>AGAP007293-PA

FB|FBgn0003691 - symbol:th "thread" species:7227 "Drosophila mel...   221   7e-058
UNIPROT|P41437 - symbol:IAP3_NPVOP "IAP3, IAP: Apoptosis inhibit...   183   2e-046
FB|FBgn0015247 - symbol:Iap2 "Inhibitor of apoptosis 2" species:...   115   9e-026
MGI|MGI:1197007 - symbol:Birc3 "baculoviral IAP repeat-containin...   109   4e-024
UNIPROT|Q13075 - symbol:BIRC1_HUMAN "BIRC1, NAIP: Baculoviral IA...   106   4e-023
UNIPROT|Q13489 - symbol:BIRC3_HUMAN "BIRC3, API2, IAP1, MIHC, RN...   103   2e-022
UNIPROT|Q96CA5 - symbol:BIRC7_HUMAN "BIRC7, KIAP, UNQ5800/PRO196...   101   1e-021
UNIPROT|Q13490 - symbol:BIRC2_HUMAN "BIRC2, API1, IAP2, MIHB, RN...    97   3e-020
UNIPROT|P98170 - symbol:BIRC4_HUMAN "BIRC4, API3, IAP3, XIAP: Ba...    96   6e-020
MGI|MGI:1197009 - symbol:Birc2 "baculoviral IAP repeat-containin...    92   1e-018
MGI|MGI:107572 - symbol:Birc4 "baculoviral IAP repeat-containing...    90   3e-018
UNIPROT|Q90660 - symbol:BIR_CHICK "ITA, IAP1: Inhibitor of apopt...    90   4e-018
UNIPROT|Q8I009 - symbol:BIRC5_CANFA "BIRC5: Baculoviral IAP repe...    57   2e-008
UNIPROT|Q6I6F4 - symbol:BIRC5_FELCA "BIRC5: Baculoviral IAP repe...    57   2e-008
UNIPROT|Q9GLN5 - symbol:BIRC5_PIG "BIRC5: Baculoviral IAP repeat...    56   5e-008
UNIPROT|Q5RAH9 - symbol:BIRC5_PONPY "BIRC5: Baculoviral IAP repe...    55   9e-008
UNIPROT|O15392 - symbol:BIRC5_HUMAN "BIRC5, API4, IAP4: Baculovi...    55   9e-008
UNIPROT|Q6J1J1 - symbol:BIRC5_BOVIN "BIRC5: Baculoviral IAP repe...    55   1e-007
GENEDB_SPOMBE|SPCC962.02c - symbol:SPCC962.02c "survivin" specie...    54   2e-007
MGI|MGI:1203517 - symbol:Birc5 "baculoviral IAP repeat-containin...    54   3e-007
UNIPROT|Q9JHY7 - symbol:BIRC5_RAT "Birc5: Baculoviral IAP repeat...    50   3e-006
TAIR|gene:2195532 - symbol:AT1G63900.1 species:3702 "Arabidopsis...    50   4e-006
TAIR|gene:2156338 - symbol:AT5G44690.1 species:3702 "Arabidopsis...    49   6e-006
UNIPROT|Q9NR09 - symbol:BIRC6_HUMAN "BIRC6, KIAA1289: Baculovira...    49   1e-005
TAIR|gene:2179186 - symbol:AT5G01450.1 species:3702 "Arabidopsis...    48   1e-005


==> FB|FBgn0003691 - symbol:th "thread" species:7227 "Drosophila
           melanogaster" [GO:0006916 "anti-apoptosis"
           evidence=IGI;NAS;IDA;TAS] [GO:0006915 "apoptosis"
           evidence=NAS;TAS;IPI] [GO:0043154 "negative regulation
           of caspase activity" evidence=TAS] [GO:0043066 "negative
           regulation of apoptosis" evidence=ISS;IMP;TAS]
           [GO:0006513 "protein monoubiquitination" evidence=TAS]
           [GO:0004842 "ubiquitin-protein ligase activity"
           evidence=TAS] [GO:0007275 "multicellular organismal
           development" evidence=TAS] [GO:0042787 "protein
           ubiquitination during ubiquitin-dependent protein
           catabolic process" evidence=TAS] [GO:0007289 "spermatid
           nuclear differentiation" evidence=IMP] [GO:0007298
           "border follicle cell migration (sensu Insecta)"
           evidence=IGI;IMP] [GO:0008354 "germ cell migration"
           evidence=TAS] [GO:0048800 "antennal morphogenesis"
           evidence=IMP] [GO:0007423 "sensory organ development"
           evidence=IMP] InterPro:IPR001841 Pfam:PF00097
           InterPro:IPR001370 Prosite:PS00518 GO:GO:0005515
           GO:GO:0043154 GO:GO:0006916 GO:GO:0007423 SMART:SM00184
           PROSITE:PS50089 EMBL:AE014296 GO:GO:0007289
           GO:GO:0004842 GO:GO:0048800 Pfam:PF00653 SMART:SM00238
           PROSITE:PS01282 PROSITE:PS50143 GO:GO:0007298
           GO:GO:0042787 GO:GO:0008354 PDB:1JD5 EMBL:L49440
           EMBL:AY119524 UniGene:Dm.6466 PDB:1JD4 PDB:1JD6 PDB:1Q4Q
           PDB:1SDZ PDB:1SE0 IntAct:Q24306 MEROPS:I32.009
           Ensembl:CG12284 KEGG:dme:Dmel_CG12284
           FlyBase:FBgn0003691 GermOnline:CG12284 GO:GO:0006513
           Uniprot:Q24306
          Length = 438

 Score =  221 bits (564), Expect = 7e-058
 Identities = 129/403 (32%), Positives = 188/403 (46%), Gaps = 93/403 (23%)

Query: 27  LNYEVNRLRTFPLWTVPYIYPEELARWGFFYTGYRDCVRCYFCRIELGGWDEHDVVIEEH 86
           LN E  RL+TF  W + ++   +LA+ G ++T   D V+C+FC +E+G W++ D  + EH
Sbjct: 41  LNREETRLKTFTDWPLDWLDKRQLAQTGMYFTHAGDKVKCFFCGVEIGCWEQEDQPVPEH 100

Query: 87  LKWSPHCRLMTKRPTNNVPIDPDFLDQL------------------------------GE 116
            +WSP+C L+ +R TNNVPI+ + LD++                               +
Sbjct: 101 QRWSPNCPLLRRRTTNNVPINAEALDRILPPISYDICGANDSTLEMREHAYAEGVIPMSQ 160

Query: 117 IVPDTTGTGSTSAWSAAATAA----VAVAMESNRLNR-----QNELERQSQRTQNDTIPF 167
           ++         +A S   TAA    V VA  ++   +     Q E  R S  + N     
Sbjct: 161 LIQSIGMNAVNAAGSVTGTAAPQPRVTVATHASTATQATGDVQPETCRPSAASGN----- 215

