>AGAP007514-PA

FB|FBgn0001133 - symbol:grau "grauzone" species:7227 "Drosophila...   179   7e-045
ZFIN|ZDB-GENE-991213-3 - symbol:drl "draculin" species:7955 "Dan...   142   7e-034
UNIPROT|P10072 - symbol:HKR1_HUMAN "HKR1: Krueppel-related zinc ...   125   1e-028
UNIPROT|Q9HCG1 - symbol:KR18_HUMAN "KIAA1611: Zinc finger protei...   124   2e-028
UNIPROT|P10075 - symbol:GLI4_HUMAN "GLI4, HKR4: Zinc finger prot...   100   5e-021
MGI|MGI:109447 - symbol:Ctcf "CCCTC-binding factor" species:1009...    98   3e-020
UNIPROT|P49711 - symbol:CTCF_HUMAN "CTCF: Transcriptional repres...    98   3e-020
UNIPROT|Q08705 - symbol:CTCF_CHICK "CTCF: Transcriptional repres...    98   3e-020
MGI|MGI:103170 - symbol:Gfi1 "growth factor independent 1" speci...    89   1e-017
UNIPROT|Q99684 - symbol:GFI1_HUMAN "GFI1, ZNF163: Zinc finger pr...    89   1e-017
FB|FBgn0028420 - symbol:Kr-h1 "Kruppel homolog 1" species:7227 "...    88   2e-017
MGI|MGI:107187 - symbol:Bcl6 "B-cell leukemia/lymphoma 6" specie...    85   2e-016
UNIPROT|P41182 - symbol:BCL6_HUMAN "BCL6, BCL5, LAZ3, ZBTB27, ZN...    84   3e-016
FB|FBgn0004893 - symbol:bowl "brother of odd with entrails limit...    82   2e-015
UNIPROT|Q03112 - symbol:EVI1_HUMAN "EVI1: Ecotropic virus integr...    80   4e-015
MGI|MGI:95457 - symbol:Evi1 "ecotropic viral integration site 1"...    78   3e-014
SGD|S000006390 - symbol:PZF1 "Transcription factor IIIA (TFIIIA)...    77   4e-014
SGD|S000003592 - symbol:ZAP1 "Zinc-regulated transcription facto...    75   2e-013
FB|FBgn0005694 - symbol:Aef1 "Adult enhancer factor 1" species:7...    74   3e-013
MGI|MGI:1278332 - symbol:Bcl6b "B-cell CLL/lymphoma 6, member B"...    70   5e-012
MGI|MGI:1929869 - symbol:Hic2 "hypermethylated in cancer 2" spec...    70   6e-012
UNIPROT|Q96JB3 - symbol:HIC2_HUMAN "HIC2, HRG22, KIAA1020, ZBTB3...    70   6e-012
FB|FBgn0002573 - symbol:sens "senseless" species:7227 "Drosophil...    70   6e-012
MGI|MGI:1338823 - symbol:Maz "MYC-associated zinc finger protein...    66   1e-010
FB|FBgn0001325 - symbol:Kr "Kruppel" species:7227 "Drosophila me...    66   1e-010


==> FB|FBgn0001133 - symbol:grau "grauzone" species:7227 "Drosophila
           melanogaster" [GO:0007349 "cellularization"
           evidence=IMP] [GO:0007279 "pole cell formation"
           evidence=IMP] [GO:0003704 "specific RNA polymerase II
           transcription factor activity" evidence=IMP;NAS]
           [GO:0005634 "nucleus" evidence=IDA;NAS] [GO:0007143
           "female meiosis" evidence=IMP] [GO:0045143 "homologous
           chromosome segregation" evidence=TAS] [GO:0006357
           "regulation of transcription from RNA polymerase II
           promoter" evidence=TAS] [GO:0007343 "egg activation"
           evidence=IMP] InterPro:IPR007087 Pfam:PF00096
           Prosite:PS00028 InterPro:IPR012934 GO:GO:0005515
           GO:GO:0005634 GO:GO:0006357 SMART:SM00355
           PROSITE:PS50157 EMBL:AE003452 GO:GO:0007279
           GO:GO:0003704 GO:GO:0007343 GO:GO:0007143 GO:GO:0045143
           EMBL:AF208016 EMBL:AY047537 UniGene:Dm.19597 PDB:1PZW
           DIP:DIP:20107N IntAct:Q9U405 Ensembl:CG33133
           KEGG:dme:Dmel_CG33133 FlyBase:FBgn0001133
           BioCyc:DMEL-XXX-02:DMEL-XXX-02-005732-MONOMER
           GermOnline:CG33133 Pfam:PF07776 Uniprot:Q9U405
          Length = 570

 Score =  179 bits (454), Expect = 7e-045
 Identities = 143/552 (25%), Positives = 232/552 (42%), Gaps = 74/552 (13%)

Query: 1   MASVTRCEICFSTADSDRKAIFAEENSHIVGIVAKHLGFEITPTVENASM-CSKCWSALQ 59
           +  V+  ++C    D D         S +  ++ +H  FE+ P  E + + C+ CW+ + 
Sbjct: 8   LRGVSGAQMCLQIFDVD------SGESKVAEVLRQHFWFEVLPNDEISKVICNVCWTQVS 61

Query: 60  EFHKYYCEIE------AVRQQHEHELLAIGDKQQEEVTVVCDSLEPSYRTEFFEVKVEPF 113
           EFH++Y  I+      A   + + +   +     EEV +  D L         ++ V P 
Sbjct: 62  EFHQFYVSIQEAQVIYATTSKFKQDPEMVNTSWPEEVLMPADVLAVDNDVGA-QINVNPL 120

Query: 114 EQTDVFEQENSNCSDEKPLHCAFVKCEEPPIDLD----PTAPSSDEDSAVPQGSRSDSSS 169
           ++ D+ +  +   S         +K E    D++          DED    +   +D   
Sbjct: 121 DELDLSQPMSPEDSK------VGIKTERQSPDMELLFEDANNEQDEDYEDDEDDDTDDLI 174

Query: 170 PDRRKPKRERNPKRPQTSDNET----------------------KQSKVAAQKEEDESLH 207
             R   KR+R+  +P  +   T                      K  ++    +EDE L 
Sbjct: 175 VTRSGRKRKRDVAKPAKTKRGTVSVGRKGKEKMVVKRGPPKRIFKMERLPPFCKEDEELI 234

Query: 208 NFYKRIVCEVCDIQRMLVGEPQIDFGTWRALLRHTKEVHKHDKVYVKCPVCEMKMRTKQT 267
             Y  + CE+C    + + E   DF   R    H K+ H  ++ Y+KC  C  K+  +  
Sbjct: 235 KRYIVMGCELC----IFLAE---DFDGIR---EHFKDKHPDERPYIKC--CGRKLNKRCL 282

Query: 268 LLQHMDWHENPEKYRCELCGEKHQN---MKEHIQNKH---QERQFCCDVCGKKFPFKKRL 321
           + +H   HENPE  +C+ CG+   N   ++ H    H   +E  F C+ CGK+F  +  L
Sbjct: 283 IQEHARRHENPEYIKCKDCGKVFANSSVLRAHWLVHHVPDEECDFQCEDCGKRFSRRNLL 342

Query: 322 TVHMKKMHV---EKDIICDQCQKP---FTKYTIEDHKRSVH-SARFVCEHCPKTFNSRFR 374
            +H K  HV   E+  IC QC K     T+Y ++ H    H  A  +C  C K    +  
Sbjct: 343 ELH-KGSHVPVNERKFICPQCPKHNAFATEYHMQVHISMQHRKAANICHVCGKKIKDKAV 401

Query: 375 LLQHMEEHDESLRNSTSVPCTICGQVMRDKYILTRHIKLMHTVQPAVSCETCGKTFKCKR 434
             +H+  H E        P   C   ++D+  L +H++  +       C  CGK+ K  R
Sbjct: 402 FEKHVRLHFEESGPRIKCPRPDCESWLKDEDNLKQHLRRHNDEGKLFICSECGKSCKNSR 461

Query: 435 NLSVHMTNVCMEPTRLYPCTICGKEFRRKNKLKEHMSTHTGKPLYMCSFCPETFRQDTHL 494
            L  H          +Y C  CGK F++   LKEHM+ HTG+PLY C FCP TF  + ++
Sbjct: 462 ALIGHKRY--SHSNVIYTCEQCGKTFKKDISLKEHMAQHTGEPLYKCPFCPRTFNSNANM 519

Query: 495 YHHRKNAHYERW 506
           + H+K  H   W
Sbjct: 520 HSHKKKMHPVEW 531



==> ZFIN|ZDB-GENE-991213-3 - symbol:drl "draculin" species:7955 "Danio
           rerio" [GO:0048276 "gastrulation (sensu Vertebrata)"
           evidence=IEP] [GO:0003677 "DNA binding" evidence=NAS]
           [GO:0008270 "zinc ion binding" evidence=ISS]
           InterPro:IPR007087 Pfam:PF00096 Prosite:PS00028
           ZFIN:ZDB-GENE-991213-3 GO:GO:0003677 SMART:SM00355
           PROSITE:PS50157 HSSP:P08046 ProDom:PD000003
           GO:GO:0048276 EMBL:AF157109 EMBL:BC095019
           UniGene:Dr.81311 Ensembl:ENSDARG00000035151
           Uniprot:Q9W747
          Length = 411

