>AGAP007452-PA UNIPROT|Q12774 - symbol:ARHG5_HUMAN "ARHGEF5, TIM: Rho guanine n... 239 3e-062 MGI|MGI:2446219 - symbol:Arhgef16 "Rho guanine nucleotide exchan... 239 5e-062 FB|FBgn0015390 - symbol:futsch "futsch" species:7227 "Drosophila... 84 2e-015 UNIPROT|Q9NZW4 - symbol:DSPP_HUMAN "DSPP: Dentin sialophosphopro... 80 5e-014 TAIR|gene:2098442 - symbol:AT3G28770.1 species:3702 "Arabidopsis... 75 9e-013 UNIPROT|Q15811 - symbol:ITSN1_HUMAN "ITSN1, ITSN, SH3D1A: Inters... 74 2e-012 MGI|MGI:1338069 - symbol:Itsn1 "intersectin 1 (SH3 domain protei... 73 4e-012 TAIR|gene:504953784 - symbol:AT2G22795.1 species:3702 "Arabidops... 72 1e-011 TAIR|gene:2170587 - symbol:AT5G40450.1 species:3702 "Arabidopsis... 69 8e-011 UNIPROT|Q9NZM3 - symbol:ITSN2_HUMAN "ITSN2, KIAA1256, SH3D1B, SW... 67 3e-010 MGI|MGI:109172 - symbol:Dspp "dentin sialophosphoprotein" specie... 66 5e-010 TAIR|gene:2098392 - symbol:AT3G28790.1 species:3702 "Arabidopsis... 64 3e-009 SGD|S000002216 - symbol:USO1 "Essential protein involved in intr... 63 6e-009 MGI|MGI:1353510 - symbol:Arhgef1 "Rho guanine nucleotide exchang... 63 6e-009 TAIR|gene:2137543 - symbol:AT4G37820.1 species:3702 "Arabidopsis... 62 1e-008 MGI|MGI:103067 - symbol:Atrx "alpha thalassemia/mental retardati... 62 1e-008 MGI|MGI:1916882 - symbol:Arhgef12 "Rho guanine nucleotide exchan... 59 6e-008 UNIPROT|Q9NZN5 - symbol:ARHGC_HUMAN "ARHGEF12, KIAA0382, LARG: R... 59 8e-008 UNIPROT|O15085 - symbol:ARHGB_HUMAN "ARHGEF11, KIAA0380: Rho gua... 57 3e-007 MGI|MGI:1306778 - symbol:Mtap1b "microtubule-associated protein ... 56 5e-007 MGI|MGI:3046938 - symbol:Hrnr "hornerin" species:10090 "Mus musc... 55 9e-007 SGD|S000005515 - symbol:HPF1 "Haze-protective mannoprotein that ... 55 1e-006 SGD|S000001800 - symbol:SRP40 "Nucleolar, serine-rich protein wi... 54 3e-006 UNIPROT|Q9H8V3 - symbol:ECT2_HUMAN "ECT2: ECT2 protein" species:... 54 3e-006 UNIPROT|P46821 - symbol:MAP1B_HUMAN "MAP1B: Microtubule-associat... 54 4e-006 ==> UNIPROT|Q12774 - symbol:ARHG5_HUMAN "ARHGEF5, TIM: Rho guanine nucleotide exchange factor 5" species:9606 "Homo sapiens" [GO:0005515 "protein binding" evidence=IPI] [GO:0005525 "GTP binding" evidence=TAS] Pfam:PF00169 InterPro:IPR000219 InterPro:IPR001331 UniProt:Q12774 InterPro:IPR001452 InterPro:IPR001849 GO:GO:0005525 GO:GO:0005515 InterPro:IPR011993 Gene3D:G3DSA:2.30.29.30 SMART:SM00233 PROSITE:PS50003 PRINTS:PR00452 ProDom:PD000066 SMART:SM00326 PROSITE:PS50002 Gene3D:G3DSA:1.20.900.10 Pfam:PF00621 SMART:SM00325 PROSITE:PS00741 PROSITE:PS50010 HSSP:O08839 EMBL:U02082 EMBL:AC004534 EMBL:BC010046 EMBL:BC011839 EMBL:BC014555 PIR:I38402 UniGene:Hs.334 UniGene:Hs.534621 IntAct:Q12774 Ensembl:ENSG00000050327 KEGG:hsa:7984 H-InvDB:HIX0007176 HGNC:HGNC:13209 MIM:600888 ArrayExpress:Q12774 GermOnline:ENSG00000050327 RZPD-ProtExp:A1121 RZPD-ProtExp:IOH14526 RZPD-ProtExp:RZPDo839E0970 InterPro:IPR011511 Pfam:PF07653 Length = 519 Score = 239 bits (611), Expect = 3e-062 Identities = 150/464 (32%), Positives = 245/464 (52%), Gaps = 27/464 (5%) Query: 2217 TLWCEVPEVRNSEILATLTPTEKRLQEAKFEILTSEASYLKSLNLLRTHFVNHPAFRDTR 2276 +LW E+P VRNS +L ++T +++LQE KFE++ SEASYL+SLN+ HF + R T Sbjct: 73 SLWQEIPVVRNSTVLLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHFQLSTSLRAT- 131 Query: 2277 ILSSSERKTLFSSIIPVQECSDRLLCDLENCWQDNIMLLGLSHSIYKHAEKHFHVYVTYC 2336 LS+ E + LFS + V++ S L DLE +++NI + + HA VY+ Y Sbjct: 132 -LSNQEHQWLFSRLQDVRDVSATFLSDLEENFENNIFSFQVCDVVLNHAPDFRRVYLPYV 190 Query: 2337 EHQAKIDRTLKALKANKPEFARTLAALEADPVCCSLSLSSFLMLPMQRITRMRLLLDAVL 2396 +Q +RT ++L + F L LE+DPVC LSL SFL+LP QRITR++LLL +L Sbjct: 191 TNQTYQERTFQSLMNSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNIL 250 Query: 2397 QRCHPDDDDEFGSWESTFVLINRILTQCNDAAHRSEQLYEMELLSRQIEFPTNVRPLAIV 2456 +R P +E + ++ L +++ CN+ + E+ LS++IEF + PL Sbjct: 251 KRTQPGSSEEAEATKAHHAL-EQLIRDCNNNVQSMRRTEELIYLSQKIEFECKIFPLI-- 307 Query: 2457 PCGIGAAPSTMHRKLEKRGDLVHVLWRGDDAKLTFGKKFSKSNVYAFLFTDLLVLTKKKS 2516 + R L K G+L + + A +K + V+ LF D L+L++ + Sbjct: 308 ---------SQSRWLVKSGELTALEF---SASPGLRRKLNTRPVHLHLFNDCLLLSRPRE 355 Query: 2517 DESYLVIDYCQRALLTVSSGDIVTGLPAKEMQTIGKNLIIMTLLENHEGKTIEMILSCPS 2576 +LV D+ + + ++ ++ KNL + L +N +G E + + Sbjct: 356 GSRFLVFDHAPFSSIRGEKCEM-------KLHGPHKNLFRLFLRQNTQGAQAEFLFRTET 408 Query: 2577 ETERERWLMVTEPPASENPDEKIYEQWDCPQVIAVHPYQALQPDELDLDIKDVVNVHRKM 2636 ++E+ RW+ P E + E ++ PQV + Y+ + DEL L+ DVV V ++ Sbjct: 409 QSEKLRWISALAMPREE---LDLLECYNSPQVQCLRAYKPRENDELALEKADVVMVTQQS 465 Query: 2637 ADGWYEGERIRDGAVGWFPSNYTKEIPSAHIRAKHIKQRHLLLT 2680 +DGW EG R+ DG GWFP + I + +RA+++K+ H + T Sbjct: 466 SDGWLEGVRLSDGERGWFPVQQVEFISNPEVRAQNLKEAHRVKT 509 ==> MGI|MGI:2446219 - symbol:Arhgef16 "Rho guanine nucleotide exchange factor (GEF) 16" species:10090 "Mus musculus" [GO:0008150 "biological_process" evidence=ND] [GO:0003674 "molecular_function" evidence=ND] [GO:0005575 "cellular_component" evidence=ND] Pfam:PF00018 Pfam:PF00169 InterPro:IPR000219 InterPro:IPR001331 InterPro:IPR001452 InterPro:IPR001849 MGI:MGI:2446219 InterPro:IPR011993 Gene3D:G3DSA:2.30.29.30 SMART:SM00233 PROSITE:PS50003 PRINTS:PR00452 ProDom:PD000066 SMART:SM00326 PROSITE:PS50002 Gene3D:G3DSA:1.20.900.10 Pfam:PF00621 SMART:SM00325 PROSITE:PS00741 PROSITE:PS50010 EMBL:AK153708 EMBL:BC020030 EMBL:BC095966 UniGene:Mm.38481 HSSP:P19878 SMR:Q3U5C8 Ensembl:ENSMUSG00000029032 ArrayExpress:Q3U5C8 GermOnline:ENSMUSG00000029032 Uniprot:Q3U5C8 Length = 713 Score = 239 bits (609), Expect = 5e-062 Identities = 158/452 (34%), Positives = 239/452 (52%), Gaps = 31/452 (6%) Query: 2219 WCEVPEVRNSEILATLTPTEKRLQEAKFEILTSEASYLKSLNLLRTHFVNHPAFRDTRIL 2278 W ++PEV S +L TL+ E++ QEA FEILTSE SYL SL++L T F+ R T + Sbjct: 267 WSQLPEVLESGVLDTLSTEERKRQEAIFEILTSEFSYLHSLSILVTEFLQSRELRAT--M 324 Query: 2279 SSSERKTLFSSIIPVQECSDRLLCDLENCWQDNIMLLGLSHSIYKHAEKHFHVYVTYCEH 2338 + +E LFS+I+ V S + LE + + + +S + HA+ HFH Y+ YC + Sbjct: 325 TQTEHHHLFSNILDVMSASQKFFEALEQRHKAQVCVEDISDILEDHAQHHFHPYIAYCSN 384 Query: 2339 QAKIDRTLKALKANKPEFARTLAALEADPVCCSLSLSSFLMLPMQRITRMRLLLDAVLQR 2398 + RTL+ L + F L +E P C L + SFL+LPMQR+TR+ LL D + + Sbjct: 385 EVYQQRTLQKLSNSNAAFRDVLKEIEKRPACGGLPMISFLILPMQRVTRLPLLTDTLCLK 444 Query: 2399 C--HPDDDDEFGSWESTFVLINRILTQCNDAAHRSEQLYEMELLSRQIEFPTNVRPLAIV 2456 HP + + + I++++ QCN+ AH+ E+ ++ L+ Q++F V+ L ++ Sbjct: 445 TQGHP---ERYKAASQALKAISKLVKQCNEGAHKMERTEQIYTLNMQLDF-GKVKSLPLI 500 Query: 2457 PCGIGAAPSTMHRKLEKRGDLVHVLWRGDDAKLTFGKKFSKSNVYAFLFTDLLVLTKKKS 2516 + R L KRG+L + + F K S+ Y FLF DLLV+TKKKS Sbjct: 501 ---------SASRWLLKRGELFLL-----EESSIFRKIASRPTCYLFLFNDLLVVTKKKS 546 Query: 2517 DESYLVIDYCQRALLTV----SSGDIVTGLPAKEMQTIGKNLIIMTLLENHEGKTIEMIL 2572 +ESYLV DY Q + V S ++ G ++ + LL N EG+ +++L Sbjct: 547 EESYLVQDYAQLDHVQVRKLEPSEPLLPGGSSRSSSV--PYPFQVNLLHNSEGRQEQILL 604 Query: 2573 SCPSETERERWLMVTEPPASENPDEKIYEQWDCPQVIAVHPYQALQPDELDLDIKDVVNV 2632 S S ++R RW +T E + I + + PQV Y A Q DE+ L D+V V Sbjct: 605 SSDSASDRARW--ITALTYKERQWQGITNKGELPQVEVTKAYFAKQADEITLQQADIVLV 662 Query: 2633 HRKMADGWYEGERIRDGAVGWFPSNYTKEIPS 2664 ++ DGW GER+RDG GWFP ++ I S Sbjct: 663 LQE-EDGWLHGERLRDGETGWFPESFAHSITS 693 ==> FB|FBgn0015390 - symbol:futsch "futsch" species:7227 "Drosophila melanogaster" [GO:0007409 "axonogenesis" evidence=IMP] [GO:0048813 "dendrite morphogenesis" evidence=IMP;TAS] [GO:0008017 "microtubule binding" evidence=ISS;IDA] [GO:0005875 "microtubule associated complex" evidence=ISS;IDA] [GO:0015630 "microtubule cytoskeleton" evidence=IDA] [GO:0000226 "microtubule cytoskeleton organization and biogenesis" evidence=IMP] [GO:0008582 "regulation of synaptic growth at neuromuscular junction" evidence=IMP] [GO:0007017 "microtubule-based process" evidence=ISS] [GO:0005515 "protein binding" evidence=IPI] [GO:0007399 "nervous system development" evidence=NAS] [GO:0007528 "neuromuscular junction development" evidence=NAS] EMBL:AE014298 GO:GO:0007528 GO:GO:0008017 GO:GO:0007409 GO:GO:0005875 GO:GO:0048813 EMBL:AL031128 PIR:T13564 UniGene:Dm.6254 Ensembl:CG3064 KEGG:dme:Dmel_CG3064 FlyBase:FBgn0015390 GermOnline:CG3064 InterPro:IPR009603 Pfam:PF06740 Uniprot:Q9W596 Length = 5412 Score = 84.3 bits (207), Expect = 2e-015 Identities = 231/1116 (20%), Positives = 417/1116 (37%), Gaps = 106/1116 (9%) Query: 434 DGVYGFTSTGRMSSARSSLR---KKHSNASATTGGGATAATATATAATSAGTAGNRTDES 490 + V G + S R S+ K S+ AT+ + + + S G++T Sbjct: 3137 ESVVGSIKDEKAESRRESVAESVKPESSKDATSAPPSKEHSRPESVLGSLKDEGDKTTSR 3196 Query: 491 SDEISSSASSKNSSLRKTGLRKRPSLRKNIY--RRPEWETGRSSLGVRKVLEMFEPNLHH 548 ++ S + S L + S +++ P ET R V + P Sbjct: 3197 RVSVADSIKDEKSLLVSQEASRPESEAESLKDAAAPSQETSRPESVTESVKDGKSPVASK 3256 Query: 549 GRGKRAESGDTGKPPPGRSKPKVPD-----KSEQVLQKTKDFKSKKVVSEVVEKSNRGAL 603 + A + K SK + P+ K+ + + SK + E+S R ++ Sbjct: 3257 EASRPASVAENAKDSADESKEQRPESLPQSKAGSIKDEKSPLASKDEAEKSKEESRRESV 3316 Query: 604 NEQVEEVRGDVATARTADEHVVDGYRQETKESSPVSKEAKS--------KDVSPKEAKKG 655 EQ V +V+ + E V D + +ES +SKEA KD + K ++ Sbjct: 3317 AEQFPLVSKEVSRPASVAESVKDEAEKSKEESPLMSKEASRPASVAGSVKDEAEKSKEES 3376 Query: 656 SNGITSKLHKNSPREASNAIVPSKGENLEPTEVLSDGNNSFGEMHPSHNWMDGTYDQIDL 715 ++ +EAS ++ E + + G + + Sbjct: 3377 RRESVAEKSPLPSKEASRPASVAESVKDEADKSKEESRRESGAEKSPLASKEASRPASVA 3436 Query: 716 EEPTNGKEISAVSKPNEMISSQKVLKEKEKSKSAVSKIQERLTFRSSKKVTVENTAPRKE 775 E + E S E ++ + L KE S+ + SK+ + ++ K Sbjct: 3437 ESIKDEAEKSKEESRRESVAEKSPLPSKEASRPTSVAESVKDEAEKSKEESRRDSVAEKS 3496 Query: 776 P---SEGVANHSDHDLGEDQAAYSSVEKGSNQVTEEPSPVKTSTGSNQELI--DVLPDGD 830 P E S + +D+A S E V E+ SP+ + S + + + + Sbjct: 3497 PLASKEASRPASVAESVQDEAEKSKEESRRESVAEK-SPLASKEASRPASVAESIKDEAE 3555 Query: 831 SSFGELHPSYNWTDGTYDRKYVEQAAQINAAYSSVEKGSKKVTEEPSPYNSVKASTGANQ 890 S E S + ++A++ + SV+ ++K EE S + + S A++ Sbjct: 3556 KSKEE---SRRESVAEKSPLASKEASRPTSVAESVKDEAEKSKEESSRDSVAEKSPLASK 3612 Query: 891 ELIEVLSDGESSFRELHPSYSWMDGTYDQIDLEEPTHGKEIAVASATTEMNASQKDPKEK 950 E S ES E S + + + + P KE AS + S KD EK Sbjct: 3613 EASRPASVAESVQDEAEKSKE--ESRRESVAEKSPLASKE---ASRPASVAESVKDDAEK 3667 Query: 951 EKGKSAVSKIQERLTFRSSKKVAVENAAPRKEPSEEVAILSDDDFGENHAEYSFLEKGSK 1010 K +S + E+ S KE S ++ + ++ AE S E + Sbjct: 3668 SKEESRRESVAEKSPLAS------------KEASRPASVA---ESVKDEAEKSKEESRRE 3712 Query: 1011 QVTEE-PSPHGAVQPDSSQTETVVTSPKEGKEKKRSKSTVSKIYERLTFRSSKKMAAPSE 1069 V E+ P P +S E+V ++ KE+ R +S K + +SKK + P+ Sbjct: 3713 SVAEKSPLPSKEASRPTSVAESVKDEAEKSKEESRRESVAEK-----SSLASKKASRPAS 3767 Query: 1070 RSDEVVIIRE-AEDANRKAPGLRRSFMSSIEI---PSIHPDERAVASPSPEASREES--- 1122 ++ V E +++ +R+ +S ++S E S+ + A S E SR ES Sbjct: 3768 VAESVKDEAEKSKEESRRESVAEKSPLASKEASRPASVAESVKDEAEKSKEESRRESVAE 3827 Query: 1123 -----TENDSSEQKILEAISAVSQRIDNLSKSFSDLTLTDDENTQAKR-TADAEQEEDVQ 1176 ++ S + E++ + + S+ S + + +A R T+ AE +D Sbjct: 3828 KSPLPSKEASRPTSVAESVKDEADKSKEESRRESGAEKSPLASMEASRPTSVAESVKDET 3887 Query: 1177 QVRPNASFLFRGMGSAGSRAGLDSKHASQHNIVEAVNTVVINKSLSMDDHHFPCARGETG 1236 + S S ++ L SK AS+ V KS + Sbjct: 3888 EKSKEES----RRESVTEKSPLPSKEASRPTSVAESVKDEAEKSKEESRRESVAEKSPLA 3943 Query: 1237 RMSLNERSRAQRGLEDDYEPVIQP--EEKLPSAAGSKFCSTPSITIDLSELTSKIESFVH 1294 + + ++D+ E Q E +P + ++ ++ S+ TS+ +S V Sbjct: 3944 SKESSRPASVAESIKDEAEGTKQESRRESMPESGKAESIKGDQSSL-ASKETSRPDSVVE 4002 Query: 1295 KSKRESDNIYQSIPIKSQGTSNTALLHQPEDAISVNSYESFENYESIEHELLSSTRKQNP 1354 K E++ S KSQ S +PE +++V S ++ +S H S ++P Sbjct: 4003 SVKDETEKPEGSAIDKSQVAS------RPE-SVAV----SAKDEKSPLHSRPESVADKSP 4051 Query: 1355 E---KASGEEDTYEICSPPPELPPAREDSRNDLTLPQPKRNLSSSPK----TLPKHLQVT 1407 + +AS E S P E P S DL+LP NL+ K TL + V Sbjct: 4052 DASKEASRSLSVAETASSPIEEGPR---SIADLSLP---LNLTGEAKGKLPTLSSPIDVA 4105 Query: 1408 YQSNYERIKYSKIPPRP---PKPEEVPLPPRNSSTASTGATSSAANVTLEASTSHSSSTE 1464 + ++ +K ++ PRP KP E P + ++ +S +E H++S Sbjct: 4106 -EGDFLEVK-AESSPRPAVLSKPAEFSQPDTGHTASTPVDEASPVLEEIEVVEQHTTSGV 4163 Query: 1465 QASSG-AGGDLLDKSPHRQERI---YEENIYDTIRS 1496 A+ A DLLD + + E + E +++T+ S Sbjct: 4164 GATGATAETDLLDLTETKSETVTKQSETTLFETLTS 4199 Score = 62.0 bits (149), Expect = 1e-008 Identities = 262/1351 (19%), Positives = 485/1351 (35%), Gaps = 168/1351 (12%) Query: 311 GGQDEPARNVTVPVQ-----EPPKDVLEKLPPIPNT-STPVTTPARQ------------- 351 G D+P V V+ +PPK + KL S+P TTPA + Sbjct: 675 GKADKPRAEVKPVVRSRIDTKPPKSMDRKLAKRDEKKSSPTTTPAARAPVAQNAKPKVLS 734 Query: 352 -PSTSSLGRKGNTPTRKISFMNNISPYNRKLLACNGTKVAALTSKFNQMIQQDAGLLAQV 410 P+T S +TP + NN K A + ++ + + +V Sbjct: 735 RPATKS--SPSSTPAKSAKEANNRKVLESKQQAARVQATSTVSRRVTSTASE-----RRV 787 Query: 411 QKRGGYLHKCGNVAYKVIEDPGSDGVYGFTSTGRMSSARSSLRKKHSNAS-----ATTGG 465 Q++ P S G + + R + S +++ A+ G Sbjct: 788 QQQAEAKTAATGATQATQRKPISRRPRGVSPSKRAPAPGSPVKQAKPKAADLKKTRLDKG 847 Query: 466 GATAATATATAATSAGTAGNRTDE--SSDEISSSASSKNSSLRKTGLRKRPSLRKNIYRR 523 G T ++ +T + TA + + +S