Query: 168 YRQKYPEYRIGGDRLATFKEWPKSIPQTPTQMADAGFFYTGKSDVVACYYCGGNLRDWLA 227
           Y  +YPEY I   RL TF+ WP+++ Q P Q+A+AGFFYTG  D V C+ CGG L DW  
Sbjct: 216 YFPQYPEYAIETARLRTFEAWPRNLKQKPHQLAEAGFFYTGVGDRVRCFSCGGGLMDWND 275

Query: 228 EDDPWVEHVRNFSECPYVKLVKTPEFIAECRGEKVTNSALIASSERSGHGNVSKDKEQDE 287
            D+PW +H    S+C +VKL+K   +I     + V       SS   G    S    ++E
Sbjct: 276 NDEPWEQHALWLSQCRFVKLMKGQLYIDTVAAKPVLAEEKEESSSIGGVAVASTQASEEE 335

Query: 288 -------------------------------------------------VSDEKCCKICY 298
                                                            + +EK CKICY
Sbjct: 336 QQTSLSSEEAVSGDVAPSVAPTAATRIFNKIVEATAVATPSTNSSGSTSIPEEKLCKICY 395

Query: 299 IRPFDTVFIPCGHVVACGKCAASTTKCPMCNESYTSVQRIFLS 341
              ++T F+PCGHVVAC KCA+S TKCP+C + +T V R++ S
Sbjct: 396 GAEYNTAFLPCGHVVACAKCASSVTKCPLCRKPFTDVMRVYFS 438



==> UNIPROT|P41437 - symbol:IAP3_NPVOP "IAP3, IAP: Apoptosis inhibitor
           3" species:262177 "Orgya pseudotsugata
           nucleopolyhedrovirus" [GO:0005515 "protein binding"
           evidence=IPI] InterPro:IPR001841 Pfam:PF00097
           InterPro:IPR001370 UniProt:P41437 Prosite:PS00518
           GO:GO:0005515 SMART:SM00184 PROSITE:PS50089 Pfam:PF00653
           SMART:SM00238 PROSITE:PS01282 PROSITE:PS50143
           EMBL:U75930 HSSP:Q24306 MEROPS:I32.010 EMBL:L22564
           PIR:A53989
          Length = 268

 Score =  183 bits (465), Expect = 2e-046
 Identities = 99/307 (32%), Positives = 143/307 (46%), Gaps = 61/307 (19%)

Query: 33  RLRTFPLWTVPYIYPEELARWGFFYTGYRDCVRCYFCRIELGGWDEHDVVIEEHLKWSPH 92
           RL T+  W V ++ P  +A  GF+Y G  D VRC FC++E+  W   D    +H +W+P 
Sbjct: 21  RLGTYTNWPVQFLEPSRMAASGFYYLGRGDEVRCAFCKVEITNWVRGDDPETDHKRWAPQ 80

Query: 93  CRLMTKRPTNNVPIDPDFLDQLGEIVPDTTGTGSTSAWSAAATAAVAVAMESNRLNRQNE 152
           C  +     NN                DT    +  A SAAA                  
Sbjct: 81  CPFVR----NNAH--------------DTPHDRAPPARSAAA------------------ 104

Query: 153 LERQSQRTQNDTIPFYRQKYPEYRIGGDRLATFKEWPKSIPQTPTQMADAGFFYTGKSDV 212
                              +P+Y     RL TF EWP+ + Q P ++A+AGFFYTG+ D 
Sbjct: 105 -------------------HPQYATEAARLRTFAEWPRGLKQRPEELAEAGFFYTGQGDK 145

Query: 213 VACYYCGGNLRDWLAEDDPWVEHVRNFSECPYVKLVKTPEFIAECRGEKVTNSALIASSE 272
             C+ C G L+DW  +D PW +H R +  C YV LVK  +F+       +T + ++  ++
Sbjct: 146 TRCFCCDGGLKDWEPDDAPWQQHARWYDRCEYVLLVKGRDFVQRV----MTEACVVRDAD 201

Query: 273 RSGHGNVSKDKEQDEVSDEKCCKICYIRPFDTVFIPCGHVVACGKCAASTTKCPMCNESY 332
              H  + +   + EV+D++ CKIC        F+PCGHVVACGKCAA  T CP+C    
Sbjct: 202 NEPH--IERPAVEAEVADDRLCKICLGAEKTVCFVPCGHVVACGKCAAGVTTCPVCRGQL 259

Query: 333 TSVQRIF 339
               R++
Sbjct: 260 DKAVRMY 266



 Score = 54.3 bits (129), Expect = 2e-007
 Identities = 28/65 (43%), Positives = 33/65 (50%), Gaps = 1/65 (1%)

Query: 30  EVNRLRTFPLWTVPYIY-PEELARWGFFYTGYRDCVRCYFCRIELGGWDEHDVVIEEHLK 88
           E  RLRTF  W       PEELA  GFFYTG  D  RC+ C   L  W+  D   ++H +
Sbjct: 111 EAARLRTFAEWPRGLKQRPEELAEAGFFYTGQGDKTRCFCCDGGLKDWEPDDAPWQQHAR 170

Query: 89  WSPHC 93
           W   C
Sbjct: 171 WYDRC 175



==> FB|FBgn0015247 - symbol:Iap2 "Inhibitor of apoptosis 2"
           species:7227 "Drosophila melanogaster" [GO:0006916
           "anti-apoptosis" evidence=ISS;NAS;IDA;TAS] [GO:0019730
           "antimicrobial humoral response" evidence=IMP]
           [GO:0007423 "sensory organ development" evidence=IMP]
           InterPro:IPR001841 Pfam:PF00097 InterPro:IPR001370
           Prosite:PS00518 GO:GO:0006916 GO:GO:0007423
           SMART:SM00184 PROSITE:PS50089 HSSP:P98170 Pfam:PF00653
           SMART:SM00238 PROSITE:PS01282 PROSITE:PS50143
           GO:GO:0019730 EMBL:L49441 EMBL:U45881 EMBL:U32373
           EMBL:M96581 EMBL:AE003809 EMBL:AY051844 EMBL:U38809
           PIR:S68452 PIR:S69545 UniGene:Dm.7173 Ensembl:CG8293
           KEGG:dme:Dmel_CG8293 FlyBase:FBgn0015247
           GermOnline:CG8293 Uniprot:Q24307
          Length = 498

 Score =  115 bits (287), Expect = 9e-026
 Identities = 75/250 (30%), Positives = 109/250 (43%), Gaps = 53/250 (21%)

Query: 21  DTPEEC----LNYEVNRLRTFPLWTVPYIYPEELARWGFFYTGYRDCVRCYFCRIELGGW 76
           D+PE C    L  E NRL TF  W  P I P+ LA+ GF+Y    D V+C +C   +  W
Sbjct: 100 DSPESCSCPDLLLEANRLVTFKDWPNPNITPQALAKAGFYYLNRLDHVKCVWCNGVIAKW 159

Query: 77  DEHDVVIEEHLKWSPHCRLMTKRPTNNVPIDPDFLDQLGEIVPDTTGTGSTSAWSAAATA 136
           +++D   EEH ++ P C  +                Q+G ++   TG             
Sbjct: 160 EKNDNAFEEHKRFFPQCPRV----------------QMGPLIEFATG------------- 190

