>AGAP006513-PA MGI|MGI:2183572 - symbol:Cntnap4 "contactin associated protein-l... 275 3e-073 UNIPROT|Q9UHC6 - symbol:CNTP2_HUMAN "CNTNAP2, CASPR2, KIAA0868: ... 270 1e-071 MGI|MGI:1914047 - symbol:Cntnap2 "contactin associated protein-l... 270 1e-071 UNIPROT|Q9BZ76 - symbol:CNTP3_HUMAN "CNTNAP3, CASPR3, KIAA1714: ... 250 9e-066 UNIPROT|P78357 - symbol:CNTP1_HUMAN "CNTNAP1, CASPR, NRXN4: Cont... 217 8e-056 MGI|MGI:1858201 - symbol:Cntnap1 "contactin associated protein-l... 214 5e-055 FB|FBgn0000368 - symbol:crb "crumbs" species:7227 "Drosophila me... 86 4e-016 UNIPROT|Q9NYQ6 - symbol:CELR1_HUMAN "CELSR1, CDHF9, FMI2: Cadher... 66 3e-010 UNIPROT|P82279 - symbol:CRUM1_HUMAN "CRB1: Crumbs homolog 1 prec... 65 9e-010 MGI|MGI:88059 - symbol:App "amyloid beta (A4) precursor protein"... 62 8e-009 UNIPROT|P05067 - symbol:A4_HUMAN "APP, A4, AD1: Amyloid beta A4 ... 62 8e-009 UNIPROT|P25304 - symbol:AGRIN_RAT "Agrin, Agrn: Agrin precursor"... 59 5e-008 MGI|MGI:2136343 - symbol:Crb1 "crumbs homolog 1 (Drosophila)" sp... 59 6e-008 MGI|MGI:1100883 - symbol:Celsr1 "cadherin EGF LAG seven-pass G-t... 58 8e-008 UNIPROT|O00468 - symbol:AGRIN_HUMAN "AGRIN, AGRN: Agrin precurso... 57 2e-007 UNIPROT|P31696 - symbol:AGRIN_CHICK "AGRIN, AGRN: Agrin precurso... 57 2e-007 UNIPROT|Q9HCU4 - symbol:CELR2_HUMAN "CELSR2, CDHF10, EGFL2, KIAA... 55 7e-007 MGI|MGI:1858236 - symbol:Celsr3 "cadherin EGF LAG seven-pass G-t... 54 2e-006 UNIPROT|Q9NYQ8 - symbol:FAT2_HUMAN "FAT2, CDHF8, KIAA0811, MEGF1... 53 4e-006 UNIPROT|Q9NYQ7 - symbol:CELR3_HUMAN "CELSR3, CDHF11, EGFL1, FMI1... 53 4e-006 UNIPROT|Q06481 - symbol:APLP2_HUMAN "APLP2, APPL2: Amyloid-like ... 52 5e-006 FB|FBgn0032655 - symbol:CadN2 "CadN2" species:7227 "Drosophila m... 52 5e-006 FB|FBgn0015609 - symbol:CadN "Cadherin-N" species:7227 "Drosophi... 52 6e-006 MGI|MGI:1858235 - symbol:Celsr2 "cadherin EGF LAG seven-pass G-t... 52 8e-006 FB|FBgn0036930 - symbol:fat2 "fat2" species:7227 "Drosophila mel... 51 1e-005 ==> MGI|MGI:2183572 - symbol:Cntnap4 "contactin associated protein-like 4" species:10090 "Mus musculus" [GO:0030425 "dendrite" evidence=IDA] [GO:0005515 "protein binding" evidence=IPI] [GO:0008150 "biological_process" evidence=ND] InterPro:IPR000421 InterPro:IPR008985 InterPro:IPR000742 InterPro:IPR006210 InterPro:IPR006209 MGI:MGI:2183572 GO:GO:0005515 InterPro:IPR013320 Gene3D:G3DSA:2.60.120.200 InterPro:IPR008979 GO:GO:0030425 InterPro:IPR013032 PROSITE:PS00022 PROSITE:PS01186 PROSITE:PS50026 SMART:SM00181 InterPro:IPR001791 Pfam:PF00008 SMART:SM00282 PROSITE:PS50025 Pfam:PF00754 InterPro:IPR012680 Pfam:PF02210 HSSP:P12259 SMART:SM00231 PROSITE:PS01285 PROSITE:PS01286 PROSITE:PS50022 EMBL:AF333770 UniGene:Mm.209232 UniGene:Mm.403088 Ensembl:ENSMUSG00000031772 KEGG:mmu:170571 ArrayExpress:Q99P47 GermOnline:ENSMUSG00000031772 Uniprot:Q99P47 Length = 1310 Score = 275 bits (703), Expect = 3e-073 Identities = 253/1000 (25%), Positives = 432/1000 (43%), Gaps = 111/1000 (11%) Query: 393 YTATVLTLRGSSYVSYRIYDWKDRVHSPITRI-SMMFKTNYDDSALFYASGESLKPQYIA 451 Y + V+ L G S + YR + SPI I S+ FKT D L + +G + +I Sbjct: 181 YRSVVIDLDGKSSLLYR---FDQNSLSPIRDIISLKFKTMESDGILLHRAGPA--GDHIT 235 Query: 452 ASIKNHSAYIEMDFGDG-------VMSATLGQDLTRHYWHNLTILHEHDKVIAILDDHVR 504 ++ ++ ++ GD +++ TLG L +WH++ I +V +D+H R Sbjct: 236 LELRRGKLFLLINSGDARLTSSSTLINLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRR 295 Query: 505 ILDLLGPIHNLLFDPEIYFGGGPNLSKRKGLASSNNFVGSLKYVFYNDVSVLFELKKGNP 564 G + L D EI FGG +K L + F G L+ +FYN V V+ +K+ +P Sbjct: 296 HFHAQGEFNYLDLDYEISFGGISAPAKSVSLPYKH-FHGCLENLFYNGVDVIGLVKEHSP 354 Query: 565 KVHYIGVLQEEFYEANVEVIPITFSYAKSHIWWPMNNPD-TLSLKFDFKSSKATAVLAYS 623 ++ +G F + + +P+TF +S++ P + + +S F F++ +L +S Sbjct: 355 QIITMG--NASFSCSQPQSMPLTFLSPRSYLVLPASTKEEAISASFQFRTWNKAGLLLFS 412 Query: 624 EVKTSEGNGFWELRLATDRLSFDLCPDVKSNITHTTYIRIENPTSWHSIQLTYERNDIKF 683 E++ G+ L L+ +L L KS T + + WHS+ L+ +RN + Sbjct: 413 ELQLVSGSLL--LLLSDGKLKLTLYQPGKSPSDITAGAGLGDG-QWHSVSLSAKRNHLSV 469 Query: 684 VVDYRHSVTQMY--------GLSFNIG---DKLIIGSSLKAAASGLVGCLRDLKINGVEI 732 VVD S + G F G DK GS K+ G GC+R + IN + Sbjct: 470 VVDGHISPASPWLGPEQVNSGGVFYFGGCPDKGF-GSKCKSPLGGFQGCMRLISINNKMV 528 Query: 733 EPRYLVKSERVVG---DVSLDNCKYVDPCKKPNTCEHGGKCAVKDDGIICDCKDTGYIGK 789 + + + +G D+ +D+C D C PN+CEHGG+C+ C+C +TGY G Sbjct: 529 D--LIAVQQGALGNFSDLQIDSCGISDRCL-PNSCEHGGECSQSWSTFHCNCTNTGYTGA 585 Query: 790 NCHFTKFRKTCEELALLGYSKSDVYSIDIDGNGVFPPARVKCDFQSLANATKTIVEHNLP 849 CH + + ++CE G + S Y ID DG+G P + C ++ T+++HN Sbjct: 586 TCHSSVYEQSCEAYKHQG-NASGFYYIDSDGSGPLQPFLLYC---NMTETAWTVMQHNGS 641 Query: 850 SQVDVRSATDEDFSFNIQYREFSAEMLQELISHSLYCTQYIKYDCIKAPL----ELHSST 905 + VR+ E+ + S E LQ I+ + +C Q + Y C K+ L + + Sbjct: 642 DLMRVRNTHSENAHTGVFEYTASMEQLQAAINRAEHCQQELVYYCKKSRLVNQQDGSPRS 701 Query: 906 WFKSSSNNNTVDSLGEVK-RGTCPCAIGKNCEDLNHSCNCDANLNRWLSDEGYYKEPPNL 964 W+ +N G + C C + NC D + CNCDA+LN W +D G+ +L Sbjct: 702 WWVGRTNETQTYWGGSLPVHQKCTCGLEGNCIDAQYHCNCDADLNEWTNDTGFLSYKEHL 761 Query: 965 GITQMYFLQQKNLDEESQGRVTLGPLECVETNTQKYVVTFTTSQSYIEVP---GWRKGDI 1021 +T++ S+ LGPL C +F T SY+ P G D+ Sbjct: 762 PVTKIVITDTGR--PHSEAAYKLGPLLCRGDRPFWNAASFNTEASYLHFPTFHGELSADV 819 Query: 1022 AFSFRTTGEKAILLFQPPIRSNYPSFMVALTGDYQLTFNFTLNTGTPKTLVIDTNRKLNG 1081 +F F+TT + L I + L +TF+F + G P L + + N Sbjct: 820 SFFFKTTALSGVFLENLGITD---FIRIELRSPTTVTFSFDVGNG-PFELSVHSPTHFND 875 Query: 1082 GEWHKIWIDYNEHHVRFMINTDTRMVDLQPEEEFGPFEG--------SMFIGGAPTEISK 1133 +WH + ++ N M R+ +L P+ + P +G +F+GG T Sbjct: 876 NQWHHVRVERN------MKEASLRVDELPPKIQAAPTDGHVLLQLNSQLFVGGTATR--- 926 Query: 1134 KYTVKQGLIGCFRGLVVNGEILDIYSFMSVHLSEIIKDCKPSC--VPNPCKNGAYCRELW 1191 ++G +GC R L +NG LD+ +V + C+ C C++G CRE Sbjct: 927 ----QRGFLGCIRSLQLNGMALDLEERATV-TPGVQPGCRGHCGSYGKLCRHGGKCREKP 981 Query: 1192 STFECVCQNRWAHLGQHCETNINE-----DALTFISRESY-LKRN----YLSDPEDMRDE 1241 S F C C + A G C I+ ++ + +E+Y L +N S DM+ Sbjct: 982 SGFFCDCSSS-AFAGPFCSKEISAYFGSGSSVIYNFQENYSLSKNSSFHAASFHGDMKLS 1040 Query: 1242 REKLRAILNSSLLVNLRTYDRHAFVLYANDHYNNFIHLYLTDQSEMVYLYN----YGSDI 1297 RE ++ + RT + +L+ + Y ++ + + + Y + D+ Sbjct: 1041 REMIK--------FSFRTTRAPSLLLHMSSFYKEYLSIIIAKNGSLQIRYKLNKYHEPDV 1092 Query: 1298 VNLTIE--------HSELNNARSIQVAVIRTETNTTLYVN 1329 ++ ++ H ++N + I T Y++ Sbjct: 1093 ISFDLKSMADGQLHHIKINREEGMVFVEIDENTRRQTYLS 1132 Score = 58.9 bits (141), Expect = 5e-008 Identities = 45/163 (27%), Positives = 67/163 (41%), Gaps = 21/163 (12%) Query: 1391 TELEGYIGCIRGLKIGENLISLREMATQNNAHVTDGVLNGCQMKCDA--EPCKNGGICTE 1448 T G++GCIR L++ + L E AT VT GV GC+ C + + C++GG C E Sbjct: 925 TRQRGFLGCIRSLQLNGMALDLEERAT-----VTPGVQPGCRGHCGSYGKLCRHGGKCRE 979 Query: 1449 NFVRQESTCNCEHTSFLGEFCSEEKGASFSGEATLLRRLA------------LADTVGSV 1496 C+C ++F G FCS+E A F ++++ A G + Sbjct: 980 K--PSGFFCDCSSSAFAGPFCSKEISAYFGSGSSVIYNFQENYSLSKNSSFHAASFHGDM 1037 Query: 1497 RLQLAFSSNDMRRANRVMLLLQSRNDRSYYLMVAITAENHLYI 1539 +L R LLL + YL + I L I Sbjct: 1038 KLSREMIKFSFRTTRAPSLLLHMSSFYKEYLSIIIAKNGSLQI 1080 Score = 56.2 bits (134), Expect = 3e-007 Identities = 92/408 (22%), Positives = 158/408 (38%), Gaps = 63/408 (15%) Query: 176 TFQLRLCREISFQFRTRLPHGLLVYHNVKTPAGVKLD---PYALYVIVEKGQLKVVHVFG 232 TF L ++SF F+T G+ + N+ ++++ P + + G G Sbjct: 810 TFHGELSADVSFFFKTTALSGVFL-ENLGITDFIRIELRSPTTVTFSFDVGN-------G 861 Query: 233 NHSTSVTVGEGLNRDEWHSVMVRIDVHGARLIARVDNNKEEVYLKGLNHETNYGVSINLM 292 SV N ++WH V V ++ A L RVD ++ T+ V + L Sbjct: 862 PFELSVHSPTHFNDNQWHHVRVERNMKEASL--RVDELPPKIQAA----PTDGHVLLQLN 915 Query: 293 SVVLVGGLSSEEKLHGVKYIIESFVGCIRNVVLSSGKAASDLLPITPLIATKHENVKEGC 352 S + VGG ++ ++ F+GCIR++ L+ A DL AT V+ GC Sbjct: 916 SQLFVGGTATRQR---------GFLGCIRSLQLNG--MALDLEER----ATVTPGVQPGC 960 Query: 353 RNKCHSRQNLCFTGSRCINHYYDISCDCFGTKYEGEHCDIYTATVLTLRGSSYV------ 406 R C S LC G +C CDC + + G C + GSS + Sbjct: 961 RGHCGSYGKLCRHGGKCREKPSGFFCDCSSSAFAGPFCSKEISAYFG-SGSSVIYNFQEN 1019 Query: 407 -------SYRIYDWKDRVHSPITRISMMFKTNYDDSALFYASGESLKPQYIAASI-KNHS 458 S+ + + I F+T S L + S S +Y++ I KN S Sbjct: 1020 YSLSKNSSFHAASFHGDMKLSREMIKFSFRTTRAPSLLLHMS--SFYKEYLSIIIAKNGS 1077 Query: 459 AYIEMDFG----DGVMSATLGQDLTRHYWHNLTILHEHDKVIAILDDHVRILDLL----- 509 I V+S L + + H++ I E V +D++ R L Sbjct: 1078 LQIRYKLNKYHEPDVISFDL-KSMADGQLHHIKINREEGMVFVEIDENTRRQTYLSSGTE 1136 Query: 510 -GPIHNLLFDPEIYFGGGPNLSKRKGLASSNNFVGSLKYVFYNDVSVL 556 + +L+ + + ++ + LA+++ F G L V ++ ++ L Sbjct: 1137 FSAVKSLVLGRMLEYS---DVDQETALAAAHGFTGCLSAVQFSHIAPL 1181 Score = 50.8 bits (120), Expect = 1e-005 Identities = 47/207 (22%), Positives = 83/207 (40%), Gaps = 18/207 (8%) Query: 186 SFQFRTRLPHGLLVYHNVKTPAGVKLDPYALYVIVEKGQLKV-VHVFGNHSTSVTVGEGL 244 SFQFRT GLL++ ++ +G +L +++ G+LK+ ++ G + +T G GL Sbjct: 397 SFQFRTWNKAGLLLFSELQLVSG------SLLLLLSDGKLKLTLYQPGKSPSDITAGAGL 450 Query: 245 NRDEWHSVMVRIDVHGARLIARVDNNKEEVYLKGLNHETNYGVSINLMSVVLVGGLSSEE 304 +WHSV + + ++ + +L +N V GG + Sbjct: 451 GDGQWHSVSLSAKRNHLSVVVDGHISPASPWLG--------PEQVNSGGVFYFGGCPDKG 502 Query: 305 KLHGVKYIIESFVGCIRNVVLSSGKAASDLLPITPLIATKHENVK-EGCRNKCHSRQNLC 363 K + F GC+R ++S DL+ + +++ + C N C Sbjct: 503 FGSKCKSPLGGFQGCMR--LISINNKMVDLIAVQQGALGNFSDLQIDSCGISDRCLPNSC 560 Query: 364 FTGSRCINHYYDISCDCFGTKYEGEHC 390 G C + C+C T Y G C Sbjct: 561 EHGGECSQSWSTFHCNCTNTGYTGATC 587 Score = 45.4 bits (106), Expect = 6e-004 Identities = 90/460 (19%), Positives = 165/460 (35%), Gaps = 93/460 (20%) Query: 1021 IAFSFRTTGEKAILLFQPPIRSNYPS--------FMVALTGDYQLTFNFTLNTGTPKTLV 1072 I+ F+T ILL + ++ + F++ +GD +LT + TL T +L+ Sbjct: 210 