>AGAP006156-PA

MGI|MGI:2441697 - symbol:Gpr158 "G protein-coupled receptor 158"...   110   2e-024
UNIPROT|O75899 - symbol:GABR2_HUMAN "GABBR2, GPR51, GPRC3B: Gamm...    52   5e-007
UNIPROT|Q9UBS5 - symbol:GABR1_HUMAN "GABBR1, GPRC3A: Gamma-amino...    49   4e-006
MGI|MGI:1860139 - symbol:Gabbr1 "gamma-aminobutyric acid (GABA-B...    49   5e-006


==> MGI|MGI:2441697 - symbol:Gpr158 "G protein-coupled receptor 158"
           species:10090 "Mus musculus" [GO:0016020 "membrane"
           evidence=RCA] [GO:0016021 "integral to membrane"
           evidence=RCA] [GO:0008067 "metabotropic glutamate,
           GABA-B-like receptor activity" evidence=RCA] [GO:0007186
           "G-protein coupled receptor protein signaling pathway"
           evidence=RCA] InterPro:IPR000337 MGI:MGI:2441697
           Pfam:PF00003 PROSITE:PS00979 PROSITE:PS00980
           PROSITE:PS00981 PROSITE:PS50259 EMBL:AK083234
           EMBL:AB093287 UniGene:Mm.166647 IntAct:Q8C419
           Ensembl:ENSMUSG00000045967 ArrayExpress:Q8C419
           GermOnline:ENSMUSG00000045967 Uniprot:Q8C419
          Length = 1200

 Score =  110 bits (274), Expect = 2e-024
 Identities = 59/191 (30%), Positives = 103/191 (53%), Gaps = 8/191 (4%)

Query: 1   MYPPPSLYSCTARIWLREIGFSLTYGALMLKTWRISVIFRVRSAKAVK-ITDAYLLKRIG 59
           +Y  PS + C    W R +GF+  YG + LK  R+  +F  R+A+ +  +T   +++ + 
Sbjct: 472 LYFEPSTFRCILLRWARLLGFATVYGTVTLKLHRVLKVFLSRTAQRIPYMTGGRVMRMLA 531

Query: 60  VLC-----GFVGIALLVRTLVAPPVVIVGR--TADNLKAFLCKTDWWDHTFTSLEVLFLA 112
           V+        VG    +   +   +++VG+  T+D+L   +C  D WD+     E LFL 
Sbjct: 532 VIVLVVFWFLVGWTSSMCQNLERDILLVGQGQTSDHLTFNMCLIDRWDYMTAVAEFLFLL 591

Query: 113 WGVRLCIMVRKAPSEFNESRFISMAIYNEFLLTCFLNVSMLFLQSPANPDLLYIIFFCHT 172
           WG+ LC  VR  PS F+E R++++A++NE ++T   +     L S   PD + +++F H 
Sbjct: 592 WGIYLCYAVRTVPSAFHEPRYMAVAVHNELIITAIFHTIRFVLASRLQPDWMLMLYFAHA 651

Query: 173 QLTVTLLLALI 183
            LTVT+ + L+
Sbjct: 652 HLTVTVTIGLL 662



==> UNIPROT|O75899 - symbol:GABR2_HUMAN "GABBR2, GPR51, GPRC3B:
           Gamma-aminobutyric acid type B receptor, subunit 2
           precursor" species:9606 "Homo sapiens" [GO:0004965
           "GABA-B receptor activity" evidence=TAS] [GO:0007186
           "G-protein coupled receptor protein signaling pathway"
           evidence=TAS] [GO:0007194 "negative regulation of
           adenylate cyclase activity" evidence=TAS] [GO:0007268
           "synaptic transmission" evidence=TAS] [GO:0005887
           "integral to plasma membrane" evidence=TAS]
           InterPro:IPR000337 InterPro:IPR002455 EMBL:AF056085
           InterPro:IPR002457 UniProt:O75899 InterPro:IPR001828
           Pfam:PF01094 GO:GO:0005887 GO:GO:0007268 GO:GO:0007194
           Pfam:PF00003 PROSITE:PS00979 PROSITE:PS00980
           PROSITE:PS00981 PROSITE:PS50259 PRINTS:PR00248
           GO:GO:0004965 PRINTS:PR01176 EMBL:AJ012188 EMBL:AF069755
           EMBL:AF099033 EMBL:AF095784 EMBL:AF074483 EMBL:AL445495
           EMBL:AL353782 EMBL:AL356282 EMBL:AL591502 EMBL:BC035071
           UniGene:Hs.198612 Ensembl:ENSG00000136928 KEGG:hsa:9568
           HGNC:HGNC:4507 MIM:607340 ArrayExpress:O75899
           GermOnline:ENSG00000136928 RZPD-ProtExp:IOH28714
           PRINTS:PR01178
          Length = 941