Query: 137 AVAVAMESNRLNRQNELERQSQRTQNDTIPFYRQKYPEYRIGGDRLATFKEWPKSIPQTP 196
                        +N  E   Q T   T+P      P+Y     RL TF +WP S  Q  
Sbjct: 191 -------------KNLDELGIQPT---TLPLR----PKYACVDARLRTFTDWPISNIQPA 230

Query: 197 TQMADAGFFYTGKSDVVACYYCGGNLRDWLAEDDPWVEHVRNFSECPYVKLVKTPEFIAE 256
           + +A AG +Y    D V C++C   LR W  ED+PW EH +   +C +V L K P +++E
Sbjct: 231 SALAQAGLYYQKIGDQVRCFHCNIGLRSWQKEDEPWFEHAKWSPKCQFVLLAKGPAYVSE 290

Query: 257 CRGEKVTNSA 266
                  N++
Sbjct: 291 VLATTAANAS 300



 Score = 83.6 bits (205), Expect = 3e-016
 Identities = 63/229 (27%), Positives = 91/229 (39%), Gaps = 49/229 (21%)

Query: 27  LNYEVNRLRTFPLWTVPY-IYPEELARWGFFYTGYRDCVRCYFCRIELGGWDEHDVVIEE 85
           +  E  RL TF  W +   +  E+L   GFF TG      C+FC + +  W+  D V E 
Sbjct: 6   MELESVRLATFGEWPLNAPVSAEDLVANGFFATGNWLEAECHFCHVRIDRWEYGDQVAER 65

Query: 86  HLKWSPHCRL-MTKRPTNNVPIDPDFLDQLGEIVPDTTGTGSTSAWSAAATAAVAVAMES 144
           H + SP C + +      NVP   +  D  G  V D+  + S                  
Sbjct: 66  HRRSSPICSMVLAPNHCGNVPRSQE-SDNEGNSVVDSPESCSC----------------- 107

Query: 145 NRLNRQNELERQSQRTQNDTIPFYRQKYPEYRIGGDRLATFKEWPKSIPQTPTQMADAGF 204
                                       P+  +  +RL TFK+WP     TP  +A AGF
Sbjct: 108 ----------------------------PDLLLEANRLVTFKDWPNP-NITPQALAKAGF 138

Query: 205 FYTGKSDVVACYYCGGNLRDWLAEDDPWVEHVRNFSECPYVKLVKTPEF 253
           +Y  + D V C +C G +  W   D+ + EH R F +CP V++    EF
Sbjct: 139 YYLNRLDHVKCVWCNGVIAKWEKNDNAFEEHKRFFPQCPRVQMGPLIEF 187



 Score = 66.6 bits (161), Expect = 4e-011
 Identities = 26/66 (39%), Positives = 37/66 (56%)

Query: 276 HGNVSKDKEQDEVSDEKCCKICYIRPFDTVFIPCGHVVACGKCAASTTKCPMCNESYTSV 335
           +GN+S ++E  ++ D + CK+C       VF+PCGH+  C +CA S   CPMC       
Sbjct: 433 NGNLSLEEENRQLKDARLCKVCLDEEVGVVFLPCGHLATCNQCAPSVANCPMCRADIKGF 492

Query: 336 QRIFLS 341
            R FLS
Sbjct: 493 VRTFLS 498



==> MGI|MGI:1197007 - symbol:Birc3 "baculoviral IAP repeat-containing
           3" species:10090 "Mus musculus" [GO:0005515 "protein
           binding" evidence=IPI] InterPro:IPR001841 Pfam:PF00097
           InterPro:IPR001370 InterPro:IPR001315 MGI:MGI:1197007
           Prosite:PS00518 GO:GO:0005515 SMART:SM00184
           PROSITE:PS50089 InterPro:IPR011029 Pfam:PF00619
           SMART:SM00114 PROSITE:PS50209 Pfam:PF00653 SMART:SM00238
           PROSITE:PS01282 PROSITE:PS50143 HSSP:Q13490
           MEROPS:I32.003 EMBL:U88908 UniGene:Mm.2026 SMR:O08863
           IntAct:O08863 Ensembl:ENSMUSG00000032000 KEGG:mmu:11796
           ArrayExpress:O08863 GermOnline:ENSMUSG00000032000
           RZPD-ProtExp:IOM19575 Uniprot:O08863
          Length = 600

 Score =  109 bits (273), Expect = 4e-024
 Identities = 66/230 (28%), Positives = 98/230 (42%), Gaps = 62/230 (26%)

Query: 27  LNYEVNRLRTFPLWTVPYIYPEELARWGFFYTGYRDCVRCYFCRIELGGWDEHDVVIEEH 86
           +N E  RL T+  W + ++ P +LA+ GF+Y G  D V C+ C  +L  W+  D  + EH
Sbjct: 164 MNTEKARLLTYETWPLSFLSPAKLAKAGFYYIGPGDRVACFACDGKLSNWERKDDAMSEH 223

Query: 87  LKWSPHCRLMTKRPTNNVPIDPDFLDQLGEIVPDTTGTGSTSAWSAAATAAVAVAMESNR 146
            +  P C                FL  LG+              SA+      ++M+++ 
Sbjct: 224 QRHFPSC---------------PFLKDLGQ--------------SASRYTVSNLSMQTHA 254

Query: 147 LNRQNELERQSQRTQNDTIPFYRQKYPEYRIGGDRLATFKEWPKSIPQTPTQMADAGFFY 206
                                             R+ TF  WP S      ++A AGF+Y
Sbjct: 255 A---------------------------------RIRTFSNWPSSALVHSQELASAGFYY 281

Query: 207 TGKSDVVACYYCGGNLRDWLAEDDPWVEHVRNFSECPYVKLVKTPEFIAE 256
           TG SD V C+ C G LR W + DDPWVEH + F  C Y+  +K  EF+++
Sbjct: 282 TGHSDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEYLLRIKGQEFVSQ 331



 Score =  102 bits (255), Expect = 5e-022
 Identities = 69/245 (28%), Positives = 112/245 (45%), Gaps = 16/245 (6%)

Query: 3   SAVVSCICREIAEYRVTHDTPEECLNYEVNRLRTFPLWTVPYIYPEELARWGFFYTGYRD 62
           SA ++ + +    + + +D    C  Y ++    FP   VP +    LAR GF+YTG  D
Sbjct: 5   SAFLAKLMKSADTFELKYDF--SCELYRLSTYSAFPRG-VP-VSERSLARAGFYYTGAND 60

Query: 63  CVRCYFCRIELGGWDEHDVVIEEHLKWSPHCR-LMTKRPTNNVPIDPDFLDQLGEIVPDT 121
            V+C+ C + L  W + D  +E+H K  P C  + T  P N++   P         +P T
Sbjct: 61  KVKCFCCGLMLDNWKQGDSPMEKHRKLYPSCNFVQTLNPANSLEASP------RPSLPST 114