ISLKFKTMESDGILLHRAGPAGDHITLELRRGKLFLLINSGDARLTSSSTLINLTLGSLL 269 Query: 1073 IDTNRKLNGGEWHKIWIDYNEHHVRFMINTDTRMVDLQPEEEFGPFEGSMFIGGAPTEIS 1132 D + WH + I V F ++ R Q E + + + GG Sbjct: 270 DDQH-------WHSVLIQRLGKQVNFTVDEHRRHFHAQGEFNYLDLDYEISFGGISAPAK 322 Query: 1133 KKYTVKQGLIGCFRGLVVNGEILDIYSFMSVHLSEIIKDCKPSCVPNPCKNGAYCRELWS 1192 + GC L NG +D+ + H +II S Sbjct: 323 SVSLPYKHFHGCLENLFYNG--VDVIGLVKEHSPQIITMGNAS----------------- 363 Query: 1193 TFECVCQNRWAHLGQHCETNINEDALTFISRESYLKRNYLSDPEDMRDEREKLRAILNSS 1252 F C + LTF+S R+YL P ++E S Sbjct: 364 -FSC--------------SQPQSMPLTFLS-----PRSYLVLPASTKEEA--------IS 395 Query: 1253 LLVNLRTYDRHAFVLYAN-DHYNNFIHLYLTDQSEMVYLYNYGSDIVNLTIEHSELNNAR 1311 RT+++ +L++ + + L L+D + LY G ++T + L + + Sbjct: 396 ASFQFRTWNKAGLLLFSELQLVSGSLLLLLSDGKLKLTLYQPGKSPSDITAG-AGLGDGQ 454 Query: 1312 SIQVAVIRTETNTTLYVNEKNVTVERGFLLLDEYSNKPWTNPELEVLSPHRPPAPPTEYF 1371 V++ + ++ V+ PW PE +V S Sbjct: 455 WHSVSLSAKRNHLSVVVDGHISPAS------------PWLGPE-QVNSGG---------- 491 Query: 1372 QFNIGGYDPANLLRPNQDTTELEGYIGCIRGLKIGENLISLREMATQNNAHVTDGVLNGC 1431 F GG ++ + L G+ GC+R + I ++ L + + +D ++ C Sbjct: 492 VFYFGGCPDKGF--GSKCKSPLGGFQGCMRLISINNKMVDLIAVQQGALGNFSDLQIDSC 549 Query: 1432 QM--KCDAEPCKNGGICTENFVRQESTCNCEHTSFLGEFC 1469 + +C C++GG C++++ CNC +T + G C Sbjct: 550 GISDRCLPNSCEHGGECSQSW--STFHCNCTNTGYTGATC 587 Score = 40.4 bits (93), Expect = 0.018 Identities = 44/178 (24%), Positives = 86/178 (48%), Gaps = 24/178 (13%) Query: 156 KTFMFAKNNTFIQMDGETIQTFQ-----LRLCREI-SFQFRTRLPHGLLVYHNVKTPAG- 208 + F A + I +DG++ ++ L R+I S +F+T G+L++ PAG Sbjct: 175 EVFGCAYRSVVIDLDGKSSLLYRFDQNSLSPIRDIISLKFKTMESDGILLHR--AGPAGD 232 Query: 209 ---VKLDPYALYVIVEKGQLKVVHVFGNHSTSVTVGEGLNRDEWHSVMVRIDVHGARLIA 265 ++L L++++ G ++ + ++T+G L+ WHSV+ I G ++ Sbjct: 233 HITLELRRGKLFLLINSGDARLTS--SSTLINLTLGSLLDDQHWHSVL--IQRLGKQVNF 288 Query: 266 RVDNNKEEVYLKGLNHETNYGVSINLMSVVLVGGLSSEEKLHGVKYIIESFVGCIRNV 323 VD ++ + +G E NY ++L + GG+S+ K + Y + F GC+ N+ Sbjct: 289 TVDEHRRHFHAQG---EFNY---LDLDYEISFGGISAPAKSVSLPY--KHFHGCLENL 338 ==> UNIPROT|Q9UHC6 - symbol:CNTP2_HUMAN "CNTNAP2, CASPR2, KIAA0868: Contactin-associated protein-like 2 precursor" species:9606 "Homo sapiens" [GO:0008038 "neuron recognition" evidence=NAS] [GO:0019226 "transmission of nerve impulse" evidence=NAS] [GO:0016021 "integral to membrane" evidence=NAS] InterPro:IPR000421 UniProt:Q9UHC6 InterPro:IPR008985 InterPro:IPR000742 InterPro:IPR006210 InterPro:IPR006209 GO:GO:0016021 InterPro:IPR013320 Gene3D:G3DSA:2.60.120.200 InterPro:IPR008979 GO:GO:0019226 InterPro:IPR013032 PROSITE:PS00022 PROSITE:PS01186 PROSITE:PS50026 SMART:SM00181 InterPro:IPR001791 Pfam:PF00008 SMART:SM00282 PROSITE:PS50025 GO:GO:0008038 Pfam:PF00754 InterPro:IPR012680 Pfam:PF02210 InterPro:IPR003585 SMART:SM00294 HSSP:P12259 SMART:SM00231 PROSITE:PS01285 PROSITE:PS01286 PROSITE:PS50022 EMBL:AF193613 EMBL:AF319045 EMBL:AF318292 EMBL:AF318298 EMBL:AB020675 EMBL:CR933671 EMBL:BC093780 EMBL:BC113373 UniGene:Hs.190621 Ensembl:ENSG00000174469 KEGG:hsa:26047 HGNC:HGNC:13830 MIM:604569 MIM:610042 ArrayExpress:Q9UHC6 RZPD-ProtExp:IOH53659 Length = 1331 Score = 270 bits (690), Expect = 1e-071 Identities = 249/1023 (24%), Positives = 416/1023 (40%), Gaps = 107/1023 (10%) Query: 382 GTKYEGEHCDIYTATVLTLRGSSYVSYRIYDWKDRVHSPITRISMMFKTNYDDSALFYAS 441 G + E C Y A V+ G + YR + K + + I++ FKT+ + + + Sbjct: 173 GLRIEVYGCS-YWADVINFDGHVVLPYRFRNKKMKTLKDV--IALNFKTSESEGVILH-- 227 Query: 442 GESLKPQYIAASIKNHSAYIEMDFGD-------GVMSATLGQDLTRHYWHNLTILHEHDK 494 GE + YI +K + ++ G G S G L H+WH++ I + Sbjct: 228 GEGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVMTGSLLDDHHWHSVVIERQGRS 287 Query: 495 VIAILDDHVRILDLLGPIHNLLFDPEIYFGGGPNLSKRKGLASSNNFVGSLKYVFYNDVS 554 + LD ++ G L D EI FGG P S + +S NF G ++ + YN V+ Sbjct: 288 INLTLDRSMQHFRTNGEFDYLDLDYEITFGGIP-FSGKPSSSSRKNFKGCMESINYNGVN 346 Query: 555 VLFELKKGNPKVHYIGVLQEEFYEANVEVIPITFSYAKSHIWWPMN-NPDTLSLKFDFKS 613 + ++ + +G L E +P+ F+ A S++ P N D S+ F F++ Sbjct: 347 ITDLARRKKLEPSNVGNLSFSCVEPYT--VPVFFN-ATSYLEVPGRLNQDLFSVSFQFRT 403 Query: 614 SKATAVLAYSEVKTSEGNGFWELRLATDRLSFDLCPDVKSNITHTTYIRIE-------NP 666 +L +S + GN E+ L ++ V NIT T +I+ N Sbjct: 404 WNPNGLLVFSHFADNLGNV--EIDLTESKVG------VHINITQTKMSQIDISSGSGLND 455 Query: 667 TSWHSIQLTYERNDIKFVVD--YRHSVTQMYGLSFNIGDKLIIG--------SSLKAAAS 716 WH ++ + N +D +V L G+K G SS Sbjct: 456 GQWHEVRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSHSVLQP 515 Query: 717 GLVGCLRDLKINGVEIEPRYLVKSERV--VGDVSLDNCKYVDPCKKPNTCEHGGKCAVKD 774 GC++ ++++ ++ Y V + +VS+D C +D C PN CEHGGKC+ Sbjct: 516 SFQGCMQLIQVDD-QLVNLYEVAQRKPGSFANVSIDMCAIIDRCV-PNHCEHGGKCSQTW 573 Query: 775 DGIICDCKDTGYIGKNCHFTKFRKTCEELALLGYSKSDVYSIDIDGNGVFPPARVKCDFQ 834 D C C +TGY G CH + + +CE LG + S+ Y ID DG+G P +V C+ Sbjct: 574 DSFKCTCDETGYSGATCHNSIYEPSCEAYKHLGQT-SNYYWIDPDGSGPLGPLKVYCNMT 632 Query: 835 SLANATKTIVEHNLPSQVDVRSATDEDFSFNIQYREFSAEMLQELISHSLYCTQYIKYDC 894 + TIV H+L Q V E +S S + + + + YC QY+ Y C Sbjct: 633 E--DKVWTIVSHDLQMQTPVVGYNPEKYSVTQLVYSASMDQISAITDSAEYCEQYVSYFC 690 Query: 895 IKAPL----ELHSSTWFKSSSNNNTVDSLGEVKR-GTCPCAIGKNCEDLNHSCNCDANLN 949 + L + TW+ +N G C C I +NC D + CNCDA+ Sbjct: 691 KMSRLLNTPDGSPYTWWVGKANEKHYYWGGSGPGIQKCACGIERNCTDPKYYCNCDADYK 750 Query: 950 RWLSDEGYYKEPPNLGITQMYFLQQKNLDEESQGRVTLGPLECVETNTQKYVVTFTTSQS 1009 +W D G+ +L ++Q+ + S+ ++++GPL C +F S Sbjct: 751 QWRKDAGFLSYKDHLPVSQVVVGDTDR--QGSEAKLSVGPLRCQGDRNYWNAASFPNPSS 808 Query: 1010 YIE---VPGWRKGDIAFSFRTTGEKAILLFQPPIRSNYPSFMVALTGDYQLTFNFTLNTG 1066 Y+ G DI+F F+T + L + L +++F+F + G Sbjct: 809 YLHFSTFQGETSADISFYFKTLTPWGVFLEN---MGKEDFIKLELKSATEVSFSFDVGNG 865 Query: 1067 TPKTLVIDTNRKLNGGEWHKIWIDYNEHHVRFMINTDTRMVDLQPEEEFGPFE--GSMFI 1124 P +V+ + LN +WH++ + N ++ + + P E E +F+ Sbjct: 866 -PVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEGHTRLELYSQLFV 924 Query: 1125 GGAPTEISKKYTVKQGLIGCFRGLVVNGEILDIYSFMSVHLSEIIKDCKPSCVP--NPCK 1182 GGA + QG +GC R L +NG LD+ V S I C C C+ Sbjct: 925 GGAGGQ--------QGFLGCIRSLRMNGVTLDLEERAKV-TSGFISGCSGHCTSYGTNCE 975 Query: 1183 NGAYCRELWSTFECVCQNRWAHLGQHCETNINEDALTFISRESYLKRNYLSDPEDMRDER 1242 NG C E + + C C N A+ G C N+D F +L+ N+ + + RD Sbjct: 976 NGGKCLERYHGYSCDCSNT-AYDGTFC----NKDVGAFFEEGMWLRYNFQAPATNARDSS 1030 Query: 1243 EKL----------RAILNSSLLVNLRTYDRHAFVLYANDHYNNFIHLYLTDQSEMVYLYN 1292 ++ + + + T +LY + +F+ + + + YN Sbjct: 1031 SRVDNAPDQQNSHPDLAQEEIRFSFSTTKAPCILLYISSFTTDFLAVLVKPTGSLQIRYN 1090 Query: 1293 YGS--DIVNLTIEHSELNNARSIQVAVIRTETNTTLYVNEKNVTVERGFLLLDEYSNKPW 1350 G + N+ ++H + N + V + R +EK + FL LD Y + + Sbjct: 1091 LGGTREPYNIDVDHRNMANGQPHSVNITR---------HEKTI-----FLKLDHYPSVSY 1136 Query: 1351 TNP 1353 P Sbjct: 1137 HLP 1139 Score = 71.6 bits (174), Expect = 7e-012 Identities = 108/476 (22%), Positives = 179/476 (37%), Gaps = 68/476 (14%) Query: 176 TFQLRLCREISFQFRTRLPHGLLVYHNVKTPAGVKLDPYALYVIVEKGQLKVVHVFGNHS 235 TFQ +ISF F+T P G+ + N+ +KL+ + ++ GN Sbjct: 814 TFQGETSADISFYFKTLTPWGVFL-ENMGKEDFIKLE------LKSATEVSFSFDVGNGP 866 Query: 236 TSVTVGEG--LNRDEWHSVMVRIDVHGARLIARVDNNKEEVYLKGLNHETNYGVSINLMS 293 + V LN D+WH V +V A L +VD +++ T + L S Sbjct: 867 VEIVVRSPTPLNDDQWHRVTAERNVKQASL--QVDRLPQQIRKAPTEGHTR----LELYS 920 Query: 294 VVLVGGLSSEEKLHGVKYIIESFVGCIRNVVLSSGKAASDLLPITPLIATKHENVKEGCR 353 + VGG ++ F+GCIR++ ++ DL + + GC Sbjct: 921 QLFVGGAGGQQ----------GFLGCIRSLRMNG--VTLDLEERAKVTS----GFISGCS 964 Query: 354 NKCHSRQNLCFTGSRCINHYYDISCDCFGTKYEGEHCD---------------IYTATVL 398 C S C G +C+ Y+ SCDC T Y+G C+ + A Sbjct: 965 GHCTSYGTNCENGGKCLERYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPAT 1024 Query: 399 TLRGSSYVSYRIYDWKDRVHS----PITRISMMFKTNYDDSALFYASGESLKPQYIAASI 454 R S S R+ + D+ +S I F T L Y S S ++A + Sbjct: 1025 NARDS---SSRVDNAPDQQNSHPDLAQEEIRFSFSTTKAPCILLYIS--SFTTDFLAVLV 1079 Query: 455 K-NHSAYIEMDFGDGVMSATLGQD---LTRHYWHNLTILHEHDKVIAILDDHVRILDLLG 510 K S I + G + D + H++ I + LD + + L Sbjct: 1080 KPTGSLQIRYNLGGTREPYNIDVDHRNMANGQPHSVNITRHEKTIFLKLDHYPSVSYHLP 1139 Query: 511 PIHNLLFD-PEIYFGG----GPNLSKRKGLASSNNFVGSLKYVFYNDVSVL-FELKKGNP 564 + LF+ P+ F G + + ++ F G L V +N ++ L L++ N Sbjct: 1140 SSSDTLFNSPKSLFLGKVIETGKIDQEIHKYNTPGFTGCLSRVQFNQIAPLKAALRQTNA 1199 Query: 565 KVHYIGVLQEEFYEANVEVIPITFSYAKSHI-WWPMNNPDTLSLKFDFKSSKATAV 619 H +Q E E+N P+T S S W +++ D+ S F + + A+ Sbjct: 1200 SAHV--HIQGELVESNCGASPLTLSPMSSATDPWHLDHLDSASADFPYNPGQGQAI 1253 Score = 59.7 bits (143), Expect = 3e-008 Identities = 30/86 (34%), Positives = 49/86 (56%), Gaps = 9/86 (10%) Query: 1394 EGYIGCIRGLKIGENLISLREMATQNNAHVTDGVLNGCQMKCDA--EPCKNGGICTENFV 1451 +G++GCIR L++ + L E A VT G ++GC C + C+NGG C E + Sbjct: 931 QGFLGCIRSLRMNGVTLDLEE-----RAKVTSGFISGCSGHCTSYGTNCENGGKCLERY- 984 Query: 1452 RQESTCNCEHTSFLGEFCSEEKGASF 1477 +C+C +T++ G FC+++ GA F Sbjct: 985 -HGYSCDCSNTAYDGTFCNKDVGAFF 1009 Score = 45.4 bits (106), Expect = 6e-004 Identities = 48/210 (22%), Positives = 78/210 (37%), Gaps = 20/210 (9%) Query: 185 ISFQFRTRLPHGLLVYHNVKTPAG---VKLDPYALYVIVEKGQLKVVHVFGNHSTSVTVG 241 +SFQFRT P+GLLV+ + G + L + V + Q K+ + ++ G Sbjct: 397 VSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKMSQI------DISSG 450 Query: 242 EGLNRDEWHSVMVRIDVHGARLIARVDNNKEEVYLKGLNHETNYGVSINLMSVVLVGGLS 301 GLN +WH V + A I +D ++ TN + + GG Sbjct: 451 SGLNDGQWHEVRFLAKENFA--ILTIDGDEASAV------RTNSPLQVKTGEKYFFGGFL 502 Query: 302 SEEKLHGVKYIIESFVGCIRNVVLSSGKAASDLLPITPLIATKHENVK-EGCRNKCHSRQ 360 ++ + SF GC++ ++ +L + NV + C Sbjct: 503 NQMNNSSHSVLQPSFQGCMQ--LIQVDDQLVNLYEVAQRKPGSFANVSIDMCAIIDRCVP 560 Query: 361 NLCFTGSRCINHYYDISCDCFGTKYEGEHC 390 N C G +C + C C T Y G