839), Expect = 2e-089
 Identities = 193/536 (36%), Positives = 304/536 (56%), Gaps = 43/536 (8%)

Query: 10  LTTLLGIAVTCMVVTIIRNRATVAKLKKQLHNFTVIP---AIPVLGSAYLFKDPTPEGIF 66
           LT + G  +  +     R R  V   +K     + IP   +IP+LG          E I 
Sbjct: 3   LTLITGALILLLTWDFGRKRQRVLAFEK-----SAIPGPISIPILGCGLQALHLGAENII 57

Query: 67  ----QTFTGFHRQFGRNLITQSLFNFPSMQVCDPKVIEQIMQARTI-EKTIIYDFMVPWL 121
               + F  + + F   ++ +SL     +Q       E I+ + T+ EK  +Y+++ P+L
Sbjct: 58  GWVGEKFDKYGKTFRFWILGESLIYTKDLQY-----FETILSSTTLLEKGQLYEYLRPFL 112

Query: 122 GTGLVVSTGTKWAQRRKIITPTFHFKILEDFLVIMNHQTDVLIEKLKQNANS-TDFDIYE 180
             GL+VSTG KW  RRKI T  FHFK+LE ++ IM+  + V+++ L++ A+  T  D+ +
Sbjct: 113 NDGLLVSTGRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLK 172

Query: 181 HVTYCALDIISESAMGVKLNTQQQPNSEYVMAVKEISDIILKRLFSFLREYKWAFQFTKS 240
           +V+  ALD+I+E+AMGV++N Q  P+  Y+ A+K +  I   R+F F R Y W F     
Sbjct: 173 YVSLAALDVITEAAMGVQVNAQNDPDFPYIKALKSVVYIQPDRMFRFSRRYNWLFPLAAP 232

Query: 241 --HRRQEELVKIVHDFAHNVISERKKQLQDEREQQLTQEKLEEEDVYGKRRMTLLDLLLN 298
             HR+    ++++HDF   VISER++          T  + + +  Y           L+
Sbjct: 233 LLHRQLLSDIRVMHDFTDKVISERRE----------TVRRAKADGTYRP---------LS 273

Query: 299 LEEEDVYGKRRMTLLDLLLNVTIDGKPLSDSDIREEVDTFMFAGHDTTTSCISFAAYYLS 358
           L + ++  K +M LLD+LL  +I+ +PLSD+DIREEVDTFMF G DTT+S +S A Y ++
Sbjct: 274 LGDAEIGSKSQMALLDILLQSSINNQPLSDADIREEVDTFMFEGDDTTSSGVSHALYAIA 333

Query: 359 RDATVQQRVYDEILAIVGPDAKTQELTYGTLQELKYLDMVIKETLRINPSVPIIGRRSAG 418
           R   VQQR+++E+  ++GPDA    +T   LQ+LKYLD VIKET+R+ P VP IGR +  
Sbjct: 334 RHPEVQQRIFEELQRVLGPDASAP-VTQAQLQDLKYLDCVIKETMRLYPPVPAIGRHAQK 392

Query: 419 DMLIDGVTIPKGMDFGILIYALHNDPELYPEPARFDPERFSEEASEKRQPYSYIPFSVGA 478
           ++ I   TIP      +++Y  H D   +P+P  F PERF E+  +    ++Y+PFS G 
Sbjct: 393 ELEIGDKTIPANTSIYLVLYYAHRDANYFPDPLSFRPERFLEDQEQGHNTFAYVPFSAGP 452

Query: 479 RNCIGQRYAMLEIKTMLVKLVANYQLLPCDERNKLRIKTDMTLKPVDGAFIKIVPR 534
           +NCIGQ++A+LE+K ++ K++  Y+LLP  E  +L+   +  L+   G  + + PR
Sbjct: 453 KNCIGQKFAVLEMKVLISKVLRFYELLPLGE--ELKPMLNFILRSASGINVGLRPR 506