Query: 122 TGTGSTSAWSAAATAAVAVAMESNRLNRQNELERQSQRTQNDTIPFYRQKYPEYRIGGDR 181
             +    +++++          S+  +               T P++     E      R
Sbjct: 115 AMSTMPLSFASSENTGYFSGSYSSFPSDPVNFRANQDCPALSTSPYHFAMNTEKA----R 170

Query: 182 LATFKEWPKSIPQTPTQMADAGFFYTGKSDVVACYYCGGNLRDWLAEDDPWVEHVRNFSE 241
           L T++ WP S   +P ++A AGF+Y G  D VAC+ C G L +W  +DD   EH R+F  
Sbjct: 171 LLTYETWPLSF-LSPAKLAKAGFYYIGPGDRVACFACDGKLSNWERKDDAMSEHQRHFPS 229

Query: 242 CPYVK 246
           CP++K
Sbjct: 230 CPFLK 234



 Score = 62.0 bits (149), Expect = 9e-010
 Identities = 30/102 (29%), Positives = 54/102 (52%), Gaps = 6/102 (5%)

Query: 181 RLATFKEWPKSIPQTPTQMADAGFFYTGKSDVVACYYCGGNLRDWLAEDDPWVEHVRNFS 240
           RL+T+  +P+ +P +   +A AGF+YTG +D V C+ CG  L +W   D P  +H + + 
Sbjct: 30  RLSTYSAFPRGVPVSERSLARAGFYYTGANDKVKCFCCGLMLDNWKQGDSPMEKHRKLYP 89

Query: 241 ECPYVKLVKTPEFIAECRGEKVTNSAL------IASSERSGH 276
            C +V+ +     +       + ++A+       ASSE +G+
Sbjct: 90  SCNFVQTLNPANSLEASPRPSLPSTAMSTMPLSFASSENTGY 131



 Score = 61.6 bits (148), Expect = 1e-009
 Identities = 25/60 (41%), Positives = 36/60 (60%)

Query: 282 DKEQDEVSDEKCCKICYIRPFDTVFIPCGHVVACGKCAASTTKCPMCNESYTSVQRIFLS 341
           +++  ++ +E+ CK+C  R    VFIPCGH+V C  CA S  KCP+C  +     R FLS
Sbjct: 541 EEQLRKLQEERMCKVCMDREVSIVFIPCGHLVVCKDCAPSLRKCPICRGTIKGTVRTFLS 600



==> UNIPROT|Q13075 - symbol:BIRC1_HUMAN "BIRC1, NAIP: Baculoviral IAP
           repeat-containing protein 1" species:9606 "Homo sapiens"
           [GO:0006916 "anti-apoptosis" evidence=TAS] [GO:0007399
           "nervous system development" evidence=TAS]
           InterPro:IPR003593 InterPro:IPR001370 UniProt:Q13075
           GO:GO:0006916 GO:GO:0007399 SMART:SM00382 HSSP:P98170
           MEROPS:I32.001 InterPro:IPR007111 Pfam:PF00653
           Pfam:PF05729 SMART:SM00238 PROSITE:PS01282
           PROSITE:PS50143 PROSITE:PS50837 EMBL:U19251 EMBL:U80017
           EMBL:AC005031 EMBL:AC044797 EMBL:U21913
           UniGene:Hs.191356 UniGene:Hs.646951
           Ensembl:ENSG00000081770 KEGG:hsa:4671 HGNC:HGNC:7634
           MIM:253300 MIM:600355 ArrayExpress:Q13075
           GermOnline:ENSG00000081770
          Length = 1403

 Score =  106 bits (264), Expect = 4e-023
 Identities = 78/239 (32%), Positives = 109/239 (45%), Gaps = 42/239 (17%)

Query: 30  EVNRLRTFPLWT--VPYIYPEELARWGFFYTGYRDCVRCYFCRIELGGWDEHDVVIEEHL 87
           E  RL +F  W   V  I P  L+  GF +TG +D V+C+ C   LG W+E D   +EH 
Sbjct: 159 EEARLASFRNWPFYVQGISPCVLSEAGFVFTGKQDTVQCFSCGGCLGNWEEGDDPWKEHA 218

Query: 88  KWSPHCR-LMTKRPTNNVPIDPDFLDQLGEIVPDTTGTGSTSAWSAAATAAVAVAMESNR 146
           KW P C  L +K+ +  +     ++      V D TG    ++W                
Sbjct: 219 KWFPKCEFLRSKKSSEEIT---QYIQSYKGFV-DITGEHFVNSWV--------------- 259

Query: 147 LNRQNELERQSQRTQNDTIPFYRQKYPEYRIGGDRLATFKEWPKSIPQTPTQMADAGFFY 206
              Q EL   S    ND+I  Y +          RL +FK+WP+        +A AG FY
Sbjct: 260 ---QRELPMASAYC-NDSIFAYEEL---------RLDSFKDWPRESAVGVAALAKAGLFY 306

Query: 207 TGKSDVVACYYCGGNLRDWLAEDDPWVEHVRNFSECPYVKLVK-----TPEFIAECRGE 260
           TG  D+V C+ CGG L  W   DDP  +H R F  CP+++ +K     TP+   + RGE
Sbjct: 307 TGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNCPFLQNMKSSAEVTPDL--QSRGE 363



 Score = 93.2 bits (230), Expect = 4e-019
 Identities = 62/230 (26%), Positives = 102/230 (44%), Gaps = 54/230 (23%)

Query: 30  EVNRLRTFPLWTVPYI--YPEELARWGFFYTGYRDCVRCYFCRIELGGWDEHDVVIEEHL 87
           E  RL+TF  +  PY    P+E+A  GF++TG +  ++C+ C + L G     + IE+H 
Sbjct: 60  EAKRLKTFVTYE-PYSSWIPQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHK 118

Query: 88  KWSPHCRLMTKRPTNNVPIDPDFLDQLGEIVPDTTGTGSTSAWSAAATAAVAVAMESNRL 147
           ++ P C  +  +   N+                             A   + V    +RL
Sbjct: 119 RFHPDCGFLLNKDVGNI-----------------------------AKYDIRVKNLKSRL 149

Query: 148 NRQNELERQSQRTQNDTIPFYRQKYPEYRIGGDRLATFKEWPKSIPQ-TPTQMADAGFFY 206
            R  ++  Q +                      RLA+F+ WP  +   +P  +++AGF +
Sbjct: 150 -RGGKMRYQEEEA--------------------RLASFRNWPFYVQGISPCVLSEAGFVF 188

Query: 207 TGKSDVVACYYCGGNLRDWLAEDDPWVEHVRNFSECPYVKLVKTPEFIAE 256
           TGK D V C+ CGG L +W   DDPW EH + F +C +++  K+ E I +
Sbjct: 189 TGKQDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLRSKKSSEEITQ 238