C Sbjct: 561 NHCEHGGKCSQTWDSFKCTCDETGYSGATC 590 Score = 39.3 bits (90), Expect = 0.040 Identities = 79/462 (17%), Positives = 176/462 (38%), Gaps = 90/462 (19%) Query: 1018 KGDIAFSFRTTGEKAILLFQPPIRSNYPSFMVALTGDYQLTFNFTLNTGTP---KTLVID 1074 K IA +F+T+ + ++L + +Y + + L+ N N P T V+ Sbjct: 209 KDVIALNFKTSESEGVILHGEGQQGDYITLELK-KAKLVLSLNLGSNQLGPIYGHTSVM- 266 Query: 1075 TNRKLNGGEWHKIWIDYNEHHVRFMINTDTRMVDLQPEEEFGPFEGSMFIGGAPTEISKK 1134 T L+ WH + I+ + ++ + E ++ + + GG P Sbjct: 267 TGSLLDDHHWHSVVIERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEITFGGIPFSGKPS 326 Query: 1135 YTVKQGLIGCFRGLVVNGEILDIYSFMSVHLSEII--KDCKPSCVPNPCKNGAYCRELWS 1192 + ++ GC + NG V+++++ K +PS V N Sbjct: 327 SSSRKNFKGCMESINYNG----------VNITDLARRKKLEPSNVGN------------L 364 Query: 1193 TFECVCQNRWAHLGQHCETNINEDALTFISRESYLKRNYLSDPEDMRDEREKLRAILNSS 1252 +F CV + + +A +++ L ++ S Sbjct: 365 SFSCV---------EPYTVPVFFNATSYLEVPGRLNQDLFS------------------- 396 Query: 1253 LLVNLRTYDRHAFVLYAN--DHYNNFIHLYLTDQSEMVYLYNYGSDIVNLTIEH-SELNN 1309 + RT++ + +++++ D+ N + + LT+ V++ + + + I S LN+ Sbjct: 397 VSFQFRTWNPNGLLVFSHFADNLGN-VEIDLTESKVGVHINITQTKMSQIDISSGSGLND 455 Query: 1310 ARSIQVAVIRTETNTTLYVNEKNVTVERGFLLLDEYSNKPWTNPELEVLSPHRPPAPPTE 1369 + +V + E L ++ + R TN L+V + + Sbjct: 456 GQWHEVRFLAKENFAILTIDGDEASAVR-------------TNSPLQVKTGEK------- 495 Query: 1370 YFQFNIGGYDPANLLRPNQDTTELEGYIGCIRGLKIGENLISLREMATQNNAHVTDGVLN 1429 YF GG+ N + + + + GC++ +++ + L++L E+A + + ++ Sbjct: 496 YF---FGGF--LNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVSID 550 Query: 1430 GCQM--KCDAEPCKNGGICTENFVRQESTCNCEHTSFLGEFC 1469 C + +C C++GG C++ + C C+ T + G C Sbjct: 551 MCAIIDRCVPNHCEHGGKCSQTW--DSFKCTCDETGYSGATC 590 ==> MGI|MGI:1914047 - symbol:Cntnap2 "contactin associated protein-like 2" species:10090 "Mus musculus" [GO:0016021 "integral to membrane" evidence=RCA] InterPro:IPR000421 InterPro:IPR008985 InterPro:IPR000742 InterPro:IPR006210 InterPro:IPR006209 MGI:MGI:1914047 InterPro:IPR013320 Gene3D:G3DSA:2.60.120.200 InterPro:IPR008979 InterPro:IPR013032 PROSITE:PS00022 PROSITE:PS01186 PROSITE:PS50026 SMART:SM00181 InterPro:IPR001791 Pfam:PF00008 SMART:SM00282 PROSITE:PS50025 Pfam:PF00754 InterPro:IPR012680 Pfam:PF02210 InterPro:IPR003585 SMART:SM00294 SMART:SM00231 PROSITE:PS01285 PROSITE:PS01286 PROSITE:PS50022 EMBL:AK017341 EMBL:AK013139 EMBL:AK129232 EMBL:BC029826 EMBL:BC064467 UniGene:Mm.321004 HSSP:O14786 Ensembl:ENSMUSG00000039419 KEGG:mmu:66797 ArrayExpress:Q9CPW0 GermOnline:ENSMUSG00000039419 Uniprot:Q9CPW0 Length = 1332 Score = 270 bits (689), Expect = 1e-071 Identities = 245/986 (24%), Positives = 409/986 (41%), Gaps = 93/986 (9%) Query: 393 YTATVLTLRGSSYVSYRIYDWKDRVHSPITRISMMFKTNYDDSALFYASGESLKPQYIAA 452 Y A V+ G + YR + K + + I++ FKT+ + L + GE + YI Sbjct: 183 YWADVINFDGHGVLPYRFRNKKMKTLKDV--IALKFKTSESEGVLLH--GEGQQGDYITL 238 Query: 453 SIKNHSAYIEMDFGD-------GVMSATLGQDLTRHYWHNLTILHEHDKVIAILDDHVRI 505 +K + ++ G G S T G L H+WH++ I + + LD ++ Sbjct: 239 ELKKAKLVLSLNLGSNQLGPIYGHTSVTSGSLLDDHHWHSVLIERQGRSINLTLDRSMQH 298 Query: 506 LDLLGPIHNLLFDPEIYFGGGPNLSKRKGLASSNNFVGSLKYVFYNDVSV--LFELKKGN 563 G L D EI FGG P S + ++ NF G ++ + YN V++ L KK Sbjct: 299 FRTNGEFDYLDLDYEITFGGIP-FSGKPSSSNRKNFKGCMESINYNGVNITDLARRKKLG 357 Query: 564 PKVHYIGVLQEEFYEANVEVIPITFSYAKSHIWWPMN-NPDTLSLKFDFKSSKATAVLAY 622 P +G L E +P+ F+ A S++ P N D S+ F F++ + +L + Sbjct: 358 PS--NMGNLSFSCVEPYT--VPVFFN-ATSYLEVPGRLNQDLFSVSFQFRTWNPSGLLLF 412 Query: 623 SEVKTSEGNGFWELRLATDRLSFDLCPDVKSNITHTTYIRIE-----NPTSWHSIQLTYE 677 S + GN + D + + + + T T+ I I N WH ++ + Sbjct: 413 SHFADNLGN------VEIDLVESKVGVHINNTQTKTSQIDISSGSGLNDGQWHEVRFLAK 466 Query: 678 RNDIKFVVD--YRHSVTQMYGLSFNIGDKLIIG--------SSLKAAASGLVGCLRDLKI 727 N +D +V L G+K G +S A GC++ +++ Sbjct: 467 ENFAVLTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNHMNNASYSALQPSFQGCMQLIQV 526 Query: 728 NGVEIEPRYLVKSERV--VGDVSLDNCKYVDPCKKPNTCEHGGKCAVKDDGIICDCKDTG 785 + ++ Y V + +V++D C +D C PN CEHGGKC+ D C C +TG Sbjct: 527 DD-QLVNLYEVAQRKPGSFANVTIDMCAIIDRCV-PNHCEHGGKCSQTWDSFKCTCDETG 584 Query: 786 YIGKNCHFTKFRKTCEELALLGYSKSDVYSIDIDGNGVFPPARVKCDFQSLANATKTIVE 845 Y G CH + + +CE LG + S+ Y ID DG+G P +V C+ + TIV Sbjct: 585 YSGATCHNSIYEPSCEAYKHLGQT-SNYYWIDPDGSGPLGPLKVYCNMTE--DKVWTIVS 641 Query: 846 HNLPSQVDVRSATDEDFSFNIQYREFSAEMLQELISHSLYCTQYIKYDCIKAPL----EL 901 H+L Q V E +S S + + + S + YC QY+ Y C + L + Sbjct: 642 HDLQMQTTVVGYNPEKYSVTQLIYSASMDQISAITSSAEYCEQYVSYFCRMSRLLNTPDG 701 Query: 902 HSSTWFKSSSNNNTVDSLG-EVKRGTCPCAIGKNCEDLNHSCNCDANLNRWLSDEGYYKE 960 TW+ +N G E C C I +NC D + CNCDA+ +W D G+ Sbjct: 702 SPYTWWVGKANEKHYYWGGSEPGIQKCACGIERNCTDPKYYCNCDADYKQWRKDAGFLSY 761 Query: 961 PPNLGITQMYFLQQKNLDEESQGRVTLGPLECVETNTQKYVVTFTTSQSYIE---VPGWR 1017 +L ++Q+ + S+ ++++GPL C +F SY+ G Sbjct: 762 KDHLPVSQVVVGDTDR--QGSEAKLSVGPLRCQGDRNYWNAASFPNPSSYLHFSTFQGET 819 Query: 1018 KGDIAFSFRTTGEKAILLFQPPIRSNYPSFMVALTGDYQLTFNFTLNTGTPKTLVIDTNR 1077 DI+F F+T + + L N + L +++F+F + G P +V+ + Sbjct: 820 SADISFYFKTLIPRGVFLEN---LGNTDFIKLELKSATEVSFSFDVGNG-PVEIVVRSPS 875 Query: 1078 KLNGGEWHKIWIDYNEHHVRFMINTDTRMVDLQPEEEFGPFE--GSMFIGGAPTEISKKY 1135 LN +WH++ + N ++ + + P E E +F+GGA + Sbjct: 876 PLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEGHTRLELYSQLFVGGAGGQ----- 930 Query: 1136 TVKQGLIGCFRGLVVNGEILDIYSFMSVHLSEIIKDCKPSCVP--NPCKNGAYCRELWST 1193 QG +GC R L +NG LD+ V S C C C+NG C E + Sbjct: 931 ---QGFLGCIRSLRMNGVTLDLEERAKV-TSGFKSGCSGHCTSYGANCENGGKCIEKYHG 986 Query: 1194 FECVCQNRWAHLGQHCETNINEDALTFISRESYLKRNYL----------SDPEDMRDERE 1243 + C C N A+ G C N+D F +L+ N+ S E+ D+++ Sbjct: 987 YSCDCSNT-AYDGTFC----NKDVGAFFEEGMWLRYNFQAPAVTARDTGSRAENSADQQQ 1041 Query: 1244 KLRA-ILNSSLLVNLRTYDRHAFVLYANDHYNNFIHLYLTDQSEMVYLYNYGS--DIVNL 1300 L + + + T +LY + +F+ + + + YN G + N+ Sbjct: 1042 HLAPDLAQEQIHFSFSTTKAPCILLYVSSLTTDFLAVLVKPTGNLQIRYNLGGTREPFNI 1101 Query: 1301 TIEHSELNNARSIQVAVIRTETNTTL 1326 ++H + N + V + R E L Sbjct: 1102 DVDHRNMANGQPHSVNITRHERTIIL 1127 Score = 79.7 bits (195), Expect = 3e-014 Identities = 108/474 (22%), Positives = 183/474 (38%), Gaps = 63/474 (13%) Query: 176 TFQLRLCREISFQFRTRLPHGLLVYHNVKTPAGVKLDPYALYVIVEKGQLKVVHVFGNHS 235 TFQ +ISF F+T +P G+ + N+ +KL+ + ++ GN Sbjct: 814 TFQGETSADISFYFKTLIPRGVFL-ENLGNTDFIKLE------LKSATEVSFSFDVGNGP 866 Query: 236 TSVTVGEG--LNRDEWHSVMVRIDVHGARLIARVDNNKEEVYLKGLNHETNYGVSINLMS 293 + V LN D+WH V +V A L +VD +++ T + L S Sbjct: 867 VEIVVRSPSPLNDDQWHRVTAERNVKQASL--QVDRLPQQIRKAPTEGHTR----LELYS 920 Query: 294 VVLVGGLSSEEKLHGVKYIIESFVGCIRNVVLSSGKAASDLLPITPLIATKHENVKEGCR 353 + VGG ++ F+GCIR++ ++ DL + + K GC Sbjct: 921 QLFVGGAGGQQ----------GFLGCIRSLRMNG--VTLDLEERAKVTS----GFKSGCS 964 Query: 354 NKCHSRQNLCFTGSRCINHYYDISCDCFGTKYEGEHCD---------------IYTATVL 398 C S C G +CI Y+ SCDC T Y+G C+ + A + Sbjct: 965 GHCTSYGANCENGGKCIEKYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPAV 1024 Query: 399 TLRGSSYVSYRIYDWKDRVHSPIT--RISMMFKTNYDDSALFYASGESLKPQYIAASIK- 455 T R + + D + + + +I F T L Y S SL ++A +K Sbjct: 1025 TARDTGSRAENSADQQQHLAPDLAQEQIHFSFSTTKAPCILLYVS--SLTTDFLAVLVKP 1082 Query: 456 NHSAYIEMDFGDGVMSATLGQD---LTRHYWHNLTILHEHDKVIAILDDHVRILDLLGPI 512 + I + G + D + H++ I +I LD + + L Sbjct: 1083 TGNLQIRYNLGGTREPFNIDVDHRNMANGQPHSVNITRHERTIILKLDHYPAVGYHLPSS 1142 Query: 513 HNLLFD-PEIYFGG----GPNLSKRKGLASSNNFVGSLKYVFYNDVSVL-FELKKGNPKV 566 + LF+ P+ F G + + ++ F G L V +N ++ L L++ N Sbjct: 1143 SDTLFNSPKSLFLGKVIETGKIDQEIHKYNTPGFTGCLSRVQFNHIAPLKAALRQTNASA 1202 Query: 567 HYIGVLQEEFYEANVEVIPITFSYAKSHI-WWPMNNPDTLSLKFDFKSSKATAV 619 H +Q E E+N P+T S S W +++ D+ S F + + A+ Sbjct: 1203 HV--HIQGELVESNCGASPLTLSPMSSATDPWHLDHLDSASADFPYNPGQGQAI 1254 Score = 59.3 bits (142), Expect = 4e-008 Identities = 53/212 (25%), Positives = 91/212 (42%), Gaps = 39/212 (18%) Query: 1394 EGYIGCIRGLKIGENLISLREMATQNNAHVTDGVLNGCQMKCDA--EPCKNGGICTENFV 1451 +G++GCIR L++ + L E A VT G +GC C + C+NGG C E + Sbjct: 931 QGFLGCIRSLRMNGVTLDLEE-----RAKVTSGFKSGCSGHCTSYGANCENGGKCIEKY- 984 Query: 1452 RQESTCNCEHTSFLGEFCSEEKGASFS----------------------GEATLLRRLAL 1489 +C+C +T++ G FC+++ GA F E + ++ L Sbjct: 985 -HGYSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPAVTARDTGSRAENSADQQQHL 1043 Query: 1490 ADTVGSVRLQLAFSSNDMRRANRVMLLLQSRNDRSYYLMVAITAENHLYIEEDREGATYA 1549 A + ++ +FS+ +A ++L + S + +L V + +L I + G Sbjct: 1044 APDLAQEQIHFSFSTT---KAPCILLYVSSLT--TDFLAVLVKPTGNLQIRYNLGGTREP 1098 Query: 1550 ARIE---GNFMDDARHSVYYTRHGDEASLLVD 1578 I+ N + HSV TRH L +D Sbjct: 1099 FNIDVDHRNMANGQPHSVNITRHERTIILKLD 1130 Score = 42.0 bits (97), Expect = 0.006 Identities = 46/210 (21%), Positives = 75/210 (35%), Gaps = 20/210 (9%) Query: 185 ISFQFRTRLPHGLLVYHNVKTPAG---VKLDPYALYVIVEKGQLKVVHVFGNHSTSVTVG 241 +SFQFRT P GLL++ + G + L + V + Q K + ++ G Sbjct: 397 VSFQFRTWNPSGLLLFSHFADNLGNVEIDLVESKVGVHINNTQTKTSQI------DISSG 450 Query: 242 EGLNRDEWHSVMVRIDVHGARLIARVDNNKEEVYLKGLNHETNYGVSINLMSVVLVGGLS 301 GLN +WH V + A + +D ++ TN + + GG Sbjct: 451 SGLNDGQWHEVRFLAKENFA--VLTIDGDEASAV------RTNSPLQVKTGEKYFFGGFL 502 Query: 302 SEEKLHGVKYIIESFVGCIRNVVLSSGKAASDLLPITPLIATKHENVK-EGCRNKCHSRQ 360 + + SF GC++ ++ +L + NV + C Sbjct: 503 NHMNNASYSALQPSFQGCMQ--LIQVDDQLVNLYEVAQRKPGSFANVTIDMCAIIDRCVP 560 Query: 361 NLCFTGSRCINHYYDISCDCFGTKYEGEHC 390 N C G +C + C C T Y G C Sbjct: 561 NHCEHGGKCSQTWDSFKCTCDETGYSGATC 590 Score = 39.3 bits (90), Expect = 0.040 Identities = 17/74 (22%), Positives = 39/74 (52%), Gaps = 4/74 (5%) Query: 1398 GCIRGLKIGENLISLREMATQNNAHVTDGVLNGCQM--KCDAEPCKNGGICTENFVRQES 1455 GC++ +++ + L++L E+A + + ++ C + +C