==> FB|FBgn0015032 - symbol:Cyp4c3 "Cytochrome P450-4c3" species:7227
           "Drosophila melanogaster" [GO:0009055 "electron carrier
           activity" evidence=NAS] [GO:0005792 "microsome"
           evidence=NAS] [GO:0016020 "membrane" evidence=NAS]
           InterPro:IPR001128 Pfam:PF00067 InterPro:IPR002401
           EMBL:AE014297 Gene3D:G3DSA:1.10.630.10 PRINTS:PR00463
           PRINTS:PR00385 PROSITE:PS00086 PANTHER:PTHR19383
           EMBL:BT010108 EMBL:U34323 UniGene:Dm.1904 Ensembl:CG1438
           KEGG:dme:Dmel_CG1438 FlyBase:FBgn0015032
           BioCyc:DMEL-XXX-02:DMEL-XXX-02-014251-MONOMER
           GermOnline:CG1438 Uniprot:Q9VA27
          Length = 535

 Score =  327 bits (837), Expect = 3e-089
 Identities = 189/536 (35%), Positives = 294/536 (54%), Gaps = 26/536 (4%)

Query: 2   VIKMFLVLLTTLLGIAVTCMVVTIIRNRATVAKLKKQLHNFTVIPAIPVLGSAYLFKDPT 61
           VI  +  +   LLG  +  +VV   R     ++L K +       A+P LG+A       
Sbjct: 22  VISGYSPITVFLLGSILIFLVVYNKRR----SRLVKYIEKIPGPAAMPFLGNAIEMNVDH 77

Query: 62  PEGIFQTFTGFHRQFGRNLITQSLFN--FPSMQVCDPKVIEQIMQART-IEKTIIYDFMV 118
            E +F    G  + +G  +    ++    P + + +P+ +E I+ ++  + K+  YD++ 
Sbjct: 78  DE-LFNRVIGMQKLWGTRIGINRVWQGTAPRVLLFEPETVEPILNSQKFVNKSHDYDYLH 136

Query: 119 PWLGTGLVVSTGTKWAQRRKIITPTFHFKILEDFLVIMNHQTDVLIEKLKQNANSTDFDI 178
           PWLG GL+ ST  KW  RRKI+TP FHFKIL+DF+ + N Q+ VL  KL     S  F++
Sbjct: 137 PWLGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEVGSEAFNL 196

Query: 179 YEHVTYCALDIISESAMGVKLNTQQQPNSEYVMAVKEISDIILKRLFSFLREYKWAFQFT 238
           + +VT C LDI+ E+AMG ++  Q    SEYV AV  I  I+  R      +  + F  T
Sbjct: 197 FPYVTLCTLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLT 256

Query: 239 KSHRRQEELVKIVHDFAHNVISERKKQLQDEREQQLTQEKLEEEDVYGKRRMTLLDLLLN 298
             ++  +  +  +H F++ VI ERK +L   +E           D Y             
Sbjct: 257 AEYKLHQSYINTLHGFSNMVIRERKAELAILQENN-NNNNNNAPDAY------------- 302

Query: 299 LEEEDVYGKRRMTLLDLLLNVTIDGKPLSDSDIREEVDTFMFAGHDTTTSCISFAAYYLS 358
              +DV  K+R+  LDLL++ + +G  LS+ DIREEVDTFMF GHDTT++ IS+  + L 
Sbjct: 303 ---DDVGKKKRLAFLDLLIDASKEGTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLG 359

Query: 359 RDATVQQRVYDEILAIVGPDAKTQELTYGTLQELKYLDMVIKETLRINPSVPIIGRRSAG 418
                Q+RV +E+ +I G D +T   T   L +++YL+  IK++LR+ PSVP++ R    
Sbjct: 360 CHPEYQERVVEELDSIFGDDKET-PATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGE 418

Query: 419 DMLIDGVTIPKGMDFGILIYALHNDPELYPEPARFDPERFSEEASEKRQPYSYIPFSVGA 478
           D+ I G  +P G    I+ YALH +P ++P+P +F+P+ F  E    R P++YIPFS G 
Sbjct: 419 DVNIGGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPENCAGRHPFAYIPFSAGP 478

Query: 479 RNCIGQRYAMLEIKTMLVKLVANYQLLPCDERNKLRIKTDMTLKPVDGAFIKIVPR 534
           RNCIGQ++A+LE K ++  ++  Y++   D R  L +  ++ L+P DG  +KI PR
Sbjct: 479 RNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGELILRPKDGLRVKITPR 534



==> FB|FBgn0030615 - symbol:Cyp4s3 "Cyp4s3" species:7227 "Drosophila
           melanogaster" [GO:0009055 "electron carrier activity"
           evidence=ISS;NAS] [GO:0005792 "microsome" evidence=NAS]
           [GO:0016020 "membrane" evidence=NAS] InterPro:IPR001128
           Pfam:PF00067 InterPro:IPR002401 GO:GO:0005515
           EMBL:AE014298 Gene3D:G3DSA:1.10.630.10 PRINTS:PR00463
           PRINTS:PR00385 PROSITE:PS00086 PANTHER:PTHR19383
           HSSP:P14779 UniGene:Dm.19710 DIP:DIP:19604N
           IntAct:Q9VXY0 Ensembl:CG9081 KEGG:dme:Dmel_CG9081
           FlyBase:FBgn0030615
           BioCyc:DMEL-XXX-02:DMEL-XXX-02-001936-MONOMER
           GermOnline:CG9081 Uniprot:Q9VXY0
          Length = 495

 Score =  322 bits (824), Expect = 9e-088
 Identities = 176/441 (39%), Positives = 266/441 (60%), Gaps = 34/441 (7%)

Query: 95  DPKVIEQIM-QARTIEKTIIYDFMVPWLGTGLVVSTGTKWAQRRKIITPTFHFKILEDFL 153
           DP+ I+Q++   + + K+  Y+ + PWLG GL+ + G  W +RRK++TP FHF+IL +F 
Sbjct: 81  DPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESWHRRRKLLTPGFHFRILSEFK 140

Query: 154 VIMNHQTDVLIEKLKQNANSTDFDIYEHVTYCALDIISESAMGVKLNTQQQPNSEYVMAV 213
             M     +L+ +L+  AN   FDIY ++T  ALD I E+AMG+K + Q Q +SEYV AV
Sbjct: 141 EPMEENCRILVRRLRTKANGESFDIYPYITLFALDAICETAMGIKKHAQLQSDSEYVQAV 200

Query: 214 KEISDIILKRLFSFLREYKWAFQFTKSHRRQEELVKIVHDFAHNVISERKKQLQDEREQQ 273
           + I  ++ K+ FSF +     F+ TK  + +E  +K++HD  + VI  R++QL  ER + 
Sbjct: 201 QSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLRREQLIQERNE- 259

Query: 274 LTQEKLEEEDVYGKRRMTLLDLLLNLEEEDVYGKRRMTLLDLLLNVTIDGKPLSDSDIRE 333
             + + E++DV  KRR+  LD+LL  + E                    G  LSD+DIRE
Sbjct: 260 -WKPEAEQDDVGAKRRLAFLDMLLLTQME-------------------GGAELSDTDIRE 299

Query: 334 EVDTFMFAGHDTTTSCISFAAYYLSRDATVQQRVYDEILAIVGPDAKTQELTYGTLQELK 393
           EVDTFMF GHDTT+S I+FA   LS++  VQQR ++E   + G +           + + 
Sbjct: 300 EVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASELEGREK----------ESMP 349

Query: 394 YLDMVIKETLRINPSVPIIGRRSAGDMLIDGVTIPKGMDFGILIYALHNDPELYPEPARF 453
           YL+ VIKETLRI PSVP   R+   D+ +  +T+PKG     LIY LH DP+ +P+P RF
Sbjct: 350 YLEAVIKETLRIYPSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERF 409

Query: 454 DPERFSEEASEKRQPYSYIPFSVGARNCIGQRYAMLEIKTMLVKLVANYQLLPCDERNKL 513
           DP+RF     ++  P+++  FS G RNCIGQ++AMLE+KT L  L+ +Y+ LP D+ ++ 
Sbjct: 410 DPDRFLVN-EKQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLP-DKDHQP 467