 Score =  142 bits (359), Expect = 7e-034
 Identities = 94/327 (28%), Positives = 142/327 (43%), Gaps = 24/327 (7%)

Query: 184 PQTSDNETKQSKVAAQKEEDESLHNFYKRIVCEVCDIQRMLVGEPQIDFGTWRALLRHTK 243
           P T D   +  K   Q     +LH  YK   C+ C+            +G    L RH K
Sbjct: 91  PYTCDECGESFKTRLQLRSHMTLHPKYKPYKCDQCEKS----------YGREDHLQRHMK 140

Query: 244 EVHKHDKVYVKCPVCEMKMRTKQTLLQHMDWHENPEKYRCELCGEKH---QNMKEHIQNK 300
            +H  +K + KC  C      +  L  H+  H   + Y C+ CG+     ++  EH+   
Sbjct: 141 -LHTGEKPH-KCEHCGKSFPMRDLLRSHLMVHSEVKPYTCDQCGKGFTLKKSYNEHMNIH 198

Query: 301 HQERQFCCDVCGKKFPFKKRLTVHMKKMHVEKDIICDQCQKPFTKYTIEDHKRSVHSAR- 359
             ER + CD CGK FP+++ L +HM+    EK   CDQC + F++    +    +H+   
Sbjct: 199 TGERPYTCDQCGKGFPYEQSLNLHMRFHREEKPFTCDQCGQSFSQKGAYNIHMKIHTGEK 258

Query: 360 -FVCEHCPKTFNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKYILTRHIKLMHTVQ 418
            + C+ C  +F   + L  HM  H           C  C +       L  HIK  H   
Sbjct: 259 PYTCDQCGMSFRHGYSLKLHMTHH----TGEKPFHCDQCDKCYSTALFLKNHIK-THDKA 313

Query: 419 PAVSCETCGKTFKCKRNLSVHMTNVCMEPTRLYPCTICGKEFRRKNKLKEHMSTHTGKPL 478
              SC TCGKTF   R L +H     +  T+ + C  CGK +    +LK+H+  H+ +  
Sbjct: 314 QIYSCLTCGKTFNQLRGLRLHEKRHSL--TKPFMCFDCGKCYFTDTELKQHLPVHSNERP 371

Query: 479 YMCSFCPETFRQDTHLYHHRKNAHYER 505
           YMCS C ++F +   L  H K  + E+
Sbjct: 372 YMCSLCFKSFPRMGSLIVHEKTHNGEK 398



 Score =  122 bits (307), Expect = 8e-028
 Identities = 80/260 (30%), Positives = 117/260 (45%), Gaps = 22/260 (8%)

Query: 250 KVYVKCPVCEMKMRTKQTLLQHMDWHENPEKYRCELCGE---KHQNMKEHIQNKHQERQF 306
           K  V C  C+ +   K  L  HM  H   + YRC+ CG+     Q++K H+    +   +
Sbjct: 33  KKSVACSHCKKRFTHKVHLQIHMRVHTGEKPYRCDQCGKCFPYKQSLKLHLDIHAKGNPY 92

Query: 307 CCDVCGKKFPFKKRLTVHMKKMHVEKDIICDQCQKPFTKYTIEDHKR---SVHSAR--FV 361
            CD CG+ F  + +L  HM      K   CDQC+K    Y  EDH +    +H+      
Sbjct: 93  TCDECGESFKTRLQLRSHMTLHPKYKPYKCDQCEK---SYGREDHLQRHMKLHTGEKPHK 149

Query: 362 CEHCPKTFNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKYILTRHIKLMHTVQPAV 421
           CEHC K+F  R  L  H+  H E         C  CG+    K     H+ + HT +   
Sbjct: 150 CEHCGKSFPMRDLLRSHLMVHSE----VKPYTCDQCGKGFTLKKSYNEHMNI-HTGERPY 204

Query: 422 SCETCGKTFKCKRNLSVHMTNVCMEPTRLYPCTICGKEFRRKNKLKEHMSTHTGKPLYMC 481
           +C+ CGK F  +++L++HM        + + C  CG+ F +K     HM  HTG+  Y C
Sbjct: 205 TCDQCGKGFPYEQSLNLHMR--FHREEKPFTCDQCGQSFSQKGAYNIHMKIHTGEKPYTC 262

Query: 482 SFCPETFRQ----DTHLYHH 497
             C  +FR       H+ HH
Sbjct: 263 DQCGMSFRHGYSLKLHMTHH 282



==> UNIPROT|P10072 - symbol:HKR1_HUMAN "HKR1: Krueppel-related zinc
           finger protein 1" species:9606 "Homo sapiens"
           [GO:0008270 "zinc ion binding" evidence=NAS] [GO:0006355
           "regulation of transcription, DNA-dependent"
           evidence=NAS] [GO:0007275 "multicellular organismal
           development" evidence=NAS] [GO:0005634 "nucleus"
           evidence=NAS] InterPro:IPR007087 Pfam:PF00096
           Prosite:PS00028 InterPro:IPR001909 UniProt:P10072
           GO:GO:0007275 GO:GO:0005634 GO:GO:0008270 GO:GO:0006355
           SMART:SM00355 PROSITE:PS50157 ProDom:PD000003
           HSSP:P08047 Pfam:PF01352 SMART:SM00349 PROSITE:PS50805
           EMBL:AB013897 EMBL:BC004513 EMBL:M20675 PIR:C31201
           UniGene:Hs.244651 Ensembl:ENSG00000181666
           KEGG:hsa:284459 HGNC:HGNC:4928 MIM:165250 LinkHub:P10072
           ArrayExpress:P10072 GermOnline:ENSG00000181666
          Length = 640

 Score =  125 bits (314), Expect = 1e-028
 Identities = 83/268 (30%), Positives = 121/268 (45%), Gaps = 18/268 (6%)

Query: 238 LLRHTKEVHKHDKVYVKCPVCEMKMRTKQTLLQHMDWHENPEKYRCELCGEKHQ---NMK 294
           L+RH K  H  +K Y+ C  CE     K  L++H+  H   + Y C  CG       N+K
Sbjct: 381 LVRH-KRTHSGEKPYI-CRECEQGFSQKSHLIRHLRTHTGEKPYVCTECGRHFSWKSNLK 438

Query: 295 EHIQNKHQERQFCCDVCGKKFPFKKRLTVHMKKMHVEKDIICDQCQKPFT-KYTIEDHKR 353
            H +     + + C  CG+ F  K  L  H +    EK  +C +C + FT K T+  H+R
Sbjct: 439 THQRTHSGVKPYVCLECGQCFSLKSNLNKHQRSHTGEKPFVCTECGRGFTRKSTLITHQR 498

Query: 354 SVHSAR--FVCEHCPKTFNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKYILTRHI 411
           + HS    FVC  C + FN +  L+ H   H           C  CG+  R K  L RH 
Sbjct: 499 T-HSGEKPFVCAECGRGFNDKSTLISHQRTHS----GEKPFMCRECGRRFRQKPNLFRH- 552

Query: 412 KLMHTVQPAVSCETCGKTFKCKRNLSVHMTNVCMEPTRLYPCTICGKEFRRKNKLKEHMS 471
           K  H+   A  C  CG+ F  K  L  H         + + C  CG+ F R++ L  H  
Sbjct: 553 KRAHS--GAFVCRECGQGFCAKLTLIKHQR--AHAGGKPHVCRECGQGFSRQSHLIRHQR 608

Query: 472 THTGKPLYMCSFCPETFRQDTHLYHHRK 499
           TH+G+  Y+C  C   F + ++L  H++
Sbjct: 609 THSGEKPYICRKCGRGFSRKSNLIRHQR 636



 Score =  123 bits (308), Expect = 6e-028
 Identities = 79/280 (28%), Positives = 128/280 (45%), Gaps = 16/280 (5%)

Query: 232 FGTWRALLRHTKEVHKHDKVYVKCPVCEMKMRTKQTLLQHMDWHENPEKYRCELCGEKH- 290
           FG+   L+++ +  H   K YV C  C      K  L+ H   H   + Y C+ CG    
Sbjct: 263 FGSMSVLIKNPR-THSGGKPYV-CRECGRGFTWKSNLITHQRTHSGEKPYVCKDCGRGFT 320

Query: 291 --QNMKEHIQNKHQERQFCCDVCGKKFPFKKRLTVHMKKMHVEKDIICDQCQKPFTKYT- 347
              N+  H +     + + C  CG+ F  K  L  H +    EK  +C +C + F +++ 
Sbjct: 321 WKSNLFTHQRTHSGLKPYVCKECGQSFSLKSNLITHQRAHTGEKPYVCRECGRGFRQHSH 380

Query: 348 IEDHKRSVHSAR--FVCEHCPKTFNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKY 405
           +  HKR+ HS    ++C  C + F+ +  L++H+  H           CT CG+    K 
Sbjct: 381 LVRHKRT-HSGEKPYICRECEQGFSQKSHLIRHLRTHT----GEKPYVCTECGRHFSWKS 435