 Score = 52.4 bits (124), Expect = 5e-007
 Identities = 50/203 (24%), Positives = 90/203 (44%), Gaps = 43/203 (21%)

Query: 10  CTARIWLREIGFSLTYGALMLKTWRISVIFRVRSAKAVKITDAYLLKRIGVLCGFVGIAL 69
           CT R W+  +G++  +GA+  KTWR+  IF+    K   I D  LL  +G +   + + +
Sbjct: 553 CTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGML-LIDLCI 611

Query: 70  LVRTLVAPPVVIVGRTAD-------------NLKAFL--CK----TDWWDHTFTSLEVL- 109
           L+      P   + RT +             +++  L  C+    T W    +    +L 
Sbjct: 612 LICWQAVDP---LRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLM 668

Query: 110 ----FLAWGVRLCIMVRKAPSEFNESRFISMAIYNEFLLTCFLNVSMLFLQSPANPDLLY 165
               FLAW  R       +    N+S++I M++YN  ++ C +  ++ FL +   P++ +
Sbjct: 669 LFGCFLAWETR-----NVSIPALNDSKYIGMSVYNVGIM-CIIGAAVSFL-TRDQPNVQF 721

Query: 166 -----IIFFCHTQLTVTLLLALI 183
                +I FC    T+TL L  +
Sbjct: 722 CIVALVIIFCS---TITLCLVFV 741



==> UNIPROT|Q9UBS5 - symbol:GABR1_HUMAN "GABBR1, GPRC3A:
           Gamma-aminobutyric acid type B receptor, subunit 1
           precursor" species:9606 "Homo sapiens" [GO:0004965
           "GABA-B receptor activity" evidence=TAS] [GO:0007194
           "negative regulation of adenylate cyclase activity"
           evidence=TAS] [GO:0007214 "gamma-aminobutyric acid
           signaling pathway" evidence=TAS] [GO:0005887 "integral
           to plasma membrane" evidence=TAS] InterPro:IPR000337
           InterPro:IPR002455 InterPro:IPR002456 UniProt:Q9UBS5
           InterPro:IPR001828 Pfam:PF01094 GO:GO:0005887
           GO:GO:0007194 InterPro:IPR000436 Pfam:PF00084
           SMART:SM00032 PROSITE:PS50923 Pfam:PF00003
           PROSITE:PS00979 PROSITE:PS00980 PROSITE:PS00981
           PROSITE:PS50259 HSSP:P08174 GO:GO:0007214 EMBL:AJ225028
           EMBL:AJ225029 EMBL:AJ012185 EMBL:AJ012186 EMBL:AF099148
           EMBL:Y11044 EMBL:AJ012187 EMBL:AJ010170 EMBL:AJ010171
           EMBL:AJ010172 EMBL:AJ010173 EMBL:AJ010174 EMBL:AJ010175
           EMBL:AJ010176 EMBL:AJ010177 EMBL:AJ010178 EMBL:AJ010179
           EMBL:AJ010180 EMBL:AJ010181 EMBL:AJ010182 EMBL:AJ010183
           EMBL:AJ010184 EMBL:AJ010185 EMBL:AJ010186 EMBL:AJ010187
           EMBL:AJ010188 EMBL:AJ010189 EMBL:AJ010190 EMBL:AJ010191
           EMBL:AJ012288 EMBL:AL031983 EMBL:BC042598 EMBL:BC050532
           PIR:JE0356 UniGene:Hs.167017 SMR:Q9UBS5
           Ensembl:ENSG00000206511 KEGG:hsa:2550 HGNC:HGNC:4070
           MIM:603540 DrugBank:APRD00551 ArrayExpress:Q9UBS5
           GermOnline:ENSG00000204681 RZPD-ProtExp:IOH27756
           RZPD-ProtExp:IOH39488 RZPD-ProtExp:T2073 GO:GO:0004965
           PRINTS:PR01177 PRINTS:PR01176
          Length = 961