==> UNIPROT|Q13489 - symbol:BIRC3_HUMAN "BIRC3, API2, IAP1, MIHC,
           RNF49: Baculoviral IAP repeat-containing protein 3"
           species:9606 "Homo sapiens" [GO:0004842
           "ubiquitin-protein ligase activity" evidence=IDA]
           [GO:0005515 "protein binding" evidence=IPI] [GO:0006916
           "anti-apoptosis" evidence=TAS] [GO:0007166 "cell surface
           receptor linked signal transduction" evidence=TAS]
           [GO:0005634 "nucleus" evidence=IDA] [GO:0005737
           "cytoplasm" evidence=IDA] InterPro:IPR001841
           EMBL:AF070674 Pfam:PF00097 InterPro:IPR001370
           InterPro:IPR001315 UniProt:Q13489 Prosite:PS00518
           GO:GO:0005515 GO:GO:0005737 GO:GO:0005634 GO:GO:0006916
           SMART:SM00184 PROSITE:PS50089 GO:GO:0007166
           GO:GO:0004842 InterPro:IPR011029 Pfam:PF00619
           SMART:SM00114 PROSITE:PS50209 Pfam:PF00653 SMART:SM00238
           PROSITE:PS01282 PROSITE:PS50143 HSSP:Q13490 EMBL:L49432
           EMBL:U45878 EMBL:U37546 EMBL:AY764389 EMBL:BC037420
           EMBL:AF178945 PIR:S68449 UniGene:Hs.127799 SMR:Q13489
           IntAct:Q13489 MEROPS:I32.003 Ensembl:ENSG00000023445
           KEGG:hsa:329 HGNC:HGNC:591 MIM:601721
           ArrayExpress:Q13489 GermOnline:ENSG00000023445
           RZPD-ProtExp:IOH25952
          Length = 604

 Score =  103 bits (258), Expect = 2e-022
 Identities = 72/229 (31%), Positives = 104/229 (45%), Gaps = 28/229 (12%)

Query: 26  CLNYEVNRLRTFPLWTVPYIYPEELARWGFFYTGYRDCVRCYFCRIELGGWDEHDVVIEE 85
           C  Y ++   TFP   VP +    LAR GF+YTG  D V+C+ C + L  W   D   E+
Sbjct: 28  CELYRMSTYSTFPAG-VP-VSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEK 85

Query: 86  HLKWSPHCRLMTK-RPTNNVPI--DPDF----LDQLGEIVPDTTGTGSTSAWSAAATAAV 138
           H K  P CR +      NN+     P F     +    ++P T  +G      + +    
Sbjct: 86  HKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSP--- 142

Query: 139 AVAMESNRLNRQNELERQSQRTQNDTIPFYRQKYP-EYRIGGDRLATFKEWPKSIPQTPT 197
                SN +N          R   D     R  Y         RL TF+ WP +   +PT
Sbjct: 143 -----SNPVN---------SRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTF-LSPT 187

Query: 198 QMADAGFFYTGKSDVVACYYCGGNLRDWLAEDDPWVEHVRNFSECPYVK 246
            +A AGF+Y G  D VAC+ CGG L +W  +D+   EH+R+F +CP+++
Sbjct: 188 DLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIE 236



 Score = 84.3 bits (207), Expect = 2e-016
 Identities = 36/76 (47%), Positives = 46/76 (60%)

Query: 181 RLATFKEWPKSIPQTPTQMADAGFFYTGKSDVVACYYCGGNLRDWLAEDDPWVEHVRNFS 240
           R  TF  WP S+   P Q+A AGF+Y G SD V C+ C G LR W + DDPWV+H + F 
Sbjct: 258 RFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFP 317

Query: 241 ECPYVKLVKTPEFIAE 256
            C Y+  +K  EFI +
Sbjct: 318 RCEYLIRIKGQEFIRQ 333



 Score = 60.8 bits (146), Expect = 2e-009
 Identities = 24/60 (40%), Positives = 35/60 (58%)

Query: 282 DKEQDEVSDEKCCKICYIRPFDTVFIPCGHVVACGKCAASTTKCPMCNESYTSVQRIFLS 341
           +++   + +E+ CK+C  +    VFIPCGH+V C  CA S  KCP+C  +     R FLS
Sbjct: 545 EEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 604



 Score = 59.3 bits (142), Expect = 6e-009
 Identities = 31/102 (30%), Positives = 54/102 (52%), Gaps = 6/102 (5%)

Query: 181 RLATFKEWPKSIPQTPTQMADAGFFYTGKSDVVACYYCGGNLRDWLAEDDPWVEHVRNFS 240
           R++T+  +P  +P +   +A AGF+YTG +D V C+ CG  L +W   D P  +H + + 
Sbjct: 32  RMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYP 91

Query: 241 ECPYVKLVKTPEFIAECR----GEKVTNS--ALIASSERSGH 276
            C +V+ + +   +           VTNS  +L+  +E SG+
Sbjct: 92  SCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGY 133



 Score = 49.7 bits (117), Expect = 5e-006
 Identities = 24/67 (35%), Positives = 35/67 (52%), Gaps = 1/67 (1%)

Query: 33  RLRTFPLW-TVPYIYPEELARWGFFYTGYRDCVRCYFCRIELGGWDEHDVVIEEHLKWSP 91
           R +TF  W +   + PE+LA  GF+Y G  D V+C+ C   L  W+  D    +H KW P
Sbjct: 258 RFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFP 317

Query: 92  HCRLMTK 98
            C  + +
Sbjct: 318 RCEYLIR 324



==> UNIPROT|Q96CA5 - symbol:BIRC7_HUMAN "BIRC7, KIAP,
           UNQ5800/PRO19607/PRO21344, LIVIN, MLIAP, RNF50:
           Baculoviral IAP repeat-containing protein 7"
           species:9606 "Homo sapiens" [GO:0019899 "enzyme binding"
           evidence=NAS] [GO:0006309 "DNA fragmentation during
           apoptosis" evidence=NAS] [GO:0006916 "anti-apoptosis"
           evidence=NAS] [GO:0007257 "activation of JNK activity"
           evidence=NAS] InterPro:IPR001841 Pfam:PF00097
           InterPro:IPR001370 UniProt:Q96CA5 Prosite:PS00518
           GO:GO:0019899 GO:GO:0006916 SMART:SM00184
           PROSITE:PS50089 EMBL:AL121827 GO:GO:0006309 Pfam:PF00653
           SMART:SM00238 PROSITE:PS01282 PROSITE:PS50143
           EMBL:AF301009 EMBL:AJ309298 EMBL:AF311388 EMBL:AY358835
           EMBL:AY358836 EMBL:BC014475 PIR:JC7568 UniGene:Hs.256126
           PDB:1OXN PDB:1OXQ PDB:1OY7 PDB:1TW6 IntAct:Q96CA5
           MEROPS:I32.007 Ensembl:ENSG00000101197 KEGG:hsa:79444
           HGNC:HGNC:13702 MIM:605737 LinkHub:Q96CA5
           ArrayExpress:Q96CA5 GermOnline:ENSG00000101197
           RZPD-ProtExp:IOH12830 RZPD-ProtExp:IOH44697
           RZPD-ProtExp:RZPDo839G0268 RZPD-ProtExp:RZPDo839G0278
           RZPD-ProtExp:W1020 RZPD-ProtExp:Z9972 GO:GO:0007257
          Length = 298

 Score =  101 bits (252), Expect = 1e-021
 Identities = 64/210 (30%), Positives = 92/210 (43%), Gaps = 50/210 (23%)