Query: 406 ILTRHIKLMHTVQPAVSCETCGKTFKCKRNLSVHMTNVCMEPTRLYPCTICGKEFRRKNK 465
            L  H +    V+P V C  CG+ F  K NL+ H  +   E  + + CT CG+ F RK+ 
Sbjct: 436 NLKTHQRTHSGVKPYV-CLECGQCFSLKSNLNKHQRSHTGE--KPFVCTECGRGFTRKST 492

Query: 466 LKEHMSTHTGKPLYMCSFCPETFRQDTHLYHHRKNAHYER 505
           L  H  TH+G+  ++C+ C   F   + L  H++    E+
Sbjct: 493 LITHQRTHSGEKPFVCAECGRGFNDKSTLISHQRTHSGEK 532



 Score =  112 bits (279), Expect = 1e-024
 Identities = 79/304 (25%), Positives = 127/304 (41%), Gaps = 26/304 (8%)

Query: 207 HNFYKRIVCEVCDIQRMLVGEPQIDFGTWRALLRHTKEVHKHDKVYVKCPVCEMKMRTKQ 266
           H+  K  VC+ C       G+    F     L+ H +  H  +K YV C  C    R   
Sbjct: 332 HSGLKPYVCKEC-------GQ---SFSLKSNLITHQR-AHTGEKPYV-CRECGRGFRQHS 379

Query: 267 TLLQHMDWHENPEKYRCELCGE---KHQNMKEHIQNKHQERQFCCDVCGKKFPFKKRLTV 323
            L++H   H   + Y C  C +   +  ++  H++    E+ + C  CG+ F +K  L  
Sbjct: 380 HLVRHKRTHSGEKPYICRECEQGFSQKSHLIRHLRTHTGEKPYVCTECGRHFSWKSNLKT 439

Query: 324 HMKKMHVEKDIICDQCQKPFT-KYTIEDHKRSVHSAR-FVCEHCPKTFNSRFRLLQHMEE 381
           H +     K  +C +C + F+ K  +  H+RS    + FVC  C + F  +  L+ H   
Sbjct: 440 HQRTHSGVKPYVCLECGQCFSLKSNLNKHQRSHTGEKPFVCTECGRGFTRKSTLITHQRT 499

Query: 382 HDESLRNSTSVPCTICGQVMRDKYILTRHIKLMHTVQPAVSCETCGKTFKCKRNLSVHMT 441
           H           C  CG+   DK  L  H +  H+ +    C  CG+ F+ K NL  H  
Sbjct: 500 HS----GEKPFVCAECGRGFNDKSTLISHQRT-HSGEKPFMCRECGRRFRQKPNLFRHKR 554

Query: 442 NVCMEPTRLYPCTICGKEFRRKNKLKEHMSTHTGKPLYMCSFCPETFRQDTHLYHHRKNA 501
                 +  + C  CG+ F  K  L +H   H G   ++C  C + F + +HL  H++  
Sbjct: 555 ----AHSGAFVCRECGQGFCAKLTLIKHQRAHAGGKPHVCRECGQGFSRQSHLIRHQRTH 610

Query: 502 HYER 505
             E+
Sbjct: 611 SGEK 614



 Score = 88.2 bits (217), Expect = 2e-017
 Identities = 60/210 (28%), Positives = 89/210 (42%), Gaps = 11/210 (5%)

Query: 234 TWRALLRHTKEVHKHDKVYVKCPVCEMKMRTKQTLLQHMDWHENPEKYRCELCGE---KH 290
           +W++ L+  +  H   K YV C  C      K  L +H   H   + + C  CG    + 
Sbjct: 432 SWKSNLKTHQRTHSGVKPYV-CLECGQCFSLKSNLNKHQRSHTGEKPFVCTECGRGFTRK 490

Query: 291 QNMKEHIQNKHQERQFCCDVCGKKFPFKKRLTVHMKKMHVEKDIICDQCQKPFT-KYTIE 349
             +  H +    E+ F C  CG+ F  K  L  H +    EK  +C +C + F  K  + 
Sbjct: 491 STLITHQRTHSGEKPFVCAECGRGFNDKSTLISHQRTHSGEKPFMCRECGRRFRQKPNLF 550

Query: 350 DHKRSVHSARFVCEHCPKTFNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKYILTR 409
            HKR+ HS  FVC  C + F ++  L++H   H           C  CGQ    +  L R
Sbjct: 551 RHKRA-HSGAFVCRECGQGFCAKLTLIKHQRAH----AGGKPHVCRECGQGFSRQSHLIR 605

Query: 410 HIKLMHTVQPAVSCETCGKTFKCKRNLSVH 439
           H +  H+ +    C  CG+ F  K NL  H
Sbjct: 606 H-QRTHSGEKPYICRKCGRGFSRKSNLIRH 634



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 36/147 (24%), Positives = 55/147 (37%), Gaps = 32/147 (21%)

Query: 238 LLRHTKEVHKHDKVYVKCPVCEMKMRTKQTLLQHMDWHENPEKYRCELCGEKHQNMKEHI 297
           L+ H +  H  +K +V C  C      K TL+ H   H   + + C  CG + +      
Sbjct: 493 LITHQR-THSGEKPFV-CAECGRGFNDKSTLISHQRTHSGEKPFMCRECGRRFRQKPNLF 550

Query: 298 QNKHQER-QFCCDVCGKKFPFKKRLTVHMK-----KMHV--------------------- 330
           ++K      F C  CG+ F  K  L  H +     K HV                     
Sbjct: 551 RHKRAHSGAFVCRECGQGFCAKLTLIKHQRAHAGGKPHVCRECGQGFSRQSHLIRHQRTH 610

Query: 331 --EKDIICDQCQKPFT-KYTIEDHKRS 354
             EK  IC +C + F+ K  +  H+R+
Sbjct: 611 SGEKPYICRKCGRGFSRKSNLIRHQRT 637



==> UNIPROT|Q9HCG1 - symbol:KR18_HUMAN "KIAA1611: Zinc finger protein
           Kr18" species:9606 "Homo sapiens" [GO:0006355
           "regulation of transcription, DNA-dependent"
           evidence=NAS] [GO:0030097 "hemopoiesis" evidence=NAS]
           [GO:0005634 "nucleus" evidence=NAS] InterPro:IPR007087
           Pfam:PF00096 Prosite:PS00028 InterPro:IPR001909
           InterPro:IPR007086 UniProt:Q9HCG1 GO:GO:0005634
           GO:GO:0030097 GO:GO:0006355 SMART:SM00355
           PROSITE:PS50157 ProDom:PD000003 HSSP:P08047
           PRINTS:PR00048 Pfam:PF01352 SMART:SM00349
           PROSITE:PS50805 EMBL:AF277623 EMBL:AB046831
           EMBL:AK024442 UniGene:Hs.467236 Ensembl:ENSG00000170949
           LinkHub:Q9HCG1 ArrayExpress:Q9HCG1
           GermOnline:ENSG00000170949 RZPD-ProtExp:IOH3072
           RZPD-ProtExp:V0167
          Length = 818

 Score =  124 bits (312), Expect = 2e-028
 Identities = 76/270 (28%), Positives = 116/270 (42%), Gaps = 13/270 (4%)

Query: 235 WRALLRHTKEVHKHDKVYVKCPVCEMKMRTKQTLLQHMDWHENPEKYRCELCGE---KHQ 291
           + + L   + VH  +K Y KC  C         L  H   H   + ++C  C +   ++ 
Sbjct: 436 YNSYLGRHRRVHTGEKPY-KCNECGKAFSMHSNLATHQVIHTGTKPFKCNECSKVFTQNS 494

Query: 292 NMKEHIQNKHQERQFCCDVCGKKFPFKKRLTVHMKKMHVEKDIICDQCQKPFTKYTIEDH 351
            +  H +    E+ + C+ CGK F  +  LT H      EK   C +C K FT+ +    
Sbjct: 495 QLANHRRIHTGEKPYKCNECGKAFSVRSSLTTHQAIHSGEKPYKCIECGKSFTQKSHLRS 554

Query: 352 KRSVHSAR--FVCEHCPKTFNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKYILTR 409
            R +HS    + C  C K F    +L +H   H           C  CG+   D+  LT 
Sbjct: 555 HRGIHSGEKPYKCNECGKVFAQTSQLARHWRVH----TGEKPYKCNDCGRAFSDRSSLTF 610

Query: 410 HIKLMHTVQPAVSCETCGKTFKCKRNLSVHMTNVCMEPTRLYPCTICGKEFRRKNKLKEH 469
           H + +HT +    C  CGK F+    L+ H      E  + Y C  CGK F   + L  H
Sbjct: 611 H-QAIHTGEKPYKCHECGKVFRHNSYLATHRRIHTGE--KPYKCNECGKAFSMHSNLTTH 667

Query: 470 MSTHTGKPLYMCSFCPETFRQDTHLYHHRK 499
              HTG+  Y C+ C + F Q++HL +H++
Sbjct: 668 KVIHTGEKPYKCNQCGKVFTQNSHLANHQR 697



 Score =  123 bits (309), Expect = 5e-028
 Identities = 75/271 (27%), Positives = 118/271 (43%), Gaps = 13/271 (4%)

Query: 234 TWRALLRHTKEVHKHDKVYVKCPVCEMKMRTKQTLLQHMDWHENPEKYRCELCGE---KH 290
           T  + L + + +H  +K Y KC  C      + +L  H   H   + Y+C  CG+   + 
Sbjct: 491 TQNSQLANHRRIHTGEKPY-KCNECGKAFSVRSSLTTHQAIHSGEKPYKCIECGKSFTQK 549