Query: 514 RIKTDMTLKPVDGAFIKIVPR 534
           +   ++  K  +G  ++I+PR
Sbjct: 468 KPLAELVTKSGNGIRLRILPR 488



==> FB|FBgn0015034 - symbol:Cyp4e1 "Cytochrome P450-4e1" species:7227
           "Drosophila melanogaster" [GO:0009055 "electron carrier
           activity" evidence=ISS;NAS] [GO:0005792 "microsome"
           evidence=NAS] [GO:0016020 "membrane" evidence=NAS]
           InterPro:IPR001128 Pfam:PF00067 InterPro:IPR002401
           Gene3D:G3DSA:1.10.630.10 PRINTS:PR00463 PRINTS:PR00385
           PROSITE:PS00086 PANTHER:PTHR19383 EMBL:AE003837
           EMBL:AY118793 UniGene:Dm.30895 Ensembl:CG2062
           KEGG:dme:Dmel_CG2062 FlyBase:FBgn0015034
           BioCyc:DMEL-XXX-02:DMEL-XXX-02-003435-MONOMER
           GermOnline:CG2062 Uniprot:Q9V4T5
          Length = 531

 Score =  314 bits (804), Expect = 2e-085
 Identities = 171/495 (34%), Positives = 282/495 (56%), Gaps = 35/495 (7%)

Query: 36  KKQLHNFTVIPAIPVLGSAYLFKDPTPEGIFQTFTGFHRQFGRNLITQSLFNFPSMQVCD 95
           K+ L+ F     +P++G+A+   + TP  I   F G+  ++G++     +  + ++ V +
Sbjct: 27  KRMLNKFQGPSMLPLVGNAHQMGN-TPTEILNRFFGWWHEYGKDNFRYWIGYYSNIMVTN 85

Query: 96  PKVIEQIMQART-IEKTIIYDFMVPWLGTGLVVSTGTKWAQRRKIITPTFHFKILEDFLV 154
           PK +E I+ ++T I K+ +YD   PWLG GL+ STG+KW + RK+ITP FHF IL+DF  
Sbjct: 86  PKYMEFILSSQTLISKSDVYDLTHPWLGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHE 145

Query: 155 IMNHQTDVLIEKLKQNANSTD-FDIYEHVTYCALDIISESAMGVKLNTQQQPNSEYVMAV 213
           +MN  +   I++LK+ A+  + FD  E   Y  LD+I ++AMGV +N  +  +S  V A 
Sbjct: 146 VMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVICDTAMGVSINAMENRSSSVVQAF 205

Query: 214 KEISDIILKRLFSFLREYKWAFQFTKSHRRQEELVKIVHDFAHNVISERKKQLQDEREQQ 273
           K+I+  I  R FS  +  K+ F F   +    + +K + DF + +I++R +  +   E  
Sbjct: 206 KDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQDFTNEIIAKRIEVRKSGLEVG 265

Query: 274 LTQEKLEEEDVYGKRRMTLLDLLLNLEEEDVYGKRRMTLLDLLLNVTIDGKPLSDSDIRE 333
           +                          + D + +++M  LD LL+  +DG+PL+  ++ E
Sbjct: 266 I--------------------------KADEFSRKKMAFLDTLLSSKVDGRPLTSQELYE 299

Query: 334 EVDTFMFAGHDTTTSCISFAAYYLSRDATVQQRVYDEILAIVGPDAKTQELTYGTLQELK 393
           EV TFMF GHDTTTS + FA Y LSR    Q+++++E   ++G     ++ T+  +  +K
Sbjct: 300 EVSTFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMK 359

Query: 394 YLDMVIKETLRINPSVPIIGRRSAGDMLIDGVTIPKGMDFGILIYALHNDPELYPEPARF 453
           +LD+ IKE  R+ PSVP IGR +  D +IDG  +PKG    + +  L  +  ++ +P +F
Sbjct: 360 HLDLFIKEAQRLYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKF 419

Query: 454 DPERFSEEASEKRQPYSYIPFSVGARNCIGQRYAMLEIKTMLVKLVANYQLLPCDERNKL 513
            PERF     EK  P+ Y+PFS G RNCIGQ++A+LEIKT++ K++ N+++LP  +    
Sbjct: 420 QPERFDR---EKPGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVS 476