 Score = 49.3 bits (116), Expect = 4e-006
 Identities = 44/172 (25%), Positives = 71/172 (41%), Gaps = 27/172 (15%)

Query: 8   YSCTARIWLREIGFSLTYGALMLKTWRISVIFRVRSAKAV--KITDAY-LLKRIGVLCGF 64
           + C AR+WL  +GFSL YG++  K W +  +F  +  K    K  + + L   +G+L G 
Sbjct: 661 FVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGM 720

Query: 65  VGIALLVRTLVAPPVVIVGRTADNLKAFLCKTD------------------WWDHTFTSL 106
             + L +  +V P    + RT +       K D                   W   F   
Sbjct: 721 DVLTLAIWQIVDP----LHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGY 776

Query: 107 EVLFLAWGVRLCIMVRKAPSE-FNESRFISMAIYNEFLLTCFLNVSMLFLQS 157
           + L L  G+ L    +   +E  N+ R + MAIYN  +L C +   +  + S
Sbjct: 777 KGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVL-CLITAPVTMILS 827



==> MGI|MGI:1860139 - symbol:Gabbr1 "gamma-aminobutyric acid (GABA-B)
           receptor, 1" species:10090 "Mus musculus" [GO:0005737
           "cytoplasm" evidence=IDA] [GO:0005515 "protein binding"
           evidence=IPI] InterPro:IPR000337 InterPro:IPR002455
           InterPro:IPR002456 InterPro:IPR001828 MGI:MGI:1860139
           Pfam:PF01094 GO:GO:0005515 GO:GO:0005737
           InterPro:IPR000436 Pfam:PF00084 SMART:SM00032
           PROSITE:PS50923 Pfam:PF00003 PROSITE:PS00979
           PROSITE:PS00980 PROSITE:PS00981 PROSITE:PS50259
           HSSP:P08174 PRINTS:PR01177 PRINTS:PR01176 EMBL:AF114168
           EMBL:AF120255 EMBL:AF008649 EMBL:AL078630 EMBL:BC054735
           UniGene:Mm.32191 SMR:Q9WV18 IntAct:Q9WV18
           Ensembl:ENSMUSG00000024462 KEGG:mmu:54393
           ArrayExpress:Q9WV18 GermOnline:ENSMUSG00000024462
           Uniprot:Q9WV18
          Length = 960

 Score = 48.9 bits (115), Expect = 5e-006
 Identities = 44/172 (25%), Positives = 71/172 (41%), Gaps = 27/172 (15%)

Query: 8   YSCTARIWLREIGFSLTYGALMLKTWRISVIFRVRSAKAV--KITDAY-LLKRIGVLCGF 64
           + C AR+WL  +GFSL YG++  K W +  +F  +  K    K  + + L   +G+L G 
Sbjct: 660 FVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGM 719

Query: 65  VGIALLVRTLVAPPVVIVGRTADNLKAFLCKTD------------------WWDHTFTSL 106
             + L +  +V P    + RT +       K D                   W   F   
Sbjct: 720 DILTLAIWQIVDP----LHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGIFYGY 775

Query: 107 EVLFLAWGVRLCIMVRKAPSE-FNESRFISMAIYNEFLLTCFLNVSMLFLQS 157
           + L L  G+ L    +   +E  N+ R + MAIYN  +L C +   +  + S
Sbjct: 776 KGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVL-CLITAPVTMILS 826