Query: 291 QNMKEHIQNKHQERQFCCDVCGKKFPFKKRLTVHMKKMHVEKDIICDQCQKPFTKYTIED 350
            +++ H      E+ + C+ CGK F    +L  H +    EK   C+ C + F+  +   
Sbjct: 550 SHLRSHRGIHSGEKPYKCNECGKVFAQTSQLARHWRVHTGEKPYKCNDCGRAFSDRSSLT 609

Query: 351 HKRSVHSAR--FVCEHCPKTFNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKYILT 408
             +++H+    + C  C K F     L  H   H           C  CG+       LT
Sbjct: 610 FHQAIHTGEKPYKCHECGKVFRHNSYLATHRRIHT----GEKPYKCNECGKAFSMHSNLT 665

Query: 409 RHIKLMHTVQPAVSCETCGKTFKCKRNLSVHMTNVCMEPTRLYPCTICGKEFRRKNKLKE 468
            H K++HT +    C  CGK F    +L+ H      E  + Y C  CGK F  ++ L  
Sbjct: 666 TH-KVIHTGEKPYKCNQCGKVFTQNSHLANHQRTHTGE--KPYRCNECGKAFSVRSSLTT 722

Query: 469 HMSTHTGKPLYMCSFCPETFRQDTHLYHHRK 499
           H + HTGK  Y C+ C + F Q+ HL +HR+
Sbjct: 723 HQAIHTGKKPYKCNECGKVFTQNAHLANHRR 753



 Score =  123 bits (308), Expect = 6e-028
 Identities = 79/271 (29%), Positives = 116/271 (42%), Gaps = 14/271 (5%)

Query: 234 TWRALLRHTKEVHKHDKVYVKCPVCEMKMRTKQTLLQHMDWHENPEKYRCELCGEKHQNM 293
           T ++ LR  + +H  +K Y KC  C         L +H   H   + Y+C  CG    + 
Sbjct: 547 TQKSHLRSHRGIHSGEKPY-KCNECGKVFAQTSQLARHWRVHTGEKPYKCNDCGRAFSDR 605

Query: 294 KE---HIQNKHQERQFCCDVCGKKFPFKKRLTVHMKKMHVEKDIICDQCQKPFTKYTIED 350
                H      E+ + C  CGK F     L  H +    EK   C++C K F+ ++   
Sbjct: 606 SSLTFHQAIHTGEKPYKCHECGKVFRHNSYLATHRRIHTGEKPYKCNECGKAFSMHSNLT 665

Query: 351 HKRSVHSAR--FVCEHCPKTFNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKYILT 408
             + +H+    + C  C K F     L  H   H           C  CG+    +  LT
Sbjct: 666 THKVIHTGEKPYKCNQCGKVFTQNSHLANHQRTHT----GEKPYRCNECGKAFSVRSSLT 721

Query: 409 RHIKLMHTVQPAVSCETCGKTFKCKRNLSVHMTNVCMEPTRLYPCTICGKEFRRKNKLKE 468
            H + +HT +    C  CGK F    +L+ H      E  + Y CT CGK FR ++ L  
Sbjct: 722 TH-QAIHTGKKPYKCNECGKVFTQNAHLANHRRIHTGE--KPYRCTECGKAFRVRSSLTT 778

Query: 469 HMSTHTGKPLYMCSFCPETFRQDTHL-YHHR 498
           HM+ HTG+  Y C+ C + FRQ ++L  HHR
Sbjct: 779 HMAIHTGEKRYKCNECGKVFRQSSNLASHHR 809



 Score =  114 bits (285), Expect = 3e-025
 Identities = 79/254 (31%), Positives = 116/254 (45%), Gaps = 16/254 (6%)

Query: 232 FGTWRALLRHTKEVHKHDKVYVKCPVCEMKMRTKQTLLQHMDWHENPEKYRCELCGE--K 289
           F     L RH + VH  +K Y KC  C      + +L  H   H   + Y+C  CG+  +
Sbjct: 574 FAQTSQLARHWR-VHTGEKPY-KCNDCGRAFSDRSSLTFHQAIHTGEKPYKCHECGKVFR 631

Query: 290 HQN-MKEHIQNKHQERQFCCDVCGKKFPFKKRLTVHMKKMHV-EKDIICDQCQKPFTKYT 347
           H + +  H +    E+ + C+ CGK F     LT H K +H  EK   C+QC K FT+ +
Sbjct: 632 HNSYLATHRRIHTGEKPYKCNECGKAFSMHSNLTTH-KVIHTGEKPYKCNQCGKVFTQNS 690

Query: 348 -IEDHKRSVHSAR-FVCEHCPKTFNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKY 405
            + +H+R+    + + C  C K F+ R  L  H   H           C  CG+V     
Sbjct: 691 HLANHQRTHTGEKPYRCNECGKAFSVRSSLTTHQAIHT----GKKPYKCNECGKVFTQNA 746

Query: 406 ILTRHIKLMHTVQPAVSCETCGKTFKCKRNLSVHMTNVCMEPTRLYPCTICGKEFRRKNK 465
            L  H ++ HT +    C  CGK F+ + +L+ HM     E  + Y C  CGK FR+ + 
Sbjct: 747 HLANHRRI-HTGEKPYRCTECGKAFRVRSSLTTHMAIHTGE--KRYKCNECGKVFRQSSN 803

Query: 466 LKEHMSTHTGKPLY 479
           L  H   HTG+  Y
Sbjct: 804 LASHHRMHTGEKPY 817



 Score =  109 bits (273), Expect = 7e-024
 Identities = 72/268 (26%), Positives = 106/268 (39%), Gaps = 13/268 (4%)

Query: 237 ALLRHTKEVHKHDKVYVKCPVCEMKMRTKQTLLQHMDWHENPEKYRCELCGEK---HQNM 293
           +LL   ++ +   K Y KC  C         L  H   H   + Y+C  CG+      N+
Sbjct: 242 SLLTQRRKANSCGKPY-KCNECGKAFTQNSNLTSHRRIHSGEKPYKCSECGKTFTVRSNL 300

Query: 294 KEHIQNKHQERQFCCDVCGKKFPFKKRLTVHMKKMHVEKDIICDQCQKPFTKYTIEDHKR 353
             H      E+ + C  CGK F     L  H +    EK   C++C K F  ++     +
Sbjct: 301 TIHQVIHTGEKPYKCHECGKVFRHNSYLATHRRIHTGEKPYKCNECGKAFRGHSNLTTHQ 360

Query: 354 SVHSAR--FVCEHCPKTFNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKYILTRHI 411
            +H+    F C  C K F     L+ H   H           C  CG+    +  L  H 
Sbjct: 361 LIHTGEKPFKCNECGKLFTQNSHLISHWRIHT----GEKPYKCNECGKAFSVRSSLAIH- 415

Query: 412 KLMHTVQPAVSCETCGKTFKCKRNLSVHMTNVCMEPTRLYPCTICGKEFRRKNKLKEHMS 471
           + +HT +    C  CGK F+    L  H      E  + Y C  CGK F   + L  H  
Sbjct: 416 QTIHTGEKPYKCNECGKVFRYNSYLGRHRRVHTGE--KPYKCNECGKAFSMHSNLATHQV 473

Query: 472 THTGKPLYMCSFCPETFRQDTHLYHHRK 499
            HTG   + C+ C + F Q++ L +HR+
Sbjct: 474 IHTGTKPFKCNECSKVFTQNSQLANHRR 501



==> UNIPROT|P10075 - symbol:GLI4_HUMAN "GLI4, HKR4: Zinc finger protein
           GLI4" species:9606 "Homo sapiens" [GO:0003674
           "molecular_function" evidence=ND] [GO:0008150
           "biological_process" evidence=ND] [GO:0005634 "nucleus"
           evidence=NAS] InterPro:IPR007087 Pfam:PF00096
           Prosite:PS00028 InterPro:IPR007086 UniProt:P10075
           GO:GO:0005634 SMART:SM00355 PROSITE:PS50157 HSSP:P08046
           ProDom:PD000003 PRINTS:PR00048 EMBL:BC014165 EMBL:M20678
           EMBL:M20679 PIR:F31201 UniGene:Hs.400533
           Ensembl:ENSG00000181638 KEGG:hsa:2738 HGNC:HGNC:4320
           MIM:165280 ArrayExpress:P10075
           GermOnline:ENSG00000181638 RZPD-ProtExp:IOH12330
           RZPD-ProtExp:T2616
          Length = 376

 Score =  100 bits (248), Expect = 5e-021
 Identities = 59/198 (29%), Positives = 86/198 (43%), Gaps = 10/198 (5%)

Query: 308 CDVCGKKFPFKKRLTVHMKKMHVEKDIICDQCQKPFTKYT--IEDHKRSVHSARFVCEHC 365
           C+ CGK F +   L  H +    EK   C +C K F  ++  I+ H+       + C  C
Sbjct: 185 CEACGKSFKYNSLLLKHQRIHTGEKPYACHECGKRFRGWSGFIQHHRIHTGEKPYECGQC 244