Query: 181 RLATFKEWPKSIPQTPTQMADAGFFYTGKSDVVACYYCGGNLRDWLAEDDPWVEHVRNFS 240
           RLA+F +WP +    P  +A AGFF+TG  D V C++C G L+ W   DDPW EH + F 
Sbjct: 90  RLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRCFFCYGGLQSWKRGDDPWTEHAKWFP 149

Query: 241 ECPYVKLVKTPEFIAECR------------GEKVTNSALIASS-ERSGH----------- 276
            C ++   K  +F+   +             E+  ++A +A S   SG+           
Sbjct: 150 SCQFLLRSKGRDFVHSVQETHSQLLGSWDPWEEPEDAAPVAPSVPASGYPELPTPRREVQ 209

Query: 277 -------GNVSKDKEQ------------------DEVSDEKCCKICYIRPFDTVFIPCGH 311
                  G VS  + Q                    + +E+ CK+C  R    VF+PCGH
Sbjct: 210 SESAQEPGGVSPAEAQRAWWVLEPPGARDVEAQLRRLQEERTCKVCLDRAVSIVFVPCGH 269

Query: 312 VVACGKCAASTTKCPMCNESYTSVQRIFLS 341
           +V C +CA     CP+C     S  R FLS
Sbjct: 270 LV-CAECAPGLQLCPICRAPVRSRVRTFLS 298



 Score = 56.2 bits (134), Expect = 5e-008
 Identities = 28/67 (41%), Positives = 38/67 (56%), Gaps = 1/67 (1%)

Query: 33  RLRTFPLWTVPY-IYPEELARWGFFYTGYRDCVRCYFCRIELGGWDEHDVVIEEHLKWSP 91
           RL +F  W +   + PE LA  GFF+TG++D VRC+FC   L  W   D    EH KW P
Sbjct: 90  RLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRCFFCYGGLQSWKRGDDPWTEHAKWFP 149

Query: 92  HCRLMTK 98
            C+ + +
Sbjct: 150 SCQFLLR 156



==> UNIPROT|Q13490 - symbol:BIRC2_HUMAN "BIRC2, API1, IAP2, MIHB,
           RNF48: Baculoviral IAP repeat-containing protein 2"
           species:9606 "Homo sapiens" [GO:0004871 "signal
           transducer activity" evidence=IEP] [GO:0005515 "protein
           binding" evidence=IPI] [GO:0007166 "cell surface
           receptor linked signal transduction" evidence=TAS]
           [GO:0043123 "positive regulation of I-kappaB
           kinase/NF-kappaB cascade" evidence=IEP]
           InterPro:IPR001841 UniProt:Q13490 Pfam:PF00097
           InterPro:IPR001370 InterPro:IPR001315 Prosite:PS00518
           GO:GO:0005515 GO:GO:0043123 SMART:SM00184
           PROSITE:PS50089 GO:GO:0007166 GO:GO:0004871
           InterPro:IPR011029 Pfam:PF00619 SMART:SM00114
           PROSITE:PS50209 Pfam:PF00653 SMART:SM00238
           PROSITE:PS01282 PROSITE:PS50143 EMBL:L49431 EMBL:U45879
           EMBL:U37547 EMBL:DQ068066 EMBL:BC016174 EMBL:BC028578
           PIR:S68450 UniGene:Hs.503704 PDB:1QBH IntAct:Q13490
           MEROPS:I32.002 Ensembl:ENSG00000110330 KEGG:hsa:330
           H-InvDB:HIX0010063 HGNC:HGNC:590 MIM:601712
           LinkHub:Q13490 ArrayExpress:Q13490
           GermOnline:ENSG00000110330 RZPD-ProtExp:B0151
           RZPD-ProtExp:IOH10027
          Length = 618

 Score = 96.7 bits (239), Expect = 3e-020
 Identities = 66/228 (28%), Positives = 106/228 (46%), Gaps = 28/228 (12%)

Query: 26  CLNYEVNRLRTFPLWTVPYIYPEELARWGFFYTGYRDCVRCYFCRIELGGWDEHDVVIEE 85
           C  Y ++   TFP   VP +    LAR GF+YTG  D V+C+ C + L  W   D  I++
Sbjct: 45  CELYRMSTYSTFPAG-VP-VSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQK 102

Query: 86  HLKWSPHCRLMTKRPTNNVPIDPDFLDQLGEIVPDTTGTGSTSAWSAAAT-------AAV 138
           H +  P C  +    + +          LG    +T+   ++ A S + T       +  
Sbjct: 103 HKQLYPSCSFIQNLVSAS----------LGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGS 152

Query: 139 AVAMESNRLNRQNELERQSQRTQNDTIPFYRQKYPEYRIGGDRLATFKEWPKSIPQTPTQ 198
             ++  N LN +   +  S RT   +     ++         R  T+  WP +   +P++
Sbjct: 153 YSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEA--------RFLTYHMWPLTF-LSPSE 203

Query: 199 MADAGFFYTGKSDVVACYYCGGNLRDWLAEDDPWVEHVRNFSECPYVK 246
           +A AGF+Y G  D VAC+ CGG L +W  +DD   EH R+F  CP+++
Sbjct: 204 LARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLE 251



 Score = 90.9 bits (224), Expect = 2e-018
 Identities = 41/99 (41%), Positives = 60/99 (60%), Gaps = 1/99 (1%)

Query: 181 RLATFKEWPKSIPQTPTQMADAGFFYTGKSDVVACYYCGGNLRDWLAEDDPWVEHVRNFS 240
           R+ TF  WP S+P  P Q+A AGF+Y G++D V C+ C G LR W + DDPWVEH + F 
Sbjct: 272 RMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFP 331

Query: 241 ECPYVKLVKTPEFIAECRGE-KVTNSALIASSERSGHGN 278
            C ++  +K  EF+ E +G        L+++S+ +G  N
Sbjct: 332 RCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEEN 370



 Score = 62.0 bits (149), Expect = 9e-010
 Identities = 29/78 (37%), Positives = 43/78 (55%), Gaps = 3/78 (3%)

Query: 264 NSALIASSERSGHGNVSKDKEQDEVSDEKCCKICYIRPFDTVFIPCGHVVACGKCAASTT 323
           N   I + + SG   +S +++   + +E+ CK+C  +    VFIPCGH+V C +CA S  
Sbjct: 544 NMKYIPTEDVSG---LSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLR 600

Query: 324 KCPMCNESYTSVQRIFLS 341
           KCP+C        R FLS
Sbjct: 601 KCPICRGIIKGTVRTFLS 618



 Score = 57.4 bits (137), Expect = 2e-008
 Identities = 36/98 (36%), Positives = 48/98 (48%), Gaps = 9/98 (9%)

Query: 33  RLRTFPLW--TVPYIYPEELARWGFFYTGYRDCVRCYFCRIELGGWDEHDVVIEEHLKWS 90
           R+RTF  W  +VP + PE+LA  GF+Y G  D V+C+ C   L  W+  D    EH KW 
Sbjct: 272 RMRTFMYWPSSVP-VQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWF 330