E+ + + L++ + + R Sbjct: 848 GTTDSSLVSTPSADEATAAKKLQDLTASQELDAEKQRELDDLKE---------EQEVVRE 898 Query: 524 PEWETGRSSLGVRKVLEMFEPNLHHGRGKRAESGDTGKPPPGRSKPKVPDKSEQVLQKTK 583 E R + R+ + + L R AE G+ P + + + E+V Q T+ Sbjct: 899 IEAVFSRDEMK-RQQHQQIKAEL---REMPAEGTGDGENEPDEEEEYLIIEKEEVEQYTE 954 Query: 584 DF----KSKKVVSEVVEKSNRGALNEQVEEVRGDVATARTADEHVVDGYRQETKESSPVS 639 D +S E ++K R + + + + A V R+ E + Sbjct: 955 DSIVEQESSMTKEEEIQKHQRDSQESEKKRKKSAEEEIEAAIAKVEAAERKARLEGASAR 1014 Query: 640 KEAKSKDVSPKEAK---KGSNGITSKLHKNSPREASNAIVPSKGENLEPTEVLSDGNNSF 696 ++ DV P+++K + + I + R P++ E PT Sbjct: 1015 QDESELDVEPEQSKIKAEVQDIIATAKDIAKSRTEEQLAKPAEEELSSPTP--------- 1065 Query: 697 GEMHPSHNWMDGTYDQIDLEE---PTNGKEISAVSKPNEMISS----QKVLKEKEKSKSA 749 E S D DQI P N +E K + I S L E E+ Sbjct: 1066 -EEKLSKKTSDTKDDQIGAPVDVLPVNLQESLPEEKFSATIESGATTAPTLPEDERIPLD 1124 Query: 750 VSK----IQERLTFRSSKK-----VTVENTAPRKEPS--EGVANHSDHDLGEDQAAYSSV 798 K I+E+ +K+ V T P P + + + D +D A + Sbjct: 1125 QIKEDLVIEEKYVKEETKEAEAIVVATVQTLPEAAPLAIDTILASATKDAPKDANAEALG 1184 Query: 799 EKGSNQVTEEPSPVKTSTGSNQELI-DVLPDGDSSFGELHPSYNWTD-GTYDRKYVEQAA 856 E + E P+K + + Q L+ DV+ D +L P + D G Y++ + A Sbjct: 1185 ELPDSG--ERVLPMKMTFEAQQNLLRDVIKTPDE-VADL-PVHEEADLGLYEKDSQDAGA 1240 Query: 857 Q-INAAYSSVEKGSKKVTEEPSPYNSVKASTGANQ-ELIEVLSDGESSFRELHPSYSWMD 914 + I+ S ++ + E+ + ++ N+ ++ VL + S +E+ ++ Sbjct: 1241 KSISHKEESAKEEKETDDEKENKVGEIELGDEPNKVDISHVLL--KESVQEVAEKVVVIE 1298 Query: 915 GTYDQIDLEEPTHGKEIAVASATTEMNASQKDPKEKEK-----------GKSAVSKIQER 963 T ++ EE + ++ KD +E E+ K + S +E+ Sbjct: 1299 TTVEKKQ-EEIVEATTVITQENQEDLMEQVKDKEEHEQKIESGIITEKEAKKSASTPEEK 1357 Query: 964 LT--FRSSKKVAVENAAPRKEPSEEVAILSDDDFGENHA---EYSFLEKGSKQVTEEP-- 1016 T S ++ + A P P + D E+ E +E +KQ ++P Sbjct: 1358 ETSDITSDDELPAQLADPTTVPPKSAKDREDTGSIESPPTIEEAIEVEVQAKQEAQKPVP 1417 Query: 1017 SPHGAVQPD--------SSQTETVVTSPKEGKEKKRSKSTVSKIYERLTFRSSKKMAAPS 1068 +P A++ + +S+ E+ S KE E+ +SK + + K A Sbjct: 1418 APEEAIKTEKSPLASKETSRPESATGSVKEDTEQTKSKKSPVPSRPESEAKDKKSPFASG 1477 Query: 1069 ERSDEVVIIREAEDANRKAPGLRRSFMSSIEIPSIHPDERAVASPSPEASREESTENDSS 1128 E S + +D KA R S I H DE ++ + SR ES Sbjct: 1478 EASRPESVAESVKDEAGKAESRRES------IAKTHKDESSLDKAKEQESRRESLAESIK 1531 Query: 1129 EQKILEAISAVSQRIDNLSKSFSDLTLTDDENTQAKRTADAEQEEDVQQVRPNASFLFRG 1188 + ++ SA++ + + +S +D + + AE +D + P+ G Sbjct: 1532 PESGIDEKSALASKEASRPESVTDKSKEPSRRESIAESLKAESTKDEKSAPPSKEASRPG 1591 Query: 1189 --MGSAGSRAGLDSKHASQHNIVEAVNTVVINKSLSMDDHHFPCARGETGR--------M 1238 + S + + + +I E+ + + +S + + E+ + + Sbjct: 1592 SVVESVKDETEKSKEPSRRESIAESAKPPIEFREVSRPESVIDGIKDESAKPESRRDSPL 1651 Query: 1239 SLNERSRAQRGLEDDYEPVIQPEEKLPSAAGSKFCSTPSITIDLSELTSKIESFVHKSKR 1298 + E SR + LE + I+ EK + ++ S + S LTSK + + + Sbjct: 1652 ASKEASRPESVLESVKDEPIKSTEKSRRESVAESFKADSTKDEKSPLTSK---DISRPES 1708 Query: 1299 ESDNIYQSI--PIKSQGTSNTAL--LHQPEDAISVNSYESFENYESIEHELLSSTRKQNP 1354 +N+ ++ +SQ S TA + +PE +++ + + + ES+ ++ ++ Sbjct: 1709 AVENVMDAVGSAERSQPESVTASRDVSRPE-SVAESEKDDTDKPESVVESVIPASDVVEI 1767 Query: 1355 EKASGEED-----TYEICSP-PPELPPAREDSRNDLTLPQPKRNLSSSPKTLPKHLQVTY 1408 EK + +++ + EI P P +R + P+ +R SS+ LP H + Sbjct: 1768 EKGAADKEKGVFVSLEIGKPDSPSEVISRPGPVVESVKPESRRE-SSTEIVLPCHAE--- 1823 Query: 1409 QSNYERIKYSKIPPRPPKPEEVPLPPRNSSTASTGATSSAANVTLEASTSHSSSTEQASS 1468 SK P RP E ST S A + +S E A Sbjct: 1824 --------DSKEPSRPESKVECLKDESEVLKGSTRRESVAESDKSSQPFKETSRPESAVG 1875 Query: 1469 GAGGDLLDKSPHRQERIYE--ENIYDTIRSADGVD-YDDPACGSAELD-PMQTTQ---PG 1521 + + K P R+E + + +T R A + D A EL P TTQ G Sbjct: 1876 SMKDESMSKEPSRRESVKDGAAQSRETSRPASVAESAKDGADDLKELSRPESTTQSKEAG 1935 Query: 1522 GIRVGLSSRARQQPSPPADNVSLVSSNCYES 1552 I+ S A ++ S PA V +S Sbjct: 1936 SIKDEKSPLASEEASRPASVAESVKDEAEKS 1966 Score = 57.8 bits (138), Expect = 2e-007 Identities = 369/1902 (19%), Positives = 659/1902 (34%), Gaps = 246/1902 (12%) Query: 449 RSSLRKKHSNASATTGGGATAATATATAATSAGTAGNRTDESSDEISSSASSKNSSLRKT 508 +S L K ++ A+ + T + ++ S E S AS S + Sbjct: 2200 KSPLPSKEASRPASVAESIKDEAEKSKEETRRESVAEKSPLPSKEASRPASVAESIKDEA 2259 Query: 509 GLRKRPSLRKNIYRR---PEWETGRSSLGVRKVLEMFEPNLHHGRGKR-AESGDTGKPPP 564 K S R++ + P E R + V + + + R + AESG Sbjct: 2260 EKSKEESRRESAAEKSPLPSKEASRPASVAESVKDEADKSKEESRRESMAESGKAQSIKG 2319 Query: 565 GRSKPKVPDKSEQVLQKTKD--FKSKK------VVSEVVEKSNRGALN--EQVEEVRGDV 614 +S K + E V + KD KSK+ V V S R + E R + Sbjct: 2320 DQSPLKEVSRPESVAESVKDDPVKSKEPSRRESVAGSVTADSARDDQSPLESKGASRPES 2379 Query: 615 ATARTADEHVVDGYRQETKESSPVSKEAKSKDVSPKEAKKGSNGITSKLHKNSPREASNA 674 DE R+E+K S + +AK D SPKE + + +T + +++ + + Sbjct: 2380 VVDSVKDEAEKQESRRESKTESVIPPKAKD-DKSPKEVLQPVS-MTETIREDADQPMKPS 2437 Query: 675 IVPSKGENLEPTEVLSDGNNSFGEMHPSHNWMDGTYDQ---IDLEEPTNGKEISAV--SK 729 S+ E++ + S + + G+ + DL++P K+ + S+ Sbjct: 2438 QAESRRESIAESIKASSPRDEKSPLASKEASRPGSVAESIKYDLDKPQIIKDDKSTEHSR 2497 Query: 730 PNEMISSQKVLKEKEKSK--SAVSKIQERLTFRSSKKVTVENTAPRKEPSEG-VANHSDH 786 + V EK S+ S S + + K ++ +P+ + G VA Sbjct: 2498 RESLEDKSAVTSEKSVSRPLSVASDHEAAVAIEDDAKSSI---SPKDKSRPGFVAETVSS 2554 Query: 787 DLGEDQAAYSSVEKGSNQVTEEPS-PVKTSTGSNQELIDVLPDGDSSFGEL-HPSYNWTD 844 + E +S +E V E+ S + GS +L D + G+ H + + Sbjct: 2555 PIEEATMEFSKIE-----VVEKSSLALSLQGGSGGKLQTDSSPVDVAEGDFSHAVASVST 2609 Query: 845 GTYDRKYVEQAAQINAAYSSVEKGSKKVTEEPSPYNSVKASTGANQELIEVLSDGESSFR 904 T + AQI AA +V + PS + + + E ++ + S + Sbjct: 2610 VTPTLTKPAELAQIGAA-KTVSSPLDEALRTPSAPEHISRADSPAECASEEIASQDKSPQ 2668 Query: 905 ELHPSY--SWMDGTYDQI--------DLEEPTHGKEI-----AVASATTEMNASQKDPKE 949 L S +W+ + D DL P EI A +A++ + + KD E Sbjct: 2669 VLKESSRPAWVAESKDDAAQLKSSVEDLRSPVASTEISRPASAGETASSPIEEAPKDFAE 2728 Query: 950 KEKGKSAVSKIQERL-----TFRSSKKVA----VENAAPRKEP---SEEVAILSDDDF-- 995 E+ + AV + L T S VA + + P P S + A LS D Sbjct: 2729 FEQAEKAVLPLTIELKGNLPTLSSPVDVAHGDFPQTSTPTSSPTVASVQPAELSKVDIEK 2788 Query: 996 -------------------------GENHAEYSFLEKGSKQVTEEPSPHGAVQPDSSQ-- 1028 E+ + + + SK + PS + + DS++ Sbjct: 2789 TASSPIDEAPKSLIGCPAEERPESPAESAKDAAESVEKSKDASRPPSVVESTKADSTKGD 2848 Query: 1029 ----TETVVTSPKEGKEKKRSKSTVSKIYERLTFRSSKKMAAPSERSDEVVIIREAEDAN 1084 E+V+ PK+ EK + S + +T S+K ++ P+ ++ +D + Sbjct: 2849 ISPSPESVLEGPKDDVEKSKESSRPPSVSASITGDSTKDVSRPAS------VVESVKDEH 2902 Query: 1085 RKAPGLRRSFM-------------SSIEIPSIHPDERAVASPSPEASREESTENDSSE-- 1129 KA R S S DE++ + S EASR ES S + Sbjct: 2903 DKAESRRESIAKVESVIDEAGKSDSKSSSQDSQKDEKSTLA-SKEASRRESVVESSKDDA 2961 Query: 1130 ---QKILEAISAVSQRIDNLSKSFSDLTLTDDENTQAKRTADAEQEEDVQQVRPNASFLF 1186 + E++ A + + SKS D T + + + AE E+ QQ R Sbjct: 2962 EKSESRPESVIASGEPVPRESKSPLDSKDTSRPGSMVE-SVTAEDEKSEQQSRRE----- 3015 Query: 1187 RGMGSAGSRAGLDSKHASQHNIVEAVNTVVINKSLSMDDHHFPCARGETGRMSLNERSRA 1246 S D+K + EA +++ L DD + E+ R S+ +A Sbjct: 3016 ----SVAESVKADTKKDGKSQ--EASRPSSVDELLKDDDE-----KQESRRQSITGSHKA 3064 Query: 1247 QRGLEDDYEPVIQPEEKLPSAAGSKFCSTP-SITIDLSELTSKIESFVHKSKRES--DNI 1303 + D E + A SK S P S+ + +K E S+R+S ++I Sbjct: 3065 MSTMGD--------ESPMDKADKSKEPSRPESVAESIKHENTKDEESPLGSRRDSVAESI 3116 Query: 1304 YQSIPIKSQGTSNTALLHQPEDAISVNSYESFENYESIEHELLSSTRKQNPEKASGEEDT 1363 I + + + +PE + SI+ E S R+ E E Sbjct: 3117 KSDITKGEKSPLPSKEVSRPESVVG-----------SIKDEKAESRRESVAESVKPESS- 3164 Query: 1364 YEICSPPPELPPAREDSRNDLTLPQPKRNLSSSPKTLPKHLQVTYQSNYERIKYSKIPPR 1423 PP++E SR + L K KT + + V E+ Sbjct: 3165 ----KDATSAPPSKEHSRPESVLGSLK---DEGDKTTSRRVSVADSIKDEKSLLVSQEAS 3217 Query: 1424 PPKPEEVPLPPRNSSTASTGATSSAANVTLEASTSHSSSTEQASSGAGGDLLDKSPHRQE 1483 P+ E L + + T S + + +S + + D + +E Sbjct: 3218 RPESEAESLKDAAAPSQETSRPESVTESVKDGKSPVASKEASRPASVAENAKDSADESKE 3277 Query: 1484 RIYEENIYDTIRSADGVDYDDPACGSAELDPMQTTQPGGIRVGLSSR---ARQQPSPPAD 1540 + E ++ + D A D + ++ R ++ + ++ S PA Sbjct: 3278 QRPE-----SLPQSKAGSIKDEKSPLASKDEAEKSKEESRRESVAEQFPLVSKEVSRPAS 3332 Query: 1541 NVSLVSSNCYESIGLRLEYERSMMLARRNLAGGSTTTLASDQITNSL-YGVTAGLASLTP 1599 V +S E S ++++ S D+ S +A +P Sbjct: 3333 VAESVKDEAEKS------KEESPLMSKEASRPASVAGSVKDEAEKSKEESRRESVAEKSP 3386 Query: 1600 -PSERGSDTSNSA----DWTDISDEDETGERADVTTAMATGGSKRPNFI---VVRERKRT 1651 PS+ S ++ A D D S E+ E + +A+ + RP + + E +++ Sbjct: 3387 LPSKEASRPASVAESVKDEADKSKEESRRESGAEKSPLASKEASRPASVAESIKDEAEKS 3446 Query: 1652 HQTPLRSRKLARISHPKIDDDSDHHYESLYSIGSNDGRHQHQHDANYTTLPPHVDGSLLS 1711 + R + P + + + + + D+ P + Sbjct: 3447 KEESRRESVAEKSPLPSKEASRPTSVAESVKDEAEKSKEESRRDSVAEKSPLASKEASRP 3506 Query: 1712 GNAASGVNFHEHRAGGGGGDASAAMLLP--------PDDEFDSFDSDDTDYEDEDDDRNR 1763 + A V ++ S A P P +S D+ + E+ R Sbjct: 3507 ASVAESVQDEAEKSKEESRRESVAEKSPLASKEASRPASVAESI-KDEAEKSKEESRRES 3565 Query: 1764 ARTDSGVDIRNAKLPDPPPSSSQVYVLVQKIKNLGTLSEIAKSFHKLSKKKGTKGATTAT 1823 S + + A P S V +K K + +A+ L+ K+ ++ A+ A Sbjct: 3566 VAEKSPLASKEASRPTSVAES--VKDEAEKSKEESSRDSVAEK-SPLASKEASRPASVAE 3622 Query: 1824 GA--GAGGGTYENTSSNVSGNVPKAPGTAGFSPADGATRKKSKSTKSLRSKLRKSLVSDS 1881 A E+ +V+ P A A PA A K + KS R+S+ S Sbjct: 3623 SVQDEAEKSKEESRRESVAEKSPLASKEAS-RPASVAESVKDDAEKSKEESRRESVAEKS 3681 Query: 1882 TSLNIGSSFNGSRSTFYVTSAD---VDSGIFNGSDGCLNPS-----ASSVSQS-QEMPTK 1932 + +S S + A+ +S + ++ PS +SV++S ++ K Sbjct: 3682 PLASKEASRPASVAESVKDEAEKSKEESRRESVAEKSPLPSKEASRPTSVAESVKDEAEK 3741 Query: 1933 SAEDNRRKSIA--SATGTTGHGRPTIPPPPPPAEAGKRTAASSSVSPLLAASNSKSVSKK 1990 S E++RR+S+A S+ + RP EA K S S A S SK+ Sbjct: 3742 SKEESRRESVAEKSSLASKKASRPASVAESVKDEAEKSKEESRRES---VAEKSPLASKE 3798 Query: 1991 LGATSWYAECGVFKQPHSFGTGSDQSLSNGKGDGSISPRSSLPPKDGG-PTGAGPGGGTG 2049 + AE S +++S + + S++ +S LP K+ PT Sbjct: 3799 ASRPASVAE--------SVKDEAEKSKEESRRE-SVAEKSPLPSKEASRPTSVAESVKDE 3849 Query: 2050 GGGGNDRTLTSNGHTSASSWYADIYQTSGASVASSSESSGVSTGGEGGPGDDHSHSMFVN 2109 + + +G + S A + + SVA S V E + S+ Sbjct: 3850 ADKSKEESRRESG--AEKSPLASMEASRPTSVAES-----VKDETEKSKEESRRESVTEK 3902 Query: 2110 EPLYQIYNAAKLESITRDIDAEISGRSEAELYDDGYEK--IAERNRRRKTGGA----GEQ 2163 PL A++ S+ + E E + EK +A + R A E Sbjct: 3903 SPL-PSKEASRPTSVAESVKDEAEKSKEESRRESVAEKSPLASKESSRPASVAESIKDEA 3961 Query: 2164 EGAEEGDEGGCSSSSGSSSTDGDDRGDDSSMHLRKPSRPTAL 2205 EG ++ SG + + +GD SS+ ++ SRP ++ Sbjct: 3962 EGTKQESRRESMPESGKAES---IKGDQSSLASKETSRPDSV 4000 Score = 57.8 bits (138), Expect = 2e-007 Identities = 268/1431 (18%), Positives = 496/1431 (34%), Gaps = 207/1431 (14%) Query: 19 PKKESSQPQD-TRKVSSFIQRFYLFGNSP-STPHGAEAEPEAPKVKKTKVSNQQTTGDTQ 76 P +E+S+P+ T V G SP ++ + A K + +++ ++ Sbjct: 3232 PSQETSRPESVTESVKD--------GKSPVASKEASRPASVAENAKDSADESKEQRPESL 3283 Query: 77 PNSKSAATARPGSTP--STDGTVSSSSEPSEELHPVQYPSYSVQRLRQFWNNRLLSNQQP 134 P SK A + + +P S D S E E Q+P S + R + ++ Sbjct: 3284 PQSK-AGSIKDEKSPLASKDEAEKSKEESRRESVAEQFPLVSKEVSRPASVAESVKDEAE 3342 Query: 135 TGSSIDTLVRKAKS---ATIGAPTGAAART--------VLRKSPSPKATTRFQRNGSITR 183 L+ K S + G+ A ++ V KSP P R S+ Sbjct: 3343 KSKEESPLMSKEASRPASVAGSVKDEAEKSKEESRRESVAEKSPLPSKEA--SRPASVAE 3400 Query: 184 SGRRRFGTLDSSESVRSGLDVNLQRSAQPPKRSSHAALLSPDREAQRTLVEKRPCVGSTP 243 S + SG + + S + + +S A + + E + + +P Sbjct: 3401 SVKDEADKSKEESRRESGAEKSPLASKEASRPASVAESIKDEAEKSKEESRRESVAEKSP 3460 Query: 244 VTAGPSARESFPLAVSTPNGSQIHWARRTELLGIRALTQEEKKQSAKMPLRVENYVNSYI 303 + PS S P +V+ + A +++ R E+ ++K R + S Sbjct: 3461 L---PSKEASRPTSVAESVKDE---AEKSKEESRRDSVAEKSPLASKEASRPASVAESVQ 3514 Query: 304 DVDIQSVGGQDEPARNVTVPVQEPPKDVLEKLPPIPNTSTPVTTPARQPSTSSLGRKGNT 363 D ++ ++E R + V EK P ++ + A S K Sbjct: 3515 D---EAEKSKEESRR----------ESVAEKSPLASKEASRPASVAE--SIKDEAEKSKE 3559 Query: 364 PTRKISFMNNISPYNRKLLACNGTKVAALTSKFNQMIQQDAGLLAQVQKRGGYLHKCGNV 423 +R+ S SP +K A+ + + ++ +A + R K + Sbjct: 3560 ESRRESVAEK-SPL--------ASKEASRPTSVAESVKDEAEKSKEESSRDSVAEK-SPL 3609 Query: 424 AYKVIEDPGS--DGVYGFTSTGRMSSARSSLRKKHSNASATTGGGATAATATATAATSAG 481 A K P S + V + S R S+ +K AS A+ A + A + Sbjct: 3610 ASKEASRPASVAESVQDEAEKSKEESRRESVAEKSPLASKEASRPASVAESVKDDAEKSK 3669 Query: 482 TAGNRTDES------SDEISSSASSKNSSLRKTGLRKRPSLRKNIYRR---PEWETGRSS 532 R + S E S AS S + K S R+++ + P E R + Sbjct: 3670 EESRRESVAEKSPLASKEASRPASVAESVKDEAEKSKEESRRESVAEKSPLPSKEASRPT 3729 Query: 533 LGVRKVLEMFEPNLHHGRGKRAESGDTGKPPPGRSKPKVPDKSEQVLQKTKDFKSKKVVS 592 V + E + R + + V + + +K+K+ ++ V+ Sbjct: 3730 SVAESVKDEAEKSKEESRRESVAEKSSLASKKASRPASVAESVKDEAEKSKEESRRESVA 3789 Query: 593 EVVEKSNRGALNEQ--VEEVRGDVATARTADEHVVDGYRQETKESSPVSKEAKSKDVSPK 650 E +++ A E V+ + A++ + R+ E SP+ + S+ S Sbjct: 3790 EKSPLASKEASRPASVAESVKDE------AEKSKEESRRESVAEKSPLPSKEASRPTSVA 3843 Query: 651 EAKKGSNGITSKLHKNSPREASNAIVP-SKGENLEPTEVLSDGNNSFGEMHPSHNWMDGT 709 E+ K K + S RE+ P + E PT V + E S + Sbjct: 3844 ESVKDE---ADKSKEESRRESGAEKSPLASMEASRPTSVAESVKD---ETEKSKE--ESR 3895 Query: 710 YDQIDLEEPTNGKEISAVSKPNEMISSQKVLKEKEKSKSAVSKIQERLTFRSSKKVTVEN 769 + + + P KE S+P + S K EK K +S + E+ S + + Sbjct: 3896 RESVTEKSPLPSKE---ASRPTSVAESVKDEAEKSKEESRRESVAEKSPLASKESSRPAS 3952 Query: 770 TAPR-KEPSEGVANHSDHD----------LGEDQAAYSSVE-----------KGSNQVTE 807 A K+ +EG S + + DQ++ +S E K + E Sbjct: 3953 VAESIKDEAEGTKQESRRESMPESGKAESIKGDQSSLASKETSRPDSVVESVKDETEKPE 4012 Query: 808 EPSPVKTSTGSNQELIDVLPDGDSSFGELHPSYNWTDGTYDR-----KYVEQAAQI-NAA 861 + K+ S E + V S+ E P ++ + D+ K ++ + A Sbjct: 4013 GSAIDKSQVASRPESVAV-----SAKDEKSPLHSRPESVADKSPDASKEASRSLSVAETA 4067 Query: 862 YSSVEKGSKKVTEEPSPYNSVKASTGANQELIEVLSDGESSFREL--------------- 906 S +E+G + + + P N + G L + E F E+ Sbjct: 4068 SSPIEEGPRSIADLSLPLNLTGEAKGKLPTLSSPIDVAEGDFLEVKAESSPRPAVLSKPA 4127 Query: 907 --------HPSYSWMDGT---YDQIDLEEPTHGKEIAVASATTEMNASQ-KDPKEKEKGK 954 H + + +D ++I++ E + AT E + + K + K Sbjct: 4128 EFSQPDTGHTASTPVDEASPVLEEIEVVEQHTTSGVGATGATAETDLLDLTETKSETVTK 4187 Query: 955 SAVSKIQERLTFRSSKKVAVENAAPR-------------------------KEPSE---E 986 + + + E LT + KV V ++ + K+ SE E Sbjct: 4188 QSETTLFETLTSKVESKVEVLESSVKQVEEKVQTSVKQAETTVTDSLEQLTKKSSEQLTE 4247 Query: 987 VAILSDDDFGENH---AEYSFLEKGSKQVTEEPSPHGAVQPDSSQTETVVTSPKEGKEKK 1043 + + D +F E A+ + + K K +T+ Q + T T + K + Sbjct: 4248 IKSVLDTNFEEVAKIVADVAKVLKSDKDITDIIPDFDERQLEEKLKSTADTEEESDKSTR 4307 Query: 1044 RSKSTVSKIYERLTFRSSKKMAAPSERSDEVVIIREAEDANRKAPGLRRSFMSSIEIPSI 1103 KS +I ++ S K ++P ++S + I + + + LR+ ++S S+ Sbjct: 4308 DEKSL--EISVKVEIESEK--SSPDQKSGPISIEEKDKIEQSEKAQLRQGILTSSRPESV 4363 Query: 1104 HPDERAVASPSPEASREESTENDSSEQKILE-------AISAVSQRIDNLSKSFSDL--- 1153 +V SPS A+ E E + SE E S VS++ S+ S Sbjct: 4364 ASQPESVPSPSQSAASHEHKEVELSESHKAEKSSRPESVASQVSEKDMKTSRPASSTSQF 4423 Query: 1154 -TLTDDENTQAKRTADAEQEEDVQQVRPNASFLFRGMGSAGSRAGLDSKHASQHNIVEAV 1212 T DE T E V+ + F + ++ +++ + S S + E Sbjct: 4424 STKEGDEETTESLLHSLTTTETVETKQMEEKSSFESVSTSVTKSTVLSSQ-STVQLREES 4482 Query: 1213 NTVVINKSLSMDD----HHFPCARGETGRMSLNERSRAQRGLEDDYEPVIQPEEKLPSAA 1268 + ++ SL ++D E G ++ N + ED Q EE L Sbjct: 4483 TSESLSSSLKVEDSSRRESLSSLLAEKGGIATNTSLK-----EDTSASASQLEELL---V 4534 Query: 1269 GSKFCSTPSITIDLSELTSKIESFVHKSKRESDNIYQSIPIKSQGTSNTAL 1319 S+ CS+ SI ++ ++ + K RE+ Q S T + +L Sbjct: 4535 QSEECSSESIVSEIQTSIAQKSNKEIKDARETKVTSQFTTTTSSATKDDSL 4585 Score = 57.4 bits (137), Expect = 2e-007 Identities = 167/833 (20%), Positives = 293/833 (35%), Gaps = 118/833 (14%) Query: 483 AGNRTDESSDEISSSASSKNSSLRKTGLRKRPSLRKNIYRRPEWETGR--SSLGVRKVLE 540 A + + S E S + K R+ + +P ET R S++G K Sbjct: 1822 AEDSKEPSRPESKVECLKDESEVLKGSTRRESVAESDKSSQPFKETSRPESAVGSMKDES 1881 Query: 541 MF-EPNLHHG-RGKRAESGDTGKPPPGRSKPKVPDKSEQVLQKTKDFKSKKVVSEVVEKS 598 M EP+ + A+S +T +P +E D K + Sbjct: 1882 MSKEPSRRESVKDGAAQSRETSRPA---------SVAESAKDGADDLKELSRPESTTQSK 1932 Query: 599 NRGALNEQVEEVRGDVATARTADEHVVDGYRQETKESSPVSKEAKSKDVSPKEAKKGSNG 658 G++ ++ + + A+ + V +++KE S A+ + KEA + ++ Sbjct: 1933 EAGSIKDEKSPLASEEASRPASVAESVKDEAEKSKEESRRESVAEKSPLPSKEASRPASV 1992 Query: 659 ITS------KLHKNSPRE--ASNAIVPSKGENLEPTEVLSDGNNSFGEMHPSHNWMDGTY 710 S K + S RE A + +PSK E + S + E S + Sbjct: 1993 AESIKDEAEKSKEESRRESVAEKSPLPSK----EASRPASVAESIKDEAEKSKE--ESRR 2046 Query: 711 DQIDLEEPTNGKEISAVSKPNEMISSQKVLKEKEKSKSAVSKIQERLTFRSSKKVTVENT 770 + + + P KE S+P + S K EK K +S + E+ + Sbjct: 2047 ESVAEKSPLPSKE---ASRPASVAESIKDEAEKSKEESRRESVAEK------------SP 2091 Query: 771 APRKEPSEGVANHSDHDLGEDQAAYSSVEKGSNQVTEE-PSPVKTSTGSNQELIDVLPDG 829 P KE S S + +D+A S E V E+ P P K ++ + + Sbjct: 2092 LPSKEASRPA---SVAESIKDEAEKSKEESRRESVAEKSPLPSKEASRPASVAESIKDEA 2148 Query: 830 DSSFGELHPSYNWTDGTYDRKYVEQAAQI-----NAAYSSVEKGSKKVTEEPSPYNSVKA 884 + S E K + A + + A S E+ ++ E SP S +A Sbjct: 2149 EKSKEESRRESVAEKSPLPSKEASRPASVAESIKDEAEKSKEESRRESVAEKSPLPSKEA 2208 Query: 885 STGANQELIEVLSDGESSFRELHPSYSWMDGTYDQIDLEEPTHGKEIAVASATTEMNASQ 944 S A+ + E + D +E + + + + P KE AS + S Sbjct: 2209 SRPAS--VAESIKDEAEKSKE--------ETRRESVAEKSPLPSKE---ASRPASVAESI 2255 Query: 945 KDPKEKEKGKSAVSKIQERLTFRSSKKVAVENAAPRKEPSEEVAILSD-----DDFGENH 999 KD EK K +S + A ++ P KE S ++ D E Sbjct: 2256 KDEAEKSKEES------------RRESAAEKSPLPSKEASRPASVAESVKDEADKSKEES 2303 Query: 1000 AEYSFLEKGSKQ-VTEEPSPHGAVQPDSSQTETVVTSPKEGKEKKRSKSTVSKIYERLTF 1058 S E G Q + + SP V S E+V P + KE R +S + T Sbjct: 2304 RRESMAESGKAQSIKGDQSPLKEVSRPESVAESVKDDPVKSKEPSRRESVAGSV----TA 2359 Query: 1059 RSSKKMAAPSE---RSDEVVIIREAEDANRKAPGLRRSFMSSIEIPSIHPDERAVASPSP 1115 S++ +P E S ++ +D K R S S+ P D+ P Sbjct: 2360 DSARDDQSPLESKGASRPESVVDSVKDEAEKQESRRESKTESVIPPKAKDDKSPKEVLQP 2419 Query: 1116 EASREESTENDSSEQKILEAISAVSQRIDNLSKSFSDLTLTDDENTQAKRTADAEQEEDV 1175 + E E+ K +A S R +++++S + D+++ A + A Sbjct: 2420 VSMTETIREDADQPMKPSQAES----RRESIAESIKASSPRDEKSPLASKEAS------- 2468 Query: 1176 QQVRPNASFLFRGMGSAGSRAGLDSKHASQHNIVEAVNTVVINKSLSMDDHHFPCARGET 1235 RP GS A + I++ + ++ S++D + Sbjct: 2469 ---RP------------GSVAESIKYDLDKPQIIKDDKSTEHSRRESLEDKSAVTSEKSV 2513 Query: 1236 GR-MSLNERSRAQRGLEDDYEPVIQPEEKLPSAAGSKFCSTP--SITIDLSEL 1285 R +S+ A +EDD + I P++K ++ S+P T++ S++ Sbjct: 2514 SRPLSVASDHEAAVAIEDDAKSSISPKDKSRPGFVAETVSSPIEEATMEFSKI 2566 Score = 41.6 bits (96), Expect = 0.014 Identities = 108/576 (18%), Positives = 216/576 (37%), Gaps = 69/576 (11%) Query: 583 KDFKSKKVVSEVVEKSNRGALNEQVEEVRGDVATARTADEHVVDGYRQET-KESSPVSKE 641 +D K+K+ + + A + + D EH D +T E++P +E Sbjct: 546 QDNKAKEAAAAAAAAAAAAASAATIARAKADSMDTDAEPEHEADPEPADTGDEAAPTEQE 605 Query: 642 AKSK-----DVSPKEAKKGSNGITSKLHK--NSPREASNAIVPSKGENLEPTEVLSDGNN 694 +++ + P+ + G K+ P++A+ A++ + G+ + + S Sbjct: 606 PEAETEPEPEHEPEAEQDKDVGEEKKVEVLIMKPQQATPAVIAASGK--DGVDAASADAT 663 Query: 695 SFGEMHPSHNWMDGTYDQIDLE-EPTNGKEISAVSKPNEMISSQKVLKEKEKSKSAVSKI 753 G++ + G D+ E +P I +KP + + + ++++KS + Sbjct: 664 PTGKLSKAS--AKGKADKPRAEVKPVVRSRID--TKPPKSMDRKLAKRDEKKSSPTTTPA 719 Query: 754 QERLTFRSSKKVTVENTAPRKEPSEGVANHSDHDLGEDQAAYSSVEKGSNQVTEEPSPVK 813 +++K + A + PS A S + + S + Q T S Sbjct: 720 ARAPVAQNAKPKVLSRPATKSSPSSTPAK-SAKEANNRKVLESKQQAARVQATSTVSRRV 778 Query: 814 TSTGSNQELIDVLPDGDSSFGELHPSYNWTDGTYDRKYVEQAAQINAAYSSVEKGSKKVT 873 TST S + + ++ G QA Q S +G Sbjct: 779 TSTASERRVQQQAEAKTAATG-----------------ATQATQ-RKPISRRPRGVSPSK 820 Query: 874 EEPSPYNSVKASTGANQELIEV-LSDGESSFRELHPSYSWMDGTYDQIDLEEPTHGKEIA 932 P+P + VK + +L + L G ++ L + S +E T K++ Sbjct: 821 RAPAPGSPVKQAKPKAADLKKTRLDKGGTTDSSLVSTPS----------ADEATAAKKLQ 870 Query: 933 VASATTEMNASQK----DPKEKEKGKSAVSKIQERLTFRSSKKVAVENAAPRKEPSEEVA 988 +A+ E++A ++ D KE+++ + + R + + ++ A R+ P+E Sbjct: 871 DLTASQELDAEKQRELDDLKEEQEVVREIEAVFSRDEMKRQQHQQIK-AELREMPAEGTG 929 Query: 989 ILSDDDFGENHAEYSFLEKGSKQVTEEPSPHGAVQPDSSQT--ETVVTSPKEGKE--KKR 1044 ++ + EY +EK + E+ + V+ +SS T E + ++ +E KKR Sbjct: 930 --DGENEPDEEEEYLIIEK---EEVEQYTEDSIVEQESSMTKEEEIQKHQRDSQESEKKR 984 Query: 1045 SKSTVSKIYERLT----FRSSKKMAAPSERSDEVVIIREAEDANRKAP------GLRRSF 1094 KS +I + ++ S R DE + E E + KA + Sbjct: 985 KKSAEEEIEAAIAKVEAAERKARLEGASARQDESELDVEPEQSKIKAEVQDIIATAKDIA 1044 Query: 1095 MSSIEIPSIHPDERAVASPSPEASREESTENDSSEQ 1130 S E P E ++SP+PE + T + +Q Sbjct: 1045 KSRTEEQLAKPAEEELSSPTPEEKLSKKTSDTKDDQ 1080 ==> UNIPROT|Q9NZW4 - symbol:DSPP_HUMAN "DSPP: Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein" species:9606 "Homo sapiens" [GO:0005201 "extracellular matrix structural constituent" evidence=TAS] [GO:0005509 "calcium ion binding" evidence=TAS] [GO:0005518 "collagen binding" evidence=TAS] [GO:0001503 "ossification" evidence=TAS] [GO:0007275 "multicellular organismal development" evidence=TAS] [GO:0005578 "proteinaceous extracellular matrix" evidence=TAS] UniProt:Q9NZW4 GO:GO:0005518 GO:GO:0005509 GO:GO:0005578 GO:GO:0001503 GO:GO:0005201 EMBL:AF163151 EMBL:AF094508 UniGene:Hs.128556 Ensembl:ENSG00000152591 KEGG:hsa:1834 HGNC:HGNC:3054 MIM:125485 MIM:125490 MIM:605594 ArrayExpress:Q9NZW4 GermOnline:ENSG00000152591 Length = 1253 Score = 79.7 bits (195), Expect = 5e-014 Identities = 148/757 (19%), Positives = 258/757 (34%), Gaps = 115/757 (15%) Query: 1436 NSSTASTGATSSAANVTLEASTSHSSSTEQASSGAGGDLLDKSPHRQERIYEENIYDTIR 1495 NSS +S + SS ++ + ++S S S S++ S + D S + N D+ Sbjct: 600 NSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSS-------DSNSSDSSD 652 Query: 1496 SADGVDYDDPACGSAELDPMQTTQPGGIRVGLSSRARQQPSPPADNVSLVSSNCYESIGL 1555 ++D D + + S D ++ SS S +D+ SSN ES Sbjct: 653 NSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSSSSDSSNSSDSSDSSD--SSNSSES--- 707 Query: 1556 RLEYERSMMLARRNLAGGSTTTLASDQITNSLYGVTAGLASLTPPSERGSDTSNSADWTD 1615 + + + S ++ +SD ++ + +S + S SD+SNS+D +D Sbjct: 708 ----------SDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSDSSDSSNSSDSSD 757 Query: 1616 ISDEDETGERADVTTAMATGGSKRPNFIVVRERKRTHQTPLRSRKLARISHPKIDDDSDH 1675 SD + + +D + + + S + D +D Sbjct: 758 SSDSSNSSDSSDSSDSSDSSDSSNSS-----------------------------DSNDS 788 Query: 1676 HYESLYSIGSNDGRHQHQHDANYTTLPPHVDGSLLSGNAASGVNFHEHRAGGGGGDASAA 1735 S S SN + D++ ++ D S N++ N + D+S Sbjct: 789 SNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSS----NSSDSSNSSDSSDSSNSSDSS-- 842 Query: 1736 MLLPPDDEFDSFDSDDTDYEDEDDDRNRARTDSGVDIRNAKLPDPPPSSSQVYVLVQKIK 1795 D DS DS D+D + D N + + D N+ SS Sbjct: 843 ------DSSDSSDSSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSSD--------S 888 Query: 1796 NLGTLSEIAKSFHKLSKKKGTKGATTATGAGAGGGTYENTSSNVSGNVPKAPGTAGFSPA 1855 N + S + S + + ++ + + + + SSN S N + + + Sbjct: 889 NESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSS 948 Query: 1856 DGATRKKSKSTKSLRSKLRKSLVSDSTSLNIGSSFNGSRSTFYVTSADVDSGIFNGSDGC 1915 D + S + + S SDS S + S N S S+ S+D + SD Sbjct: 949 DSSDSSNSSDSSNSGDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSS----DSSDSS 1004 Query: 1916 LNPSASSVSQSQEMPTKSAEDNRRKSIASATGTTGHGRPTIPPPPPPAEAGKRTAASSSV 1975 + +S S S + S N S S+ + + ++ SS Sbjct: 1005 NSSDSSDSSDSSDSSNSSDSSNSSDSSDSSDSSDSSD-----------SSDSSNSSDSSD 1053 Query: 1976 SPLLAASNSKSVSKKLGATSWYAECGVFKQPHSFGTGSDQSLSNGKGDGSISPRSSLPPK 2035 S + S+ S S +S ++ SD S S+ D S S SS Sbjct: 1054 SSDSSDSSDSSGSSDSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSDSSDSS-DSS 1112 Query: 2036 DGGPTGAGPGGGTGGGGGNDRTLTSNGHTSASSWYADIYQTSGASVASSSESSGVSTGGE 2095 D + N + + +S SS +D +S +S SS+SS S + Sbjct: 1113 DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSS--DSSDSSDSSDSSD 1170 Query: 2096 GGPGDDHSHSMFVNEPLYQIYNAAKLESITRDIDAEISGRSEAELYDDGYEKIAERNRRR 2155 D S S NE +S ++ S S++ D + ++ N Sbjct: 1171 SSDSSDSSDSSDSNE---------SSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSN--- 1218 Query: 2156 KTGGAGEQEGAEEGDEGGCSSSSGSSSTDGDDRGDDS 2192 DE S SG+ + +G D DS Sbjct: 1219 --------------DESDSQSKSGNGNNNGSDSDSDS 1241 Score = 78.2 bits (191), Expect = 1e-013 Identities = 121/600 (20%), Positives = 220/600 (36%), Gaps = 38/600 (6%) Query: 1605 SDTSNSADWTDISDEDETGERADVTTAMATGGSKRPNFIVVRERKRTHQTPLRSRKLARI 1664 SD+SNS+D +D SD ++ + +D + + + + ++ S + Sbjct: 596 SDSSNSSDSSDSSDSSDSSDSSDSSDSKS-------------DSSKSESDSSDSDSKSDS 642 Query: 1665 SHPKIDDDSDHHYESLYSIGSNDGRHQHQHDANYTTLPPHVDGSLLSGNAASGVNFHEHR 1724 S D SD+ S S SN D++ ++ S S N++ + + Sbjct: 643 SDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSSSSDSSNSSDSSDSSDSS 702 Query: 1725 AGGGGGDASAAMLLPPDDEFDSFDSDDTDYEDEDDDRNRARTDSGVDIRNAKLPDPPPSS 1784 D+S + D DS DS +++ D D + +DS ++ D SS Sbjct: 703 NSSESSDSSDSS---DSDSSDSSDSSNSNSSDSDSSNSSDSSDSSDSSDSSNSSDSSDSS 759 Query: 1785 SQVYVLVQKIKNLGTLSEIAKSFHKLSKKKGTKGATTATGAGAGGGTYENTSSNVSGNVP 1844 N S+ + S + ++ + + + + SSN S + Sbjct: 760 DS--------SNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSD 811 Query: 1845 KAPGTAGFSPADGATRKKSKSTKSLRSK-----LRKSLVSDSTSLNIGSSFNGSRSTFYV 1899 + + S + S S+ S S S SDS S N S N S S+ Sbjct: 812 SSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDSSDSDSSNRSDSSNSSDSSDSS 871 Query: 1900 TSADVDSGIFNGSDGCLNPSASSVSQSQEMPTKSAEDNRRKSIASATGTTGHGRPTIPPP 1959 S++ S + SD + +S+ S S + S D+ S +S + + + + Sbjct: 872 DSSN-SSDSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESS 930 Query: 1960 PPPAEAGKRTAASSSVSPLLAASNSKSVSKKLGATSWYAECGVFKQPHSFGTG--SDQSL 2017 + +++SS S + S++ S S G +S ++ S + SD S Sbjct: 931 NSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSGDSSNSSDSSDSNSSDSSDSSNSSDSSD 990 Query: 2018 SNGKGDGSISPRSSLPPKDGGPTGAGPGGGTGGGGGNDRTLTSNGHTSASSWYADIYQTS 2077 S+ D S S SS D + N + + +S SS +D +S Sbjct: 991 SSDSSDSSDSSDSS-NSSDSSDSSDSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSNSS 1049 Query: 2078 GASVAS----SSESSGVSTGGEGGPGDDHSHSMFVNEPLYQIYNAAKLESITRDIDAEIS 2133 +S +S SS+SSG S + D S S ++ ++ +S ++ S Sbjct: 1050 DSSDSSDSSDSSDSSGSSDSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSDSSDSS 1109 Query: 2134 GRSEAELYDDGYEKIAERNRRRKTGGAGEQEGAEEGDEGGCSSSSGSS-STDGDDRGDDS 2192 S++ D + + + + + ++ D S SS SS S+D D D S Sbjct: 1110 DSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1169 Score = 72.0 bits (175), Expect = 1e-011 Identities = 111/593 (18%), Positives = 213/593 (35%), Gaps = 20/593 (3%) Query: 1601 SERGSDTSNSADWTDISDEDETGERADVTTAMATGGSKRPNFIVVRERKRTHQTPLRSRK 1660 S+ SD +S D+ D S + + +D + S+ N R + + Sbjct: 443 SDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNG 502 Query: 1661 LARISHPKIDDDSDHHYESLYSIGSNDGRHQHQHDANYTTLPPHVDGSLLSGNAASGVNF 1720 S DDDSD ++ S + +G + + + + D S + +S + Sbjct: 503 NGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSD 562 Query: 1721 HEHRAGGGGGDASAAMLLPPDDEFDSFDSDDTDYEDEDDDRNRARTDSGVDIRNAKLPDP 1780 + D++++ + DS DSD +D D D + +DS ++ D Sbjct: 563 SSDSSDSDSSDSNSS------SDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDS 616 Query: 1781 PPSSSQVYVLVQKIKNLGTLSEIAKSFHKLSKKKGTKGATTATGAGAGGGTYENTSSNVS 1840 SS K+ + SE S K + + ++ + + + SSN S Sbjct: 617 SDSSDS--------KSDSSKSESDSS--DSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSS 666 Query: 1841 GNVPKAPGTAGFSPADGATRKKSKSTKSLRSKLRKSLVSDSTSLNIGSSFNGSRSTFYVT 1900 + + + S +D ++ S ++ S S+S+ + S + S S+ Sbjct: 667 DSSDSSDSSDSSSSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSN 726 Query: 1901 SADVDSGIFNGSDGCLNPSASSVSQSQEMPTKSAEDNRRKSIASATGTTGHGRPTIPPPP 1960 S DS N SD + +S S S + S N S S+ + Sbjct: 727 SNSSDSDSSNSSDSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSN 786 Query: 1961 PPAEAGKRTAASSSVSPLLAASNSKSVSKKLGATSWYAECGVFKQPHSFGTGSDQSLSNG 2020 + + + +S+S ++ +S S +S ++ SD S S+ Sbjct: 787 DSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSD 846 Query: 2021 KGDGSISPRSSLPPKDGGPTGAGPGGGTGGGGGNDRTLTSNGHTSASSWYADIYQTSGAS 2080 D S S S+ + + +D + +S+ + S++S +D +S +S Sbjct: 847 SSDSSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSNESSNS--SDSSDSSNSS 904 Query: 2081 VASSSESSGVSTGGEGGPGDDHSHSMFVNEPLYQIYNAAKLESITRDIDAEISGRSEAEL 2140 + SS+SS S + D S S ++ ++ +S + D+ S S Sbjct: 905 DSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDS-SDSSDSSNSSDSSNSG 963 Query: 2141 YDDGYEKIAERNRRRKTGGAGEQEGAEEGDEGGCSSSSGSS-STDGDDRGDDS 2192 ++ N + + + ++ D S SS SS S+D D D S Sbjct: 964 DSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1016 Score = 70.5 bits (171), Expect = 3e-011 Identities = 143/753 (18%), Positives = 265/753 (35%), Gaps = 94/753 (12%) Query: 1441 STGATSSAANVTLEASTSHSSSTEQASSGAGGDLLDKSPHRQERIYEENIYDTIRSADGV 1500 S + S +++ + + +S SS ++ + S + D D S + + D+ S+D Sbjct: 547 SDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDS-DSSDSDSSDSSDSDSSDSSNSSDSS 605 Query: 1501 DYDDPACGSAELDPMQTTQPGGIRVGLSSRARQQPSPPADNVSLVSSNCYESIGLRLEYE 1560 D D + S D + S + + S +D+ S S+ S + Sbjct: 606 DSSDSSDSSDSSDSSDS----------KSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSD 655 Query: 1561 RSMMLARRNLAGGSTTTLASDQITNSLYGVTAGLASLTPPSERGSDTSNSADWTDISDED 1620 S N + S ++ +SD ++S S SD+SNS+D +D SD Sbjct: 656 SSDSSNSSNSSDSSDSSDSSDSSSSS-------------DSSSSSDSSNSSDSSDSSDSS 702 Query: 1621 ETGERADVTTAMATGGSKRPNFIVVRERKRTHQTPLRSRKLARISHPKIDDDSDHHYESL 1680 + E +D + + + S + ++ + S + S D SD S Sbjct: 703 NSSESSDSSDSSDSDSSDSS------DSSNSNSSDSDSSNSSDSS-----DSSDSSDSSN 751 Query: 1681 YSIGSNDGRHQHQHDANYTTLPPHVDGSLLSGNAASGVNFHEHRAGGGGGDASAAMLLPP 1740 S S+ + D++ ++ S S ++ N + D+S + Sbjct: 752 SSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNS----- 806 Query: 1741 DDEFDSFDSDDTDYEDEDDDRNRARTDSGVDIRNAKLPDPPPSSSQVYVLVQKIKNLGTL 1800 D DS DS D+D + D N + DS ++ D SS + Sbjct: 807 SDSSDSSDSSDSDSSNSSDSSNSS--DSSDSSNSSDSSDSSDSSD-------------SS 851 Query: 1801 SEIAKSFHKLSKKKGTKGATTATGAGAGGGTYENTSSNVSGNVPKAPGTAGFSPADGATR 1860 + + S + ++ ++ + + +++ SN S N + ++ S +D Sbjct: 852 DSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSNESSNSSDSSDSSNSSDSDS--- 908 Query: 1861 KKSKSTKSLRSKLRKSLVSDSTSLNIGSSFNGSRSTFYVTSADVDSGIFNGSDGCLNPSA 1920 S S+ S S + S S N + N S S+ S+D S N SD + + Sbjct: 909 --SDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSD-SSDSSNSSDSSNSGDS 965 Query: 1921 SSVSQSQEMPTKSAEDNRRKSIASATGTTGHGRPTIPPPPPPAEAGKRTAASSSVSPLLA 1980 S+ S S + + + D+ S +S + + + ++ SS S Sbjct: 966 SNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDS--------SDSSNSSDSSDSSDSSD 1017 Query: 1981 ASNSKSVSKKLGATSWYAECGVFKQPHSFGTGSDQSLSNGKGDGSISPRSSLPPKDGGPT 2040 +SNS S SD S S+ D S S SS D + Sbjct: 1018 SSNSSDSSNS-------------------SDSSDSSDSSDSSDSSDSSNSS----DSSDS 1054 Query: 2041 GAGPGGGTGGGGGNDRTLTSNGHTSASSWYADIYQTSGASVASSSESSGVSTGGEGGPGD 2100 G + + + +S SS +D +S +S SS+SS S + Sbjct: 1055 SDSSDSSDSSGSSDSSDSSDSSDSSDSSDSSDSSDSSDSS--ESSDSSDSSDSSDSSDSS 1112 Query: 2101 DHSHSMFVNEPLYQIYNAAKLESITRDIDAEISGRSEAELYDDGYEKIAERNRRRKTGGA 2160 D S S ++ ++ +S ++ S S++ D + + + + Sbjct: 1113 DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1172 Query: 2161 GEQEGAEEGDEGGCSSSSGSSSTDGDDRGDDSS 2193 + ++ D S SS SS + DSS Sbjct: 1173 DSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSS 1205 Score = 64.3 bits (155), Expect = 2e-009 Identities = 200/1108 (18%), Positives = 407/1108 (36%), Gaps = 97/1108 (8%) Query: 545 NLHHGRGKRAESGDTGKPPPGRSKPKVPDKSEQVLQKTKDFKSKKVVSEVVEKSNRGALN 604 N + K ++GD G V + QV ++ E++E S R N Sbjct: 153 NTNGNTDKNTQNGDVGDAGHNEDVAVVQEDGPQVAGSNNSTDNE---DEIIENSCRNEGN 209 Query: 605 EQVEEVRGDVATAR--TADEHVVDGYRQETKESSPVSKEAKSKDVSPKEAKKGSNGITSK 662 E+ + + R T + V G ++ + S + S + + ++ +GS + Sbjct: 210 --TSEITPQINSKRNGTKEAEVTPGTGEDAGLDN--SDGSPSGNGADEDEDEGSGDDEDE 265 Query: 663 LHKNSPREASNAIVPSKGENLEPTEVLSDGNNSFGEMHPSHNWMDGTYDQIDLEEPTNGK 722 N ++N SKG+ + D ++S G+ S + YD E+P N Sbjct: 266 EAGNGKDSSNN----SKGQEGQDHGKEDDHDSSIGQNSDSKEY----YDPEGKEDPHNEV 317 Query: 723 EISAVSKPNEMIS-------SQKVLKEKEKSKSAVSKIQERLTFRSSKKV---TVENTAP 772 + SK E + SQ++ ++ + +++ R+T S + + Sbjct: 318 DGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQDKGIE 377 Query: 773 RKEPSEGVANHSDHDLGEDQAAYSSVEKGSNQVTEEPSPVKTSTGSNQELIDVLPDGDSS 832 K PS G N + ++G+ +KG + + VKT E++++ G S Sbjct: 378 IKGPSSGNRNITK-EVGKGNEGKE--DKGQHGMILGKGNVKTQG----EVVNIEGPGQKS 430 Query: 833 F--GELHPSYNWTDGTYDRKYVEQAAQINAAYSSVEKGSKKVT-EEPSPYNSVKASTGAN 889 ++ S +D D Y S + K + ++P+ + + AN Sbjct: 431 EPGNKVGHSNTGSDSNSD------------GYDSYDFDDKSMQGDDPNSSDESNGNDDAN 478 Query: 890 QELIEVLSDGESSFRELHPSYSWMDGTYDQIDLEEPTHGKEIAVASATTEMNASQKDPKE 949 E SD SS R D +Y+ + ++ +G + A + S + + Sbjct: 479 SE-----SDNNSSSRG--------DASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSD 525 Query: 950 KEKGKSAVSKIQERLTFRSSKKVAVENAAPRKEPSEEVAILSDDDFGENHA--EYSFLEK 1007 + + ++ K + ++ + S + + SD D ++++ + + Sbjct: 526 SNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDS 585 Query: 1008 GSKQVTEEPSPHGAVQPDSSQTETVVTSPKEGKEKKRSKSTVSKIYERLTFRSSKKMAAP 1067 S ++ S + DSS + S + + SKS SK + SK ++ Sbjct: 586 DSSDSSDSDSSDSSNSSDSSDSSDSSDS-SDSSDSSDSKSDSSKSESDSSDSDSKSDSSD 644 Query: 1068 SERSDEVVIIREAEDANRKAPGLRRSFMSSIEIPSIHPDERAVASPSPEASREESTENDS 1127 S SD ++ +N S SS S + + +S S +S + S +DS Sbjct: 645 SNSSDSSDNSDSSDSSN--------SSNSSDSSDSSDSSDSSSSSDSSSSS-DSSNSSDS 695 Query: 1128 SEQKILEAISAVSQRIDNLSKSFSDLTLTDDENTQAKRTADAEQEEDVQQVRPNASFLFR 1187 S+ S S D+ SD + + + N+ ++++ D +++ Sbjct: 696 SDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSDSSDSSN---- 751 Query: 1188 GMGSAGSRAGLDSKHASQHNIVEAVNTVVINKSLSMDDHHFPCARGETGRMSLNERSRAQ 1247 S+ S DS ++S + ++ ++ + S + D + ++ S + S Sbjct: 752 ---SSDSSDSSDSSNSSDSS--DSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNS 806 Query: 1248 RGLEDDYEPVIQPEEKLPSAAGSKFCSTPSITIDLSELTSKIESFVHKSKRESDNIYQSI 1307 D + ++ S S S + D S+ + +S S SD+ S Sbjct: 807 SDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDSSDSDSSNRSDSSNSSD 866 Query: 1308 PIKSQGTSNTALLHQPEDAI----SVNSYESFENYESIEHELLSSTRKQNPEKASGEEDT 1363 S +SN++ D+ S NS +S ++ S + + S+ + +S D+ Sbjct: 867 SSDSSDSSNSSDSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDS 926 Query: 1364 YEICSPPPELPPAREDSRNDLTLPQPKRNLSSSPKTLPKHLQVTYQSNYERIKYSKIPPR 1423 E + + + +D + N S S + + S+ S Sbjct: 927 SESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSGDS----SNSSDSSDSNSSDSSDS 982 Query: 1424 PPKPEEVPLPPRNSSTASTGATSSAANVTLEASTSHSSSTEQASSGAGGDLLDKSPHRQE 1483 + + S+ S+ +++S+ + S+ S+S++ ++S D D S + Sbjct: 983 SNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSDSSDSS-DSSD 1041 Query: 1484 RIYEENIYDTIRSADGVDYDDPACGSAELDPMQTTQPGGIRVGLSSRARQQPSPPADNV- 1542 N D+ S+D D D + S D ++ S S +D+ Sbjct: 1042 SSDSSNSSDSSDSSDSSDSSDSSGSSDSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSD 1101 Query: 1543 ---SLVSSNCYESIGLRLEYERSMMLARRNLAGGSTTTLASDQITNSLYGVTAGLASLTP 1599 S SS+ +S + S N + S ++ +SD ++S + +S + Sbjct: 1102 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS-SDSSDSSDSSDSSDSS 1160 Query: 1600 PSERGSDTSNSADWTDISDEDETGERAD 1627 S SD+S+S+D +D SD ++ E +D Sbjct: 1161 DSSDSSDSSDSSDSSDSSDSSDSNESSD 1188 Score = 63.9 bits (154), Expect = 3e-009 Identities = 99/472 (20%), Positives = 179/472 (37%), Gaps = 27/472 (5%) Query: 1742 DEFDSFDSDDTDYEDEDDDRNRARTDSGVDIRNAKLPDPPPSSSQVYVLVQKIKNLGTLS 1801 D +DS+D DD + DD N + +G D N++ + S + K+ G S Sbjct: 448 DGYDSYDFDDKSMQG--DDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGS 505 Query: 1802 EIAKSFHKLSKKKGTKGATTATGAGAGGGTYENTSSNVSGNVPKAPGTAGFSP--ADGAT 1859 + + S + + G G G + S + G + + S +D + Sbjct: 506 DSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSD 565 Query: 1860 RKKSKSTKSLRSKLRKSLVSDSTSLNIGSSFNGSRSTFYVTSADV-DSGIFNGSDGCLNP 1918 S S+ S S S SDS+ + S + S S+ S+D DS + S + Sbjct: 566 SSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSD 625 Query: 1919 SASSVSQSQEMPTKS---------AEDNRRKSIASATGTTGHGRPTIPPPPPPAEAGKRT 1969 S+ S S S + +KS + DN S +S + + + + + + Sbjct: 626 SSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSS 685 Query: 1970 AASSSVSPLLAASNSKSVSKKLGATSWYAECGVFKQPHSFGTGSDQSLSNGKGDGSISPR 2029 ++ SS S + S+ S S + +S ++ S + S S S+ D S S Sbjct: 686 SSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSD 745 Query: 2030 SSLPPKDGGPTGAGPGGGTGGGG----GNDRTLTSNGH----TSASSWYADIYQTSGASV 2081 SS + + + +D + +SN +S SS +D +S +S Sbjct: 746 SSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSN 805 Query: 2082 ASSSESSGVSTGGEGGPGDDHSHSMFVNEPLYQIYNAAKLESITRDIDAEISGRSEAELY 2141 +S S S S+ + D S+S ++ ++ +S + D++ S RS++ Sbjct: 806 SSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDS-SDSSDSDSSNRSDSSNS 864 Query: 2142 DDGYEKIAERNRRRKTGGAGEQEGAEEGDEGGCSSSSGSSSTDGDDRGDDSS 2193 D + N + + + + + +E SS S SS D DSS Sbjct: 865 SDSSDSSDSSN----SSDSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSS 912 Score = 53.1 bits (126), Expect = 5e-006 Identities = 136/797 (17%), Positives = 271/797 (34%), Gaps = 48/797 (6%) Query: 421 GNVAYKVIEDPGSDGVYGFTSTGRM---SSARSSLRKKHSNASATTGGG----ATAATAT 473 G+ +Y D D G S G S + S SN + G + + Sbjct: 489 GDASYN--SDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGK 546 Query: 474 ATAATSAGTAGNRTDESSDEISSSASSKNSSLRKTGLRKRPSLRKNIYRRPEWETGRSSL 533 + ++ S + + + +SSD S +S NSS S + + SS Sbjct: 547 SDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSS- 605 Query: 534 GVRKVLEMFEPNLHHGRGKRAESGDTGKPPPGRSKPKVPD---KSEQVLQKTKDFKSKKV 590 + + ++S D+ K +S+ D KS+ + D Sbjct: 606 ---------DSSDSSDSSDSSDSSDS-KSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSD 655 Query: 591 VSEVVEKSNRGALNEQVEEVRGDVATARTADEHVVDGYRQETKESSPVSKEAKSKDVSPK 650 S+ SN ++ + D +++ + ++ +SS S ++S D S Sbjct: 656 SSDSSNSSNSSDSSDSSDS--SDSSSSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDS 713 Query: 651 EAKKGSNGITSKLHKNSPREASNAIVPSKGENLEPTEVLSDGNNSFGEMHPSHNWMDGTY 710 S+ S +S ++SN+ S + + SD ++S + S Sbjct: 714 SDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSDSSDSSNSSDSSDSSDSSNSS-------- 765 Query: 711 DQIDLEEPTNGKEISAVSKPNEMISSQKVLKEKEKSKSAVSKIQERLTFRSSKKVTVENT 770 D D + ++ + S S N+ +S S S+ S + S + + Sbjct: 766 DSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSD 825 Query: 771 APRKEPSEGVANHSDHDLGEDQAAYSSVEKGSNQVTEEPSPVKTSTGSNQELIDVLPDGD 830 + S +N SD D + SS SN+ S + + + D D Sbjct: 826 SSNSSDSSDSSNSSDSSDSSDSSD-SSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSD 884 Query: 831 SSFGELHPSYNWTDGTYDRKYVEQAAQINAAYSSVEKGSKKVTEEPSPYNSVKASTGANQ 890 SS + + + + + + + N++ SS S +E + ++ +S +N Sbjct: 885 SSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNS 944 Query: 891 ELIEVLSDGESSFRELHP---SYSWMDGTYDQIDLEEPTHGKEIAVASATTEMNASQKDP 947 SD +S + S S + D + ++ + + +S +++ + S Sbjct: 945 SDSSDSSDSSNSSDSSNSGDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1004 Query: 948 KEKEKGKSAVSKIQERLTFRSSKKVAVENAAPRKEPSEEVAILSDDDFGENHAEYSFLEK 1007 + S+ S + S+ + +++ + S D + + S Sbjct: 1005 NSSDSSDSSDSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 1064 Query: 1008 GSKQVTEEPSPHGAVQPDSSQTETVVTSPKEGKEKKRSKSTVSKIYERLTFRSSKKMAAP 1067 GS ++ S + DSS + S + S S+ S + S ++ Sbjct: 1065 GSSDSSD--SSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSD 1122 Query: 1068 SERSDEVVIIREAEDANRKAPGLRRSFMSSIEIPSIHPDERAVASPSPEASREESTENDS 1127 S S + ++ D++ + S S S D + S + +S+++ Sbjct: 1123 SSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1182 Query: 1128 SEQKILEAISAVSQRIDNLSKSFSDLTLTDDENTQAKRTADAEQEEDVQQVRPNASFLFR 1187 S + + S+ S N S S D + + T+D+ E D Q N + Sbjct: 1183 SNESSDSSDSSDSSDSSNSSDS-------SDSSDSSDSTSDSNDESDSQSKSGNGNN--N 1233 Query: 1188 GMGSAGSRAGLDSKHAS 1204 G S G DS H++ Sbjct: 1234 GSDSDSDSEGSDSNHST 1250 Score = 47.8 bits (112), Expect = 2e-004 Identities = 71/276 (25%), Positives = 103/276 (37%), Gaps = 47/276 (17%) Query: 1959 PPPPAEAGKRTAASSSVSPLLAASNSKSVSKKLGATSWYAECGVFKQPHSFGTGSDQSLS 2018 P P ++ +R S LLA SN SV +L A+ E GV H G ++ Sbjct: 17 PVPQSKPLERHVEKSMNLHLLARSNV-SVQDELNASGTIKESGVLV--HEGDRGRQENTQ 73 Query: 2019 NG-KGDG-----------SISPRSSLPPKDG------GPTGAGPGGGTGGGGGNDRTLTS 2060 +G KG+G S S S+L ++G G TG G G G + +T+ Sbjct: 74 DGHKGEGNGSKWAEVGGKSFSTYSTLANEEGNIEGWNGDTGKAETYGHDGIHGKEENITA 133 Query: 2061 NG--------------HTSASSWYADIYQTSGASVASSSESSGVSTGGEGGPGDDHSHSM 2106 NG + S ++ D T V + + V+ E GP S++ Sbjct: 134 NGIQGQVSIIDNAGATNRSNTNGNTD-KNTQNGDVGDAGHNEDVAVVQEDGPQVAGSNNS 192 Query: 2107 FVNEPLY---QIYNAAKLESITRDIDAEISGRSEAELYDDGYEKIAERNRRRKTGGAGEQ 2163 NE N IT I+++ +G EAE+ E N G G Sbjct: 193 TDNEDEIIENSCRNEGNTSEITPQINSKRNGTKEAEVTPGTGEDAGLDNSDGSPSGNGAD 252 Query: 2164 EGAEEG---DE-----GGCSSSSGSSSTDGDDRGDD 2191 E +EG DE G SS+ S +G D G + Sbjct: 253 EDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKE 288 ==> TAIR|gene:2098442 - symbol:AT3G28770.1 species:3702 "Arabidopsis thaliana" [GO:0008150 "biological_process" evidence=ND] [GO:0003674 "molecular_function" evidence=ND] GenBank:NM_113798.1 Ncbi:NP_189519 Length = 2081 Score = 75.5 bits (184), Expect = 9e-013 Identities = 169/895 (18%), Positives = 334/895 (37%), Gaps = 100/895 (11%) Query: 537 KVLEMFEPNLHHGRGKRAES-GDTGKPPPGRSKPKVPDKSE-----QVLQKTKDFKSKKV 590 K +E+ + H + KR E+ G+ G+ + DK E V KT + S + Sbjct: 570 KSVEVTTNDGDHTKEKREETQGNNGESVKNENLENKEDKKELKDDESVGAKTNNETSLEE 629 Query: 591 VSEVVEKSNRGALNEQVEEVRGDVATARTADE-HVVDGYRQ---ETKESSPVSKEAKSKD 646 E +K + ++N ++ + +G A + E HV D E+KE + E K D Sbjct: 630 KREQTQKGHDNSINSKIVDNKGGNADSNKEKEVHVGDSTNDNNMESKEDTKSEVEVKKND 689 Query: 647 VSPKEAKKGS----NGITSKLHKNSPREASNAIVPSKGENLEPTEVLSDGNNSFGEMHPS 702 S ++ ++G + + K +N + + S + E ++ + + Sbjct: 690 GSSEKGEEGKENNKDSMEDKKLENKESQTDSKDDKSVDDKQEEAQIYGGESKDDKSVEAK 749 Query: 703 HNWMDGTYDQIDLEEPTNGKEISAVSKPNEMISSQKVLKEKEKSKSAVSKIQERLTFRSS 762 G + + T E +K + ++K ++ EK + SK + + + + Sbjct: 750 -----GKKKESKENKKTKTNENRVRNKEENVQGNKKESEKVEKGEKKESKDAKSVETKDN 804 Query: 763 KKVT-VENTAPRKEPSEGVANHSDHDLGEDQAAYSSVEKGSNQVTEEPSPVKTSTGSNQE 821 KK++ EN KE S G N D + +D + + EK N V T+ G+ ++ Sbjct: 805 KKLSSTENRDEAKERS-GEDNKEDKEESKDYQSVEAKEKNEN------GGVDTNVGNKED 857 Query: 822 LIDVLPDG--------DSSFGELHPSYNWTDGTYDRKY----------VEQAAQINAAYS 863 D+ D + S + D + ++ V++ + + Y Sbjct: 858 SKDLKDDRSVEVKANKEESMKKKREEVQRNDKSSTKEVRDFANNMDIDVQKGSGESVKYK 917 Query: 864 SVEKGSKKVTEEPSPYNSVKASTGANQELIEVLSDGESSFRELHPSYSWMDGTYDQIDLE 923 EK E N+ G +++ + S + ++ +++ +L+ Sbjct: 918 KDEKKEGNKEENKDTINTSSKQKGKDKKKKKKESKNSNMKKKEEDKKEYVNN-----ELK 972 Query: 924 EPTHGKEIAVASATTEMNASQKDPKEKEKGKSAVSKIQERLTFRSSKKVAVENAAPRKEP 983 + K+ S +++ KD KEK++ + + SK +E+ + K E A K+ Sbjct: 973 KQEDNKKETTKSENSKLKEENKDNKEKKESEDSASKNREKKEYEEKKSKTKEEAKKEKKK 1032 Query: 984 SEEVAIL---SDDDFGENHAEYS------FLEKGSKQVTEEPSPHGAVQPDSSQTETVVT 1034 S++ S++ + E S E+ +K+ E + + D + E + Sbjct: 1033 SQDKKREEKDSEERKSKKEKEESRDLKAKKKEEETKEKKESENHKSKKKEDKKEHEDNKS 1092 Query: 1035 SPKE--GKEKK-------RSKSTVSKIYERLTFRSSKKMAA---PSERSDEVVIIREAED 1082 KE KEKK R K K E+L ++S K ++S V ++++ D Sbjct: 1093 MKKEEDKKEKKKHEESKSRKKEEDKKDMEKLEDQNSNKKKEDKNEKKKSQHVKLVKKESD 1152 Query: 1083 ANRKAPGLRRSFMSSIEIPSIHPDERAVASPSPEASREESTENDSSEQKILEAISAVSQR 1142 K +S IE +E +E+ + D ++K E + ++ Sbjct: 1153 KKEKKENEEKSETKEIESSKSQKNE--------VDKKEKKSSKDQQKKKEKEMKESEEKK 1204 Query: 1143 IDNLSKSFSDLTLTDDENTQAKRTADAEQ--EEDVQQVRPNASFLFRGMGSAGSRAGLDS 1200 + + T + +EN + K T + ++D + + M S A Sbjct: 1205 LKKNEEDRKKQT-SVEENKKQKETKKEKNKPKDDKKNTTKQSGGKKESMESESKEAENQQ 1263 Query: 1201 KH--ASQHNIVEAVNTVVINKSLSMDDHHFPCARGETGR----MSLNERSRAQRGLEDDY 1254 K +Q + E+ N +++ D H A + + M + ++ QR E+D Sbjct: 1264 KSQATTQADSDESKNEILMQADSQADSHSDSQADSDESKNEILMQADSQATTQRNNEEDR 1323 Query: 1255 EPVIQPEEKLPSAAGSKFCSTPSITIDLSELTSKIESFVHKSKRESDNIYQSIPIKSQGT 1314 + E + + P D + T+K +S K ES++ KSQ T Sbjct: 1324 KKQTSVAENKKQKETKEEKNKPK---DDKKNTTK-QSGGKKESMESESKEAENQQKSQAT 1379 Query: 1315 -------SNTALLHQPEDAISVNSYESFENYESIEHELLSSTRKQNPEKASGEED 1362 S +L Q + +S ++ ES ++E+L Q + + EED Sbjct: 1380 TQADSDESKNEILMQADSQADSHSDSQADSDES-KNEILMQADSQATTQRNNEED 1433 Score = 73.9 bits (180), Expect = 3e-012 Identities = 141/839 (16%), Positives = 309/839 (36%), Gaps = 92/839 (10%) Query: 489 ESSDEISSSASSKNSSLRKTGLRKRPSLRKNIYRRPEWETGRSSLGVRKVLEMFEPNLHH 548 + D+ SKNS+++K K+ + + ++ + + + K+ E + N Sbjct: 940 KGKDKKKKKKESKNSNMKKKEEDKKEYVNNELKKQEDNKKETTKSENSKLKEENKDNKEK 999 Query: 549 GRGKRAESGDTGKPPPGRSKPKVPDKSEQVLQKTKDFKSKKVVSEVVEKSNRGALNEQVE 608 + + S + K K K +++++ +K++D K ++ SE + E+ Sbjct: 1000 KESEDSASKNREKKEYEEKKSKTKEEAKKEKKKSQDKKREEKDSEERKSKKE---KEESR 1056 Query: 609 EVRGDVATARTADEHVVDGYRQETKESSPVSKEAKS--KDVSPKEAKKGSNGITSKLH-- 664 +++ T ++ + ++ + KE ++ KS K+ KE KK + K Sbjct: 1057 DLKAKKKEEETKEKKESENHKSKKKEDKKEHEDNKSMKKEEDKKEKKKHEESKSRKKEED 1116 Query: 665 ---------KNSPREASNAIVPSKGENLEPTEVLSDGNNSFGEMHPSH----NWMDGTYD 711 +NS ++ + K ++++ + SD S + Sbjct: 1117 KKDMEKLEDQNSNKKKEDKNEKKKSQHVKLVKKESDKKEKKENEEKSETKEIESSKSQKN 1176 Query: 712 QIDLEEPTNGKEISAVSKPNEMISSQKVLKEKEKSKSAVSKIQERLTFRSSKKVTVENTA 771 ++D +E + K+ + S +K LK+ E+ + + ++E + +KK Sbjct: 1177 EVDKKEKKSSKDQQKKKEKEMKESEEKKLKKNEEDRKKQTSVEENKKQKETKK------- 1229 Query: 772 PRKEPSEGVANHSDHDLGEDQAAYSSVEKGSNQVTEEPSPVKTSTGSNQELI-------- 823 + +P + N + G+ ++ S ++ NQ + + S S E++ Sbjct: 1230 EKNKPKDDKKNTTKQSGGKKESMESESKEAENQQKSQATTQADSDESKNEILMQADSQAD 1289 Query: 824 ---DVLPDGDSSFGELHPSYNWTDGTYDRKYVEQAAQINAAYSSVEKGSKKVTEEP--SP 878 D D D S E+ + T ++ Q + A + +K +K+ +P Sbjct: 1290 SHSDSQADSDESKNEILMQADSQATTQRNNEEDRKKQTSVAENKKQKETKEEKNKPKDDK 1349 Query: 879 YNSVKASTGANQELIEVLSDGESSFRELHPSYSWMDGTYDQI----DLEEPTHG------ 928 N+ K S G + + + E+ + + + D + ++I D + +H Sbjct: 1350 KNTTKQSGGKKESMESESKEAENQQKSQATTQADSDESKNEILMQADSQADSHSDSQADS 1409 Query: 929 ----KEI---AVASATTEMNASQKDPKEKE--KGKSAVSKIQERLTFRSSKKVAVENAAP 979 EI A + ATT+ N + K+ + K +E+ + KK E + Sbjct: 1410 DESKNEILMQADSQATTQRNNEEDRKKQTSVAENKKQKETKEEKNKPKDDKKNTTEQSGG 1469 Query: 980 RKEPSEEVAILSDDDFGENHAEYSFLEKGSK---------QVTEEPSPHGAVQPDSSQTE 1030 +KE E S+ EN + +G Q + H Q DS +++ Sbjct: 1470 KKESME-----SESKEAENQQKSQATTQGESDESKNEILMQADSQADTHANSQGDSDESK 1524 Query: 1031 TVVTSPKEGKEKKRSKSTVSKIYERLTFRSSKKMAAPSERSDEVVIIREAEDA------- 1083 + + + ++ S SK + S S+ S ++++ A Sbjct: 1525 NEILMQADSQADSQTDSDESKNEILMQADSQADSQTDSDESKNEILMQADSQAKIGESLE 1584 Query: 1084 NRKAPG-------LRRSFMSSIEIPSIHPDERAVASPSPEASREESTENDSSEQKILEAI 1136 + K G + + +IE+ H +E + +E STE S + I+E Sbjct: 1585 DNKVKGKEDNGDEVGKENSKTIEVKGRH-EESKDGKTNENGGKEVSTEEGSKDSNIVERN 1643 Query: 1137 SAVSQRIDNLSKSFSDLTLTDDENTQAKRTADAEQEEDVQQVRPNASFLFRGMGSAGSRA 1196 I S+ + + E + + + E+ ++ + N++ G Sbjct: 1644 GGKEDSIKEGSEDGKTVEINGGEELSTEEGSKDGKIEEGKEGKENST--KEGSKDDKIEE 1701 Query: 1197 GLDSKHASQHNIVE--AVNTVVINKSLSMDDHHFPCARGETGRMSLNERSRAQRGLEDD 1253 G++ K S + +N + +K +M++ TG+ S + +S G++DD Sbjct: 1702 GMEGKENSTKESSKDGKINEIHGDKEATMEEGSKDGGTNSTGKDSKDSKSVEINGVKDD 1760 Score = 57.0 bits (136), Expect = 3e-007 Identities = 266/1444 (18%), Positives = 512/1444 (35%), Gaps = 213/1444 (14%) Query: 470 ATATATAATSAGTAGNRTDESSDEISSSASSKNSSLRKTGLRKRPSLRKNIYRRPEWETG 529 +++ A++ S+ T N S+ + ++ + S+ K + + Sbjct: 187 SSSEASSEESSSTEHNNVTTGSNMVETNGENSESTQEKGD---------GVEGSNGGDVS 237 Query: 530 RSSLGVRKVLEMFEPNLHHGRGKRAESGDTGKPPPGRSKPKVPDKSEQVLQKT--KDFKS 587 +L KV ++ E N G+ E+ G+ ++ +V + E + K+ +S Sbjct: 238 MENLQGNKVEDLKEGNNVVENGETKENN--GENVESNNEKEVEGQGESIGDSAIEKNLES 295 Query: 588 KKVVSEVVE--KSNRGALNEQVEEVRGDVATARTADEHVVDGYRQETKESSPVSKEAKSK 645 K+ V VE K++ ++ E + E +G+ + +E V+G + E+ E S + K +SK Sbjct: 296 KEDVKSEVEAAKNDGSSMTENLGEAQGNNGVSTIDNEKEVEG-QGESIEDSDIEKNLESK 354 Query: 646 DVSPKE---AKKGSNGITSKL------------------HKNSPREASNAIVPS------ 678 + E AK + +T KL +K S ++ +V + Sbjct: 355 EDVKSEVEAAKNAGSSMTGKLEEAQRNNGVSTNETMNSENKGSGESTNDKMVNATTNDED 414 Query: 679 -KGENLEPTEVLSDGNNSFGEMHPSHNWMDGTYDQIDLEEPTNGKEI------------- 724 K EN E T ++G + GE + + + +LE +E+ Sbjct: 415 HKKENKEETHE-NNGESVKGENLENKAGNEESMKGENLENKVGNEELKGNASVEAKTNNE 473 Query: 725 -SAVSKPNEMISSQKVLKEKEKSKSAVSKIQERLTFRSSKKVTVENTAPRK-----EPSE 778 S K E S +V KE +K IQ S+K ++EN K S+ Sbjct: 474 SSKEEKREESQRSNEVYMNKETTKGENVNIQGESIGDSTKDNSLENKEDVKPKVDANESD 533 Query: 779 GVANHSDHDLGEDQAAYSSVEK-----GSNQVTEEPSPVKTSTGSNQELIDVLPDGDSSF 833 G + H + S+ +K G+++ + V+ +T + + + Sbjct: 534 GNSTKERHQEAQVNNGVSTEDKNLDNIGADEQKKNDKSVEVTTNDGDHTKEKREETQGNN 593 Query: 834 GELHPSYNWTDGTYDRKYVEQ----AAQINAAYSSVEKGSKKVTEEPSPYNS-VKASTGA 888 GE + N + D+K ++ A+ N S EK + + NS + + G Sbjct: 594 GESVKNEN-LENKEDKKELKDDESVGAKTNNETSLEEKREQTQKGHDNSINSKIVDNKGG 652 Query: 889 NQELIEVLSDGESSFRELHPSYSWMDGTYDQIDLEEPTHGKEIAVASATTEMNASQKDPK 948 N + + +E+H S D + KE + + N + Sbjct: 653 NAD--------SNKEKEVHVGDSTNDNNME---------SKEDTKSEVEVKKNDGSSEKG 695 Query: 949 EKEKGKSAVSKIQERLTFRSSKKVAVENAAPRKEPSEEVAILSDDDFGENHAEYSFLEKG 1008 E+ K + S ++L + S+ + ++ + + EE I + + E +K Sbjct: 696 EEGKENNKDSMEDKKLENKESQTDSKDDKSV-DDKQEEAQIYGGESKDDKSVEAKGKKKE 754 Query: 1009 SKQVTEEPSPHGAVQPDSSQTETVVTSPKEGKEKKRSKSTVSKIYERLTFRSSKKMAAPS 1068 SK+ + + V+ ++ E V + KE ++ ++ + SK + + + +KK+++ Sbjct: 755 SKENKKTKTNENRVR---NKEENVQGNKKESEKVEKGEKKESKDAKSVETKDNKKLSSTE 811 Query: 1069 ER--------------SDEVVIIREAEDANRKAPGLRRSFMSSIEIPSIHPDERAV---- 1110 R +E + E + G + + + E D+R+V Sbjct: 812 NRDEAKERSGEDNKEDKEESKDYQSVEAKEKNENGGVDTNVGNKEDSKDLKDDRSVEVKA 871 Query: 1111 -ASPSPEASREESTENDSSEQKILEAISAVSQRIDNLSKSFSDLTLTDDENTQAKRTADA 1169 S + REE ND S K V +N+ D+ + K D Sbjct: 872 NKEESMKKKREEVQRNDKSSTK------EVRDFANNM-----DIDVQKGSGESVKYKKDE 920 Query: 1170 EQEEDVQQVRPNASFLFRGMGSAGSRAGLDSKHASQHNIVEAVNTVVINKSLSMDDHHFP 1229 ++E + ++ + + + G + +SK+++ E V N+ +D+ Sbjct: 921 KKEGNKEENKDTINTSSKQKGKDKKKKKKESKNSNMKKKEEDKKEYVNNELKKQEDNKKE 980 Query: 1230 CARGETGRM-SLNERSRAQRGLED---------DYEPV-----------------IQPEE 1262 + E ++ N+ ++ ++ ED +YE + EE Sbjct: 981 TTKSENSKLKEENKDNKEKKESEDSASKNREKKEYEEKKSKTKEEAKKEKKKSQDKKREE 1040 Query: 1263 KLPSAAGSKFCSTPSITIDL----SELTSKIESFVHKSKRESD--NIYQSIPIKSQGTSN 1316 K SK S + E K ES HKSK++ D + +K + Sbjct: 1041 KDSEERKSKKEKEESRDLKAKKKEEETKEKKESENHKSKKKEDKKEHEDNKSMKKEEDKK 1100 Query: 1317 TALLHQP----------------EDAISVNSYESFENYESIEHELLSSTRKQNPEKASGE 1360 H+ ED S E + +H L EK E Sbjct: 1101 EKKKHEESKSRKKEEDKKDMEKLEDQNSNKKKEDKNEKKKSQHVKLVKKESDKKEKKENE 1160 Query: 1361 E--DTYEI---CSPPPELPPAREDSRNDLTLPQPKRNLSSSPKTLPKH-----LQVTYQS 1410 E +T EI S E+ + S D + K S K L K+ Q + + Sbjct: 1161 EKSETKEIESSKSQKNEVDKKEKKSSKDQQKKKEKEMKESEEKKLKKNEEDRKKQTSVEE 1220 Query: 1411 NYERIKYSKIPPRPPKPEEVPLPPRNSSTASTGATSSAANVTLEASTSH-SSSTEQASSG 1469 N ++ K +K PK ++ +N++ S G S + + EA S +T QA S Sbjct: 1221 N-KKQKETKKEKNKPKDDK-----KNTTKQSGGKKESMESESKEAENQQKSQATTQADSD 1274 Query: 1470 AGGDLLDKSPHRQERIYEENIYDTIRSADGV--DYDDPACGSAELDPMQTTQPGGIRVGL 1527 + + Q + ++ D+ S + + D A + + Q Sbjct: 1275 ESKNEILMQADSQADSHSDSQADSDESKNEILMQADSQATTQRNNEEDRKKQTSVAENKK 1334 Query: 1528 SSRARQQPSPPADNVSLVSSNCYESIGLRLEYERSMMLARRNLAGGSTTTLASDQITNSL 1587 +++ + P D+ + +S G + E A +TT SD+ N + Sbjct: 1335 QKETKEEKNKPKDD---KKNTTKQSGGKKESMESESKEAENQQKSQATTQADSDESKNEI 1391 Query: 1588 YGVTAGLASLTPPSERGSDTSNSADWTDISDEDETGERADVTTAMATGGSKRPNFIVVRE 1647 + S+ S + + AD +D S + + T R V E Sbjct: 1392 L--------MQADSQADSHSDSQAD-SDESKNEILMQADSQATTQRNNEEDRKKQTSVAE 1442 Query: 1648 RKRTHQTPLRSRKLARISHPKIDDDSDHHYESLYSIGSNDGRHQHQHDANYTTLPPHVDG 1707 K+ +T K + + S ES+ S S + +Q + A Sbjct: 1443 NKKQKETKEEKNK-PKDDKKNTTEQSGGKKESMES-ESKEAENQQKSQATTQGESDESKN 1500 Query: 1708 SLLSGNAASGVNFHEHRAGGGGGDASAAMLLPPDDEFDS-FDSDDTDYE--DEDDDRNRA 1764 +L A S + H + + G ++ +L+ D + DS DSD++ E + D + + Sbjct: 1501 EILM-QADSQADTHAN-SQGDSDESKNEILMQADSQADSQTDSDESKNEILMQADSQADS 1558 Query: 1765 RTDS 1768 +TDS Sbjct: 1559 QTDS 1562 Score = 56.2 bits (134), Expect = 5e-007 Identities = 153/866 (17%), Positives = 310/866 (35%), Gaps = 93/866 (10%) Query: 489 ESSDEISSSASSKNSSLRKTGLRKRPSLRKNIYRRPEWETGRSSLGVRKVLEMFEPNLHH 548 ES + S K ++K ++ ++ E R +K +E E + Sbjct: 1072 ESENHKSKKKEDKKEHEDNKSMKKEEDKKEK--KKHEESKSRKKEEDKKDMEKLEDQ--N 1127 Query: 549 GRGKRAESGDTGKPPPGRSKPKVPDKSE----QVLQKTKDFKSKKVVSEVVEKSNRGALN 604 K+ + + K + K DK E + +TK+ +S K V+K + + Sbjct: 1128 SNKKKEDKNEKKKSQHVKLVKKESDKKEKKENEEKSETKEIESSKSQKNEVDKKEKKSSK 1187 Query: 605 EQVEEVRGDVATA--RTADEHVVDGYRQETKESSPVSKEAKSKDVSPKEAKKGSNGITSK 662 +Q ++ ++ + + ++ D +Q + E + KE K + PK+ KK + + Sbjct: 1188 