Query: 366 PKTFNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKYILTRHIKLMHTVQPAVSCET 425
            + F+      QH+  H+          C  CGQ       L RH +L HT +   +C  
Sbjct: 245 GRAFSHSSHFTQHLRIHN----GEKPYKCGECGQAFSQSSNLVRHQRL-HTGEKPYACSQ 299

Query: 426 CGKTFKCKRNLSVHMTNVCMEPTRLYPCTICGKEFRRKNKLKEHMSTHTGKPLYMCSFCP 485
           CGK F     L  H      E  + Y C+ CGK FR ++    H+ THTG+  + C  C 
Sbjct: 300 CGKAFIWSSVLIEHQRIHTGE--KPYECSDCGKAFRGRSHFFRHLRTHTGEKPFACGACG 357

Query: 486 ETFRQDTHLYHHRKNAHY 503
           + F Q + L  H++  HY
Sbjct: 358 KAFGQSSQLIQHQR-VHY 374



 Score = 80.5 bits (197), Expect = 4e-015
 Identities = 47/191 (24%), Positives = 79/191 (41%), Gaps = 10/191 (5%)

Query: 254 KCPVCEMKMRTKQTLLQHMDWHENPEKYRCELCGEKHQNMKEHIQNKH---QERQFCCDV 310
           +C  C    +    LL+H   H   + Y C  CG++ +     IQ+      E+ + C  
Sbjct: 184 RCEACGKSFKYNSLLLKHQRIHTGEKPYACHECGKRFRGWSGFIQHHRIHTGEKPYECGQ 243

Query: 311 CGKKFPFKKRLTVHMKKMHVEKDIICDQCQKPFTKYTIEDHKRSVHSAR--FVCEHCPKT 368
           CG+ F      T H++  + EK   C +C + F++ +     + +H+    + C  C K 
Sbjct: 244 CGRAFSHSSHFTQHLRIHNGEKPYKCGECGQAFSQSSNLVRHQRLHTGEKPYACSQCGKA 303

Query: 369 FNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKYILTRHIKLMHTVQPAVSCETCGK 428
           F     L++H   H           C+ CG+  R +    RH++  HT +   +C  CGK
Sbjct: 304 FIWSSVLIEHQRIH----TGEKPYECSDCGKAFRGRSHFFRHLR-THTGEKPFACGACGK 358

Query: 429 TFKCKRNLSVH 439
            F     L  H
Sbjct: 359 AFGQSSQLIQH 369



 Score = 71.2 bits (173), Expect = 3e-012
 Identities = 44/178 (24%), Positives = 70/178 (39%), Gaps = 11/178 (6%)

Query: 238 LLRHTKEVHKHDKVYVKCPVCEMKMRTKQTLLQHMDWHENPEKYRCELCGEKHQNMK--- 294
           LL+H + +H  +K Y  C  C  + R     +QH   H   + Y C  CG    +     
Sbjct: 198 LLKHQR-IHTGEKPYA-CHECGKRFRGWSGFIQHHRIHTGEKPYECGQCGRAFSHSSHFT 255

Query: 295 EHIQNKHQERQFCCDVCGKKFPFKKRLTVHMKKMHVEKDIICDQCQKPFTKYTIEDHKRS 354
           +H++  + E+ + C  CG+ F     L  H +    EK   C QC K F   ++    + 
Sbjct: 256 QHLRIHNGEKPYKCGECGQAFSQSSNLVRHQRLHTGEKPYACSQCGKAFIWSSVLIEHQR 315

Query: 355 VHSAR--FVCEHCPKTFNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKYILTRH 410
           +H+    + C  C K F  R    +H+  H           C  CG+       L +H
Sbjct: 316 IHTGEKPYECSDCGKAFRGRSHFFRHLRTH----TGEKPFACGACGKAFGQSSQLIQH 369



==> MGI|MGI:109447 - symbol:Ctcf "CCCTC-binding factor" species:10090
           "Mus musculus" [GO:0010216 "maintenance of DNA
           methylation" evidence=IMP] [GO:0003677 "DNA binding"
           evidence=IDA] [GO:0020037 "heme binding" evidence=RCA]
           [GO:0006118 "electron transport" evidence=RCA]
           [GO:0009048 "dosage compensation, by inactivation of X
           chromosome" evidence=TAS] [GO:0006306 "DNA methylation"
           evidence=IDA] [GO:0006349 "imprinting" evidence=IMP;IDA]
           [GO:0006355 "regulation of transcription, DNA-dependent"
           evidence=IDA] [GO:0005515 "protein binding"
           evidence=IPI] [GO:0005634 "nucleus" evidence=IDA]
           [GO:0009055 "electron carrier activity" evidence=RCA]
           InterPro:IPR007087 Pfam:PF00096 Prosite:PS00028
           UniProt:Q61164 MGI:MGI:109447 GO:GO:0005515
           GO:GO:0005634 GO:GO:0003677 GO:GO:0006355 SMART:SM00355
           PROSITE:PS50157 HSSP:P08046 GO:GO:0009048 EMBL:U51037
           EMBL:BC037456 EMBL:BC046398 EMBL:BC049131 EMBL:BC058240
           EMBL:AK076192 UniGene:Mm.269474 SMR:Q61164 IntAct:Q61164
           TRANSFAC:T02285 Ensembl:ENSMUSG00000005698
           KEGG:mmu:13018 ArrayExpress:Q61164
           GermOnline:ENSMUSG00000005698 GO:GO:0006349
           GO:GO:0010216
          Length = 736

 Score = 97.8 bits (242), Expect = 3e-020
 Identities = 72/275 (26%), Positives = 118/275 (42%), Gaps = 18/275 (6%)

Query: 238 LLRHTKEVHKHDKVYVKCPVCEMKMRTKQTLLQHMDWHENPEK-YRCELC---GEKHQNM 293
           LLR+    H   + + KCP C+M   T   L++H  +    EK ++C +C     +   +
Sbjct: 308 LLRNHLNTHTGTRPH-KCPDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKL 366

Query: 294 KEHIQNKHQERQFCCDVCGKKFPFKKRLTVHMKKMHVEKDIICDQCQKPFTKY-TIEDH- 351
           K HI++   ER F C +C        +L  HM+    EK   C  C   FT+  T++ H 
Sbjct: 367 KRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARFTQSGTMKMHI 426

Query: 352 --KRSVHSARFVCEHCPKTFNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKYILTR 409
             K + + A+F C HC      +  L  H+ +    +       C  C  V  ++Y L +
Sbjct: 427 LQKHTENVAKFHCPHCDTVIARKSDLGVHLRKQHSYIEQGKK--CRYCDAVFHERYALIQ 484

Query: 410 HIKLMHTVQPAVSCETCGKTFKCKRNLSVHMTNVCMEPTRLYPCTICGKEFRRKNKLKEH 469
           H K  H  +    C+ C    + +R++ +H      E  + Y C+ C K FR+K  L  H
Sbjct: 485 HQK-SHKNEKRFKCDQCDYACRQERHMIMHKRTHTGE--KPYACSHCDKTFRQKQLLDMH 541

Query: 470 MSTHTGKPL----YMCSFCPETFRQDTHLYHHRKN 500
              +         ++CS C +TF +   +  H  N
Sbjct: 542 FKRYHDPNFVPAAFVCSKCGKTFTRRNTMARHADN 576



 Score = 92.8 bits (229), Expect = 9e-019
 Identities = 69/253 (27%), Positives = 101/253 (39%), Gaps = 29/253 (11%)

Query: 207 HNFYKRIVCEVCDIQRMLVGEPQIDFGTWRALLRHTKEVHKHDKVYVKCPVCEMKMRTKQ 266
           H   K   C +CD   + V +          L RH +  H  ++ + +C +C    R   
Sbjct: 345 HTHEKPFKCSMCDYASVEVSK----------LKRHIRS-HTGERPF-QCSLCSYASRDTY 392

Query: 267 TLLQHMDWHENPEKYRCELCGEKHQN---MKEHIQNKHQER--QFCCDVCGKKFPFKKRL 321
            L +HM  H   + Y C +C  +      MK HI  KH E   +F C  C      K  L
Sbjct: 393 KLKRHMRTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIARKSDL 452

Query: 322 TVHMKKMH--VEKDIICDQCQKPF-TKYTIEDHKRS-VHSARFVCEHCPKTFNSRFRLLQ 377
            VH++K H  +E+   C  C   F  +Y +  H++S  +  RF C+ C         ++ 
Sbjct: 453 GVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQCDYACRQERHMIM 512

Query: 378 HMEEHDESLRNSTSVPCTICGQVMRDKYILTRHIKLMHT---VQPAVSCETCGKTFKCKR 434
           H   H           C+ C +  R K +L  H K  H    V  A  C  CGKTF  + 
Sbjct: 513 HKRTHT----GEKPYACSHCDKTFRQKQLLDMHFKRYHDPNFVPAAFVCSKCGKTFTRRN 568

Query: 435 NLSVHMTNVCMEP 447
            ++ H  N C  P
Sbjct: 569 TMARHADN-CAGP 580



 Score = 64.3 bits (155), Expect = 3e-010
 Identities = 51/212 (24%), Positives = 74/212 (34%), Gaps = 40/212 (18%)