C++GG C++ + Sbjct: 519 GCMQLIQVDDQLVNLYEVAQRKPGSFANVTIDMCAIIDRCVPNHCEHGGKCSQTW--DSF 576 Query: 1456 TCNCEHTSFLGEFC 1469 C C+ T + G C Sbjct: 577 KCTCDETGYSGATC 590 ==> UNIPROT|Q9BZ76 - symbol:CNTP3_HUMAN "CNTNAP3, CASPR3, KIAA1714: Contactin-associated protein-like 3 precursor" species:9606 "Homo sapiens" [GO:0008037 "cell recognition" evidence=NAS] [GO:0016021 "integral to membrane" evidence=NAS] InterPro:IPR000421 InterPro:IPR002181 UniProt:Q9BZ76 InterPro:IPR008985 InterPro:IPR000742 InterPro:IPR006210 InterPro:IPR006209 GO:GO:0016021 InterPro:IPR013320 Gene3D:G3DSA:2.60.120.200 InterPro:IPR008979 InterPro:IPR013032 PROSITE:PS00022 PROSITE:PS01186 PROSITE:PS50026 SMART:SM00181 InterPro:IPR001791 Pfam:PF00008 SMART:SM00282 PROSITE:PS50025 GO:GO:0005488 SMART:SM00186 PROSITE:PS00514 Pfam:PF00754 InterPro:IPR012680 Pfam:PF02210 GO:GO:0008037 HSSP:P12259 SMART:SM00231 PROSITE:PS01285 PROSITE:PS01286 PROSITE:PS50022 EMBL:AF333769 EMBL:AB051501 UniGene:Hs.128474 UniGene:Hs.521495 UniGene:Hs.604441 Ensembl:ENSG00000106714 KEGG:hsa:79937 HGNC:HGNC:13834 MIM:610517 LinkHub:Q9BZ76 ArrayExpress:Q9BZ76 GermOnline:ENSG00000106714 Length = 1288 Score = 250 bits (639), Expect = 9e-066 Identities = 241/985 (24%), Positives = 409/985 (41%), Gaps = 89/985 (9%) Query: 393 YTATVLTLRGSSYVSYRIYDWKDRVHSPITR-ISMMFKTNYDDSALFYASGESLKPQYIA 451 Y + V+ G S + YR+ + PI IS+ FK + L + G+ +I Sbjct: 179 YKSEVVYFDGQSALLYRL---DKKPLKPIRDVISLKFKAMQSNGILLHREGQH--GNHIT 233 Query: 452 ASIKNHSAYIEMDFGDGVMSAT-------LGQDLTRHYWHNLTILHEHDKVIAILDDHVR 504 + ++ G+ + +T LG L +WH++ I +V +D H Sbjct: 234 LELIKGKLVFFLNSGNAKLPSTIAPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKHTH 293 Query: 505 ILDLLGPIHNLLFDPEIYFGGGPNLSKRKGLASSNNFVGSLKYVFYNDVSVLFELKKGNP 564 G L + EI FGG P + + + F G L+ ++YN V V KK P Sbjct: 294 HFQAKGDSSYLDLNFEISFGGIPTPGRSRAFRRKS-FHGCLENLYYNGVDVTELAKKHKP 352 Query: 565 KVHYIGVLQEEFYEANVEVIPITFSYAKSHIWWPMNN-PDTLSLKFDFKSSKATAVLAYS 623 ++ +G + F + +P+TF ++S++ P N+ D +S+ F F++ L + Sbjct: 353 QILMMGNVS--FSCPQPQTVPVTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRAGHLLFG 410 Query: 624 EVKTSEGNGFWELRLATDRLSFDLCPDVKS--NITHTTYIRIENPTSWHSIQLTYERNDI 681 E++ G+G + L L +L L +S N+T + N WHS+ + + + + Sbjct: 411 ELR--RGSGSFVLFLKDGKLKLSLFQPGQSPRNVTAGAGL---NDGQWHSVSFSAKWSHM 465 Query: 682 KFVVDYRHSVTQMYGLSFNIGDKLIIGSSL--------KAAASGLVGCLRDLKINGVEIE 733 VVD +V + + + GD G L K+ G GCLR + I ++ Sbjct: 466 NVVVDDDTAVQPLVAVLIDSGDTYYFGGCLDNSSGSGCKSPLGGFQGCLRLITIGDKAVD 525 Query: 734 PRYLVKSERVVG---DVSLDNCKYVDPCKKPNTCEHGGKCAVKDDGIICDCKDTGYIGKN 790 P ++ + +G D+ +D+C D C P+ CEHGG+C+ D CDC TGY G+ Sbjct: 526 P--ILVQQGALGSFRDLQIDSCGITDRCL-PSYCEHGGECSQSWDTFSCDCLGTGYTGET 582 Query: 791 CHFTKFRKTCEELALLGYSKSDVYSIDIDGNGVFPPARVKCDFQSLANATKTIVEHNLPS 850 CH + + ++CE G + S +Y ID DG+G P V C+ A+A T+V+H P Sbjct: 583 CHSSLYEQSCEAHKHRG-NPSGLYYIDADGSGPLGPFLVYCNM--TADAAWTVVQHGGPD 639 Query: 851 QVDVRSATDEDFSFNIQYR-EFSAEMLQELISHSLYCTQYIKYDCIKA---------PLE 900 V +R A + + A L+ ++ + C Q + C A PL Sbjct: 640 AVTLRGAPSGHPRSAVSFAYAAGAGQLRSAVNLAERCEQRLALRCGTARRPDSRDGTPL- 698 Query: 901 LHSSTWFKSSSNNNTV--DSLGEVKRGTCPCAIGKNCEDLNHSCNCDANLNRWLSDEGYY 958 S W ++ +T SL + ++ C C + NC D + CNCDA N W SD Sbjct: 699 ---SWWVGRTNETHTYWGGSLPDAQK--CTCGLEGNCIDSQYYCNCDAGRNEWTSDTIVL 753 Query: 959 KEPPNLGITQMYFLQQKNLDEESQGRVTLGPLECVETNTQKYVVTFTTSQSYIEVP---G 1015 + +L +TQ+ + S+ TLGPL C + +F T SY+ P G Sbjct: 754 SQKEHLPVTQI--VMTDTGQPHSEADYTLGPLLCRGDQSFWNSASFNTETSYLHFPAFHG 811 Query: 1016 WRKGDIAFSFRTTGEKAILLFQPPIRSNYPSFMVALTGDYQLTFNFTLNTGTPKTLVIDT 1075 D+ F F+TT + + I + L ++TF+F + G P + + + Sbjct: 812 ELTADVCFFFKTTVSSGVFMENLGITD---FIRIELRAPTEVTFSFDVGNG-PCEVTVQS 867 Query: 1076 NRKLNGGEWHKIWIDYNEHHVRFMINTDTRMVDLQPEEEFG----PFEGSMFIGGAPTEI 1131 N +WH + + N + D +QP G +FIGG T Sbjct: 868 PTPFNDNQWHHVRAERNVKGASLQV--DQLPQKMQPAPADGHVRLQLNSQLFIGGTATR- 924 Query: 1132 SKKYTVKQGLIGCFRGLVVNGEILDIYSFMSVHLSEIIKDCKPSC--VPNPCKNGAYCRE 1189 ++G +GC R L +NG LD+ +V + C C + C+NG CRE Sbjct: 925 ------QRGFLGCIRSLQLNGVALDLEERATV-TPGVEPGCAGHCSTYGHLCRNGGRCRE 977 Query: 1190 LWSTFECVCQNRWAHLGQHCETNINEDALTFISRESYLKRNYL--SDPEDMRDEREKLRA 1247 C C A+ G C I+ T S + + +Y + + + Sbjct: 978 KRRGVTCDCAFS-AYDGPFCSNEISAYFATGSSMTYHFQEHYTLSENSSSLVSSLHRDVT 1036 Query: 1248 ILNSSLLVNLRTYDRHAFVLYANDHYNNFIHLYLTDQSEMVYLYNYG--SDIVNLTIEHS 1305 + + ++ RT + +LY + Y ++ + L + + Y + T + Sbjct: 1037 LTREMITLSFRTTRTPSLLLYVSSFYEEYLSVILANNGSLQIRYKLDRHQNPDAFTFDFK 1096 Query: 1306 ELNNARSIQVAVIRTETNTTLYVNE 1330 + + + QV + R E + VN+ Sbjct: 1097 NMADGQLHQVKINREEAVVMVEVNQ 1121 Score = 63.9 bits (154), Expect = 2e-009 Identities = 45/151 (29%), Positives = 70/151 (46%), Gaps = 9/151 (5%) Query: 1391 TELEGYIGCIRGLKIGENLISLREMATQNNAHVTDGVLNGCQMKCDA--EPCKNGGICTE 1448 T G++GCIR L++ + L E AT VT GV GC C C+NGG C E Sbjct: 923 TRQRGFLGCIRSLQLNGVALDLEERAT-----VTPGVEPGCAGHCSTYGHLCRNGGRCRE 977 Query: 1449 NFVRQESTCNCEHTSFLGEFCSEEKGASFSGEATLLRRLALADTVGSVRLQLAFSSNDMR 1508 R+ TC+C +++ G FCS E A F+ +++ T+ L S + Sbjct: 978 K--RRGVTCDCAFSAYDGPFCSNEISAYFATGSSMTYHFQEHYTLSENSSSLVSSLHRDV 1035 Query: 1509 RANRVMLLLQSRNDRSYYLMVAITAENHLYI 1539 R M+ L R R+ L++ +++ Y+ Sbjct: 1036 TLTREMITLSFRTTRTPSLLLYVSSFYEEYL 1066 Score = 62.8 bits (151), Expect = 3e-009 Identities = 62/242 (25%), Positives = 103/242 (42%), Gaps = 37/242 (15%) Query: 232 GNHSTSVTVGEG--LNRDEWHSVMVRIDVHGARLIARVDNNKEEVYLKGLNHETNYGVSI 289 GN VTV N ++WH V +V GA L +VD +++ + V + Sbjct: 857 GNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASL--QVDQLPQKMQPAPADGH----VRL 910 Query: 290 NLMSVVLVGGLSSEEKLHGVKYIIESFVGCIRNVVLSSGKAASDLLPITPLIATKHENVK 349 L S + +GG ++ ++ F+GCIR++ L+ A DL AT V+ Sbjct: 911 QLNSQLFIGGTATRQR---------GFLGCIRSLQLNG--VALDLEER----ATVTPGVE 955 Query: 350 EGCRNKCHSRQNLCFTGSRCINHYYDISCDCFGTKYEGEHC----DIYTATVLTLRGSSY 405 GC C + +LC G RC ++CDC + Y+G C Y AT ++ Sbjct: 956 PGCAGHCSTYGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNEISAYFATGSSMTYHFQ 1015 Query: 406 VSYRIYDWKDRVHSPITR--------ISMMFKTNYDDSALFYASGESLKPQYIAASIKNH 457 Y + + + S + R I++ F+T S L Y S S +Y++ + N+ Sbjct: 1016 EHYTLSENSSSLVSSLHRDVTLTREMITLSFRTTRTPSLLLYVS--SFYEEYLSVILANN 1073 Query: 458 SA 459 + Sbjct: 1074 GS 1075 Score = 60.8 bits (146), Expect = 1e-008 Identities = 50/207 (24%), Positives = 82/207 (39%), Gaps = 18/207 (8%) Query: 185 ISFQFRTRLPHGLLVYHNVKTPAGVKLDPYALYVIVEKGQLKV-VHVFGNHSTSVTVGEG 243 ++FQFRT G L++ ++ +G + + ++ G+LK+ + G +VT G G Sbjct: 394 VTFQFRTWNRAGHLLFGELRRGSG------SFVLFLKDGKLKLSLFQPGQSPRNVTAGAG 447 Query: 244 LNRDEWHSVMVRIDVHGARLIARVDNNKEEVYLKGLNHETNYGVSINLMSVVLVGGLSSE 303 LN +WHSV ++ D + + V I+ GG Sbjct: 448 LNDGQWHSVSFSAKWSHMNVVVDDDTAVQPLV----------AVLIDSGDTYYFGGCLDN 497 Query: 304 EKLHGVKYIIESFVGCIRNVVLSSGKAASDLLPITPLIATKHENVKEGCRNKCHSRQNLC 363 G K + F GC+R + + KA +L + + + + C + C Sbjct: 498 SSGSGCKSPLGGFQGCLRLITIGD-KAVDPILVQQGALGSFRDLQIDSCGITDRCLPSYC 556 Query: 364 FTGSRCINHYYDISCDCFGTKYEGEHC 390 G C + SCDC GT Y GE C Sbjct: 557 EHGGECSQSWDTFSCDCLGTGYTGETC 583 ==> UNIPROT|P78357 - symbol:CNTP1_HUMAN "CNTNAP1, CASPR, NRXN4: Contactin-associated protein 1 precursor" species:9606 "Homo sapiens" [GO:0004872 "receptor activity" evidence=TAS] [GO:0005070 "SH3/SH2 adaptor activity" evidence=TAS] [GO:0007165 "signal transduction" evidence=TAS] [GO:0005887 "integral to plasma membrane" evidence=TAS] InterPro:IPR000421 InterPro:IPR002181 UniProt:P78357 InterPro:IPR008985 InterPro:IPR000742 InterPro:IPR006210 InterPro:IPR006209 GO:GO:0007165 GO:GO:0005887 GO:GO:0005070 InterPro:IPR013320 Gene3D:G3DSA:2.60.120.200 GO:GO:0004872 InterPro:IPR008979 InterPro:IPR013032 PROSITE:PS00022 PROSITE:PS01186 PROSITE:PS50026 SMART:SM00181 InterPro:IPR001791 Pfam:PF00008 SMART:SM00282 PROSITE:PS50025 Pfam:PF00147 SMART:SM00186 PROSITE:PS00514 Pfam:PF00754 InterPro:IPR012680 Pfam:PF02210 InterPro:IPR003585 SMART:SM00294 EMBL:U87223 UniGene:Hs.408730 HSSP:P12259 Ensembl:ENSG00000108797 KEGG:hsa:8506 HGNC:HGNC:8011 MIM:602346 ArrayExpress:P78357 GermOnline:ENSG00000108797 SMART:SM00231 PROSITE:PS01285 PROSITE:PS01286 PROSITE:PS50022 Length = 1384 Score = 217 bits (553), Expect = 8e-056 Identities = 211/881 (23%), Positives = 360/881 (40%), Gaps = 75/881 (8%) Query: 393 YTATVLTLRGSSYVSYRIYDWKDRVHSPITRISMMFKTNYDDSALFYASGESLKPQYIAA 452 Y A +L G +SYR R + S FKT D L +A G + Y+ Sbjct: 170 YKADILYFDGDDAISYRFPRGVSRSLWDVFAFS--FKTEEKDGLLLHAEGA--QGDYVTL 225 Query: 453 SIKNHSAYIEMDFGD-------GVMSATLGQDLTRHYWHNLTILHEHDKVIAILDDHVRI 505 ++ + M G G + + G L +WH + + V LD +V+ Sbjct: 226 ELEGAHLLLHMSLGSSPIQPRPGHTTVSAGGVLNDQHWHYVRVDRFGRDVNFTLDGYVQR 285 Query: 506 LDLLGPIHNLLFDPEIYFGGGPNLSKRKGLASSNNFVGSLKYVFYNDVSVLFELKKGNPK 565 L G L D E++ GG + RK LA +NF G ++ V +N V++ + + + Sbjct: 286 FILNGDFERLNLDTEMFIGGLVGAA-RKNLAYRHNFRGCIENVIFNRVNIADLAVRRHSR 344 Query: 566 VHYIGVLQEEFYEANVEVIPITFSYAKSHIWWP-MNNPDTLSLKFDFKSSKATAVLAYSE 624 + + G + F + PI F + + P L++ F F++ T +L +S Sbjct: 345 ITFEGKVA--FRCLDPVPHPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLFSR 402 Query: 625 VKTSEGNGFWELRLATDRLSFDLCPDVKSNITHTTYIRIENPTSWHSIQLTYERNDIKFV 684 + +G G EL L+ +++ + + + R+ N WH + + N Sbjct: 403 L--GDGLGHVELTLSEGQVNVSIAQSGRKKLQFAAGYRL-NDGFWHEVNFVAQENHAVIS 459 Query: 685 VDYRHS--VTQMYGLSFNIGDKLIIGSSLKAAA--------SGLVGCLRDLKINGVEIEP 734 +D V Y L G G K A+ + GC+ LK++G ++ Sbjct: 460 IDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWDCHSNQTAFHGCMELLKVDG-QLVN 518 Query: 735 RYLVKSERV--VGDVSLDNCKYVDPCKKPNTCEHGGKCAVKDDGIICDCKDTGYIGKNCH 792 