DQQKKKEKEMKESEEKKLKKNEEDRKKQTSVEENKKQKETKKEKNKPKDDKKNTTKQSGG 1247 Query: 663 LHKNSPREASNAIVPSKGENLEPTEVLSDGNNSFGEMHPSHNWMDGTYDQIDLEEPTNGK 722 ++ E+ A K + T+ SD + + M + Q D +E N Sbjct: 1248 KKESMESESKEAENQQKSQ--ATTQADSDESKNEILMQADSQADSHSDSQADSDESKNEI 1305 Query: 723 EISAVSKPNEMISSQKVLKEK----EKSKSAVSKIQERLTFRSSKKVTVENTAPRKEPSE 778 + A S+ ++++ K++ E K +K +E+ + KK T + + +KE E Sbjct: 1306 LMQADSQATTQRNNEEDRKKQTSVAENKKQKETK-EEKNKPKDDKKNTTKQSGGKKESME 1364 Query: 779 GVANHSDHDLGEDQAAYSSVEKGSNQVTEEPSPVKTSTGSNQELIDVLPDGDSSFGELHP 838 + +++ + ++ N++ + S +Q D D S E+ Sbjct: 1365 SESKEAENQQKSQATTQADSDESKNEILMQADSQADSHSDSQA------DSDESKNEILM 1418 Query: 839 SYNWTDGTYDRKYVEQAAQINAAYSSVEKGSKKVTEEPSP--YNSVKASTGANQELIEVL 896 + T ++ Q + A + +K +K+ +P N+ + S G + + Sbjct: 1419 QADSQATTQRNNEEDRKKQTSVAENKKQKETKEEKNKPKDDKKNTTEQSGGKKESMESES 1478 Query: 897 SDGESSFRELHPSYSWMDGTYDQI----DLEEPTHGK----------EIAVASATTEMNA 942 + E+ + + D + ++I D + TH EI + + + + Sbjct: 1479 KEAENQQKSQATTQGESDESKNEILMQADSQADTHANSQGDSDESKNEILMQADSQADSQ 1538 Query: 943 SQKDPKEKEKGKSAVSKIQERLTFRSSKK---VAVENAAPRKEPSEEVAILSDDDFG--- 996 + D + E A S+ + SK + ++ A E E+ + +D G Sbjct: 1539 TDSDESKNEILMQADSQADSQTDSDESKNEILMQADSQAKIGESLEDNKVKGKEDNGDEV 1598 Query: 997 --------------ENHAEYSFLEKGSKQV-TEEPSPHGAVQPDSSQTETVVTSPKEGKE 1041 E + E G K+V TEE S + + E + KEG E Sbjct: 1599 GKENSKTIEVKGRHEESKDGKTNENGGKEVSTEEGSKDSNIVERNGGKEDSI---KEGSE 1655 Query: 1042 KKRSKSTVSKIYERLTFRSSKKMAAPSERSDEVVIIREAEDANRKAPGLRRSFMSSIE-- 1099 ++ ++ E T SK + + +E ++ G+ S+ E Sbjct: 1656 DGKTVE-INGGEELSTEEGSKDGKIEEGKEGKENSTKEGSKDDKIEEGMEGKENSTKESS 1714 Query: 1100 ----IPSIHPDERAVASPSPEASREESTENDSSEQKILEAISAVSQRIDNLSKSFSDLTL 1155 I IH D+ A + ST DS + K +E + + SK+ + Sbjct: 1715 KDGKINEIHGDKEATMEEGSKDGGTNSTGKDSKDSKSVEINGVKDDSLKDDSKNGDINEI 1774 Query: 1156 TDDENTQAKRTADAEQEEDVQQVRPNASFLFRGMGSAGSRAGLDSKHASQHNIVEAVNTV 1215 + + K ++V +++ N + L S + LD+ S N NT+ Sbjct: 1775 NNGKEDSVK--------DNVTEIQGNDNSLTNSTSSEPNGDKLDTNKDSMKN-----NTM 1821 Query: 1216 VINKSLSMDDHHFPCARGETGRMSLNERSRAQRGLEDDYEPVIQPEEKLPSAAGSKFCST 1275 + D + + +S+N ++ G ++ + G ST Sbjct: 1822 EAQGGSNGDSTNGETEETKESNVSMNNQNMQDVGSNEN------SMNNQTTGTGDDIIST 1875 Query: 1276 PSITIDLSELTSK-IESFVHKSKRES 1300 T D TSK + SF+ + +S Sbjct: 1876 ---TTDTESNTSKEVTSFISNLEEKS 1898 ==> UNIPROT|Q15811 - symbol:ITSN1_HUMAN "ITSN1, ITSN, SH3D1A: Intersectin-1" species:9606 "Homo sapiens" [GO:0005085 "guanyl-nucleotide exchange factor activity" evidence=NAS] [GO:0005509 "calcium ion binding" evidence=NAS] [GO:0005515 "protein binding" evidence=IPI] [GO:0048488 "synaptic vesicle endocytosis" evidence=TAS] [GO:0005575 "cellular_component" evidence=ND] UniProt:Q15811 Prosite:PS00018 GO:GO:0005515 PROSITE:PS50222 PROSITE:PS50003 PROSITE:PS50002 PROSITE:PS50004 PROSITE:PS00741 PROSITE:PS50010 GO:GO:0005509 GO:GO:0048488 GO:GO:0005085 PDB:1KI1 PROSITE:PS50031 EMBL:AF064244 EMBL:AF064247 EMBL:AF064245 EMBL:AF064246 EMBL:AF064243 EMBL:AF114488 EMBL:AF114487 EMBL:U61166 EMBL:AF180522 UniGene:Hs.160324 SMR:Q15811 IntAct:Q15811 Ensembl:ENSG00000205726 KEGG:hsa:6453 HGNC:HGNC:6183 MIM:602442 LinkHub:Q15811 ArrayExpress:Q15811 GermOnline:ENSG00000205726 RZPD-ProtExp:T7439 Length = 1721 Score = 74.3 bits (181), Expect = 2e-012 Identities = 67/297 (22%), Positives = 116/297 (39%), Gaps = 28/297 (9%) Query: 2219 WCEVPEVRNSEILATLTPTEKRLQEAKFEILTSEASYLKSLNLLRTHFVNHPAFRDTRIL 2278 WC + +L LTPTE++ Q E++ +E +Y+ L L+ F ++ +L Sbjct: 1221 WCS-----DLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIF--QKPLMESELL 1273 Query: 2279 SSSERKTLFSSIIPVQECSDRLLCDLE--NCWQDNIMLLGLSHSIYKHAEKHFHVYVTYC 2336 + E +F + + C+ +LL L M + + I H Y+ +C Sbjct: 1274 TEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFC 1333 Query: 2337 EHQAKIDRTLKALKANKPEFARTLAALEADPVCCSLSLSSFLMLPMQRITRMRLLLDAVL 2396 Q ++ P+F + L DP C + LSSF++ PMQR+TR L++ +L Sbjct: 1334 SRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNIL 1393 Query: 2397 QRCHPDDDDEFGSWESTFVLINRILTQCNDAAHRSEQLYEMELLSRQIEFPTNVRPLAIV 2456 + P++ + + + +Q N+ E +E + ++ L Sbjct: 1394 ENT-PENHPDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFN 1452 Query: 2457 PCGIGAAPSTMHRKLEKRGDLVHVLWRGDDAKLTFGKKFSKSNVYAFLFTDLLVLTK 2513 P RK G L K S +Y FLF D L+LT+ Sbjct: 1453 SVTNCLGP----RKFLHSGKLY--------------KAKSNKELYGFLFNDFLLLTQ 1491 Score = 44.3 bits (103), Expect = 0.002 Identities = 30/96 (31%), Positives = 40/96 (41%), Gaps = 10/96 (10%) Query: 2607 QVIAVHPYQALQPDELDLDIKDVVNVHRKMADGWYEGERIRDGAVGWFPSNYTKEIPSAH 2666 QVI ++ Y A DEL + ++NV K W++GE +G VG FPSNY K Sbjct: 1159 QVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGE--VNGQVGLFPSNYVKLTTDMD 1216 Query: 2667 IRAKHIKQRHLLLTYTSKYIDTATKAHHHYHNYYHQ 2702 + HLL D T Y H+ Sbjct: 1217 PSQQWCSDLHLL--------DMLTPTERKRQGYIHE 1244 Score = 43.1 bits (100), Expect = 0.005 Identities = 23/57 (40%), Positives = 33/57 (57%), Gaps = 5/57 (8%) Query: 2607 QVIAVHPYQALQPDELDLDIKDVVNVHRKMADGWYEGE---RIRDGAVGWFPSNYTK 2660 QVIA Y A P++L L ++ + +K GW+EGE R + +GWFP+NY K Sbjct: 1080 QVIA--SYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVK 1134 Score = 42.7 bits (99), Expect = 0.006 Identities = 22/67 (32%), Positives = 35/67 (52%), Gaps = 9/67 (13%) Query: 2610 AVHPYQALQPDELDLDIKDVVNVHRKMAD-------GWYEGERIRDGAVGWFPSNYTKEI 2662 A++P+++ DE+ + D+V V + D GW GE G GWFP+NY ++I Sbjct: 747 ALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGEL--KGKTGWFPANYAEKI 804 Query: 2663 PSAHIRA 2669 P + A Sbjct: 805 PENEVPA 811 ==> MGI|MGI:1338069 - symbol:Itsn1 "intersectin 1 (SH3 domain protein 1A)" species:10090 "Mus musculus" [GO:0030027 "lamellipodium" evidence=IDA] [GO:0005515 "protein binding" evidence=IPI] [GO:0007264 "small GTPase mediated signal transduction" evidence=IDA] Pfam:PF00018 Pfam:PF00169 InterPro:IPR002048 InterPro:IPR000219 InterPro:IPR011992 Pfam:PF00036 Pfam:PF00168 InterPro:IPR000008 InterPro:IPR001331 InterPro:IPR001452 InterPro:IPR001849 InterPro:IPR000261 UniProt:Q9Z0R4 MGI:MGI:1338069 Prosite:PS00018 GO:GO:0005515 GO:GO:0007264 Gene3D:G3DSA:1.10.238.10 PROSITE:PS50222 InterPro:IPR011993 Gene3D:G3DSA:2.30.29.30 SMART:SM00233 PROSITE:PS50003 SMART:SM00054 PRINTS:PR00452 ProDom:PD000066 SMART:SM00326 PROSITE:PS50002 GO:GO:0030027 Gene3D:G3DSA:1.20.900.10 Pfam:PF00621 SMART:SM00239 SMART:SM00325 PROSITE:PS50004 PROSITE:PS00741 PROSITE:PS50010 InterPro:IPR013315 PRINTS:PR01887 HSSP:Q15811 PRINTS:PR00360 SMART:SM00027 PROSITE:PS50031 EMBL:AF132481 EMBL:AF132478 EMBL:AF169621 EMBL:AF356517 UniGene:Mm.392174 UniGene:Mm.40546 SMR:Q9Z0R4 IntAct:Q9Z0R4 Ensembl:ENSMUSG00000022957 KEGG:mmu:16443 ArrayExpress:Q9Z0R4 GermOnline:ENSMUSG00000022957 Length = 1714 Score = 73.2 bits (178), Expect = 4e-012 Identities = 67/297 (22%), Positives = 116/297 (39%), Gaps = 28/297 (9%) Query: 2219 WCEVPEVRNSEILATLTPTEKRLQEAKFEILTSEASYLKSLNLLRTHFVNHPAFRDTRIL 2278 WC + +L LTPTE++ Q E++ +E +Y+ L L+ F ++ +L Sbjct: 1214 WCS-----DLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIF--QKPLTESELL 1266 Query: 2279 SSSERKTLFSSIIPVQECSDRLLCDLE--NCWQDNIMLLGLSHSIYKHAEKHFHVYVTYC 2336 + E +F + + C+ +LL L M + + I H Y+ +C Sbjct: 1267 TEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFC 1326 Query: 2337 EHQAKIDRTLKALKANKPEFARTLAALEADPVCCSLSLSSFLMLPMQRITRMRLLLDAVL 2396 Q ++ P+F + L DP C + LSSF++ PMQR+TR L++ +L Sbjct: 1327 SCQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNIL 1386 Query: 2397 QRCHPDDDDEFGSWESTFVLINRILTQCNDAAHRSEQLYEMELLSRQIEFPTNVRPLAIV 2456 + P++ + + + +Q N+ E +E + ++ L Sbjct: 1387 ENT-PENHPDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFN 1445 Query: 2457 PCGIGAAPSTMHRKLEKRGDLVHVLWRGDDAKLTFGKKFSKSNVYAFLFTDLLVLTK 2513 P RK G L K S +Y FLF D L+LT+ Sbjct: 1446 SVTNCLGP----RKFLHSGKLY--------------KAKSNKELYGFLFNDFLLLTQ 1484 Score = 43.5 bits (101), Expect = 0.004 Identities = 30/96 (31%), Positives = 38/96 (39%), Gaps = 10/96 (10%) Query: 2607 QVIAVHPYQALQPDELDLDIKDVVNVHRKMADGWYEGERIRDGAVGWFPSNYTKEIPSAH 2666 QVI ++ Y A DEL ++NV K W++GE G VG FPSNY K Sbjct: 1152 QVIGMYDYTAQNDDELAFSKGQIINVLNKEDPDWWKGE--VSGQVGLFPSNYVKLTTDMD 1209 Query: 2667 IRAKHIKQRHLLLTYTSKYIDTATKAHHHYHNYYHQ 2702 + HLL D T Y H+ Sbjct: 1210 PSQQWCSDLHLL--------DMLTPTERKRQGYIHE 1237 Score = 43.1 bits (100), Expect = 0.005 Identities = 23/57 (40%), Positives = 33/57 (57%), Gaps = 5/57 (8%) Query: 2607 QVIAVHPYQALQPDELDLDIKDVVNVHRKMADGWYEGE---RIRDGAVGWFPSNYTK 2660 QVIA Y A P++L L ++ + +K GW+EGE R + +GWFP+NY K Sbjct: 1073 QVIA--SYAATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVK 1127 Score = 42.0 bits (97), Expect = 0.011 Identities = 20/60 (33%), Positives = 32/60 (53%), Gaps = 4/60 (6%) Query: 2610 AVHPYQALQPDELDLDIKDVVNVHRKMAD--GWYEGERIRDGAVGWFPSNYTKEIPSAHI 2667 A++P+++ DE+ + D+V V GW GE G GWFP+NY ++IP + Sbjct: 745 ALYPFESRSHDEITIQPGDIVMVDESQTGEPGWLGGEL--KGKTGWFPANYAEKIPENEV 802 ==> TAIR|gene:504953784 - symbol:AT2G22795.1 species:3702 "Arabidopsis thaliana" [GO:0008150 "biological_process" evidence=ND] [GO:0003674 "molecular_function" evidence=ND] GenBank:NM_179701.1 Ncbi:NP_850032 Length = 734 Score = 71.6 bits (174), Expect = 1e-011 Identities = 116/618 (18%), Positives = 234/618 (37%), Gaps = 61/618 (9%) Query: 591 VSEVVEKSNRGALN--EQVEEVRGDVATARTADEHVVDGYRQETKESSP--VSKEAKSKD 646 V EV E + G+ N E GD + +V+G + ++ S VS E + + Sbjct: 73 VVEVDEAEDEGSKNVVESFNSGNGD-----DKENEIVEGGEENKEKESEGIVSNEDSNSE 127 Query: 647 VSPKEAKKGSNGITSKLHKNSPREASNAIVPSKGENLEPTEVLSDGNNSFGEMHPSHNWM 706 + E KK S G+ R+ ++ E +EV +N E N Sbjct: 128 I---EEKKDSGGVEES-EVEEKRDNGGGTEENEKSGTEESEVEERKDNGGTE----ENEK 179 Query: 707 DGTYD-QIDLEEPTNGKEISAVSKPNEMISSQKV----LKEKEKSKSAVSKIQERL---- 757 GT + +++ + G E + S E ++ +E EKS S S+++E+ Sbjct: 180 SGTEESEVEERKDNGGTEENEKSGTEESEVEERKENGGTEENEKSGSEESEVEEKKDNGG 239 Query: 758 TFRSSKKVTVENTAPRKEPSEGVANHSDHDLGEDQAAYSSVEKGSNQVTEEPSPVKTSTG 817 T S +K E + ++ G + S+ + ++ E+ + +E + ++ + Sbjct: 240 TEESREKSGTEESEVEEKKDNGSSEESEVEEKKENRGIDESEESKEKDIDEKANIEEARE 299 Query: 818 SNQELIDVLPDGDSSFGEL-HPSYNWTDGTYDRKYVEQAAQI------NAAYSSVEKGSK 870 +N + GD + E+ H S T + + + VE + I ++ SV + Sbjct: 300 NNYK-------GDDASSEVVHESEEKTSESENSEKVEDKSGIKTEEVEDSVIKSVLPNTT 352 Query: 871 KVTEEPSPYNSVKASTGANQELIE-VLSDGESSFRELHPSYSWMDGTYDQIDLEEPTHGK 929 E S S +S+G + +E + S+GES + ++ ++ + E GK Sbjct: 353 DNGESSSDEKSTGSSSGHESDSLEGIKSEGESMEKN-----ELLEKEFNDSNGESSVTGK 407 Query: 930 EIAVASATTEMNASQKDPKEKEKGKSAVSKIQERLTFRSSKKVAVENAAPRKEPSEEVAI 989 ++ S+ +E+ KGK + +K +E + + K ++E S + Sbjct: 408 STGSGDGGSQ-ETSEVSSQEESKGKESETKDKEESSSQEESKDRETETKEKEESSSQEET 466 Query: 990 LSDDDFGENHAEYSFLEKGSKQVTEEPSPHGAVQPDSSQTETVVTSPKEGKEKKRSKSTV 1049 + + + E S EK + TE+ + + ET +EK K T Sbjct: 467 MDKETEAKEKVESSSQEKNEDKETEKIESSFLEETKEKEDETKEKEESSSQEKTEEKETE 526 Query: 1050 SKIYERLTFRS----------SKKMAAPSERSDEVVIIREAEDANRKAPGLRRSFMSSIE 1099 +K E + + K+ A+ E S E + ++ + + IE Sbjct: 527 TKDNEESSSQEETKDKENEKIEKEEASSQEESKENETETKEKEESSSQEETKEKENEKIE 586 Query: 1100 IPSIHPDERAVASPSPEASREESTENDSSEQKILEAISAVSQRIDNLSKSFSDLTLTDDE 1159 P E + + +EES + +++K E ++ ++ S + T+ E Sbjct: 587 KEESAPQEETKEKENEKIEKEESASQEETKEKETE----TKEKEESSSNESQENVNTESE 642 Query: 1160 NTQAKRTADAEQEEDVQQ 1177 + + + +ED + Sbjct: 643 KKEQVEENEKKTDEDTSE 660 Score = 68.2 bits (165), Expect = 1e-010 Identities = 132/650 (20%), Positives = 246/650 (37%), Gaps = 108/650 (16%) Query: 561 KPPPGRSKPKVPDKSEQVLQKTKDFKSKKVVSEVVEKSNRGALN---------EQVEEVR 611 K G + +V +K + ++ KS SEV E+ + G +VEE + Sbjct: 132 KDSGGVEESEVEEKRDNGGGTEENEKSGTEESEVEERKDNGGTEENEKSGTEESEVEERK 191 Query: 612 GDVATARTADEHVVDGYRQETKESSPVSKEAKSKDVSPKEAKKGSNGITSKLHKNSPREA 671 + T + +E KE+ + KS + +K NG T + + S E Sbjct: 192 DNGGTEENEKSGTEESEVEERKENGGTEENEKSGSEESEVEEKKDNGGTEESREKSGTEE 251 Query: 672 SNAIVPSKGENLEPTEVLSDGNNSFGEMHPSHNWMDGTYDQIDLEEPTNGKEISAVSKPN 731 S V K +N G+ ++ ++EE K N Sbjct: 252 SE--VEEKKDN-------------------------GSSEESEVEE----------KKEN 274 Query: 732 EMISSQKVLKEKEKSKSAVSKIQERLTFRSSKKVTVENTAPRKEPSEGVANHSDHDLGED 791 I + KEK+ I E+ ++ EN + S V + S+ E Sbjct: 275 RGIDESEESKEKD--------IDEKANIEEAR----ENNYKGDDASSEVVHESEEKTSES 322 Query: 792 QAAYSSVEKGSNQVTEEPSPVKTSTGSNQELIDVLP----DGDSSFGELHPSYNWTDGTY 847 + +++ E+ S +KT + + VLP +G+SS E + G+ Sbjct: 323 E---------NSEKVEDKSGIKTEEVEDSVIKSVLPNTTDNGESSSDEK------STGSS 367 Query: 848 DRKYVEQAAQINAAYSSVEKGS--KKVTEEPSPYNSVKAST-----GANQELIEVLSDGE 900 + I + S+EK +K + + +SV + G +QE EV S E Sbjct: 368 SGHESDSLEGIKSEGESMEKNELLEKEFNDSNGESSVTGKSTGSGDGGSQETSEVSSQEE 427 Query: 901 SSFRELHPSYSWMDGTYDQIDLEEPTHGKEIAVASATTEMNASQKDPKEKEKGKSAVSKI 960 S +E + ++ + T KE +S+ E + + KEK + S+ K Sbjct: 428 SKGKESETKDKEESSSQEE-SKDRETETKEKEESSSQEETMDKETEAKEKVE-SSSQEKN 485 Query: 961 QERLTFRSSKKVAVENAAPRKEPSEEVAILSDDDFGENHAEYSFLEKGSKQ-VTEEPSPH 