Query: 297 IQNKHQERQFCCDVCGKKFPFKKRLTVHMKKMHVEKDIICDQCQKPFTKYTIEDHKRSVH 356
           I+ K  ++ F C++C    P +  L  HMK    E+   C  C + F   T+        
Sbjct: 257 IKKKGVKKTFQCELCSYTCPRRSNLDRHMKSHTDERPHKCHLCGRAFRTVTL-------- 308

Query: 357 SARFVCEHCPKTFNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKYILTRHIKLMHT 416
                             L  H+  H  +  +     C  C         L RH +  HT
Sbjct: 309 ------------------LRNHLNTHTGTRPHK----CPDCDMAFVTSGELVRHRRYKHT 346

Query: 417 VQPAVSCETCG----KTFKCKRNLSVHMTNVCMEPTRLYPCTICGKEFRRKNKLKEHMST 472
            +    C  C     +  K KR++  H         R + C++C    R   KLK HM T
Sbjct: 347 HEKPFKCSMCDYASVEVSKLKRHIRSHTGE------RPFQCSLCSYASRDTYKLKRHMRT 400

Query: 473 HTGKPLYMCSFCPETFRQDTHLYHHRKNAHYE 504
           H+G+  Y C  C   F Q   +  H    H E
Sbjct: 401 HSGEKPYECYICHARFTQSGTMKMHILQKHTE 432



 Score = 60.8 bits (146), Expect = 4e-009
 Identities = 40/152 (26%), Positives = 63/152 (41%), Gaps = 10/152 (6%)

Query: 360 FVCEHCPKTFNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKYILTRHIKLMHTVQP 419
           F CE C  T   R  L +HM+ H +   +     C +CG+  R   +L  H+   HT   
Sbjct: 266 FQCELCSYTCPRRSNLDRHMKSHTDERPHK----CHLCGRAFRTVTLLRNHLNT-HTGTR 320

Query: 420 AVSCETCGKTFKCKRNLSVHMTNVCMEPTRLYPCTICGKEFRRKNKLKEHMSTHTGKPLY 479
              C  C   F     L  H         + + C++C       +KLK H+ +HTG+  +
Sbjct: 321 PHKCPDCDMAFVTSGELVRHRRYKHTHE-KPFKCSMCDYASVEVSKLKRHIRSHTGERPF 379

Query: 480 MCSFCP----ETFRQDTHLYHHRKNAHYERWL 507
            CS C     +T++   H+  H     YE ++
Sbjct: 380 QCSLCSYASRDTYKLKRHMRTHSGEKPYECYI 411



==> UNIPROT|P49711 - symbol:CTCF_HUMAN "CTCF: Transcriptional repressor
           CTCF" species:9606 "Homo sapiens" [GO:0003700
           "transcription factor activity" evidence=IDA]
           [GO:0003702 "RNA polymerase II transcription factor
           activity" evidence=TAS] [GO:0003714 "transcription
           corepressor activity" evidence=TAS] [GO:0005515 "protein
           binding" evidence=IPI] [GO:0008270 "zinc ion binding"
           evidence=TAS] [GO:0000122 "negative regulation of
           transcription from RNA polymerase II promoter"
           evidence=TAS] [GO:0045893 "positive regulation of
           transcription, DNA-dependent" evidence=IDA] [GO:0005634
           "nucleus" evidence=IDA] InterPro:IPR007087 Pfam:PF00096
           Prosite:PS00028 UniProt:P49711 GO:GO:0005634
           GO:GO:0000074 GO:GO:0003700 GO:GO:0008270 SMART:SM00355
           PROSITE:PS50157 GO:GO:0045893 GO:GO:0003714
           GO:GO:0003702 GO:GO:0000122 EMBL:U25435 EMBL:AF145477
           EMBL:AF145468 EMBL:AF145469 EMBL:AF145470 EMBL:AF145471
           EMBL:AF145472 EMBL:AF145473 EMBL:AF145474 EMBL:AF145475
           EMBL:AF145476 EMBL:BC014267 PIR:G01792 UniGene:Hs.368367
           PDB:1X6H PDB:2CT1 IntAct:P49711 TRANSFAC:T02284
           Ensembl:ENSG00000102974 KEGG:hsa:10664
           H-InvDB:HIX0013150 HGNC:HGNC:13723 MIM:604167
           ArrayExpress:P49711 GermOnline:ENSG00000102974
           RZPD-ProtExp:F0480
          Length = 727

 Score = 97.8 bits (242), Expect = 3e-020
 Identities = 72/275 (26%), Positives = 118/275 (42%), Gaps = 18/275 (6%)

Query: 238 LLRHTKEVHKHDKVYVKCPVCEMKMRTKQTLLQHMDWHENPEK-YRCELC---GEKHQNM 293
           LLR+    H   + + KCP C+M   T   L++H  +    EK ++C +C     +   +
Sbjct: 308 LLRNHLNTHTGTRPH-KCPDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKL 366

Query: 294 KEHIQNKHQERQFCCDVCGKKFPFKKRLTVHMKKMHVEKDIICDQCQKPFTKY-TIEDH- 351
           K HI++   ER F C +C        +L  HM+    EK   C  C   FT+  T++ H 
Sbjct: 367 KRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARFTQSGTMKMHI 426

Query: 352 --KRSVHSARFVCEHCPKTFNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKYILTR 409
             K + + A+F C HC      +  L  H+ +    +       C  C  V  ++Y L +
Sbjct: 427 LQKHTENVAKFHCPHCDTVIARKSDLGVHLRKQHSYIEQGKK--CRYCDAVFHERYALIQ 484

Query: 410 HIKLMHTVQPAVSCETCGKTFKCKRNLSVHMTNVCMEPTRLYPCTICGKEFRRKNKLKEH 469
           H K  H  +    C+ C    + +R++ +H      E  + Y C+ C K FR+K  L  H
Sbjct: 485 HQK-SHKNEKRFKCDQCDYACRQERHMIMHKRTHTGE--KPYACSHCDKTFRQKQLLDMH 541

Query: 470 MSTHTGKPL----YMCSFCPETFRQDTHLYHHRKN 500
              +         ++CS C +TF +   +  H  N
Sbjct: 542 FKRYHDPNFVPAAFVCSKCGKTFTRRNTMARHADN 576



 Score = 92.8 bits (229), Expect = 9e-019
 Identities = 69/253 (27%), Positives = 101/253 (39%), Gaps = 29/253 (11%)

Query: 207 HNFYKRIVCEVCDIQRMLVGEPQIDFGTWRALLRHTKEVHKHDKVYVKCPVCEMKMRTKQ 266
           H   K   C +CD   + V +          L RH +  H  ++ + +C +C    R   
Sbjct: 345 HTHEKPFKCSMCDYASVEVSK----------LKRHIRS-HTGERPF-QCSLCSYASRDTY 392

Query: 267 TLLQHMDWHENPEKYRCELCGEKHQN---MKEHIQNKHQER--QFCCDVCGKKFPFKKRL 321
            L +HM  H   + Y C +C  +      MK HI  KH E   +F C  C      K  L
Sbjct: 393 KLKRHMRTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIARKSDL 452

Query: 322 TVHMKKMH--VEKDIICDQCQKPF-TKYTIEDHKRS-VHSARFVCEHCPKTFNSRFRLLQ 377
            VH++K H  +E+   C  C   F  +Y +  H++S  +  RF C+ C         ++ 
Sbjct: 453 GVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQCDYACRQERHMIM 512

Query: 378 HMEEHDESLRNSTSVPCTICGQVMRDKYILTRHIKLMHT---VQPAVSCETCGKTFKCKR 434
           H   H           C+ C +  R K +L  H K  H    V  A  C  CGKTF  + 
Sbjct: 513 HKRTHT----GEKPYACSHCDKTFRQKQLLDMHFKRYHDPNFVPAAFVCSKCGKTFTRRN 568

Query: 435 NLSVHMTNVCMEP 447
            ++ H  N C  P
Sbjct: 569 TMARHADN-CAGP 580



 Score = 64.3 bits (155), Expect = 3e-010
 Identities = 51/212 (24%), Positives = 74/212 (34%), Gaps = 40/212 (18%)

Query: 297 IQNKHQERQFCCDVCGKKFPFKKRLTVHMKKMHVEKDIICDQCQKPFTKYTIEDHKRSVH 356
           I+ K  ++ F C++C    P +  L  HMK    E+   C  C + F   T+        
Sbjct: 257 IKKKGVKKTFQCELCSYTCPRRSNLDRHMKSHTDERPHKCHLCGRAFRTVTL-------- 308

Query: 357 SARFVCEHCPKTFNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKYILTRHIKLMHT 416
                             L  H+  H  +  +     C  C         L RH +  HT
Sbjct: 309 ------------------LRNHLNTHTGTRPHK----CPDCDMAFVTSGELVRHRRYKHT 346

Query: 417 VQPAVSCETCG----KTFKCKRNLSVHMTNVCMEPTRLYPCTICGKEFRRKNKLKEHMST 472
            +    C  C     +  K KR++  H         R + C++C    R   KLK HM T
Sbjct: 347 HEKPFKCSMCDYASVEVSKLKRHIRSHTGE------RPFQCSLCSYASRDTYKLKRHMRT 400

Query: 473 HTGKPLYMCSFCPETFRQDTHLYHHRKNAHYE 504
           H+G+  Y C  C   F Q   +  H    H E
Sbjct: 401 HSGEKPYECYICHARFTQSGTMKMHILQKHTE 432