Query: 91  PHCRLMTKRPTNNVPID-----PDFLDQLGEIVPDTTG 123
           P C  + +        +     P  L+QL     DTTG
Sbjct: 331 PRCEFLIRMKGQEFVDEIQGRYPHLLEQLLS-TSDTTG 367



==> UNIPROT|P98170 - symbol:BIRC4_HUMAN "BIRC4, API3, IAP3, XIAP:
           Baculoviral IAP repeat-containing protein 4"
           species:9606 "Homo sapiens" [GO:0005515 "protein
           binding" evidence=IPI] [GO:0043027 "caspase inhibitor
           activity" evidence=IDA] [GO:0006916 "anti-apoptosis"
           evidence=TAS] [GO:0005737 "cytoplasm" evidence=TAS]
           [GO:0005829 "cytosol" evidence=TAS] InterPro:IPR001841
           UniProt:P98170 InterPro:IPR001370 Prosite:PS00518
           GO:GO:0005515 Reactome:REACT_578.1 GO:GO:0006916
           GO:GO:0005829 SMART:SM00184 PROSITE:PS50089
           GO:GO:0043027 Pfam:PF00653 SMART:SM00238 PROSITE:PS01282
           PROSITE:PS50143 EMBL:U45880 EMBL:U32974 EMBL:AY886519
           EMBL:AL121601 EMBL:BC032729 PIR:S69544 UniGene:Hs.356076
           PDB:1C9Q PDB:1F9X PDB:1G3F PDB:1G73 PDB:1I3O PDB:1I4O
           PDB:1I51 PDB:1KMC PDB:1NW9 PDB:1TFQ DIP:DIP:27626N
           IntAct:P98170 MEROPS:I32.004 Ensembl:ENSG00000101966
           KEGG:hsa:331 H-InvDB:HIX0017033 HGNC:HGNC:592 MIM:300079
           MIM:300635 LinkHub:P98170 ArrayExpress:P98170
           GermOnline:ENSG00000101966 RZPD-ProtExp:IOH21984
           RZPD-ProtExp:T0104
          Length = 497

 Score = 95.9 bits (237), Expect = 6e-020
 Identities = 76/233 (32%), Positives = 102/233 (43%), Gaps = 33/233 (14%)

Query: 24  EECLNYEVNRLRTFPLW-TVPYIYPEELARWGFFYTGYRDCVRCYFCRIELGGWDEHDVV 82
           EE    E NRL+TF  + +   +    LAR GF YTG  D VRC+ C   +  W   D  
Sbjct: 20  EEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSA 79

Query: 83  IEEHLKWSPHCRLMTKRPTNNVPIDPDFLDQLGEIVPDTTGTGSTSAWSAAATAAVAVAM 142
           +  H K SP+CR +      N                  + T ST++        V   +
Sbjct: 80  VGRHRKVSPNCRFINGFYLEN------------------SATQSTNSGIQNGQYKVENYL 121

Query: 143 ESN---RLNRQNE-----LERQSQRTQ-NDTI-PFYRQKYPEYRIGGDRLATFKEWPKSI 192
            S     L+R +E     L R  Q    +DTI P     Y E      RL +F+ WP   
Sbjct: 122 GSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEA----RLKSFQNWPDYA 177

Query: 193 PQTPTQMADAGFFYTGKSDVVACYYCGGNLRDWLAEDDPWVEHVRNFSECPYV 245
             TP ++A AG +YTG  D V C+ CGG L++W   D  W EH R+F  C +V
Sbjct: 178 HLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFV 230



 Score = 91.3 bits (225), Expect = 1e-018
 Identities = 61/246 (24%), Positives = 100/246 (40%), Gaps = 50/246 (20%)

Query: 30  EVNRLRTFPLWT-VPYIYPEELARWGFFYTGYRDCVRCYFCRIELGGWDEHDVVIEEHLK 88
           E  RL++F  W    ++ P ELA  G +YTG  D V+C+ C  +L  W+  D    EH +
Sbjct: 163 EEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRR 222

Query: 89  WSPHCRLMTKRPTNNVPIDPDFLDQLGEIVPDTTGTGSTSAWSAAATAAVAVAMESNRLN 148
             P+C  +  R  N                                     +  ES+ ++
Sbjct: 223 HFPNCFFVLGRNLN-------------------------------------IRSESDAVS 245

Query: 149 RQNELERQSQRTQNDTIPFYRQKYPEYRIGGDRLATFKEWPKSIPQTPTQMADAGFFYTG 208
                   +   +N ++  Y            R+ TF  W  S+ +   Q+A AGF+  G
Sbjct: 246 SDRNFPNSTNLPRNPSMADYEA----------RIFTFGTWIYSVNKE--QLARAGFYALG 293

Query: 209 KSDVVACYYCGGNLRDWLAEDDPWVEHVRNFSECPYVKLVKTPEFIAECRGEKVTNSALI 268
           + D V C++CGG L DW   +DPW +H + +  C Y+   K  E+I            L+
Sbjct: 294 EGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLV 353

Query: 269 ASSERS 274
            ++E++
Sbjct: 354 RTTEKT 359



 Score = 70.1 bits (170), Expect = 3e-012
 Identities = 31/72 (43%), Positives = 44/72 (61%)

Query: 270 SSERSGHGNVSKDKEQDEVSDEKCCKICYIRPFDTVFIPCGHVVACGKCAASTTKCPMCN 329
           SS+ S    +S +++   + +EK CKIC  R    VF+PCGH+V C +CA +  KCPMC 
Sbjct: 426 SSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCY 485

Query: 330 ESYTSVQRIFLS 341
              T  Q+IF+S
Sbjct: 486 TVITFKQKIFMS 497



 Score = 47.4 bits (111), Expect = 2e-005
 Identities = 29/103 (28%), Positives = 44/103 (42%), Gaps = 5/103 (4%)

Query: 165 IPFYRQKYPEYRIGGDRLATFKEWPKSIPQTPTQMADAGFFYTGKSDVVACYYCGGNLRD 224
           +P    K  E+    +RL TF  +P   P + + +A AGF YTG+ D V C+ C   +  
Sbjct: 13  VPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDR 72

Query: 225 WLAEDDPWVEHVRNFSECPYVKLVKTPEFIAECRGEKVTNSAL 267
           W   D     H +    C ++       F  E    + TNS +
Sbjct: 73  WQYGDSAVGRHRKVSPNCRFIN-----GFYLENSATQSTNSGI 110



 Score = 47.4 bits (111), Expect = 2e-005
 Identities = 25/72 (34%), Positives = 39/72 (54%), Gaps = 2/72 (2%)

Query: 28  NYEVNRLRTFPLWTVPYIYPEELARWGFFYTGYRDCVRCYFCRIELGGWDEHDVVIEEHL 87
           +YE  R+ TF  W +  +  E+LAR GF+  G  D V+C+ C   L  W   +   E+H 
Sbjct: 264 DYEA-RIFTFGTW-IYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHA 321