LV+ R+ +V D C D C PN CEH G+C D IC C+ TGY G+ CH Sbjct: 519 LTLVEGRRLGFYAEVLFDTCGITDRCS-PNMCEHDGRCYQSWDDFICYCELTGYKGETCH 577 Query: 793 FTKFRKTCEELALLGYSKSDVYSIDIDGNGVFPPARVKCDFQSLANATKTIVEHN-LPSQ 851 ++++CE L G + + ++ID DG+G P V CD + N T+V H+ L + Sbjct: 578 TPLYKESCEAYRLSGKTSGN-FTIDPDGSGPLKPFVVYCDIRE--NRAWTVVRHDRLWTT 634 Query: 852 VDVRSATDEDFSFNIQYREFSAEMLQELISHSLYCTQYIKYDCIKAPL-----ELHSSTW 906 S+ + F IQY S E + L + S +C Q+I++ C + L S W Sbjct: 635 RVTGSSMERPFLGAIQYWNASWEEVSALANASQHCEQWIEFSCYNSRLLNTAGGYPYSFW 694 Query: 907 FKSSSNNNTVDSLGEVKRGTCPCAIGKNCEDLNHSCNCDANLNRWLSDEGYYKEPPNLGI 966 + + + C C + ++C D CNCDA+ +W +D+G +L + Sbjct: 695 IGRNEEQHFYWGGSQPGIQRCACGLDRSCVDPALYCNCDADQPQWRTDKGLLTFVDHLPV 754 Query: 967 TQMYFLQQKNLDEESQGRVTLGPLECVETNTQKYVVTFTTSQSYIEVPGWRKG---DIAF 1023 TQ+ E+Q L PL C ++F T + + P R D++F Sbjct: 755 TQVVIGDTNRSTSEAQ--FFLRPLRCYGDRNSWNTISFHTGAA-LRFPPIRANHSLDVSF 811 Query: 1024 SFRTTGEKAILLFQ---PPIRSNYPSFMVALTGDYQLTFNFTLNTGTPKTLVIDTNRKLN 1080 FRT+ + L P + P V L + F F + G V + + N Sbjct: 812 YFRTSAPSGVFLENMGGPYCQWRRPYVRVELNTSRDVVFAFDVGNGDENLTVHSDDFEFN 871 Query: 1081 GGEWHKIWIDYNEHHVRFMINTDTRMVDLQPEEEF--GPFEGSMFIGGAPTEISKKYTVK 1138 EWH + + N R ++ ++ P + + ++ +++G A + + Sbjct: 872 DDEWHLVRAEINVKQARLRVDHRPWVLRPMPLQTYIWMEYDQPLYVGSAELK-------R 924 Query: 1139 QGLIGCFRGLVVNGEILDIYSFMSVHLSEIIKDCKPSCVPN------PCKNGAYCRELWS 1192 + +GC R + +NG L++ + + P+C + PC +G C E +S Sbjct: 925 RPFVGCLRAMRLNGVTLNLEG-----RANASEGTSPNCTGHCAHPRLPCFHGGRCVERYS 979 Query: 1193 TFECVCQNRWAHLGQHCETNINEDALTFISRESYLKRNYLS 1233 + C C + A G +C N D F ++++ N S Sbjct: 980 YYTCDC-DLTAFDGPYC----NHDIGGFFEPGTWMRYNLQS 1015 Score = 58.5 bits (140), Expect = 6e-008 Identities = 55/211 (26%), Positives = 85/211 (40%), Gaps = 25/211 (11%) Query: 184 EISFQFRTRLPHGLLVYHNVKTPAGVKLDPYALYVIVEKGQLKVVHVFGNHSTSVTVGEG 243 ++SF FRT P G+ + N+ P PY + + GN ++TV Sbjct: 808 DVSFYFRTSAPSGVFL-ENMGGPYCQWRRPYVRVELNTSRDVVFAFDVGNGDENLTVHSD 866 Query: 244 ---LNRDEWHSVMVRIDVHGARLIARVDNNKEEVYLKGLNHETNYGVSINLMSVVLVGGL 300 N DEWH V I+V ARL RVD+ L+ + +T + + + VG Sbjct: 867 DFEFNDDEWHLVRAEINVKQARL--RVDHRPW--VLRPMPLQTYIWMEYD--QPLYVGSA 920 Query: 301 SSEEKLHGVKYIIESFVGCIRNVVLSSGKAASDLLPITPLIATKHENVKEGCRNKCHSRQ 360 + + FVGC+R + L+ + A E C C + Sbjct: 921 ELKRR---------PFVGCLRAMRLNGVTLNLEGR------ANASEGTSPNCTGHCAHPR 965 Query: 361 NLCFTGSRCINHYYDISCDCFGTKYEGEHCD 391 CF G RC+ Y +CDC T ++G +C+ Sbjct: 966 LPCFHGGRCVERYSYYTCDCDLTAFDGPYCN 996 Score = 48.1 bits (113), Expect = 9e-005 Identities = 45/204 (22%), Positives = 85/204 (41%), Gaps = 39/204 (19%) Query: 1276 FIHLYLTDQSEMVYLYNYGSDIVNLTIEHSELNNARSIQVAVIRTETNTTLYVNEKNVTV 1335 ++ + L ++V+ ++ G+ NLT+ HS+ + ++R E N V Sbjct: 837 YVRVELNTSRDVVFAFDVGNGDENLTV-HSDDFEFNDDEWHLVRAEIN-----------V 884 Query: 1336 ERGFLLLDEYSNKPWTNPELEVLSPHRPPAPPTEYFQFNIGGYDPANLLRPNQDTTELEG 1395 ++ L +D ++PW P P Y YD L + Sbjct: 885 KQARLRVD---HRPWV----------LRPMPLQTYIWME---YDQP--LYVGSAELKRRP 926 Query: 1396 YIGCIRGLKIGENLISLREMATQNNAHVTDGVLNGCQMKCDAE--PCKNGGICTENFVRQ 1453 ++GC+R +++ ++L + A+ ++G C C PC +GG C E + Sbjct: 927 FVGCLRAMRLNGVTLNL-----EGRANASEGTSPNCTGHCAHPRLPCFHGGRCVERY--S 979 Query: 1454 ESTCNCEHTSFLGEFCSEEKGASF 1477 TC+C+ T+F G +C+ + G F Sbjct: 980 YYTCDCDLTAFDGPYCNHDIGGFF 1003 Score = 38.5 bits (88), Expect = 0.069 Identities = 71/342 (20%), Positives = 120/342 (35%), Gaps = 47/342 (13%) Query: 50 GQCQTFDYRYRFEQTINNCTQFIWGGCGGNLQNNFETYEQCMQQCANETQTPQPPVPLTT 109 G Q F FE+ +N T+ GG G + N Y + C + Sbjct: 281 GYVQRFILNGDFER-LNLDTEMFIGGLVGAARKNL-AYRHNFRGCIENV--------IFN 330 Query: 110 TVDPSSTSVRTQTQEAWSLHSSSSTLAPVPDELRGSELTFKETGYEKTFMFAKNNTFIQM 169 V+ + +VR ++ + + L PVP + F + F+Q+ Sbjct: 331 RVNIADLAVRRHSRITFEGKVAFRCLDPVPHPIN----------------FGGPHNFVQV 374 Query: 170 DGETIQTFQLRLCREISFQFRTRLPHGLLVYHNVKTPAGVKLDPYALYVIVEKGQLKV-V 228 G F R +SF+FRT GLL++ + G + + + +GQ+ V + Sbjct: 375 PG-----FPRRGRLAVSFRFRTWDLTGLLLFSRLGDGLG------HVELTLSEGQVNVSI 423 Query: 229 HVFGNHSTSVTVGEGLNRDEWHSVMVRIDVHGARLIARVDNNKEEVYLKGLNHETNYGVS 288 G G LN WH V + A + +D+ ++G +Y + Sbjct: 424 AQSGRKKLQFAAGYRLNDGFWHEVNFVAQENHA--VISIDD------VEGAEVRVSYPLL 475 Query: 289 INLMSVVLVGGLSSEEKLHGVKYIIESFVGCIRNVVLSSGKAASDLLPITPLIATKHENV 348 I + GG +F GC+ ++ G+ + L + E + Sbjct: 476 IRTGTSYFFGGCPKPASRWDCHSNQTAFHGCME-LLKVDGQLVNLTLVEGRRLGFYAEVL 534 Query: 349 KEGCRNKCHSRQNLCFTGSRCINHYYDISCDCFGTKYEGEHC 390 + C N+C RC + D C C T Y+GE C Sbjct: 535 FDTCGITDRCSPNMCEHDGRCYQSWDDFICYCELTGYKGETC 576 ==> MGI|MGI:1858201 - symbol:Cntnap1 "contactin associated protein-like 1" species:10090 "Mus musculus" [GO:0005615 "extracellular space" evidence=RCA] [GO:0016021 "integral to membrane" evidence=RCA] InterPro:IPR000421 InterPro:IPR002181 InterPro:IPR008985 InterPro:IPR000742 InterPro:IPR006210 InterPro:IPR006209 MGI:MGI:1858201 InterPro:IPR013320 Gene3D:G3DSA:2.60.120.200 InterPro:IPR008979 InterPro:IPR013032 PROSITE:PS00022 PROSITE:PS01186 PROSITE:PS50026 SMART:SM00181 InterPro:IPR001791 Pfam:PF00008 SMART:SM00282 PROSITE:PS50025 Pfam:PF00147 PROSITE:PS00514 Pfam:PF00754 InterPro:IPR012680 Pfam:PF02210 InterPro:IPR003585 SMART:SM00294 HSSP:P12259 SMART:SM00231 PROSITE:PS01285 PROSITE:PS01286 PROSITE:PS50022 EMBL:AF039833 PIR:T14158 UniGene:Mm.435534 IntAct:O54991 Ensembl:ENSMUSG00000017167 KEGG:mmu:53321 ArrayExpress:O54991 GermOnline:ENSMUSG00000017167 Uniprot:O54991 Length = 1385 Score = 214 bits (546), Expect = 5e-055 Identities = 213/878 (24%), Positives = 356/878 (40%), Gaps = 69/878 (7%) Query: 393 YTATVLTLRGSSYVSYRIYDWKDRVHSPITRISMMFKTNYDDSALFYASGESLKPQYIAA 452 YT+++L G +SYR + S + FKT D L + G + Y+ Sbjct: 171 YTSSILYFDGDDAISYRFQ--RGASQSLWDVFAFSFKTEEKDGLLLHTEGS--QGDYVTL 226 Query: 453 SIKNHSAYIEMDFGD-------GVMSATLGQDLTRHYWHNLTILHEHDKVIAILDDHVRI 505 ++ + M G G + +LG L WH + + LD + Sbjct: 227 ELQGAHLLLHMSLGSSPIQPRPGHTTVSLGGVLNDLSWHYVRVDRYGRDANFTLDGYAHH 286 Query: 506 LDLLGPIHNLLFDPEIYFGGGPNLSKRKGLASSNNFVGSLKYVFYNDVSVLFELKKGNPK 565 L G L + EI+ GG + RK LA +NF G ++ V YN +++ + + Sbjct: 287 FVLNGDFERLNLENEIFIGGLVGAA-RKNLAYRHNFRGCIENVIYNRINIAEMAVMRHSR 345 Query: 566 VHYIGVLQEEFYEANVEVIPITFSYAKSHIWWP-MNNPDTLSLKFDFKSSKATAVLAYSE 624 + + G + F + PI F + + P L++ F F++ T +L +S Sbjct: 346 ITFEGNVA--FRCLDPVPHPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLFSH 403 Query: 625 VKTSEGNGFWELRLATDRLSFDLCPDVKSNITHTTYIRIENPTSWHSIQLTYERNDIKFV 684 + +G G EL L+ +++ + + + R+ N WH + + N Sbjct: 404 L--GDGLGHVELMLSEGQVNVSIAQTGRKKLQFAAGYRL-NDGFWHEVNFVAQENHAVIS 460 Query: 685 VDYRHS--VTQMYGLSFNIGDKLIIGSSLKAAA--------SGLVGCLRDLKINGVEIEP 734 +D V Y L G G K A+ + GC+ LK++G ++ Sbjct: 461 IDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWGCHSNQTAFHGCMELLKVDG-QLVN 519 Query: 735 RYLVKSERV--VGDVSLDNCKYVDPCKKPNTCEHGGKCAVKDDGIICDCKDTGYIGKNCH 792 LV+ ++ +V D C D C PN CEH G+C D IC C+ TGY G CH Sbjct: 520 LTLVEFRKLGYFAEVLFDTCGITDRCS-PNMCEHDGRCYQSWDDFICYCELTGYKGVTCH 578 Query: 793 FTKFRKTCEELALLGYSKSDVYSIDIDGNGVFPPARVKCDFQSLANATKTIVEHN-LPSQ 851 ++++CE L G S Y+ID DG+G P V CD + N T+V H+ L + Sbjct: 579 EPLYKESCEAYRLSG-KYSGNYTIDPDGSGPLKPFVVYCDIRE--NRAWTVVRHDRLWTT 635 Query: 852 VDVRSATDEDFSFNIQYREFSAEMLQELISHSLYCTQYIKYDCIKAPL-----ELHSSTW 906 S+ D F IQY S E + L + S +C Q+I++ C + L S W Sbjct: 636 RVTGSSMDRPFLGAIQYWNASWEEVSALANASQHCEQWIEFSCYNSRLLNTAGSYPYSFW 695 Query: 907 FKSSSNNNTVDSLGEVKRGTCPCAIGKNCEDLNHSCNCDANLNRWLSDEGYYKEPPNLGI 966 + + + C C + ++C D CNCDA+ +W +D+G +L + Sbjct: 696 IGRNEEQHFYWGGSQPGIQRCACGLDQSCVDPALHCNCDADQPQWRTDKGLLTFVDHLPV 755 Query: 967 TQMYFLQQKNLDEESQGRVTLGPLECVETNTQKYVVTFTTSQSYIEVPGWRKG---DIAF 1023 TQ+ + E+Q L PL C ++F T + + P R D++F Sbjct: 756 TQVVVGDTNRSNSEAQ--FFLRPLRCYGDRNSWNTISFHTGAA-LRFPPIRANHSLDVSF 812 Query: 1024 SFRTTGEKAILLFQ---PPIRSNYPSFMVALTGDYQLTFNFTLNTGTPKTLVIDTNRKLN 1080 FRT+ + L P R P V L + F F + G V + + N Sbjct: 813 YFRTSAPSGVFLENMGGPFCRWRRPYVRVELNTSRDVVFAFDIGNGDENLTVHSDDFEFN 872 Query: 1081 GGEWHKIWIDYNEHHVRFMINTDTRMVDLQPEEEF--GPFEGSMFIGGAPTEISKKYTVK 1138 EWH + + N R ++ ++ P + + ++ +++G A + + Sbjct: 873 DDEWHLVRAEINVKQARLRVDHRPWVLRPMPLQTYIWLVYDQPLYVGSAELK-------R 925 Query: 1139 QGLIGCFRGLVVNGEILDIYSFMSVHLSE-IIKDCKPSCVPN--PCKNGAYCRELWSTFE 1195 + +GC R + +NG L++ + SE +C C PC +G C E +S + Sbjct: 926 RPFVGCLRAMRLNGVTLNLEG--RANASEGTFPNCTGHCTHPRFPCFHGGRCVERYSYYT 983 Query: 1196 CVCQNRWAHLGQHCETNINEDALTFISRESYLKRNYLS 1233 C C + A G +C N D F ++++ N S Sbjct: 984 CDC-DLTAFDGPYC----NHDIGGFFETGTWMRYNLQS 1016 Score = 57.8 bits (138), Expect = 1e-007 Identities = 57/215 (26%), Positives = 86/215 (40%), Gaps = 33/215 (15%) Query: 184 EISFQFRTRLPHGLLVYHNVKTPAGVKLDPYALYVIVEKGQLKVVHVFGNHSTSVTVGEG 243 ++SF FRT P G+ + N+ P PY + + GN ++TV Sbjct: 809 DVSFYFRTSAPSGVFL-ENMGGPFCRWRRPYVRVELNTSRDVVFAFDIGNGDENLTVHSD 867 Query: 244 ---LNRDEWHSVMVRIDVHGARLIARVDNNKEEVYLKGLNHETNYGVSINLMSVVLVGGL 300 N DEWH V I+V ARL RVD+ L+ + +T + + + VG Sbjct: 868 DFEFNDDEWHLVRAEINVKQARL--RVDHRPW--VLRPMPLQTYIWLVYD--QPLYVGSA 921 Query: 301 SSEEKLHGVKYIIESFVGCIRNVVLSSGKAASDLLPITPLIATKHENVKEG----CRNKC 356 + + FVGC+R + L+ L N EG C C Sbjct: 922 ELKRR---------PFVGCLRAMRLNG----------VTLNLEGRANASEGTFPNCTGHC 962 Query: 357 HSRQNLCFTGSRCINHYYDISCDCFGTKYEGEHCD 391 + CF G RC+ Y +CDC T ++G +C+ Sbjct: 963 THPRFPCFHGGRCVERYSYYTCDCDLTAFDGPYCN 997 Score = 48.9 bits (115), Expect = 5e-005 Identities = 46/204 (22%), Positives = 90/204 (44%), Gaps = 39/204 (19%) Query: 1276 FIHLYLTDQSEMVYLYNYGSDIVNLTIEHSELNNARSIQVAVIRTETNTTLYVNEKNVTV 1335 ++ + L ++V+ ++ G+ NLT+ HS+ + ++R E N V Sbjct: 838 