 Score = 60.8 bits (146), Expect = 4e-009
 Identities = 40/152 (26%), Positives = 63/152 (41%), Gaps = 10/152 (6%)

Query: 360 FVCEHCPKTFNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKYILTRHIKLMHTVQP 419
           F CE C  T   R  L +HM+ H +   +     C +CG+  R   +L  H+   HT   
Sbjct: 266 FQCELCSYTCPRRSNLDRHMKSHTDERPHK----CHLCGRAFRTVTLLRNHLNT-HTGTR 320

Query: 420 AVSCETCGKTFKCKRNLSVHMTNVCMEPTRLYPCTICGKEFRRKNKLKEHMSTHTGKPLY 479
              C  C   F     L  H         + + C++C       +KLK H+ +HTG+  +
Sbjct: 321 PHKCPDCDMAFVTSGELVRHRRYKHTHE-KPFKCSMCDYASVEVSKLKRHIRSHTGERPF 379

Query: 480 MCSFCP----ETFRQDTHLYHHRKNAHYERWL 507
            CS C     +T++   H+  H     YE ++
Sbjct: 380 QCSLCSYASRDTYKLKRHMRTHSGEKPYECYI 411



==> UNIPROT|Q08705 - symbol:CTCF_CHICK "CTCF: Transcriptional repressor
           CTCF" species:9031 "Gallus gallus" [GO:0005515 "protein
           binding" evidence=IPI] InterPro:IPR007087 Pfam:PF00096
           Prosite:PS00028 UniProt:Q08705 GO:GO:0005515
           SMART:SM00355 PROSITE:PS50157 HSSP:P08046 EMBL:Z22605
           PIR:A54603 UniGene:Gga.3278 SMR:Q08705 IntAct:Q08705
           TRANSFAC:T00172 Ensembl:ENSGALG00000001817
          Length = 728

 Score = 97.8 bits (242), Expect = 3e-020
 Identities = 72/275 (26%), Positives = 118/275 (42%), Gaps = 18/275 (6%)

Query: 238 LLRHTKEVHKHDKVYVKCPVCEMKMRTKQTLLQHMDWHENPEK-YRCELC---GEKHQNM 293
           LLR+    H   + + KCP C+M   T   L++H  +    EK ++C +C     +   +
Sbjct: 308 LLRNHLNTHTGTRPH-KCPDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKL 366

Query: 294 KEHIQNKHQERQFCCDVCGKKFPFKKRLTVHMKKMHVEKDIICDQCQKPFTKY-TIEDH- 351
           K HI++   ER F C +C        +L  HM+    EK   C  C   FT+  T++ H 
Sbjct: 367 KRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARFTQSGTMKMHI 426

Query: 352 --KRSVHSARFVCEHCPKTFNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKYILTR 409
             K + + A+F C HC      +  L  H+ +    +       C  C  V  ++Y L +
Sbjct: 427 LQKHTENVAKFHCPHCDTVIARKSDLGVHLRKQHSYIEQGKK--CRYCDAVFHERYALIQ 484

Query: 410 HIKLMHTVQPAVSCETCGKTFKCKRNLSVHMTNVCMEPTRLYPCTICGKEFRRKNKLKEH 469
           H K  H  +    C+ C    + +R++ +H      E  + Y C+ C K FR+K  L  H
Sbjct: 485 HQK-SHKNEKRFKCDQCDYACRQERHMVMHKRTHTGE--KPYACSHCDKTFRQKQLLDMH 541

Query: 470 MSTHTGKPL----YMCSFCPETFRQDTHLYHHRKN 500
              +         ++CS C +TF +   +  H  N
Sbjct: 542 FKRYHDPNFVPAAFVCSKCGKTFTRRNTMARHADN 576



 Score = 92.8 bits (229), Expect = 9e-019
 Identities = 69/248 (27%), Positives = 102/248 (41%), Gaps = 28/248 (11%)

Query: 207 HNFYKRIVCEVCDIQRMLVGEPQIDFGTWRALLRHTKEVHKHDKVYVKCPVCEMKMRTKQ 266
           H   K   C +CD   + V +          L RH +  H  ++ + +C +C    R   
Sbjct: 345 HTHEKPFKCSMCDYASVEVSK----------LKRHIRS-HTGERPF-QCSLCSYASRDTY 392

Query: 267 TLLQHMDWHENPEKYRCELCGEKHQN---MKEHIQNKHQER--QFCCDVCGKKFPFKKRL 321
            L +HM  H   + Y C +C  +      MK HI  KH E   +F C  C      K  L
Sbjct: 393 KLKRHMRTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIARKSDL 452

Query: 322 TVHMKKMH--VEKDIICDQCQKPF-TKYTIEDHKRS-VHSARFVCEHCPKTFNSRFRLLQ 377
            VH++K H  +E+   C  C   F  +Y +  H++S  +  RF C+ C    +   R  +
Sbjct: 453 GVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQC----DYACRQER 508

Query: 378 HMEEHDESLRNSTSVPCTICGQVMRDKYILTRHIKLMHT---VQPAVSCETCGKTFKCKR 434
           HM  H  +        C+ C +  R K +L  H K  H    V  A  C  CGKTF  + 
Sbjct: 509 HMVMHKRTHTGEKPYACSHCDKTFRQKQLLDMHFKRYHDPNFVPAAFVCSKCGKTFTRRN 568

Query: 435 NLSVHMTN 442
            ++ H  N
Sbjct: 569 TMARHADN 576



 Score = 64.3 bits (155), Expect = 3e-010
 Identities = 51/212 (24%), Positives = 74/212 (34%), Gaps = 40/212 (18%)

Query: 297 IQNKHQERQFCCDVCGKKFPFKKRLTVHMKKMHVEKDIICDQCQKPFTKYTIEDHKRSVH 356
           I+ K  ++ F C++C    P +  L  HMK    E+   C  C + F   T+        
Sbjct: 257 IKKKGVKKTFQCELCSYTCPRRSNLDRHMKSHTDERPHKCHLCGRAFRTVTL-------- 308

Query: 357 SARFVCEHCPKTFNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKYILTRHIKLMHT 416
                             L  H+  H  +  +     C  C         L RH +  HT
Sbjct: 309 ------------------LRNHLNTHTGTRPHK----CPDCDMAFVTSGELVRHRRYKHT 346

Query: 417 VQPAVSCETCG----KTFKCKRNLSVHMTNVCMEPTRLYPCTICGKEFRRKNKLKEHMST 472
            +    C  C     +  K KR++  H         R + C++C    R   KLK HM T
Sbjct: 347 HEKPFKCSMCDYASVEVSKLKRHIRSHTGE------RPFQCSLCSYASRDTYKLKRHMRT 400

Query: 473 HTGKPLYMCSFCPETFRQDTHLYHHRKNAHYE 504
           H+G+  Y C  C   F Q   +  H    H E
Sbjct: 401 HSGEKPYECYICHARFTQSGTMKMHILQKHTE 432



 Score = 60.8 bits (146), Expect = 4e-009
 Identities = 40/152 (26%), Positives = 63/152 (41%), Gaps = 10/152 (6%)

Query: 360 FVCEHCPKTFNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKYILTRHIKLMHTVQP 419
           F CE C  T   R  L +HM+ H +   +     C +CG+  R   +L  H+   HT   
Sbjct: 266 FQCELCSYTCPRRSNLDRHMKSHTDERPHK----CHLCGRAFRTVTLLRNHLNT-HTGTR 320

Query: 420 AVSCETCGKTFKCKRNLSVHMTNVCMEPTRLYPCTICGKEFRRKNKLKEHMSTHTGKPLY 479
              C  C   F     L  H         + + C++C       +KLK H+ +HTG+  +
Sbjct: 321 PHKCPDCDMAFVTSGELVRHRRYKHTHE-KPFKCSMCDYASVEVSKLKRHIRSHTGERPF 379

Query: 480 MCSFCP----ETFRQDTHLYHHRKNAHYERWL 507
            CS C     +T++   H+  H     YE ++
Sbjct: 380 QCSLCSYASRDTYKLKRHMRTHSGEKPYECYI 411



==> MGI|MGI:103170 - symbol:Gfi1 "growth factor independent 1"
           species:10090 "Mus musculus" [GO:0007638 "mechanosensory
           behavior" evidence=IMP] [GO:0045165 "cell fate
           commitment" evidence=IMP] [GO:0042491 "auditory receptor
           cell differentiation" evidence=IMP] [GO:0042472 "inner
           ear morphogenesis" evidence=IMP] [GO:0009996 "negative
           regulation of cell fate specification" evidence=IMP]
           [GO:0042660 "positive regulation of cell fate
           specification" evidence=IMP] InterPro:IPR007087
           InterPro:IPR001878 Pfam:PF00096 Prosite:PS00028
           MGI:MGI:103170 SMART:SM00355 PROSITE:PS50157
           SMART:SM00343 ProDom:PD000003 GO:GO:0042472 HSSP:P08047
           GO:GO:0009996 GO:GO:0042491 GO:GO:0007638 EMBL:U58973
           EMBL:U58972 EMBL:U78312 UniGene:Mm.2078
           Ensembl:ENSMUSG00000029275 KEGG:mmu:14581
           ArrayExpress:P70338 GermOnline:ENSMUSG00000029275
           GO:GO:0042660 Uniprot:P70338
          Length = 423