Query: 514 R---IKTDMTLKPVD 525
           +   I T + L+P +
Sbjct: 477 KDGYISTTLGLQPAE 491



==> FB|FBgn0005670 - symbol:Cyp4d1 "Cytochrome P450-4d1" species:7227
           "Drosophila melanogaster" [GO:0005792 "microsome"
           evidence=NAS] [GO:0009055 "electron carrier activity"
           evidence=ISS;NAS] [GO:0016020 "membrane" evidence=NAS]
           InterPro:IPR001128 Pfam:PF00067 InterPro:IPR002401
           EMBL:AE014298 EMBL:Z98269 Gene3D:G3DSA:1.10.630.10
           PRINTS:PR00463 PRINTS:PR00385 PROSITE:PS00086
           EMBL:X67645 EMBL:AF016992 EMBL:AF016993 EMBL:AF016994
           EMBL:AF016995 EMBL:AF016996 EMBL:AF016997 EMBL:AF016998
           EMBL:AF016999 EMBL:AF017000 EMBL:AF017001 EMBL:AF017002
           EMBL:AF017003 EMBL:AF017004 PIR:S25707 PIR:T13611
           UniGene:Dm.4852 Ensembl:CG3656 KEGG:dme:Dmel_CG3656
           FlyBase:FBgn0005670 GermOnline:CG3656 Uniprot:P33269
          Length = 512

 Score =  310 bits (795), Expect = 2e-084
 Identities = 171/466 (36%), Positives = 267/466 (57%), Gaps = 31/466 (6%)

Query: 46  PAIPVLGSAYLFKDPTPEGIFQTFTGFHRQFGRNLITQSLFNFPSMQVC--DPKVIEQIM 103
           P +P++G  + F    P  + +    F   + ++ + +     P + V   +PK +E ++
Sbjct: 38  PVLPLVGHGHHFIGKPPHEMVKKIFEFMETYSKDQVLKVWLG-PELNVLMGNPKDVEVVL 96

Query: 104 QA-RTIEKTIIYDFMVPWLGTGLVVSTGTKWAQRRKIITPTFHFKILEDFLVIMNHQTDV 162
              R  +K   Y  + PWL  GL+VS G KW +RRKIITP FHFKIL+ F+ +    +  
Sbjct: 97  GTLRFNDKAGEYKALEPWLKEGLLVSRGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRD 156

Query: 163 LIEKLKQNA---NSTDFDIYEHVTYCALDIISESAMGVKLNTQQQPNSEYVMAVKEISDI 219
           L+  ++Q+      + F +Y+ +  C +D I E+AMGV +N Q   +SEYV AVK IS +
Sbjct: 157 LLRNMEQDRLKHGESGFSLYDWINLCTMDTICETAMGVSINAQSNADSEYVQAVKTISMV 216

Query: 220 ILKRLFSFLREYKWAFQFTKSHRRQEELVKIVHDFAHNVISERKKQLQDEREQQLTQEKL 279
           + KR+F+ L  +   +  T   R +++ + ++H F   +I +R+++L  E   Q +    
Sbjct: 217 LHKRMFNILYRFDLTYMLTPLARAEKKALNVLHQFTEKIIVQRREELIREGSSQESSN-- 274

Query: 280 EEEDVYGKRRMTLLDLLLNLEEEDVYGKRRMTLLDLLLNVTIDGKPLSDSDIREEVDTFM 339
                               ++ DV  KR+M  LD+LL  T+D +PLS+ DIREEVDTFM
Sbjct: 275 --------------------DDADVGAKRKMAFLDILLQSTVDERPLSNLDIREEVDTFM 314

Query: 340 FAGHDTTTSCISFAAYYLSRDATVQQRVYDEILAIVGPDAKTQELTYGTLQELKYLDMVI 399
           F GHDTT+S + F  Y ++     Q++ ++EI ++VG D K+  ++Y  L +L Y+D+ +
Sbjct: 315 FEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGND-KSTPVSYELLNQLHYVDLCV 373

Query: 400 KETLRINPSVPIIGRRSAGDMLIDGVTIPKGMDFGILIYALHNDPELYPEPARFDPERFS 459
           KETLR+ PSVP++GR+   D  I+G  IP G + GI    L    EL+ EP  F PERF 
Sbjct: 374 KETLRMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLGRREELFSEPNSFKPERFD 433

Query: 460 -EEASEKRQPYSYIPFSVGARNCIGQRYAMLEIKTMLVKLVANYQL 504
               +EK  PY+YIPFS G RNCIGQ++AMLEIK ++  ++ +Y++
Sbjct: 434 VVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEV 479