YVRVELNTSRDVVFAFDIGNGDENLTV-HSDDFEFNDDEWHLVRAEIN-----------V 885 Query: 1336 ERGFLLLDEYSNKPWTNPELEVLSPHRPPAPPTEYFQFNIGGYDPANLLRPNQDTTELEG 1395 ++ L +D ++PW VL P P + + + + YD L + Sbjct: 886 KQARLRVD---HRPW------VLRPM-----PLQTYIWLV--YDQP--LYVGSAELKRRP 927 Query: 1396 YIGCIRGLKIGENLISLREMATQNNAHVTDGVLNGCQMKCDAE--PCKNGGICTENFVRQ 1453 ++GC+R +++ ++L + A+ ++G C C PC +GG C E + Sbjct: 928 FVGCLRAMRLNGVTLNL-----EGRANASEGTFPNCTGHCTHPRFPCFHGGRCVERY--S 980 Query: 1454 ESTCNCEHTSFLGEFCSEEKGASF 1477 TC+C+ T+F G +C+ + G F Sbjct: 981 YYTCDCDLTAFDGPYCNHDIGGFF 1004 Score = 38.5 bits (88), Expect = 0.069 Identities = 51/232 (21%), Positives = 88/232 (37%), Gaps = 21/232 (9%) Query: 160 FAKNNTFIQMDGETIQTFQLRLCREISFQFRTRLPHGLLVYHNVKTPAGVKLDPYALYVI 219 F + F+Q+ G F R +SF+FRT GLL++ ++ G + ++ Sbjct: 366 FGGPHNFVQVPG-----FPRRGRLAVSFRFRTWDLTGLLLFSHLGDGLG------HVELM 414 Query: 220 VEKGQLKV-VHVFGNHSTSVTVGEGLNRDEWHSVMVRIDVHGARLIARVDNNKEEVYLKG 278 + +GQ+ V + G G LN WH V + A + +D+ ++G Sbjct: 415 LSEGQVNVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHA--VISIDD------VEG 466 Query: 279 LNHETNYGVSINLMSVVLVGGLSSEEKLHGVKYIIESFVGCIRNVVLSSGKAASDLLPIT 338 +Y + I + GG G +F GC+ ++ G+ + L Sbjct: 467 AEVRVSYPLLIRTGTSYFFGGCPKPASRWGCHSNQTAFHGCME-LLKVDGQLVNLTLVEF 525 Query: 339 PLIATKHENVKEGCRNKCHSRQNLCFTGSRCINHYYDISCDCFGTKYEGEHC 390 + E + + C N+C RC + D C C T Y+G C Sbjct: 526 RKLGYFAEVLFDTCGITDRCSPNMCEHDGRCYQSWDDFICYCELTGYKGVTC 577 ==> FB|FBgn0000368 - symbol:crb "crumbs" species:7227 "Drosophila melanogaster" [GO:0009993 "oogenesis (sensu Insecta)" evidence=IMP] [GO:0007163 "establishment and/or maintenance of cell polarity" evidence=NAS;IMP] [GO:0005886 "plasma membrane" evidence=ISS;IDA] [GO:0016324 "apical plasma membrane" evidence=NAS;IDA;TAS] [GO:0045198 "establishment of epithelial cell polarity" evidence=TAS] [GO:0016021 "integral to membrane" evidence=NAS;TAS] [GO:0016334 "establishment and/or maintenance of polarity of follicular epithelium" evidence=IMP] [GO:0016332 "establishment and/or maintenance of polarity of embryonic epithelium" evidence=IMP] [GO:0016327 "apicolateral plasma membrane" evidence=IDA;IPI] [GO:0045218 "zonula adherens maintenance" evidence=NAS;IMP] [GO:0045186 "zonula adherens assembly" evidence=IMP;TAS] [GO:0045494 "photoreceptor cell maintenance" evidence=NAS;IMP] [GO:0046664 "dorsal closure, amnioserosa morphology change" evidence=IMP] [GO:0045197 "establishment and/or maintenance of epithelial cell polarity" evidence=NAS;TAS] [GO:0002009 "morphogenesis of an epithelium" evidence=NAS;TAS] [GO:0007043 "intercellular junction assembly" evidence=NAS] [GO:0005913 "cell-cell adherens junction" evidence=NAS] [GO:0042051 "compound eye photoreceptor development" evidence=TAS] [GO:0042052 "rhabdomere development" evidence=NAS] [GO:0030507 "spectrin binding" evidence=TAS] [GO:0035003 "subapical complex" evidence=TAS] [GO:0005918 "septate junction" evidence=TAS] [GO:0016044 "membrane organization and biogenesis" evidence=TAS] [GO:0007431 "salivary gland development" evidence=TAS] [GO:0005515 "protein binding" evidence=ISS] [GO:0008104 "protein localization" evidence=TAS] [GO:0001738 "morphogenesis of a polarized epithelium" evidence=TAS] InterPro:IPR001881 InterPro:IPR008985 InterPro:IPR000742 InterPro:IPR000152 InterPro:IPR006210 InterPro:IPR006209 EMBL:AE014297 GO:GO:0016021 GO:GO:0005918 InterPro:IPR013320 Gene3D:G3DSA:2.60.120.200 GO:GO:0009993 GO:GO:0045494 GO:GO:0016324 InterPro:IPR013032 PROSITE:PS00022 PROSITE:PS01186 PROSITE:PS50026 SMART:SM00181 InterPro:IPR001791 InterPro:IPR012679 Pfam:PF00008 Pfam:PF00054 SMART:SM00282 PROSITE:PS00010 PROSITE:PS50025 HSSP:P00740 GO:GO:0008104 GO:GO:0030507 GO:GO:0045186 InterPro:IPR013091 Pfam:PF07645 SMART:SM00179 PROSITE:PS01187 GO:GO:0016044 InterPro:IPR012680 Pfam:PF02210 GO:GO:0042052 EMBL:M33753 EMBL:AY118509 EMBL:X05144 PIR:A35672 PIR:B26637 UniGene:Dm.2365 Ensembl:CG6383 KEGG:dme:Dmel_CG6383 FlyBase:FBgn0000368 GermOnline:CG6383 GO:GO:0035003 GO:GO:0046664 GO:GO:0016332 GO:GO:0016334 GO:GO:0045198 GO:GO:0007431 GO:GO:0045218 InterPro:IPR001438 PRINTS:PR00010 Uniprot:P10040 Length = 2146 Score = 85.9 bits (211), Expect = 4e-016 Identities = 141/652 (21%), Positives = 232/652 (35%), Gaps = 117/652 (17%) Query: 746 DVSLDNCKYVDPCKKPNTCEHGGKCAVKDDGIICDCKDTGYIGKNCHFTKFRKTCEELAL 805 D+ +D+C DPC +GG+C + G CDC TGY G+NC Sbjct: 759 DIDIDDC-VGDPCL------NGGQCIDQLGGFRCDCSGTGYEGENCEL------------ 799 Query: 806 LGYSKSDVYSIDIDGNGVFPPARVKCDFQSLANATKTIVEHNLPSQVDVRSATDEDFSFN 865 D + NG RVK F N K + D+ +N Sbjct: 800 ----NIDECLSNPCTNGAKCLDRVKDYFCDCHNGYK-----GKNCEQDINECESNPCQYN 850 Query: 866 ---------IQYREFSAEMLQELISHSLYCTQYIKYDCIKAP--------LELHSSTWFK 908 Y+ L ++ S Y+C+ P + ++ Sbjct: 851 GNCLERSNITLYQMSRITDLPKVFSQPFSFENASGYECVCVPGIIGKNCEININECDSNP 910 Query: 909 SSSNNNTVDSLG---------------EVKRGTC----PCAIGKNCEDL--NHSCNCDAN 947 S + N D +G E+ C PC G C D ++ C+CDAN Sbjct: 911 CSKHGNCNDGIGTYTCECEPGFEGTHCEINIDECDRYNPCQRG-TCYDQIDDYDCDCDAN 969 Query: 948 L---NRWLSDEGYYKEPPNLG-------ITQMYFLQQKNLDEESQGRVTLGPLECVETNT 997 N + +G + P G I ++ L + QG +C +T T Sbjct: 970 YGGKNCSVLLKGCDQNPCLNGGACLPYLINEVTHLYNCTCENGFQGD------KCEKTTT 1023 Query: 998 QKYVVTFTTSQSYIEVPGWRKGDIAFSFRTTGEKAILLFQPPIRSNYP-SFMVALTGDYQ 1056 V T S + G+ DI FRTT +L F N P S+++ L Sbjct: 1024 LSMVATSLISVTTEREEGY---DINLQFRTTLPNGVLAFGTTGEKNEPVSYILELINGRL 1080 Query: 1057 LTFNFTLNTGTPKTLVIDTNRKLNGGEWHKIWIDYNEHHVRFMINTDTRMVDLQPEEEFG 1116 + LN K + KLN WHK+++ N H+ N + + + E Sbjct: 1081 NLHSSLLN----KWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQAIFPVGSYETAN 1136 Query: 1117 PFEGSM---FIGGAPTEISK--KYTVKQ--GLIGCFRGLVVNGEIL----DIYSFMSVHL 1165 + S ++GG + ++ Q +GC + ++VNG+ + + L Sbjct: 1137 NSQPSFPRTYLGGTIPNLKSYLRHLTHQPSAFVGCMQDIMVNGKWIFPDEQDANISYTKL 1196 Query: 1166 SEIIKDC--KPSCVPNPCKNGAYCRELWSTFECVCQNRWAHLGQHCETNINEDALTFISR 1223 + C C PNPC + C +LW TF C C + G C+ N+ A TF Sbjct: 1197 ENVQSGCPRTEQCKPNPCHSNGECTDLWHTFACHCPRPF--FGHTCQHNMT--AATF-GH 1251 Query: 1224 ESYLKRNYLSDPEDMRDEREKLRAILNSSLLVNLRTYDRHAFVLYANDH---YNNFIHLY 1280 E+ + + D+ R +R+IL+ S+ + R F L + N Y Sbjct: 1252 ENTTHSAVIVETTDV--ARRAIRSILDISMFIRTREPTGQVFYLGTDPRKAPTKNIGDSY 1309 Query: 1281 LTDQ---SEMVYLYNYGSDIVNLTIEHSELNNARSIQVAVIRTETNTTLYVN 1329 + + E++ + T+ +L+N + + V+R +T + +N Sbjct: 1310 VAAKLHGGELLVKMQFSGTPEAYTVGGQKLDNGYNHLIEVVRNQTLVQVKLN 1361 Score = 80.5 bits (197), Expect = 2e-014 Identities = 86/357 (24%), Positives = 148/357 (41%), Gaps = 26/357 (7%) Query: 184 EISFQFRTRLPHGLLVYHNVKTPAGVKLDPYALYVIVEKGQLKVVHVFGNHSTSVTVGEG 243 +I+ QFRT LP+G+L + G K +P + + + G+L + N V +G Sbjct: 1043 DINLQFRTTLPNGVLAFGTT----GEKNEPVSYILELINGRLNLHSSLLNKWEGVFIGSK 1098 Query: 244 LNRDEWHSVMVRIDVHGARLIARVDNNKEEVYLKGLNHETNYGVSINLMSVVLVGGLSS- 302 LN WH V V I+ L A N+++ ++ G ++ET + L G + + Sbjct: 1099 LNDSNWHKVFVAINTSHLVLSA---NDEQAIFPVG-SYETANNSQPSFPRTYLGGTIPNL 1154 Query: 303 EEKLHGVKYIIESFVGCIRNVVLSSGKAASDLLPITPLIATKHENVKEGCRNKCHSRQNL 362 + L + + +FVGC+++++++ GK + TK ENV+ GC + N Sbjct: 1155 KSYLRHLTHQPSAFVGCMQDIMVN-GKWIFPDEQDANISYTKLENVQSGCPRTEQCKPNP 1213 Query: 363 CFTGSRCINHYYDISCDCFGTKYEGEHCDIYTATVLTL----RGSSYVSYRIYDWKDRVH 418 C + C + ++ +C C + G C + T T S V D R Sbjct: 1214 CHSNGECTDLWHTFACHC-PRPFFGHTCQ-HNMTAATFGHENTTHSAVIVETTDVARRAI 1271 Query: 419 SPITRISMMFKTNYDDSALFY-------ASGESLKPQYIAASIKNHSAYIEMDFGDGVMS 471 I ISM +T +FY A +++ Y+AA + ++M F + Sbjct: 1272 RSILDISMFIRTREPTGQVFYLGTDPRKAPTKNIGDSYVAAKLHGGELLVKMQFSGTPEA 1331 Query: 472 ATL-GQDLTRHYWHNLTILHEHDKVIAILDDHVRILDLLGPIHNLLFDPEIYFGGGP 527 T+ GQ L Y H + ++ V L+ L L D ++ + GGP Sbjct: 1332 YTVGGQKLDNGYNHLIEVVRNQTLVQVKLNGTEYFRKTLSTTG--LLDAQVLYLGGP 1386 Score = 49.7 bits (117), Expect = 3e-005 Identities = 69/333 (20%), Positives = 121/333 (36%), Gaps = 57/333 (17%) Query: 1176 CVPNPCKNGAYC-----RELWSTFECVCQNRWAHLGQHCE--TNINEDALTFISRESYLK 1228 C NPC NG C E+ + C C+N + G CE T ++ A + IS + + Sbjct: 982 CDQNPCLNGGACLPYLINEVTHLYNCTCENGFQ--GDKCEKTTTLSMVATSLISVTTERE 1039 Query: 1229 RNYLSDPEDMRDEREKLRAILNSSLLVNLRTYDRHAFVLYANDHYNNFIHLY--LTDQSE 1286 Y D + R L + +L T +++ V Y + N ++L+ L ++ E Sbjct: 1040 EGY--------DINLQFRTTLPNGVLAFGTTGEKNEPVSYILELINGRLNLHSSLLNKWE 1091 Query: 1287 MVYLYNYGSDIVNLTIEHSELNNARSIQVAVIRTETNTTLYVNEKNVTVERGFLLLDEYS 1346 V++ S+LN++ +V V ++ L N++ G Sbjct: 1092 GVFI-------------GSKLNDSNWHKVFVAINTSHLVLSANDEQAIFPVG-------- 1130 Query: 1347 NKPWTNPELEVLSPHRPPAPPTEYFQFNIGGYDPANLLRPNQDTTELEGYIGCIRGLKIG 1406 E + +P P T +GG P T + ++GC++ + + Sbjct: 1131 -------SYETANNSQPSFPRTY-----LGGTIPNLKSYLRHLTHQPSAFVGCMQDIMVN 1178 Query: 1407 ENLISLREMATQNNAHVTDGVLNGCQM--KCDAEPCKNGGICTENFVRQESTCNCEHTSF 1464 I E + + V +GC +C PC + G CT+ + C+C F Sbjct: 1179 GKWIFPDEQDANISYTKLENVQSGCPRTEQCKPNPCHSNGECTD--LWHTFACHCPR-PF 1235 Query: 1465 LGEFCSEEKGASFSGEATLLRRLALADTVGSVR 1497 G C A+ G + +T R Sbjct: 1236 FGHTCQHNMTAATFGHENTTHSAVIVETTDVAR 1268 Score = 42.7 bits (99), Expect = 0.004 Identities = 20/46 (43%), Positives = 24/46 (52%), Gaps = 3/46 (6%) Query: 1170 KDCKPSCVPNPCKNGAYCRE-LWSTFECVCQNRWAHLGQHCETNIN 1214 KD C NPC+NG C E ++C C H GQHCET +N Sbjct: 302 KDNGSPCAKNPCENGGSCLENSRGDYQCFCDPN--HSGQHCETEVN 345 Score = 40.8 bits (94), Expect = 0.014 Identities = 20/56 (35%), Positives = 30/56 (53%), Gaps = 6/56 (10%) Query: 1160 FMSVHLSEIIKDCKPSCVPNPCKNGAYCRELWSTFECVCQNRWAHLGQHCETNINE 1215 F VH + +C + PC NGA C + +ECVCQ + G++CE +I+E Sbjct: 677 FTGVHCDSDVDEC----LSFPCLNGATCHNKINAYECVCQP--GYEGENCEVDIDE 726 Score = 40.0 bits (92), Expect = 0.024 Identities = 14/30 (46%), Positives = 19/30 (63%) Query: 363 CFTGSRCINHYYDISCDCFGTKYEGEHCDI 392 C G +CI+ CDC GT YEGE+C++ Sbjct: 770 CLNGGQCIDQLGGFRCDCSGTGYEGENCEL 799 Score = 40.0 bits (92), Expect = 0.024 Identities = 17/40 (42%), Positives = 23/40 (57%), Gaps = 1/40 (2%) Query: 1176 CVPNPCKNGAYCRELWSTFECVCQNRWAHLGQHCETNINE 1215 C NPC+NG C++L +EC CQ G CE +I+E Sbjct: 1954 CESNPCQNGGQCKDLVGRYECDCQGT-GFEGIRCENDIDE 1992 Score = 38.9 bits (89), Expect = 0.053 Identities = 17/44 (38%), Positives = 24/44 (54%), Gaps = 6/44 (13%) Query: 752 CKYVDPCKKPNTCEHGGK----CAVKDDGIICDCKDTGYIGKNC 791 C + DPC + C +GG+ C K D C+C + G+ GKNC Sbjct: 2026 CNFTDPCNATDLCSNGGRCVESCGAKPD-YYCECPE-GFAGKNC 2067 ==> UNIPROT|Q9NYQ6 - symbol:CELR1_HUMAN "CELSR1, CDHF9, FMI2: Cadherin EGF LAG seven-pass G-type receptor 1 precursor" species:9606 "Homo sapiens" [GO:0004930 "G-protein coupled receptor activity" evidence=NAS] [GO:0046983 "protein dimerization activity" evidence=NAS] [GO:0001843 "neural tube closure" evidence=ISS] [GO:0007417 "central nervous system development" evidence=NAS;TAS] [GO:0005887 "integral to plasma membrane" evidence=TAS] InterPro:IPR002049 InterPro:IPR000832 InterPro:IPR002126 InterPro:IPR000203 InterPro:IPR001879 UniProt:Q9NYQ6 InterPro:IPR008985 InterPro:IPR000742 InterPro:IPR000152 InterPro:IPR006210 InterPro:IPR006209 GO:GO:0005887 GO:GO:0007186 InterPro:IPR013320 Gene3D:G3DSA:2.60.120.200 GO:GO:0007417 GO:GO:0046983 InterPro:IPR013032 PROSITE:PS00022 PROSITE:PS01186 PROSITE:PS50026 SMART:SM00181 InterPro:IPR001791 Pfam:PF00008 Pfam:PF00053 SMART:SM00180 SMART:SM00282 PROSITE:PS00010 PROSITE:PS01248 PROSITE:PS50027 PROSITE:PS50025 GO:GO:0001843 GO:GO:0004930 InterPro:IPR009030 Pfam:PF00002 Pfam:PF01825 Pfam:PF02793 PRINTS:PR00249 SMART:SM00303 SMART:SM00008 PROSITE:PS00649 PROSITE:PS00650 PROSITE:PS50227 PROSITE:PS50261 PROSITE:PS50221 Pfam:PF00028 PRINTS:PR00205 SMART:SM00112 PROSITE:PS00232 PROSITE:PS50268 InterPro:IPR012680 Pfam:PF02210 EMBL:AF231024 EMBL:AL031588 EMBL:AL031597 EMBL:AL021392 EMBL:BC000059 UniGene:Hs.252387 HSSP:P00749 Ensembl:ENSG00000075275 KEGG:hsa:9620 HGNC:HGNC:1850 MIM:604523 LinkHub:Q9NYQ6 ArrayExpress:Q9NYQ6 GermOnline:ENSG00000075275 GO:GO:0001736 Length = 3014 Score = 66.2 bits (160), Expect = 3e-010 Identities = 89/374 (23%), Positives = 144/374 (38%), Gaps = 68/374 (18%) Query: 154 YEKTFMFAKNNTFIQMDGETIQTFQLRLCREISFQFRTRLPHGLLVYHNVKTPAGVKLDP 213 YE+ + +F T + + R IS F T+ +GLL+Y+ K D Sbjct: 1435 YERPYCEVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNG---RFNEKHDF 1491 Query: 214 YALYVIVEKGQLKVVHVFGNHSTSVTVG----EGLNRDEWHSVMVR-------------- 255 AL ++ E+ QL F T+ TV G++ WHSV V+ Sbjct: 1492 IALEIVDEQVQL----TFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPH 1547 Query: 256 -----------IDVHGARLIARVDNNKEEVYLKGLNHETNYGVSINLMSVVLVGG---LS 301 +D + R + +T S++L +L+GG L Sbjct: 1548 GPSGEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLTGPLLLGGVPNLP 1607 Query: 302 SEEKLHGVKYIIESFVGCIRNVVLSSGKAASDLLPITPLIATKHENVKEGC---RNKCHS 358 + +H FVGC+RN+ + + + IA + +EGC RN C Sbjct: 1608 EDFPVHN-----RQFVGCMRNLSVDGKN-----VDMAGFIA--NNGTREGCAARRNFCDG 1655 Query: 359 RQNLCFTGSRCINHYYDISCDCFGTKYEGEHCDIYTATVLTLRGSSYVSYRIYDWKDR-- 416 R+ C G C+N + C+C ++ G++C+ G S VS W D Sbjct: 1656 RR--CQNGGTCVNRWNMYLCEC-PLRFGGKNCEQAMPHPQLFSGESVVS-----WSDLNI 1707 Query: 417 VHSPITRISMMFKTNYDDSALFYASGESLKPQYIAASIKNHSAYIEMDFGDGVMSATL-- 474 + S + +MF+T +DS L A+ S P I N+ E+ G + + + Sbjct: 1708 IISVPWYLGLMFRTRKEDSVLMEAT--SGGPTSFRLQILNNYLQFEVSHGPSDVESVMLS 1765 Query: 475 GQDLTRHYWHNLTI 488 G +T WH+L I Sbjct: 1766 GLRVTDGEWHHLLI 1779 Score = 53.5 bits (127), Expect = 2e-006 Identities = 53/223 (23%), Positives = 99/223 (44%), Gaps = 28/223 (12%) Query: 1001 VVTFTTSQSYIEVPGWRKGDIAFSFRTTGEKAILLFQPPIRSNYP-SFMVALTGDYQLTF 1059 VV+++ I VP + + FRT E ++L+ S P SF + + +Y L F Sbjct: 1699 VVSWSDLNIIISVPWY----LGLMFRTRKEDSVLM---EATSGGPTSFRLQILNNY-LQF 1750 Query: 1060 NFTLNTGTPKTLVIDTNRKLNGGEWHKIWIDY-NEHHVRFMINTDTRMVDLQPEEEFGPF 1118 + +++++ + ++ GEWH + I+ N M + T +D ++ Sbjct: 1751 EVSHGPSDVESVML-SGLRVTDGEWHHLLIELKNVKEDSEMKHLVTMTLDYGMDQNKADI 1809 Query: 1119 EG--------SMFIGGAPTEISKKYTVKQGLIGCFRGLVVNGEILDIYSF-MSVHLSEII 1169 G S+ +GGA + K +V++G GC +G+ + G ++ + M+ L + Sbjct: 1810 GGMLPGLTVRSVVVGGASED---KVSVRRGFRGCMQGVRMGGTPTNVATLNMNNALKVRV 1866 Query: 1170 KD---CKPSCVPNPCKNGAYCRELWSTFECVCQNRWAHLGQHC 1209 KD C +PC + C + W + CVC +LG +C Sbjct: 1867 KDGCDVDDPCTSSPCPPNSRCHDAWEDYSCVCDK--GYLGINC 1907 Score = 43.5 bits (101), Expect = 0.002 Identities = 52/244 (21%), Positives = 94/244 (38%), Gaps = 49/244 (20%) Query: 1008 QSYIEVPGWRKG---DIAFSFRTTGEKAILLFQPPIRSNYPSFMVALTGDY-QLTFNF-- 1061 QS++ G R+ I+ +F T +LL+ + + + + QLTF+ Sbjct: 1450 QSFVTFRGLRQRFHFTISLTFATQERNGLLLYNGRFNEKHDFIALEIVDEQVQLTFSAGE 1509 Query: 1062 TLNTGTPKTLVIDTNRKLNGGEWHKIWIDY----NEHHVRF-------------MINTDT 1104 T T PK ++ G WH + + Y N H+ + + DT Sbjct: 1510 TTTTVAPKV-----PSGVSDGRWHSVQVQYYNKPNIGHLGLPHGPSGEKMAVVTVDDCDT 1564 Query: 1105 RMVDLQPEEEFGPFE-----------------GSMFIGGAPTEISKKYTVKQGLIGCFRG 1147 M ++ ++ G + G + +GG P + +GC R Sbjct: 1565 TMA-VRFGKDIGNYSCAAQGTQTGSKKSLDLTGPLLLGGVPNLPEDFPVHNRQFVGCMRN 1623 Query: 1148 LVVNGEILDIYSFMSVH-LSEIIKDCKPSCVPNPCKNGAYCRELWSTFECVCQNRWAHLG 1206 L V+G+ +D+ F++ + E + C C+NG C W+ + C C R+ G Sbjct: 1624 LSVDGKNVDMAGFIANNGTREGCAARRNFCDGRRCQNGGTCVNRWNMYLCECPLRFG--G 1681 Query: 1207 QHCE 1210 ++CE Sbjct: 1682 KNCE 1685 Score = 42.7 bits (99), Expect = 0.004 Identities = 51/212 (24%), Positives = 89/212 (41%), Gaps = 30/212 (14%) Query: 611 FKSSKATAVLAYSEVKTSEGNGFWELRLATDRLSFDLC---PDVKSNITHTTYIRIENPT 667 F++ K +VL + TS G + L++ + L F++ DV+S + + +R+ + Sbjct: 1719 FRTRKEDSVLMEA---TSGGPTSFRLQILNNYLQFEVSHGPSDVESVML--SGLRVTDG- 1772 Query: 668 SWHSIQLTYERNDIKFVVDYRHSVTQM--YGLSFNIGD-----------KLIIGSSLKAA 714 WH L E ++K + +H VT YG+ N D +++G + + Sbjct: 1773 EWH--HLLIELKNVKEDSEMKHLVTMTLDYGMDQNKADIGGMLPGLTVRSVVVGGASEDK 1830 Query: 715 AS---GLVGCLRDLKINGVEIEPRYLVKSERVVGDVSLDNCKYVDPCKKPNTCEHGGKCA 771 S G GC++ +++ G L + + V D C DPC + C +C Sbjct: 1831 VSVRRGFRGCMQGVRMGGTPTNVATLNMNNALKVRVK-DGCDVDDPCTS-SPCPPNSRCH 1888 Query: 772 VKDDGIICDCKDTGYIGKNCHFTKFRKTCEEL 803 + C C D GY+G NC CE + Sbjct: 1889 DAWEDYSCVC-DKGYLGINCVDACHLNPCENM 1919 Score = 39.3 bits (90), Expect = 0.040 Identities = 51/218 (23%), Positives = 86/218 (39%), Gaps = 37/218 (16%) Query: 185 ISFQFRTRLPHGLLVYHNVKTPAGVKLDPYALYVIVEKGQLKVVHVFGNHSTSVTVGEGL 244 + FRTR +L+ P +L Y+ Q +V H + + + G + Sbjct: 1715 LGLMFRTRKEDSVLMEATSGGPTSFRLQILNNYL-----QFEVSHGPSDVESVMLSGLRV 1769 Query: 245 NRDEWHSVMVRIDVHGARLIARVDNNKEEVYLKGLNHET-NYGVSINLMSV--------- 294 EWH +++ + N KE+ +K L T +YG+ N + Sbjct: 1770 TDGEWHHLLIELK-----------NVKEDSEMKHLVTMTLDYGMDQNKADIGGMLPGLTV 1818 Query: 295 --VLVGGLSSEEKLHGVKYIIESFVGCIRNVVLSSGKAASDLLPITPLIATKHENVKEGC 352 V+VGG +SE+K+ + F GC++ V + L + + + VK+GC Sbjct: 1819 RSVVVGG-ASEDKVS----VRRGFRGCMQGVRMGGTPTNVATLNMNNALKVR---VKDGC 1870 Query: 353 RNKCHSRQNLCFTGSRCINHYYDISCDCFGTKYEGEHC 390 + C SRC + + D SC C Y G +C Sbjct: 1871 DVDDPCTSSPCPPNSRCHDAWEDYSCVC-DKGYLGINC 1907 ==> UNIPROT|P82279 - symbol:CRUM1_HUMAN "CRB1: Crumbs homolog 1 precursor" species:9606 "Homo sapiens" [GO:0007163 "establishment and/or maintenance of cell polarity" evidence=TAS] [GO:0007267 "cell-cell signaling" evidence=TAS] InterPro:IPR001881 UniProt:P82279 InterPro:IPR008985 InterPro:IPR000742 InterPro:IPR000152 InterPro:IPR006210 InterPro:IPR006209 GO:GO:0007163 InterPro:IPR013320 Gene3D:G3DSA:2.60.120.200 GO:GO:0007267 InterPro:IPR013032 PROSITE:PS00022 PROSITE:PS01186 PROSITE:PS50026 SMART:SM00181 InterPro:IPR001791 Pfam:PF00008 SMART:SM00282 PROSITE:PS00010 PROSITE:PS50025 SMART:SM00179 PROSITE:PS01187 InterPro:IPR012680 Pfam:PF02210 MIM:268000 InterPro:IPR001438 PRINTS:PR00010 EMBL:AF154671 EMBL:AY043324 EMBL:AY043325 EMBL:AJ748821 EMBL:BX640729 EMBL:AL513325 EMBL:AL136322 EMBL:AL139136 UniGene:Hs.126135 HSSP:P08709 IntAct:P82279 Ensembl:ENSG00000134376 KEGG:hsa:23418 HGNC:HGNC:2343 MIM:172870 MIM:600105 MIM:604210 LinkHub:P82279 ArrayExpress:P82279 GermOnline:ENSG00000134376 Length = 1406 Score = 64.7 bits (156), Expect = 9e-010 Identities = 161/780 (20%), Positives = 277/780 (35%), Gaps = 156/780 (20%) Query: 750 DNCKY-VDPCKKPNTCEHGGKCAVKDDGIICDCKDTGYIGKNCHFTKFRKTCEELALLGY 808 D+C+ D C C HGG C ++ C+C +G+ G +C E L L + Sbjct: 257 DHCELNTDECAS-QPCLHGGLCVDGENRYSCNCTGSGFTGTHC---------ETLMPLCW 306 Query: 809 SKSDVYSIDIDGNGVFPPARVKCDFQSLANATKTIVEHNLPS------QVDVRSATDEDF 862 SK N C+ S+ N T H P ++D+ Sbjct: 307 SKP------CHNNAT-------CE-DSVDNYTC----HCWPGYTGAQCEIDLNECNSNPC 348 Query: 863 SFNIQYREFSAEMLQELISHSLYCTQYIK---YDCIKAP--LELHSSTWFKSSSNNNTVD 917 N + E S+E I+ Y + Y CI P +H S+N Sbjct: 349 QSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSN---- 404 Query: 918 SLGEVKRGTCPCAIGKNCEDL--NHSCNCDA-NLNRWLSDEGYYKEPPNLGITQMYFLQQ 974 PC G CE+L N++C+C NL+R G LG T L Sbjct: 405 ----------PCQNGGTCENLPGNYTCHCPFDNLSRTFYG-GRDCSDILLGCTHQQCLNN 453 Query: 975 KNLDEESQGRVTLGPLECVETNTQKYVVTFTTSQSYIEVPGWRKG----------DIAFS 1024 Q C T TT + W K +IA Sbjct: 454 GTCIPHFQDGQHGFSCLCPSGYTGSLCEIATTLSFEGDGFLWVKSGSVTTKGSVCNIALR 513 Query: 1025 FRTTGEKAILLFQPPIRSNYPSFM-VALTGDYQLTFNFTLNTGTPKTLVIDTNRKLNGGE 1083 F+T A+LLF RSN F+ + L Y + ++ +++ + + GE Sbjct: 514 FQTVQPMALLLF----RSNRDVFVKLELLSGY---IHLSIQVNNQSKVLLFISHNTSDGE 566 Query: 1084 WHKIWIDYNEHHVRFMINTDTRM-------VDLQPEEEFGPFEGSMFIGGAPTEISKK-- 1134 WH + + + E +I+ + L+ ++ F+ S F+GG P ++ Sbjct: 567 WHFVEVIFAEAVTLTLIDDSCKEKCIAKAPTPLESDQSICAFQNS-FLGGLPVGMTSNGV 625 Query: 1135 -----YTVKQ--GLIGCFRGLVVNGEILDIYSFMSVHLSEIIKDC--KPSCVPNPCKNGA 1185 Y + +GC + + ++ + + + S + C K C PC++ Sbjct: 626 ALLNFYNMPSTPSFVGCLQDIKIDWNHITLENISSGSSLNVKAGCVRKDWCESQPCQSRG 685 Query: 1186 YCRELWSTFECVCQNRWAHLGQHCETNINEDALTFISRESYLKRNYLSDPEDMRDEREKL 1245 C LW +++C C + G +C + E ++ + E D Sbjct: 686 RCINLWLSYQCDCHRPYE--GPNC---LREYVAGRFGQDDSTGYVIFTLDESYGD----- 735 Query: 1246 RAILNSSLLVNLRTYDRHAFVLYANDHYNNFIHLYLTDQSEMVYLYNYGSDIVNLTIEHS 1305 SL + +RT +L + +I ++L + N +V + Sbjct: 736 ----TISLSMFVRTLQPSGLLLALENSTYQYIRVWLERGRLAMLTPNSPKLVVKFVLNDG 791 Query: 1306 ELNNARSIQVAVIRTETNTTLYVNEKNVTVERGFLLLDEYSNKPWTNPELEVLSPHRPPA 1365 + + S+++ + E LY + +N+ GF+ S W + +V+ Sbjct: 792 NV-HLISLKIKPYKIE----LYQSSQNL----GFI-----SASTWKIEKGDVI------- 830 Query: 1366 PPTEYFQFNIGGYDPANLLRPNQDTTELEG--YIGCIRGLKIGENLISLREMATQNNAHV 1423 IGG P++ TEL G + GCI+ +++ + T NNA + Sbjct: 831 --------YIGGL-------PDKQETELNGGFFKGCIQDVRLNNQNLEFFPNPT-NNASL 874 Query: 1424 TDGVLN---GC--QMKCDAEPCKNGGICTENFVRQESTCNCEHTSFLGEFCSEEKGASFS 1478 ++N GC C + PC NGG+C + + +C+C + G+ C E + FS Sbjct: 875 NPVLVNVTQGCAGDNSCKSNPCHNGGVCHSRW--DDFSCSCPALT-SGKACEEVQWCGFS 931 Score = 57.0 bits (136), Expect = 2e-007 Identities = 50/221 (22%), Positives = 89/221 (40%), Gaps = 40/221 (18%) Query: 1020 DIAFSFRTTGEKAILLFQPPIRSNYPSFMVALTGDYQLTFNFTLNTGTPKTLVIDTN-RK 1078 +I F FRT I+L P F+ D +L F L +G ++ T+ + Sbjct: 975 NITFGFRTRDANVIILHA----EKEPEFLNISIQDSRLFFQ--LQSGNSFYMLSLTSLQS 1028 Query: 1079 LNGGEWHKIWIDYNEHHVRFMINTDTRMVDLQPEEEFGPFEGSMFIGGAPTEISKKYTVK 1138 +N G WH++ + + + T +++ E PF S G+ + + Sbjct: 1029 VNDGTWHEVTLSMTDP----LSQTSRWQMEVDNET---PFVTSTIATGSLNFLKDNTDIY 1081 Query: 1139 ---------QGLIGCFRGLVVNGEILDIYS-------------FMSVHLSEIIKDCKPS- 1175 +GL GC + + G L + F+ + + ++ C Sbjct: 1082 VGDRAIDNIKGLQGCLSTIEIGGIYLSYFENVHGFINKPQEEQFLKISTNSVVTGCLQLN 1141 Query: 1176 -CVPNPCKNGAYCRELWSTFECVCQNRWAHLGQHCETNINE 1215 C NPC +G C +++S++ C C W+ G+HCE NI+E Sbjct: 1142 VCNSNPCLHGGNCEDIYSSYHCSCPLGWS--GKHCELNIDE 1180 Score = 50.4 bits (119), Expect = 2e-005 Identities = 60/216 (27%), Positives = 91/216 (42%), Gaps = 28/216 (12%) Query: 185 ISFQFRTRLPHGLLVYHNVKTPAGVKLDPYALYV---IVEKGQLKVVHVFGNHSTSVTVG 241 I+ +F+T P LL++ + + VKL+ + Y+ I Q KV+ +F +H+TS Sbjct: 510 IALRFQTVQPMALLLFRSNRD-VFVKLELLSGYIHLSIQVNNQSKVL-LFISHNTS---- 563 Query: 242 EGLNRDEWHSVMVRIDVHGARLIARVDNNKEEVYLKGLNHETNYGVSINLMSVVLVGGLS 301 EWH V V I L D+ KE+ K SI +GGL Sbjct: 564 ----DGEWHFVEV-IFAEAVTLTLIDDSCKEKCIAKAPT-PLESDQSICAFQNSFLGGLP 617 Query: 302 SEEKLHGVKYI-------IESFVGCIRNVVLSSGKAASDLLPITPLIATKHENVKEGCRN 354 +GV + SFVGC++++ K + + + + + NVK GC Sbjct: 618 VGMTSNGVALLNFYNMPSTPSFVGCLQDI-----KIDWNHITLENISSGSSLNVKAGCVR 672 Query: 355 KCHSRQNLCFTGSRCINHYYDISCDCFGTKYEGEHC 390 K C + RCIN + CDC YEG +C Sbjct: 673 KDWCESQPCQSRGRCINLWLSYQCDCH-RPYEGPNC 707 Score = 44.7 bits (104), Expect = 0.001 Identities = 69/338 (20%), Positives = 130/338 (38%), Gaps = 71/338 (21%) Query: 185 ISFQFRTRLPHGLLVYHNVKTPAGVKLDPYALYVIVEKGQLKVVHVFGNHSTSVTVGEGL 244 +S RT P GLL+ T ++ V +E+G+L ++ +S + V L Sbjct: 739 LSMFVRTLQPSGLLLALENSTYQYIR-------VWLERGRLAMLTP---NSPKLVVKFVL 788 Query: 245 NRDEWHSVMVRIDVHGARLIARVDNNKEEVYLKGLNHETNYGVSINLMSVVLVGGL--SS 302 N H + ++I + L N L + I V+ +GGL Sbjct: 789 NDGNVHLISLKIKPYKIELYQSSQN---------LGFISASTWKIEKGDVIYIGGLPDKQ 839 Query: 303 EEKLHGVKYIIESFVGCIRNVVLSSGKAA-----SDLLPITPLIATKHENVKEGCRNKCH 357 E +L+G F GCI++V L++ ++ + P++ NV +GC Sbjct: 840 ETELNG-----GFFKGCIQDVRLNNQNLEFFPNPTNNASLNPVLV----NVTQGCAGDNS 890 Query: 358 SRQNLCFTGSRCINHYYDISCDC----------------FGTKYEGEHCDIYTATVLTLR 401 + N C G C + + D SC C F G C L+ Sbjct: 891 CKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEEVQWCGFSPCPHGAQCQ------PVLQ 944 Query: 402 GSSYVSYRIYDWKD---------RVHSPITRISMMFKTNYDDSALFYASGESLKPQYIAA 452 G ++ +++ + + +T I+ F+T + + +A E P+++ Sbjct: 945 GFECIANAVFNGQSGQILFRSNGNITRELTNITFGFRTRDANVIILHAEKE---PEFLNI 1001 Query: 453 SIKNHSAYIEMDFGDG--VMSATLGQDLTRHYWHNLTI 488 SI++ + ++ G+ ++S T Q + WH +T+ Sbjct: 1002 SIQDSRLFFQLQSGNSFYMLSLTSLQSVNDGTWHEVTL 1039 Score = 42.0 bits (97), Expect = 0.006 Identities = 16/46 (34%), Positives = 29/46 (63%), Gaps = 2/46 (4%) Query: 1176 CVPNPCKNGAYCRELWSTFECVCQNRWAHLGQHCETNINEDALTFI 1221 C +PC NG C++L + F+C+C +A G+ CE ++ +D ++ I Sbjct: 1301 CASDPCVNGGLCQDLLNKFQCLCDVAFA--GERCEVDLADDLISDI 1344 Score = 41.2 bits (95), Expect = 0.011 Identities = 47/215 (21%), Positives = 78/215 (36%), Gaps = 44/215 (20%) Query: 606 SLKFDFKSSKATAVLAYSEVKTSEGNGFWELRLATDRLSFDLCPDVKSNITHTTYIRIEN 665 ++ F F++ A ++ ++E + F + + RL F L + T ++ N Sbjct: 975 NITFGFRTRDANVIILHAEKEPE----FLNISIQDSRLFFQLQSGNSFYMLSLTSLQSVN 1030 Query: 666 PTSWHSIQLTYER-------------NDIKFVVDYRHSVTQMYGLSF-NIGDKLIIGSSL 711 +WH + L+ N+ FV S L+F + +G Sbjct: 1031 DGTWHEVTLSMTDPLSQTSRWQMEVDNETPFVT----STIATGSLNFLKDNTDIYVGDRA 1086 Query: 712 KAAASGLVGCLRDLKINGVEIEPRYLVKSERVVGDVS---------------LDNCKYVD 756 GL GCL ++I G+ YL E V G ++ + C ++ Sbjct: 1087 IDNIKGLQGCLSTIEIGGI-----YLSYFENVHGFINKPQEEQFLKISTNSVVTGCLQLN 1141 Query: 757 PCKKPNTCEHGGKCAVKDDGIICDCKDTGYIGKNC 791 C N C HGG C C C G+ GK+C Sbjct: 1142 VCNS-NPCLHGGNCEDIYSSYHCSC-PLGWSGKHC 1174 Score = 39.7 bits (91), Expect = 0.031 Identities = 24/87 (27%), Positives = 47/87 (54%), Gaps = 9/87 (10%) Query: 1396 YIGCIRGLKIGENLISLREMATQNNAHVTDGVLNGCQMK--CDAEPCKNGGICTENFVRQ 1453 ++GC++ +KI N I+L +++ ++ +V GC K C+++PC++ G C ++ Sbjct: 639 FVGCLQDIKIDWNHITLENISSGSSLNVK----AGCVRKDWCESQPCQSRGRCINLWLSY 694 Query: 1454 ESTCNCEHTSFLGEFCSEEKGASFSGE 1480 + C+C H + G C E A G+ Sbjct: 695 Q--CDC-HRPYEGPNCLREYVAGRFGQ 718 ==> MGI|MGI:88059 - symbol:App "amyloid beta (A4) precursor protein" species:10090 "Mus musculus" [GO:0051124 "synaptic growth at neuromuscular junction" evidence=IGI] [GO:0035253 "ciliary rootlet" evidence=IDA] [GO:0051233 "spindle midzone" evidence=IDA] [GO:0031175 "neurite development" evidence=IDA] [GO:0031410 "cytoplasmic vesicle" evidence=IDA] [GO:0048669 "collateral sprouting in the absence of injury" evidence=IGI] [GO:0051563 "smooth endoplasmic reticulum calcium ion homeostasis" evidence=IGI] [GO:0031594 "neuromuscular junction" evidence=IDA] [GO:0001967 "suckling behavior" evidence=IGI] [GO:0008542 "visual learning" evidence=IMP] [GO:0000085 "G2 phase of mitotic cell cycle" evidence=IMP] [GO:0016199 "axon midline choice point recognition" evidence=IMP] [GO:0006417 "regulation of translation" evidence=IDA] [GO:0006878 "copper ion homeostasis" evidence=IGI;IMP] [GO:0006378 "mRNA polyadenylation" evidence=IDA] [GO:0007409 "axonogenesis" evidence=IMP] [GO:0016358 "dendrite development" evidence=IGI;IMP] [GO:0016322 "neuron remodeling" evidence=IMP] [GO:0008088 "axon cargo transport" evidence=IMP] [GO:0045177 "apical part of cell" evidence=IDA] [GO:0045931 "positive regulation of progression through mitotic cell cycle" evidence=IMP] [GO:0045944 "positive regulation of transcription from RNA polymerase II promoter" evidence=IGI;IDA] [GO:0043005 "neuron projection" evidence=IDA] [GO:0050803 "regulation of synapse structure and activity" evidence=IMP] [GO:0030900 "forebrain development" evidence=IMP] [GO:0050885 "regulation of balance" evidence=IGI] [GO:0048471 "perinuclear region of cytoplasm" evidence=IDA] [GO:0030424 "axon" evidence=IDA] [GO:0016020 "membrane" evidence=IDA;TAS] [GO:0005624 "membrane fraction" evidence=IDA] [GO:0005737 "cytoplasm" evidence=IDA] [GO:0016021 "integral to membrane" evidence=IDA] [GO:0005794 "Golgi apparatus" evidence=IDA] [GO:0003677 "DNA binding" evidence=IDA] [GO:0007626 "locomotory behavior" evidence=IGI] [GO:0030198 "extracellular matrix organization and biogenesis" evidence=IGI] [GO:0008344 "adult locomotory behavior" evidence=IMP] [GO:0007617 "mating behavior" evidence=IGI] [GO:0040014 "regulation of body size" evidence=IMP] InterPro:IPR002223 InterPro:IPR008155 InterPro:IPR008154 InterPro:IPR013803 UniProt:P12023 MGI:MGI:88059 GO:GO:0005515 GO:GO:0048471 GO:GO:0005624 GO:GO:0016021 GO:GO:0005794 HSSP:P08592 PROSITE:PS00319 PROSITE:PS00320 MEROPS:I02.015 Gene3D:G3DSA:4.10.410.10 Pfam:PF02177 Pfam:PF00014 PRINTS:PR00203 PRINTS:PR00759 ProDom:PD000222 SMART:SM00006 SMART:SM00131 PROSITE:PS00280 PROSITE:PS50279 GO:GO:0006878 EMBL:M18373 EMBL:X59379 EMBL:U84012 EMBL:D10603 EMBL:BC005490 EMBL:M24397 EMBL:X15210 EMBL:U82624 PIR:A27485 PIR:A32282 PIR:S04855 UniGene:Mm.277585 SMR:P12023 IntAct:P12023 Ensembl:ENSMUSG00000022892 KEGG:mmu:11820 ArrayExpress:P12023 GermOnline:ENSMUSG00000022892 GO:GO:0045177 GO:GO:0030424 GO:GO:0035253 GO:GO:0031410 GO:GO:0031594 GO:GO:0051233 GO:GO:0003677 GO:GO:0008344 GO:GO:0008088 GO:GO:0016199 GO:GO:0048669 GO:GO:0016358 GO:GO:0030198 GO:GO:0030900 GO:GO:0000085 GO:GO:0007617 GO:GO:0006378 GO:GO:0016322 GO:GO:0045931 GO:GO:0045944 GO:GO:0050885 GO:GO:0040014 GO:GO:0050803 GO:GO:0006417 GO:GO:0051563 GO:GO:0001967 GO:GO:0051124 GO:GO:0008542 Length = 770 Score = 61.6 bits (148), Expect = 8e-009 Identities = 36/99 (36%), Positives = 49/99 (49%), Gaps = 11/99 (11%) Query: 30 TNAEPPKEIVYPKCTGPGEPGQCQTFDYRYRFEQTINNCTQFIWGGCGGNLQNNFETYEQ 89 T E +E+V C+ E G C+ R+ F+ T C F +GGCGGN +NNF+T E Sbjct: 278 TTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCVPFFYGGCGGN-RNNFDTEEY 336 Query: 90 CMQQCAN-ETQT---------PQPPVPLTTTVDPSSTSV 118 CM C + TQ+ PQ P L TT + +V Sbjct: 337 CMAVCGSVSTQSLLKTTSEPLPQDPDKLPTTAASTPDAV 375