Query: 88  KWSPHCRLMTKR 99
           KW P C+ + ++
Sbjct: 322 KWYPGCKYLLEQ 333



==> MGI|MGI:1197009 - symbol:Birc2 "baculoviral IAP repeat-containing
           2" species:10090 "Mus musculus" [GO:0001890 "placenta
           development" evidence=IMP] [GO:0042981 "regulation of
           apoptosis" evidence=IMP] [GO:0005515 "protein binding"
           evidence=IPI] InterPro:IPR001841 Pfam:PF00097
           InterPro:IPR001370 InterPro:IPR001315 MGI:MGI:1197009
           UniProt:Q62210 Prosite:PS00518 GO:GO:0005515
           SMART:SM00184 PROSITE:PS50089 GO:GO:0042981
           GO:GO:0001890 InterPro:IPR011029 Pfam:PF00619
           SMART:SM00114 PROSITE:PS50209 Pfam:PF00653 SMART:SM00238
           PROSITE:PS01282 PROSITE:PS50143 HSSP:Q13490
           MEROPS:I32.002 EMBL:L49433 EMBL:U88909 UniGene:Mm.335659
           SMR:Q62210 Ensembl:ENSMUSG00000057367 KEGG:mmu:11797
           ArrayExpress:Q62210 GermOnline:ENSMUSG00000057367
          Length = 612

 Score = 91.7 bits (226), Expect = 1e-018
 Identities = 61/232 (26%), Positives = 99/232 (42%), Gaps = 43/232 (18%)

Query: 26  CLNYEVNRLRTFPLWTVPYIYPEELARWGFFYTGYRDCVRCYFCRIELGGWDEHDVVIEE 85
           C  Y ++    FP   VP +    LAR GF+YTG  D V+C+ C + L  W + D  +E+
Sbjct: 45  CELYRMSTYSAFPRG-VP-VSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKQGDSPVEK 102

Query: 86  HLKWSPHCRLMTKRPTNNVPIDPDFLDQLGEIVPDTTGTGSTSAWSAAATAAVAVAMESN 145
           H ++ P C  +                              T   ++  + +  ++   +
Sbjct: 103 HRQFYPSCSFV-----------------------------QTLLSASLQSPSKNMSPVKS 133

Query: 146 RLNRQNELERQSQRTQNDTIPFYRQKYPEYRIGGD-----------RLATFKEWPKSIPQ 194
           R    + LER    +   + P   +   ++    D           R  T+  WP S   
Sbjct: 134 RFAHSSPLERGGIHSNLCSSPLNSRAVEDFSSRMDPCSYAMSTEEARFLTYSMWPLSF-L 192

Query: 195 TPTQMADAGFFYTGKSDVVACYYCGGNLRDWLAEDDPWVEHVRNFSECPYVK 246
           +P ++A AGF+Y G  D VAC+ CGG L +W  +DD   EH R+F  CP+++
Sbjct: 193 SPAELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPHCPFLE 244



 Score = 88.2 bits (217), Expect = 1e-017
 Identities = 92/365 (25%), Positives = 142/365 (38%), Gaps = 73/365 (20%)

Query: 33  RLRTFPLW--TVPYIYPEELARWGFFYTGYRDCVRCYFCRIELGGWDEHDVVIEEHLKWS 90
           RLRTF  W  +VP + PE+LA  GF+Y    D V+C+ C   L  W+  D    EH KW 
Sbjct: 265 RLRTFLYWPPSVP-VQPEQLASAGFYYVDRNDDVKCFCCDGGLRCWEPGDDPWIEHAKWF 323

Query: 91  PHCRLMTKRPTNNVPID-----PDFLDQL-------GEIVPDTTGTG------------- 125
           P C  + +        +     P  L+QL       GE   D T T              
Sbjct: 324 PRCEFLIRMKGQEFVDEIQARYPHLLEQLLSTSDTPGEENADPTETVVHFGPGESSEDVV 383

Query: 126 --STSAWSAAATAAVAVAMESNRLNRQNELERQSQRTQNDTIPFY-----------RQKY 172
             ST    AA     + ++    + RQ     ++ RT ND +              +++ 
Sbjct: 384 MMSTPVVKAALEMGFSRSLVRQTVQRQILATGENYRTVNDIVSVLLNAEDERREEEKERQ 443

Query: 173 PEYRIGGD-------RLATFKEWPKSIPQTPTQMADAGFFYTGKSDVV---------ACY 216
            E    GD       R+A F++    +P     + +A      + D++         A  
Sbjct: 444 TEEMASGDLSLIRKNRMALFQQLTHVLPILDN-LLEASVITKQEHDIIRQKTQIPLQARE 502

Query: 217 YCGGNLRDWLAEDDPWVEHVRNFSECPYVKLVKTPEFIAECRGEKVTNSALIASSERSGH 276
                L    A  + +   ++      Y  L     F+ +       N   I + + SG 
Sbjct: 503 LIDTVLVKGNAAANIFKNSLKEIDSTLYENL-----FVEK-------NMKYIPTEDVSG- 549

Query: 277 GNVSKDKEQDEVSDEKCCKICYIRPFDTVFIPCGHVVACGKCAASTTKCPMCNESYTSVQ 336
             +S +++   + +E+ CK+C  R    VFIPCGH+V C +CA S  KCP+C  +     
Sbjct: 550 --LSLEEQLRRLQEERTCKVCMDREVSIVFIPCGHLVVCQECAPSLRKCPICRGTIKGTV 607

Query: 337 RIFLS 341
           R FLS
Sbjct: 608 RTFLS 612



 Score = 61.2 bits (147), Expect = 2e-009
 Identities = 27/83 (32%), Positives = 43/83 (51%)

Query: 11  REIAEYRVTHDTPEECLNYEVNRLRTFPLWTVPYIYPEELARWGFFYTGYRDCVRCYFCR 70
           R + ++    D     ++ E  R  T+ +W + ++ P ELAR GF+Y G  D V C+ C 
Sbjct: 158 RAVEDFSSRMDPCSYAMSTEEARFLTYSMWPLSFLSPAELARAGFYYIGPGDRVACFACG 217

Query: 71  IELGGWDEHDVVIEEHLKWSPHC 93
            +L  W+  D  + EH +  PHC
Sbjct: 218 GKLSNWEPKDDAMSEHRRHFPHC 240



 Score = 59.7 bits (143), Expect = 5e-009
 Identities = 31/102 (30%), Positives = 53/102 (51%), Gaps = 3/102 (2%)

Query: 181 RLATFKEWPKSIPQTPTQMADAGFFYTGKSDVVACYYCGGNLRDWLAEDDPWVEHVRNFS 240
           R++T+  +P+ +P +   +A AGF+YTG +D V C+ CG  L +W   D P  +H + + 
Sbjct: 49  RMSTYSAFPRGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKQGDSPVEKHRQFYP 108

Query: 241 ECPYVKLVKTPEFIAECRGEKVTNSALIASS--ERSG-HGNV 279
            C +V+ + +    +  +      S    SS  ER G H N+
Sbjct: 109 SCSFVQTLLSASLQSPSKNMSPVKSRFAHSSPLERGGIHSNL 150