1019 +++ T + E E E+ S + E E E+ S Q T++ Sbjct: 486 EDKETEKIESSFLEETKEKEDETKEKEESSSQEKTEEKETETKDNEESSSQEETKDKENE 545 Query: 1020 GAVQPDSSQTETVVTSPKEGKEKKRSKSTVSKIYERLTFRSSKKMAAPSERSDEVVIIRE 1079 + ++S E + E KEK+ S S+ + E+ + K+ +AP E + E +E Sbjct: 546 KIEKEEASSQEESKENETETKEKEES-SSQEETKEKENEKIEKEESAPQEETKE----KE 600 Query: 1080 AEDANRKAPGLRRSFMSSIEIPSIHPDERAVASPSPEASREESTENDSSEQKILEAISAV 1139 E ++ + ++ E+S ES EN ++E + E + Sbjct: 601 NEKIEKEESASQEE----------TKEKETETKEKEESSSNESQENVNTESEKKEQVEEN 650 Query: 1140 SQRID-NLSKSFSDLTLTDDENTQAKRTADAEQ-----EEDVQQVRPNAS 1183 ++ D + S+S + +++D E Q++ T++ E+ E +V Q + ++S Sbjct: 651 EKKTDEDTSESSKENSVSDTEQKQSEETSEKEESNKNGETEVTQEQSDSS 700 Score = 63.2 bits (152), Expect = 4e-009 Identities = 120/541 (22%), Positives = 203/541 (37%), Gaps = 100/541 (18%) Query: 555 ESGDTGKPPPGRSKPKVPDKSEQVLQKTKDFKSKKVVSEVVEKSNRGALNE--------- 605 E D G R K E +++ KD S + SEV EK ++E Sbjct: 233 EKKDNGGTEESREKSGT---EESEVEEKKDNGSSEE-SEVEEKKENRGIDESEESKEKDI 288 Query: 606 ----QVEEVRGDVATARTADEHVVDGYRQETKESSPVSK-EAKS------------KDVS 648 +EE R + A VV ++T ES K E KS K V Sbjct: 289 DEKANIEEARENNYKGDDASSEVVHESEEKTSESENSEKVEDKSGIKTEEVEDSVIKSVL 348 Query: 649 PKEAKKGSNGITSKLHKNSPREASNAI--VPSKGENLEPTEVL------SDGNNSF-GEM 699 P G + K +S S+++ + S+GE++E E+L S+G +S G+ Sbjct: 349 PNTTDNGESSSDEKSTGSSSGHESDSLEGIKSEGESMEKNELLEKEFNDSNGESSVTGKS 408 Query: 700 HPSHNWMDGTYDQIDLEEPTNGKEISAVSKPNEMISSQKVLKEKE---KSKSAVSKIQER 756 S + ++ +E + GKE + +K E SSQ+ K++E K K S +E Sbjct: 409 TGSGDGGSQETSEVSSQEESKGKE--SETKDKEESSSQEESKDRETETKEKEESSSQEET 466 Query: 757 LTFRSSKKVTVENTAPRKEPSEGVANHSDHDLGEDQAAYSSV-EKGSNQVTEEPSPVKTS 815 + + K VE+++ K + L E + EK + E+ +T Sbjct: 467 MDKETEAKEKVESSSQEKNEDKETEKIESSFLEETKEKEDETKEKEESSSQEKTEEKETE 526 Query: 816 TGSNQELIDVLPDGDSSFGELHPSYNWTDGTYDRKYVEQAAQINAAYSSVEKGSKKVTEE 875 T N+E SS E N E+ + A+ K ++ T+E Sbjct: 527 TKDNEE--------SSSQEETKDKEN-----------EKIEKEEASSQEESKENETETKE 567 Query: 876 PSPYNSVKASTGANQELIEVLSDGESSFRELHPSYSWMDGTYDQIDLEEPTHGKEIAVAS 935 +S + + E IE E P + ++I+ EE Sbjct: 568 KEESSSQEETKEKENEKIEK--------EESAPQEETKEKENEKIEKEE----------- 608 Query: 936 ATTEMNASQKDPKEKEKGKSAVSKIQERLTFRSSKKVAVENAAPRKEPSEEVAILSDDDF 995 + ++ +K+ + KEK +S+ ++ QE + S KK VE + +D+D Sbjct: 609 SASQEETKEKETETKEKEESSSNESQENVNTESEKKEQVEENEKK----------TDEDT 658 Query: 996 GENHAEYSFLEKGSKQ-----VTEEPSPHG--AVQPDSSQTETVVTSPKEGKEKKRSKST 1048 E+ E S + KQ EE + +G V + S + + P+E K+ + T Sbjct: 659 SESSKENSVSDTEQKQSEETSEKEESNKNGETEVTQEQSDSSSDTNLPQEVKDVRTDLET 718 Query: 1049 V 1049 + Sbjct: 719 L 719 Score = 62.8 bits (151), Expect = 6e-009 Identities = 81/379 (21%), Positives = 152/379 (40%), Gaps = 57/379 (15%) Query: 488 DESSDEISSSASSKNSSLRKTGLRKR-PSLRKNIYRRPEWE------------TGRSSLG 534 + SSDE S+ +SS + S G++ S+ KN E+ TG G Sbjct: 356 ESSSDEKSTGSSSGHESDSLEGIKSEGESMEKNELLEKEFNDSNGESSVTGKSTGSGDGG 415 Query: 535 VRKVLEMFEPNLHHGRGKRAESGD----------------TGKPPPGRSKPKVPDKSEQV 578 ++ E+ + +GK +E+ D T + S+ + DK + Sbjct: 416 SQETSEV--SSQEESKGKESETKDKEESSSQEESKDRETETKEKEESSSQEETMDKETEA 473 Query: 579 LQKTKDFKSKKVVSEVVEKSNRGALNEQVEEVRGDVATARTADEHVVDGYRQETKESSPV 638 +K + +K + EK L E E+ ++ + + ETK++ Sbjct: 474 KEKVESSSQEKNEDKETEKIESSFLEETKEKEDETKEKEESSSQEKTEEKETETKDNEES 533 Query: 639 S--KEAKSKDVSPKEAKKGSNGITSKLHKNSPREASNAIVPSKGENLEPTEVLSDGNNSF 696 S +E K K+ E ++ S+ SK ++ +E + + + E ++ + Sbjct: 534 SSQEETKDKENEKIEKEEASSQEESKENETETKEKEESSSQEETKEKENEKIEKE----- 588 Query: 697 GEMHPSHNWMDGTYDQIDLEEPTNGKEISAVSKPNEMISSQKVLKEKEKSKSAVSKIQER 756 E P + ++I+ EE + +E + +K + KEK +S+ ++ QE Sbjct: 589 -ESAPQEETKEKENEKIEKEESASQEE-----------TKEKETETKEKEESSSNESQEN 636 Query: 757 LTFRSSKKVTVENTAPR--KEPSEGVANHSDHDLGEDQAAYSSVEKGSN-----QVTEEP 809 + S KK VE + ++ SE +S D + Q+ +S ++ SN +VT+E Sbjct: 637 VNTESEKKEQVEENEKKTDEDTSESSKENSVSDTEQKQSEETSEKEESNKNGETEVTQEQ 696 Query: 810 SPVKTSTGSNQELIDVLPD 828 S + T QE+ DV D Sbjct: 697 SDSSSDTNLPQEVKDVRTD 715 Score = 58.2 bits (139), Expect = 1e-007 Identities = 159/836 (19%), Positives = 313/836 (37%), Gaps = 139/836 (16%) Query: 580 QKTKDFKSKKVVSEVVEKSNRGALNEQVEEVRGDVATARTADEHVVDGYRQETKESSPVS 639 Q++K FK K + + S L QV+ A + + VV G + K Sbjct: 10 QRSKGFKVKHCIQLTLLLSVGIWLLYQVKHSHEKKAQFEESAKIVVGGVDKVVKLGR--- 66 Query: 640 KEAKSKDVSPKEAK-KGSNGITSKLHKNSPREASNAIVPSKGENLEP-TEVLSDGNNSFG 697 K+ + V EA+ +GS + + + + N IV EN E +E + +S Sbjct: 67 KDLIPRVVEVDEAEDEGSKNVVESFNSGNGDDKENEIVEGGEENKEKESEGIVSNEDSNS 126 Query: 698 EMHPSHNWMDGTYDQIDLEEPTN---GKEISAVSKPNEMISSQKV----LKEKEKSKSAV 750 E+ + G ++ ++EE + G E + S E ++ +E EKS + Sbjct: 127 EIEEKKD--SGGVEESEVEEKRDNGGGTEENEKSGTEESEVEERKDNGGTEENEKSGTEE 184 Query: 751 SKIQERL----TFRSSKKVTVENTAPRKEPSEGVANHSDHDLGEDQAAYSSVEKGSNQVT 806 S+++ER T + K T E+ ++ + G + E + EK N T Sbjct: 185 SEVEERKDNGGTEENEKSGTEESEVEERKENGGTEENEKSGSEESEVE----EKKDNGGT 240 Query: 807 EEPSPVKTSTGSNQELIDVLPDGDSSFGELHPSYNWTDGTYDRKYVEQAAQINAAYSSVE 866 EE + +G+ + ++ D SS + VE+ + S E Sbjct: 241 EES---REKSGTEESEVEEKKDNGSS---------------EESEVEEKKENRGIDESEE 282 Query: 867 KGSKKVTEEPSPYNSVKASTGANQELIEVLSDGESSFRELHPSYSWMDGTYDQIDLEEPT 926 K + E+ + + + + + EV+ + E E S D + I EE Sbjct: 283 SKEKDIDEKANIEEARENNYKGDDASSEVVHESEEKTSESENSEKVEDKS--GIKTEEVE 340 Query: 927 HGKEIAVASATTEMNASQKDPKEKEKGKSAVSKIQERLTFRSSKKVAVENAAPRKEPSEE 986 +V TT+ S D EK G S+ + S +++ E +E Sbjct: 341 DSVIKSVLPNTTDNGESSSD--EKSTGSSSGHE--------SDSLEGIKSEGESMEKNE- 389 Query: 987 VAILSDDDFGENHAEYSFLEKGSKQVTEEPSPHGAVQPDSSQTETVVTSPKEGKEKKRSK 1046 L + +F +++ E S VT + + G D ET S +E + K S+ Sbjct: 390 ---LLEKEFNDSNGESS--------VTGKSTGSG----DGGSQETSEVSSQEESKGKESE 434 Query: 1047 STVSKIYERLTFRSSKKMAAPSERSDEVVIIREAEDANRKAPGLRRSFMSSIEIPSIHPD 1106 + + ++ ++ E D +E E+++ + + D Sbjct: 435 T-----------KDKEESSSQEESKDRETETKEKEESSSQEETM---------------D 468 Query: 1107 ERAVASPSPEASREESTENDSSEQKILEAISAVSQRIDNLSKSFSDLTLTDDENTQAKRT 1166 + A E+S +E E+ +E+ + SF + T ++ T+ K Sbjct: 469 KETEAKEKVESSSQEKNEDKETEK---------------IESSFLEETKEKEDETKEKEE 513 Query: 1167 ADAEQEEDVQQVRPNASFLFRGMGSAGSRAGLDSKHASQHNIVEAVNTVVINKSLSMDDH 1226 + ++++ + ++ + + +SQ + N + + S + Sbjct: 514 SSSQEKTEEKETETKDN----------------EESSSQEETKDKENEKIEKEEASSQEE 557 Query: 1227 HFPCARGETGRMSLNERSRAQRGLEDDYEPVIQPEEKLPSAAGSKFCSTPSITIDLSELT 1286 ET E S + E + E + EK SA + + I+ E Sbjct: 558 S---KENETETKEKEESSSQEETKEKENEKI----EKEESAPQEETKEKENEKIEKEESA 610 Query: 1287 SKIESFVHKSKRESDNIYQSIPIKSQGTSNTALLHQPEDAISVNSYESFENY-ESIEHEL 1345 S+ E+ + + E+ +S +SQ NT + ++ + N ++ E+ ES + Sbjct: 611 SQEET--KEKETETKEKEESSSNESQENVNTE--SEKKEQVEENEKKTDEDTSESSKENS 666 Query: 1346 LSSTRKQNPEKASGEEDTYEICSPPPELPPAREDSRNDLTLPQPKRNLSSSPKTLP 1401 +S T ++ E+ S +E++ + + E+ + DS +D LPQ +++ + +TLP Sbjct: 667 VSDTEQKQSEETSEKEESNK--NGETEVTQEQSDSSSDTNLPQEVKDVRTDLETLP 720 Score = 38.9 bits (89), Expect = 0.091 Identities = 57/307 (18%), Positives = 108/307 (35%), Gaps = 31/307 (10%) Query: 430 DPGSDGVYGFTSTGRMSSARSSLRKKHSNASATTGGGATAATATATAATSAGTAGNRTDE 489 D GS +S S + K ++S T ++S ++ E Sbjct: 413 DGGSQETSEVSSQEESKGKESETKDKEESSSQEESKDRETETKEKEESSSQEETMDKETE 472 Query: 490 SSDEISSSASSKNSSLRKTGLRKRPSLRKNIYRRPEWETGRSSLGVRKVLEMFEPNLHHG 549 + +++ SS+ KN ++T + L + + E + S K E Sbjct: 473 AKEKVESSSQEKNED-KETEKIESSFLEETKEKEDETKEKEESSSQEKTEE--------- 522 Query: 550 RGKRAESGDTGKPPPGRSKPKVPDKSEQVLQK---TKDFKSKKVVSEVVEKSNRGALNEQ 606 K E+ D + S+ + DK + ++K + +SK+ +E EK + E Sbjct: 523 --KETETKDNEE---SSSQEETKDKENEKIEKEEASSQEESKENETETKEKEESSSQEET 577 Query: 607 VEEVRGDVATARTADEHVVDGYRQE--TKESSPVSKEAKSKDVSPKEAKKGSNGIT---- 660 E+ + +A + E KE S +E K K+ KE ++ S+ + Sbjct: 578 KEKENEKIEKEESAPQEETKEKENEKIEKEESASQEETKEKETETKEKEESSSNESQENV 637 Query: 661 -------SKLHKNSPREASNAIVPSKGENLEPTEVLSDGNNSFGEMHPSHNWMDGTYDQI 713 ++ +N + + SK ++ TE S E + + T +Q Sbjct: 638 NTESEKKEQVEENEKKTDEDTSESSKENSVSDTEQKQSEETSEKEESNKNGETEVTQEQS 697 Query: 714 DLEEPTN 720 D TN Sbjct: 698 DSSSDTN 704 ==> TAIR|gene:2170587 - symbol:AT5G40450.1 species:3702 "Arabidopsis thaliana" [GO:0005575 "cellular_component" evidence=ND] [GO:0008150 "biological_process" evidence=ND] [GO:0003674 "molecular_function" evidence=ND] GenBank:NM_123409.2 Ncbi:NP_198861 Length = 2910 Score = 68.9 bits (167), Expect = 8e-011 Identities = 213/1105 (19%), Positives = 404/1105 (36%), Gaps = 163/1105 (14%) Query: 499 SSKNSSLRKTGLRKRPSLRKNIYRRPEWETGRSSLGVRKVLEMFEPNLHHGRG--KRAES 556 + K + + + PSL N + E E + + +++ E ++H + AE Sbjct: 534 AEKEEDKEEIKIDEEPSL--NAIEKAETENVKIVIEEPEIVNNEETSVHESESLKENAEP 591 Query: 557 GDTGKPPPGRSKPKVPDKSEQVLQKTKDFKSKKVVSEVVEKSNRGALNEQVEEVRGDVAT 616 + K G + E + + K+ E+ E+ + + + +E ++ Sbjct: 592 VEAVKNSDGTEQIS----REVTVDRAKEEDIAPKTEEIQERPSESKASLEPKEEVDHISN 647 Query: 617 ARTADEHVV--DGYRQETKESSPV-SKEAKSKDVSPKEAKKGSNGITSKLHKNSPREASN 673 EHV+ D + ET ES V +KE + KE K+ T K +S S+ Sbjct: 648 ETEEHEHVLERDVQQCETIESEAVETKEDTQPSLDLKEDKETEEAETFKTVFSSDEVRSS 707 Query: 674 AIVPSK-GENLEPTEVLSDGNNSFGEMHPSHNWMDGTYDQIDLEEPTNGKEISAVSKPNE 732 A+ + GE+ EP ++++ ++GKE S K E Sbjct: 708 AVQEEQFGEHTEPCSS-------------------------EIKDESHGKEESVEVKSQE 742 Query: 733 MISSQKVLKEKEKSKSAVSKIQERLTFRSSKKVTVENTAP----RKEPSEGVANHSDHDL 788 + + ++K S E+ + V V NT K PS+ V N +L Sbjct: 743 TVQDENT-EDKHDVLKVPSTESEKYQGNEPETVLVSNTGSYEKSEKSPSDLVLNVDKEEL 801 Query: 789 GEDQAAYSSVEKGSNQVTEEPSPVKTSTGSNQELIDVLPDGDSSFGELHPSYNWTDGTYD 848 +++ V+ Q+ EEP + S G+ E ID N T+ T + Sbjct: 802 NDEKINVDQVD--GTQIMEEPIGLD-SNGAEAEQID---------------QNITNETEE 843 Query: 849 RKYVEQAAQINAAYSSVEKGSKKVTEEPSPYNSVKASTGANQELIEVLSDGESSFRELHP 908 + + ++ SVE+ K E PS + + T ++++ E + + ++E Sbjct: 844 ILVAKPVSLLDV--KSVEQMQKPKLESPSEVSEETSKT-VDEKIEEKPEEEVTLYQE--- 897 Query: 909 SYSWMDGTY------------DQIDLEEPTHGKEIAVASATTEMNASQKDPKE--KEKGK 954 +DG+Y + I+LEE +E +V T + + P E +E K Sbjct: 898 --GQVDGSYGLETKEETVSVPESIELEEQPQ-EERSVIDPTPLQKPTLESPSEVLEESSK 954 Query: 955 SAVSKIQERLTFRSSKKVAVENAA-----PRKEPSEEVAILSDDDFGENHAEYSFLEKGS 1009 + KI+E+ ++A E + P +E S + + E H E + E S Sbjct: 955 TVDEKIEEKTDSIELGEIAQEERSVTDLTPLQEESSQPNEQEKETKLEKH-EPTNEEVKS 1013 Query: 1010 KQVTE--EPSPHGAVQPDSSQTETVVTSPKEGKEKKRSKSTVSKIYERLTFRSSKKMAAP 1067 +V E SP ++ ++ + + KE +E++ ++ + T S + Sbjct: 1014 DEVIEVLSASPSKELEGETVVEAENIENIKENEEEQAAEKIQKSLETVQTVESPSSLLFS 1073 Query: 1068 SERSDEVVIIREA--EDANRKAPGL-------------------RRSFMSSIEIPSIH-- 1104 SE D V + E E A + P L R S EI SI+ Sbjct: 1074 SEEQDHVTVAEEIVDEKAKEEVPMLQIKNEDDATKIHETRVEQARDIGPSLTEICSINQN 1133 Query: 1105 -PDERAVASPSPEASREE---STENDSSEQKILEAISAVSQRIDNLSKSFSDLTLTDDEN 1160 P+E+ + S E +E ++EN +E L ++ A + +S D+ T Sbjct: 1134 QPEEQVKEACSKEEQEKEISTNSENIVNETYALHSVEAAEEETATNGESLDDVETTKSVL 1193 Query: 1161 TQAKRTADAEQEEDVQQVRPNASFLFRGMGSAGSRAGLDSKHASQHNIVEAVNTVVINKS 1220 + ++ + E+ E P + + D+K + T ++S Sbjct: 1194 LEVRK--EEEEAEMKTDAEPRLDAIEKEELETVKTVVQDAKIVNNEE-----TTAHESES 1246 Query: 1221 LSMDDHHFPCARGETGRMSLNERSRAQRGLEDDYEPVIQPEEKLPSA-AGSKFCSTPSIT 1279 L D+H A +L++ + R + D E EK+ G TP+I Sbjct: 1247 LKGDNHQEKNAEPVEATQNLDDAEQISREVTVDTEREADITEKIEKVQEGPTVIETPTIQ 1306 Query: 1280 ID--LSELTSKIESFVHKSKRESD--------NIYQSIPIKSQGTSNTAL---------- 1319 + SE + +++ V +S ++++ +I Q +K++ + + Sbjct: 1307 GEDIESETSLELKEEVDQSSKDTEEHEHVLERDIPQCETLKAEAVDTSTVEEAAILKTLE 1366 Query: 1320 --LHQPEDAISVNSYESFENYESIEHELLSS---TRKQNPEKASGEE--DTYEICSPPPE 1372 + +PE S S + + E E E + + + + A EE + E CS + Sbjct: 1367 TNISEPEAMHSETSLDLKVDKEQKEAETVKTVIFSNEVGTSDAQAEEFGEHTEPCSSEIK 1426 Query: 1373 LPPAREDSRNDLTLPQPKRNLSSSPKTLPKHLQV------TYQSNYERIKYSKIPPRPPK 1426 + ++ + + SS K + L V YQ N I K Sbjct: 1427 DESQGSEESVEVKSKETVQGESSEEKDV-NMLDVQSGESEKYQENEPDISLVSKTENGDK 1485 Query: 1427 PEEVPLPPRNSSTASTGATSSAANVTLEASTSHSSSTEQASSGAGGDLLDKSPHRQERIY 1486 EE+P + T + +V S + +E+ +S + ++ P + ++ Sbjct: 1486 FEEIPSVVEGAGLDETTHNQTLLDVESVVKQSLDTPSEEETSKTIDEKIEDKPKEEVTLH 1545 Query: 1487 EENIYDTIRSADGVDYDDPACGSAE 1511 +E + + G+D D A E Sbjct: 1546 QEGREE---GSYGLDTKDEAVSVLE 1567 Score = 67.0 bits (162), Expect = 3e-010 Identities = 215/1095 (19%), Positives = 386/1095 (35%), Gaps = 185/1095 (16%) Query: 517 RKNIYRRPEWETGRSSLGVRKVLEMFEPNLHHGRGKRAESGDTGKPPPGRSKPKVPDKSE 576 R + + E ET ++ + K++ E H + ++ P + + D + Sbjct: 1212 RLDAIEKEELETVKTVVQDAKIVNNEETTAHESESLKGDNHQEKNAEPVEATQNLDDAEQ 1271 Query: 577 QVLQKTKDFKSKKVVSEVVEKSNRGALNEQVEEVRGDVATARTADEHVVDGYRQETKESS 636 + T D + + ++E +EK G + ++G+ + T+ E ++E +SS Sbjct: 1272 ISREVTVDTEREADITEKIEKVQEGPTVIETPTIQGEDIESETSLE-----LKEEVDQSS 1326 Query: 637 PVSKEAK---SKDVSPKEAKKGSNGITSKLHKNSPREASNAIVPSKGENLEPTEVLSDGN 693 ++E + +D+ E K TS + + AI+ + N+ E Sbjct: 1327 KDTEEHEHVLERDIPQCETLKAEAVDTSTVEEA-------AILKTLETNISEPEA----- 1374 Query: 694 NSFGEMHPSHNWMDGTYDQIDLEEPTNGKEISAVSKPNEMISSQKVLKE-KEKSKSAVSK 752 MH S +D D+ E T + V NE+ +S +E E ++ S+ Sbjct: 1375 -----MH-SETSLDLKVDKEQKEAET----VKTVIFSNEVGTSDAQAEEFGEHTEPCSSE 1424 Query: 753 IQ-ERLTFRSSKKVTVENTAPRKEPSEGVANHSDHDLGE---------DQAAYSSVEKGS 802 I+ E S +V + T + E N D GE D + S E G Sbjct: 1425 IKDESQGSEESVEVKSKETVQGESSEEKDVNMLDVQSGESEKYQENEPDISLVSKTENG- 1483 Query: 803 NQVTEEPSPVKTS----TGSNQELIDVLPDGDSSFGELHPSYNWTDGTYDRKYVEQAAQI 858 ++ E PS V+ + T NQ L+DV S PS T T D K + Sbjct: 1484 DKFEEIPSVVEGAGLDETTHNQTLLDVESVVKQSLDT--PSEEETSKTIDEKIED----- 1536 Query: 859 NAAYSSVEKGSKKVTEEPSPYNSVKASTGANQELIEVLSDGESSFRELHPSYSWMDGTYD 918 K ++VT E + VL E Sbjct: 1537 --------KPKEEVTLHQEGREEGSYGLDTKDEAVSVLESRE------------------ 1570 Query: 919 QIDLEEPTHGKEIAVASATTEMNASQKDPKEK-EKGKSAVSKIQERLTFRSSKKVAVENA 977 L E +E+ +A+ Q++ +K E K VS Q+ S +V ++ Sbjct: 1571 ---LGEQPQQEELCLANEQENETKLQEEQVDKHEPTKEEVSNDQQSPVEEISNEVIQVSS 1627 Query: 978 APRKEPSEEVAILSDDDFGENHAEYSFLEKGSKQVTEEPSPHGAVQPDSSQTETVVTSPK 1037 A E E ++ + GE + S + E H ++ S + E S K Sbjct: 1628 ASLSEGPEYETVVEAEKIGEEQVADKIQK--SFETGEIVEAHSSLPSSSEEKEHETVSEK 1685 Query: 1038 EGKEKKRSKSTVSKIYER-LTFRSSKKMAAPS----ERSDEVVIIREAE--DANRKAPGL 1090 EK + + + ER L + ++ PS E DE+ I A D K Sbjct: 1686 TDDEKVKDAEPIGDMRERGLDIAETTHLSLPSVDQKEDVDEIHIPSVALPLDEQEKVTST 1745 Query: 1091 RRSFMSSIEIPSIHPDERAVASPSPEASR------------------------------E 1120 + S E PDE +S SP S E Sbjct: 1746 EKGETKSSEAEDDKPDEHVDSSTSPMLSEKNDNETQTSKTSEDVCMQQEESGTLEVPKPE 1805 Query: 1121 ESTENDSSE-QKILEAISAVSQRIDNLSKSFSDLTLT----DDENTQAKRTADAEQEEDV 1175 ES E+ S E + +E I A S + + S +D TL+ +++ Q+ + + EE+ Sbjct: 1806 ESKEDKSQEISETIEEIEATSDQTLPIETSHTDNTLSSELVSEQDDQSPKKVEEIHEEEP 1865 Query: 1176 QQVRPNASFLFRGMGSAGSRAG------LDSKHASQHNIV--EAVNTVVINKSLSMDDHH 1227 ++ + R + S A L S+ +H + E + T +I + S + Sbjct: 1866 KEAHDVEATSERNLPVETSDADNTLSSQLVSETKEEHKLQAGEILPTEIIPRESSDEALV 1925 Query: 1228 FPCARGETGRMSLNERS-----RAQRGLEDDYEPVIQPEEKLPSAAGSK--------FCS 1274 A E +++L E + R ++++ ++ EE + + Sbjct: 1926 SMLASREDDKVALQEDNCADDVRETNDIQEERSISVETEESVGETKPKEHEDEIRDAHVE 1985 Query: 1275 TPSITIDLSELTSKIESFVHKSKRESDNIYQSIPIKSQGTSNTALLHQPEDAISVNSYES 1334 TP+ I L E S E+ + ++K+ ++ I ++ E ++++ E Sbjct: 1986 TPTAPIILEENDS--ETLIAEAKKGNEEI-----------------NETERTVALDHEEE 2026 Query: 1335 FENYESIEHELLSSTRKQN-PEKASGEEDTYE----ICSPPPELPPAREDSRNDLTLPQP 1389 F N+E+ + E + Q PE A E T + I + + P+ ++D T Q Sbjct: 2027 FVNHEAPKLEETKDEKSQEIPETAKATETTIDQTLPIGTSQADQTPSLVSDKDDQTPKQV 2086 Query: 1390 KRNLSSSPKTLPKHLQVTYQSNYERIKYSKIPPRP----PKPEEVPLPPRNSSTASTGAT 1445 + L K K +Q + E + P E+ P+ P+ A+ Sbjct: 2087 EEILEEETKETHK-VQAEDIFSTETVPKESFIEAPVSMLASGEDEPVTPQEGDYAANTQE 2145 Query: 1446 SSAANVTLEASTSHSSSTEQASSGAGGDLLDKSPHRQERIYEENIYDTIRSADGVDYDDP 1505 + E + E + GA +KS +++ +E+ T G++ D P Sbjct: 2146 ERHVSAETEEKVGETKPKESQAEGA-----EKS---DDQVEDESTKKTDVEVAGLENDYP 2197 Query: 1506 ACGSAELDPMQTTQP 1520 + D +T P Sbjct: 2198 TEEAEHGDETYSTLP 2212 Score = 47.8 bits (112), Expect = 2e-004 Identities = 111/544 (20%), Positives = 209/544 (38%), Gaps = 86/544 (15%) Query: 570 KVPDKSEQVLQKTKDFKSKKVVSEVVEKSNRGALNEQV-----------EEVRGDVATAR 618 K D+ + K KD + +++VS V+K N+ A +V EEV + Sbjct: 2392 KEEDQIVDIKDKKKDDEEQEIVSSEVKKDNKDARELEVGNDFVSRDGEKEEVPHNALENE 2451 Query: 619 TADEHVVDGYRQETKESSPVSKEAKSKDVSPKEAKKGSNGITSKLHKNSPREASNAIVPS 678 VV +Q + + K ++++ P + K SN + +P++ S+ + Sbjct: 2452 EEMNEVVASEKQISDPVGVIKKASEAEHEDPVDDIK-SNDDRDFPTEQAPKDQSDEV--- 2507 Query: 679 KGENLEPTEVLSDGNNSFGEMHPSHNWMDGTYDQIDLEEPTNGKEIS-AVSKPNEMISSQ 737 + P E + + PS +D + + E TN + V +E+I S Sbjct: 2508 SADETVPKEAIGEELKV-----PSSKVLDDIQENSNTEAVTNFADRDLPVQNLSELIQSH 2562 Query: 738 KVLKEKEKSKSAVSKIQE------------RLTFRSSKKVTVENTAPRKEPSEGVANHSD 785 + + E++ +K QE + + K E A KE SE +D Sbjct: 2563 QSPNQVEETSFEFNKAQEDKKEETVDALITNVQVQDQPKEDFEAAAIEKEISEQEHKLND 2622 Query: 786 -HDLGEDQAAYSSVEKGSNQVT----EEPSPVKTSTGS----------NQELIDVLPDGD 830 D+ ED Y V+ +++ + + K T S E+ D + Sbjct: 2623 LTDVQEDIGTYVKVQVPDDEIKGDGHDSVAAQKEETSSIEEKREVEHVKAEMEDAIKHEV 2682 Query: 831 SSFGELHPSYNWTDGTYDRKYVEQAAQINAAYSSVEKGSKKVTEEPSPYNSVKASTGANQ 890 S + + S N E+ Q N + + K++ +E +N+VK + A Sbjct: 2683 SVEEKNNTSENIDHEAAKEIEQEEGKQTNIVKEEIREEEKEINQE--SFNNVKETDDAID 2740 Query: 891 EL------IEVLSDGESSFRELHPSYSWMDGTYDQIDLEEPTHGKEIAVASATTEMNASQ 944 + IE LS + + P Y + +I E P ++ ++ E + Sbjct: 2741 KTQPEIRDIESLSSVSKTQDKPEPEYEVPNQQKREITNEVP------SLENSKIEEELQK 2794 Query: 945 KDPKEKEKGKSAVSKIQERLTFRSSKKVAVENAAP--RKEPSEEVAILSDDDFGENHAEY 1002 KD +E E K S ++E T + K+ A ++ + +KEP E D++ E+H Sbjct: 2795 KD-EESENTKDLFSVVKE--TEPTLKEPARKSLSDHIQKEPKTE----EDENDDEDH--- 2844 Query: 1003 SFLEKGSKQVTEEPSPHGAVQPDSSQTETVVTSPKEGK-----EKKRSKSTVSKIYERLT 1057 + ++ SP V ++ T ++V + K+ + K ++SK+ + LT Sbjct: 2845 -------EHKDDKTSPDSIVMVEAKDTVSIVKTHKKSHGILSGVGSKVKHSISKVKKVLT 2897 Query: 1058 FRSS 1061 +SS Sbjct: 2898 GKSS 2901 Score = 43.9 bits (102), Expect = 0.003 Identities = 147/731 (20%), Positives = 271/731 (37%), Gaps = 94/731 (12%) Query: 683 LEPTEVLSDGNNSFGEMHPSHNWMDGTYDQIDLEEPT--NGKEISAVSKPNEMISSQKVL 740 L+ ++++ D S P ++I L + T N KE KP E +S +K + Sbjct: 93 LDDSKIVKDDQESIVVREPQSLNEKKEDEKIILSDVTLENKKEEDTTGKPEE-VSVEKPV 151 Query: 741 KEKEKSKSAVSKIQERLTFRSSKKVTVENTAPRKEPSEGVANHSDHDLGEDQAAYSSVEK 800 E++++++ S QE SK +T +T P K + + E V + Sbjct: 152 IEEDQTEAKHSLEQEEDIGNISKVLT--DTTPVKVDEYDIEKSLNSVCEEIPIKTDEVRE 209 Query: 801 GSNQVTEEPSPVKTSTGSNQELI--DVLPDGDSSFGE-LHPSYNWTDGT--YDRKYVEQA 855 ++ T E S T N + ++ +GD++ E + TDG +D + +++ Sbjct: 210 ETDSRTVETSVNGTEAEHNATVSVEEISRNGDNTVNETVSEDQTATDGEPLHDVETIKRE 269 Query: 856 AQINAAYSSVEKGSKKV-TEEPSPYNSVKASTGANQE----LIEVLSDG---ESSFRELH 907 A+ Y +V + +K V TEE + + S +QE +E + E S RE+ Sbjct: 270 AE--PFYKTVVEDAKIVNTEETTAHESKILKEDNHQEEYAESVEATKNSDAAEQSSREVT 327 Query: 908 PSYSWMDGTYDQID--------LEEPT-HGKEI---AVASATTEMNASQKDPKEKEKGKS 955 + I+ +E PT G++I A EM+ KD +E+E Sbjct: 328 VDKEKEEDIIQNIEEVQESPSVMESPTIQGEDIESKASLDHEEEMDKITKDTEEQEHVLV 387 Query: 956 AVSKIQERLTFRSSKKVAVENAAPRKEPSEEVAILSDDDFGENHAEYSFLEKGSKQVTEE 1015 + + T + K A + E + ++ + E H+ E G ++ E Sbjct: 388 RDVPVPQSETLVTEAKTAETFSVQEAE-----ILKTNINESEAHSAIGGEEDG-QETKEN 441 Query: 1016 PSPHGAVQPDSSQTETVVTSPKEGKEKKRSKSTVSKIYERLTFRSSKKMAAPSERSDEVV 1075 P ++ D Q ++ ++ RS ++++ T S ++ DE + Sbjct: 442 TEPSKDLKDDKEQEDSETVKTIISSDEVRSSDVQAEVFGEHTEPCSSEIKDDRHGRDESI 501 Query: 1076 IIREAEDANRKAPGLRRSFMSSIEIPSIHPDERAVASPSPEASREE----------STEN 1125 ++ A P + + + + I ER + E +EE + E Sbjct: 502 EVK----AKETGPEIETA-VDGESVHEIETTERVLLEAEKEEDKEEIKIDEEPSLNAIEK 556 Query: 1126 DSSEQK--ILEAISAVSQRIDNLSKSFS--------DLTLTDDENTQAKR--TADAEQEE 1173 +E ++E V+ ++ +S S + D Q R T D +EE Sbjct: 557 AETENVKIVIEEPEIVNNEETSVHESESLKENAEPVEAVKNSDGTEQISREVTVDRAKEE 616 Query: 1174 DVQ------QVRPNASFLFRGMGSAGSRAGLDSKHASQHNIVEAV-NTVVINKSLSMDDH 1226 D+ Q RP+ S +A L+ K H E + V+ + + Sbjct: 617 DIAPKTEEIQERPSES-----------KASLEPKEEVDHISNETEEHEHVLERDVQQ--- 662 Query: 1227 HFPCARGETGRMSLNERSRAQRGLEDDYEPVIQPEEKLPSAAGSKFCSTPSITIDLSELT 1286 C E+ + E ++ L++D E + E + S S + + Sbjct: 663 ---CETIESEAVETKEDTQPSLDLKEDKET--EEAETFKTVFSSD--EVRSSAVQEEQFG 715 Query: 1287 SKIESFVHKSKRESDNIYQSIPIKSQGTSNTALLHQPEDAISVNSYESFENYESIEHELL 1346 E + K ES +S+ +KSQ T D + V S ES E Y+ E E + Sbjct: 716 EHTEPCSSEIKDESHGKEESVEVKSQETVQDENTEDKHDVLKVPSTES-EKYQGNEPETV 774 Query: 1347 SSTRKQNPEKA 1357 + + EK+ Sbjct: 775 LVSNTGSYEKS 785 Score = 42.7 bits (99), Expect = 0.006 Identities = 132/678 (19%), Positives = 254/678 (37%), Gaps = 88/678 (12%) Query: 571 VPDKSEQVLQKTKDFKSKKVVSEVVEKSNRGALNEQVEEVRGDVATARTADEHVVDGYRQ 630 V + S +V+Q + S+ E V ++ + + ++++ T + H Sbjct: 1615 VEEISNEVIQVSSASLSEGPEYETVVEAEKIGEEQVADKIQKSFETGEIVEAHSSLPSSS 1674 Query: 631 ETKESSPVSK---EAKSKDVSP-KEAKKGSNGITSKLHKNSP-----REASNAIVPSKGE 681 E KE VS+ + K KD P + ++ I H + P + +PS Sbjct: 1675 EEKEHETVSEKTDDEKVKDAEPIGDMRERGLDIAETTHLSLPSVDQKEDVDEIHIPSVAL 1734 Query: 682 NLEPTEVLSDGNNSFGEMHPSHNWMDGTYDQID------LEEPTNGKEISAVSKPNEMIS 735 L+ E ++ + GE S D + +D L E + + + SK +E + Sbjct: 1735 PLDEQEKVT--STEKGETKSSEAEDDKPDEHVDSSTSPMLSEKNDNE--TQTSKTSEDVC 1790 Query: 736 SQ----------KVLKEKEKSKSAVSKIQERLTFRSSKKVTVENT-APRKEPSEGVANHS 784 Q K + KE +S+ E + S + + +E + SE V+ Sbjct: 1791 MQQEESGTLEVPKPEESKEDKSQEISETIEEIEATSDQTLPIETSHTDNTLSSELVSEQD 1850 Query: 785 DHDLGEDQAAYSSVEKGSNQV---TEEPSPVKTS----TGSNQELIDVLPDGDSSFGELH 837 D + + + K ++ V +E PV+TS T S+Q + + + GE+ Sbjct: 1851 DQSPKKVEEIHEEEPKEAHDVEATSERNLPVETSDADNTLSSQLVSETKEEHKLQAGEIL 1910 Query: 838 PSYNWTDGTYDRKYVEQAAQINAAYSSVEKGSKKVTEEPSPYNSVKASTGANQELIEVLS 897 P+ + D V A + K +E + + V+ T QE + Sbjct: 1911 PTEIIPRESSDEALVSMLAS--------REDDKVALQEDNCADDVR-ETNDIQEERSISV 1961 Query: 898 DGESSFRELHPSYSWMDGTYDQIDLEEPTHGKEIAVASATTEMNASQKDPKEKEKGKSAV 957 + E S E P + +E PT A E N S+ E +KG + Sbjct: 1962 ETEESVGETKPKEH--EDEIRDAHVETPT-------APIILEENDSETLIAEAKKGNEEI 2012 Query: 958 SKIQERLTFRSSKKVAVENAAPRKEPSEEVAILSDDDFGENHAEYSFLEKGSKQVTEEPS 1017 ++ ER ++ V + AP+ E +++ E E K ++ ++ Sbjct: 2013 NE-TERTVALDHEEEFVNHEAPKLEETKD----------EKSQEIPETAKATETTIDQTL 2061 Query: 1018 PHGAVQPDSSQTETVVTSPKEGKEKKRSKSTVSKIYERLTFRSSKKMAAPSERSDEVVII 1077 P G Q D QT ++V+ + K+ V +I E T + + K+ A S E V Sbjct: 2062 PIGTSQAD--QTPSLVSDKDDQTPKQ-----VEEILEEET-KETHKVQAEDIFSTETV-- 2111 Query: 1078 REAEDANRKAPGLRRSFMSSIEIPSIHPDERAVASPSPE-----ASREESTENDSSEQKI 1132 +++ +AP S ++S E + P E A+ + E A EE ++ Sbjct: 2112 --PKESFIEAP---VSMLASGEDEPVTPQEGDYAANTQEERHVSAETEEKVGETKPKESQ 2166 Query: 1133 LEAISAVSQRIDNLSKSFSDLTLTDDENTQAKRTADAEQEEDVQQVRPNASFLFRGMGSA 1192 E ++++ S +D+ + EN T +AE ++ P L + + Sbjct: 2167 AEGAEKSDDQVEDESTKKTDVEVAGLENDYP--TEEAEHGDETYSTLPVVGILTQLQTTL 2224 Query: 1193 GSRAGLDSKHASQHNIVE 1210 + ++ +S+ ++++ Sbjct: 2225 ETERAINDSASSEVSMIK 2242 ==> UNIPROT|Q9NZM3 - symbol:ITSN2_HUMAN "ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2" species:9606 "Homo sapiens" [GO:0005070 "SH3/SH2 adaptor activity" evidence=TAS] [GO:0005515 "protein binding" evidence=IPI] Pfam:PF00018 Pfam:PF00169 InterPro:IPR002048 InterPro:IPR000219 InterPro:IPR011992 Pfam:PF00036 Pfam:PF00168 InterPro:IPR000008 UniProt:Q9NZM3 InterPro:IPR001452 InterPro:IPR001849 InterPro:IPR000261 Prosite:PS00018 Gene3D:G3DSA:1.10.238.10 PROSITE:PS50222 GO:GO:0005070 InterPro:IPR011993 Gene3D:G3DSA:2.30.29.30 SMART:SM00233 PROSITE:PS50003 SMART:SM00054 PRINTS:PR00452 ProDom:PD000066 SMART:SM00326 PROSITE:PS50002 Gene3D:G3DSA:1.20.900.10 Pfam:PF00621 SMART:SM00239 SMART:SM00325 PROSITE:PS50004 PROSITE:PS50010 ProDom:PD000012 InterPro:IPR013315 PRINTS:PR01887 InterPro:IPR011511 Pfam:PF07653 PRINTS:PR00360 SMART:SM00027 PROSITE:PS50031 EMBL:AF182198 EMBL:AF182199 EMBL:AF248540 EMBL:AB033082 EMBL:AK021545 EMBL:AK000302 EMBL:AF001630 EMBL:U61167 UniGene:Hs.432562 PDB:1J3T PDB:1UDL PDB:1UE9 PDB:1UFF PDB:1UHF IntAct:Q9NZM3 Ensembl:ENSG00000198399 KEGG:hsa:50618 H-InvDB:HIX0001876 HGNC:HGNC:6184 MIM:604464 LinkHub:Q9NZM3 ArrayExpress:Q9NZM3 GermOnline:ENSG00000198399 RZPD-ProtExp:T4921 Length = 1696 Score = 67.0 bits (162), Expect = 3e-010 Identities = 70/296 (23%), Positives = 114/296 (38%), Gaps = 28/296 (9%) Query: 2219 WCEVPEVRNSEILATLTPTEKRLQEAKFEILTSEASYLKSLNLLRTHFVNHPAFRDTRIL 2278 WC + + L T+ P E++ Q E++ +E Y+ L L+ F A ++ L Sbjct: 1192 WCA-----DLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMA--ESGFL 1244 Query: 2279 SSSERKTLFSSIIPVQECSDRLLCDLE--NCWQDNIMLLGLSHSIYKHAEKHFHVYVTYC 2336 + E +F + + + +LL L M + + I H Y+ +C Sbjct: 1245 TEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFC 1304 Query: 2337 EHQAKIDRTLKALKANKPEFARTLAALEADPVCCSLSLSSFLMLPMQRITRMRLLLDAVL 2396 Q L+ +F L L +DP C + LSSFL+ PMQRITR LL+ ++L Sbjct: 1305 SCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSIL 1364 Query: 2397 QRCHPDDDDEFGSWESTFVLINRILTQCNDAAHRSEQLYEMELLSRQIEFPTNVRPLAIV 2456 + P+ + S + + +Q N+ E +E + ++ L Sbjct: 1365 ENT-PESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFN 1423 Query: 2457 PCGIGAAPSTMHRKLEKRGDLVHVLWRGDDAKLTFGKKFSKSNVYAFLFTDLLVLT 2512 P RKL G L K S ++ FLF D L+LT Sbjct: 1424 SLTNCLGP----RKLLHSGKLY--------------KTKSNKELHGFLFNDFLLLT 1461 Score = 44.7 bits (104), Expect = 0.002 Identities = 26/85 (30%), Positives = 42/85 (49%), Gaps = 5/85 (5%) Query: 2610 AVHPYQALQPDELDLDIKDVVNVHRKMAD--GWYEGERIRDGAVGWFPSNYTKEIPSAHI 2667 A++P++A DE+ + D++ V K GW G G GWFP NY +++PS+ Sbjct: 763 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF--QGNFGWFPCNYVEKMPSSE- 819 Query: 2668 RAKHIKQRHLLLTYTSKYIDTATKA 2692 K + + LL T T+T + Sbjct: 820 NEKAVSPKKALLPPTVSLSATSTSS 844 Score = 43.5 bits (101), Expect = 0.004 Identities = 23/54 (42%), Positives = 30/54 (55%), Gaps = 2/54 (3%) Query: 2607 QVIAVHPYQALQPDELDLDIKDVVNVHRKMADGWYEGERIRDGAVGWFPSNYTK 2660 QVIA++ Y A DEL ++NV K W++GE +G G FPSNY K Sbjct: 1130 QVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGE--INGVTGLFPSNYVK 1181