==> FB|FBgn0015033 - symbol:Cyp4d8 "Cytochrome P450-4d8" species:7227
           "Drosophila melanogaster" [GO:0009055 "electron carrier
           activity" evidence=ISS;NAS] [GO:0005792 "microsome"
           evidence=NAS] [GO:0016020 "membrane" evidence=NAS]
           InterPro:IPR001128 Pfam:PF00067 InterPro:IPR002401
           EMBL:AE014296 Gene3D:G3DSA:1.10.630.10 PRINTS:PR00463
           PRINTS:PR00385 PROSITE:PS00086 HSSP:P14779 EMBL:AY058442
           EMBL:U34329 UniGene:Dm.878 Ensembl:CG4321
           KEGG:dme:Dmel_CG4321 FlyBase:FBgn0015033
           BioCyc:DMEL-XXX-02:DMEL-XXX-02-015599-MONOMER
           GermOnline:CG4321 Uniprot:Q9VS79
          Length = 463

 Score =  308 bits (790), Expect = 8e-084
 Identities = 174/435 (40%), Positives = 259/435 (59%), Gaps = 36/435 (8%)

Query: 85  LFNFPSMQVCDPKVIEQIMQART-IEKTIIYDFMVPWLGTGLVVSTGTKWAQRRKIITPT 143
           +FN   +   D ++ EQ++ ++  + K  +Y  +  WLG GL++S G  W QRRKIITPT
Sbjct: 31  IFNRLLIMSGDAELNEQLLSSQEHLVKHPVYKVLGQWLGNGLLLSDGKVWHQRRKIITPT 90

Query: 144 FHFKILEDFLVIMNHQTDVLIEKLKQNANSTDFDIYEHVTYCALDIISESAMGVKLNTQQ 203
           FHF ILE F+ + + Q+++ +++L Q AN   FD+Y  +   ALDII+E+AMG K+  Q 
Sbjct: 91  FHFSILEQFVEVFDQQSNICVQRLAQKANGNTFDVYRSICAAALDIIAETAMGTKIYAQA 150

Query: 204 QPNSEYVMAVKEISDIILKRLFSFLREYKWAFQFTKSHR--RQEELVKIVHDFAHNVISE 261
             ++ Y  AV E + ++  R  S   + +  F  T  H   RQ +L++ + +F   VI +
Sbjct: 151 NESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIRTMQEFTIKVIEK 210

Query: 262 RKKQLQDEREQQLTQEKLEEEDVYGKRRMTLLDLLLNLEEEDVYGKRRMTLLDLLLNVTI 321
           R++ L+D++ + +      +EDV  KR                    RM LLD+LL  T+
Sbjct: 211 RRQALEDQQSKLM---DTADEDVGSKR--------------------RMALLDVLLMSTV 247

Query: 322 DGKPLSDSDIREEVDTFMFAGHDTTTSCISFAAYYLSRDATVQQRVYDEILAIVGPDAKT 381
           DG+PL++ +IREEVDTFMF GHDTTTS +SF  + LSR   VQ ++ +EI+ ++G D ++
Sbjct: 248 DGRPLTNDEIREEVDTFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTD-RS 306

Query: 382 QELTYGTLQELKYLDMVIKETLRINPSVPIIGRRSAGDMLI------DGVTIPKGMDFGI 435
           + ++   L ELKY++ VIKE+LR+ P VPI+GR+   D         DGV IP G +  I
Sbjct: 307 RPVSIRDLGELKYMECVIKESLRMYPPVPIVGRKLQTDFKYTHSVHGDGV-IPAGSEIII 365

Query: 436 LIYALHNDPELYPEPARFDPERFSEEASEKRQPYSYIPFSVGARNCIGQRYAMLEIKTML 495
            I+ +H  PE +P P  F PER   E   +  P+  IPFS G RNCIGQ++A LE+K ML
Sbjct: 366 GIFGVHRQPETFPNPDEFIPER--HENGSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMML 423

Query: 496 VKLVANYQLLPCDER 510
            K+V  Y+LLP  +R
Sbjct: 424 AKIVREYELLPMGQR 438