 Score = 89.4 bits (220), Expect = 1e-017
 Identities = 55/170 (32%), Positives = 78/170 (45%), Gaps = 10/170 (5%)

Query: 336 CDQCQKPF-TKYTIEDHKRSVHSAR--FVCEHCPKTFNSRFRLLQHMEEHDESLRNSTSV 392
           C +C K F T + +E H R  HS    F CE C KTF     L QH   H +      S 
Sbjct: 258 CIKCSKVFSTPHGLEVHVRRSHSGTRPFACEMCGKTFGHAVSLEQHKAVHSQE----RSF 313

Query: 393 PCTICGQVMRDKYILTRHIKLMHTVQPAVSCETCGKTFKCKRNLSVHMTNVCMEPTRLYP 452
            C ICG+  +    L+ H+ L+H+      C+ CGK F  K ++  H      E  + + 
Sbjct: 314 DCKICGKSFKRSSTLSTHL-LIHSDTRPYPCQYCGKRFHQKSDMKKHTFIHTGE--KPHK 370

Query: 453 CTICGKEFRRKNKLKEHMSTHTGKPLYMCSFCPETFRQDTHLYHHRKNAH 502
           C +CGK F + + L  H   HTG   + C  C + F++   L  HR+  H
Sbjct: 371 CQVCGKAFSQSSNLITHSRKHTGFKPFGCDLCGKGFQRKVDLRRHRETQH 420



 Score = 80.5 bits (197), Expect = 4e-015
 Identities = 51/172 (29%), Positives = 76/172 (44%), Gaps = 12/172 (6%)

Query: 308 CDVCGKKFPFKKRLTVHMKKMHV-EKDIICDQCQKPFTKYTIEDHKRSVHSAR--FVCEH 364
           C  C K F     L VH+++ H   +   C+ C K F      +  ++VHS    F C+ 
Sbjct: 258 CIKCSKVFSTPHGLEVHVRRSHSGTRPFACEMCGKTFGHAVSLEQHKAVHSQERSFDCKI 317

Query: 365 CPKTFNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKYILTRHIKLMHTVQPAVSCE 424
           C K+F     L  H+  H ++       PC  CG+    K  + +H   +HT +    C+
Sbjct: 318 CGKSFKRSSTLSTHLLIHSDT----RPYPCQYCGKRFHQKSDMKKHT-FIHTGEKPHKCQ 372

Query: 425 TCGKTFKCKRNLSVHMT-NVCMEPTRLYPCTICGKEFRRKNKLKEHMSTHTG 475
            CGK F    NL  H   +   +P   + C +CGK F+RK  L+ H  T  G
Sbjct: 373 VCGKAFSQSSNLITHSRKHTGFKP---FGCDLCGKGFQRKVDLRRHRETQHG 421



 Score = 64.7 bits (156), Expect = 3e-010
 Identities = 45/157 (28%), Positives = 68/157 (43%), Gaps = 16/157 (10%)

Query: 207 HNFYKRIVCEVCDIQRMLVGEPQIDFGTWRALLRHTKEVHKHDKVYVKCPVCEMKMRTKQ 266
           H+  +   CE+C             FG   +L +H K VH  ++ +  C +C    +   
Sbjct: 279 HSGTRPFACEMCGKT----------FGHAVSLEQH-KAVHSQERSF-DCKICGKSFKRSS 326

Query: 267 TLLQHMDWHENPEKYRCELCGEK-HQ--NMKEHIQNKHQERQFCCDVCGKKFPFKKRLTV 323
           TL  H+  H +   Y C+ CG++ HQ  +MK+H      E+   C VCGK F     L  
Sbjct: 327 TLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTFIHTGEKPHKCQVCGKAFSQSSNLIT 386

Query: 324 HMKKMHVEKDIICDQCQKPF-TKYTIEDHKRSVHSAR 359
           H +K    K   CD C K F  K  +  H+ + H  +
Sbjct: 387 HSRKHTGFKPFGCDLCGKGFQRKVDLRRHRETQHGLK 423



==> UNIPROT|Q99684 - symbol:GFI1_HUMAN "GFI1, ZNF163: Zinc finger
           protein Gfi-1" species:9606 "Homo sapiens" [GO:0003702
           "RNA polymerase II transcription factor activity"
           evidence=NR] [GO:0000083 "G1/S-specific transcription in
           mitotic cell cycle" evidence=TAS] [GO:0016032 "viral
           reproduction" evidence=TAS] InterPro:IPR007087
           InterPro:IPR001878 Pfam:PF00096 Prosite:PS00028
           UniProt:Q99684 SMART:SM00355 PROSITE:PS50157
           SMART:SM00343 ProDom:PD000003 HSSP:P08047 GO:GO:0016032
           GO:GO:0000083 EMBL:U67369 EMBL:BC032751 EMBL:BC074866
           EMBL:BC074867 UniGene:Hs.73172 Ensembl:ENSG00000162676
           KEGG:hsa:2672 HGNC:HGNC:4237 MIM:202700 MIM:600871
           MIM:607847 ArrayExpress:Q99684
           GermOnline:ENSG00000162676 InterPro:IPR011069
          Length = 422

 Score = 89.4 bits (220), Expect = 1e-017
 Identities = 55/170 (32%), Positives = 78/170 (45%), Gaps = 10/170 (5%)

Query: 336 CDQCQKPF-TKYTIEDHKRSVHSAR--FVCEHCPKTFNSRFRLLQHMEEHDESLRNSTSV 392
           C +C K F T + +E H R  HS    F CE C KTF     L QH   H +      S 
Sbjct: 257 CIKCSKVFSTPHGLEVHVRRSHSGTRPFACEMCGKTFGHAVSLEQHKAVHSQE----RSF 312

Query: 393 PCTICGQVMRDKYILTRHIKLMHTVQPAVSCETCGKTFKCKRNLSVHMTNVCMEPTRLYP 452
            C ICG+  +    L+ H+ L+H+      C+ CGK F  K ++  H      E  + + 
Sbjct: 313 DCKICGKSFKRSSTLSTHL-LIHSDTRPYPCQYCGKRFHQKSDMKKHTFIHTGE--KPHK 369

Query: 453 CTICGKEFRRKNKLKEHMSTHTGKPLYMCSFCPETFRQDTHLYHHRKNAH 502
           C +CGK F + + L  H   HTG   + C  C + F++   L  HR+  H
Sbjct: 370 CQVCGKAFSQSSNLITHSRKHTGFKPFGCDLCGKGFQRKVDLRRHRETQH 419



 Score = 80.5 bits (197), Expect = 4e-015
 Identities = 51/172 (29%), Positives = 76/172 (44%), Gaps = 12/172 (6%)

Query: 308 CDVCGKKFPFKKRLTVHMKKMHV-EKDIICDQCQKPFTKYTIEDHKRSVHSAR--FVCEH 364
           C  C K F     L VH+++ H   +   C+ C K F      +  ++VHS    F C+ 
Sbjct: 257 CIKCSKVFSTPHGLEVHVRRSHSGTRPFACEMCGKTFGHAVSLEQHKAVHSQERSFDCKI 316

Query: 365 CPKTFNSRFRLLQHMEEHDESLRNSTSVPCTICGQVMRDKYILTRHIKLMHTVQPAVSCE 424
           C K+F     L  H+  H ++       PC  CG+    K  + +H   +HT +    C+
Sbjct: 317 CGKSFKRSSTLSTHLLIHSDT----RPYPCQYCGKRFHQKSDMKKHT-FIHTGEKPHKCQ 371

Query: 425 TCGKTFKCKRNLSVHMT-NVCMEPTRLYPCTICGKEFRRKNKLKEHMSTHTG 475
            CGK F    NL  H   +   +P   + C +CGK F+RK  L+ H  T  G
Sbjct: 372 VCGKAFSQSSNLITHSRKHTGFKP---FGCDLCGKGFQRKVDLRRHRETQHG 420



 Score = 64.7 bits (156), Expect = 3e-010
 Identities = 45/157 (28%), Positives = 68/157 (43%), Gaps = 16/157 (10%)

Query: 207 HNFYKRIVCEVCDIQRMLVGEPQIDFGTWRALLRHTKEVHKHDKVYVKCPVCEMKMRTKQ 266
           H+  +   CE+C             FG   +L +H K VH  ++ +  C +C    +   
Sbjct: 278 HSGTRPFACEMCGKT----------FGHAVSLEQH-KAVHSQERSF-DCKICGKSFKRSS 325

Query: 267 TLLQHMDWHENPEKYRCELCGEK-HQ--NMKEHIQNKHQERQFCCDVCGKKFPFKKRLTV 323
           TL  H+  H +   Y C+ CG++ HQ  +MK+H      E+   C VCGK F     L  
Sbjct: 326 TLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTFIHTGEKPHKCQVCGKAFSQSSNLIT 385

Query: 324 HMKKMHVEKDIICDQCQKPF-TKYTIEDHKRSVHSAR 359
           H +K    K   CD C K F  K  +  H+ + H  +
Sbjct: 386 HSRKHTGFKPFGCDLCGKGFQRKVDLRRHRETQHGLK 422