>AGAP007518-PA

FB|FBgn0001133 - symbol:grau "grauzone" species:7227 "Drosophila...   124   1e-028
UNIPROT|Q9HCG1 - symbol:KR18_HUMAN "KIAA1611: Zinc finger protei...   121   2e-027
ZFIN|ZDB-GENE-991213-3 - symbol:drl "draculin" species:7955 "Dan...   114   2e-025
UNIPROT|P10072 - symbol:HKR1_HUMAN "HKR1: Krueppel-related zinc ...   100   2e-021
MGI|MGI:95457 - symbol:Evi1 "ecotropic viral integration site 1"...    88   2e-017
UNIPROT|Q03112 - symbol:EVI1_HUMAN "EVI1: Ecotropic virus integr...    84   3e-016
MGI|MGI:103170 - symbol:Gfi1 "growth factor independent 1" speci...    83   6e-016
UNIPROT|Q99684 - symbol:GFI1_HUMAN "GFI1, ZNF163: Zinc finger pr...    83   6e-016
UNIPROT|P10075 - symbol:GLI4_HUMAN "GLI4, HKR4: Zinc finger prot...    82   1e-015
UNIPROT|Q08705 - symbol:CTCF_CHICK "CTCF: Transcriptional repres...    80   4e-015
MGI|MGI:109447 - symbol:Ctcf "CCCTC-binding factor" species:1009...    80   5e-015
UNIPROT|P49711 - symbol:CTCF_HUMAN "CTCF: Transcriptional repres...    80   5e-015
FB|FBgn0045852 - symbol:ham "hamlet" species:7227 "Drosophila me...    79   1e-014
FB|FBgn0028420 - symbol:Kr-h1 "Kruppel homolog 1" species:7227 "...    76   6e-014
SGD|S000003592 - symbol:ZAP1 "Zinc-regulated transcription facto...    70   5e-012
MGI|MGI:107187 - symbol:Bcl6 "B-cell leukemia/lymphoma 6" specie...    70   5e-012
UNIPROT|P41182 - symbol:BCL6_HUMAN "BCL6, BCL5, LAZ3, ZBTB27, ZN...    70   5e-012
FB|FBgn0004893 - symbol:bowl "brother of odd with entrails limit...    69   7e-012
MGI|MGI:1344336 - symbol:Fiz1 "Flt3 interacting zinc finger prot...    69   1e-011
MGI|MGI:1278332 - symbol:Bcl6b "B-cell CLL/lymphoma 6, member B"...    67   4e-011
UNIPROT|P56270 - symbol:MAZ_HUMAN "MAZ: Myc-associated zinc fing...    67   4e-011
MGI|MGI:1929869 - symbol:Hic2 "hypermethylated in cancer 2" spec...    67   5e-011
UNIPROT|Q96JB3 - symbol:HIC2_HUMAN "HIC2, HRG22, KIAA1020, ZBTB3...    65   1e-010
FB|FBgn0004618 - symbol:gl "glass" species:7227 "Drosophila mela...    65   1e-010
MGI|MGI:1338823 - symbol:Maz "MYC-associated zinc finger protein...    65   2e-010


==> FB|FBgn0001133 - symbol:grau "grauzone" species:7227 "Drosophila
           melanogaster" [GO:0007349 "cellularization"
           evidence=IMP] [GO:0007279 "pole cell formation"
           evidence=IMP] [GO:0003704 "specific RNA polymerase II
           transcription factor activity" evidence=IMP;NAS]
           [GO:0005634 "nucleus" evidence=IDA;NAS] [GO:0007143
           "female meiosis" evidence=IMP] [GO:0045143 "homologous
           chromosome segregation" evidence=TAS] [GO:0006357
           "regulation of transcription from RNA polymerase II
           promoter" evidence=TAS] [GO:0007343 "egg activation"
           evidence=IMP] InterPro:IPR007087 Pfam:PF00096
           Prosite:PS00028 InterPro:IPR012934 GO:GO:0005515
           GO:GO:0005634 GO:GO:0006357 SMART:SM00355
           PROSITE:PS50157 EMBL:AE003452 GO:GO:0007279
           GO:GO:0003704 GO:GO:0007343 GO:GO:0007143 GO:GO:0045143
           EMBL:AF208016 EMBL:AY047537 UniGene:Dm.19597 PDB:1PZW
           DIP:DIP:20107N IntAct:Q9U405 Ensembl:CG33133
           KEGG:dme:Dmel_CG33133 FlyBase:FBgn0001133
           BioCyc:DMEL-XXX-02:DMEL-XXX-02-005732-MONOMER
           GermOnline:CG33133 Pfam:PF07776 Uniprot:Q9U405
          Length = 570

 Score =  124 bits (312), Expect = 1e-028
 Identities = 84/270 (31%), Positives = 123/270 (45%), Gaps = 38/270 (14%)

Query: 129 LNQHMRTVHGLESGTVKCQLCAKKFRSRVKLVEHKDMHENPERFRCGVCQEVHQN---LE 185
           + +H +  H  E   +KC  C +K   R  + EH   HENPE  +C  C +V  N   L 
Sbjct: 255 IREHFKDKHPDERPYIKC--CGRKLNKRCLIQEHARRHENPEYIKCKDCGKVFANSSVLR 312

Query: 186 EHMQNKH---QEWEFACEECGKRFPFKNRLTAHMAKVHM---KKDIICEECNKP---FTK 236
            H    H   +E +F CE+CGKRF  +N L  H    H+   ++  IC +C K     T+
Sbjct: 313 AHWLVHHVPDEECDFQCEDCGKRFSRRNLLELHKGS-HVPVNERKFICPQCPKHNAFATE 371

Query: 237 FSIEKHKKTVHGHGGTFICENCPKTFKTRVSLERHMEGHNNGEQQQPPQQQQPQPLPLPL 296
           + ++ H    H      IC  C K  K +   E+H+  H    ++  P+ + P+P     
Sbjct: 372 YHMQVHISMQHRKAAN-ICHVCGKKIKDKAVFEKHVRLHF---EESGPRIKCPRPD---- 423

Query: 297 PQQQPSSAATVSCSLCNSVLKDEYNLKAHMKRIHAEQTPATCNTCGKTFKSKHSLNTHTA 356
                          C S LKDE NLK H++R + E     C+ CGK+ K+  +L  H  
Sbjct: 424 ---------------CESWLKDEDNLKQHLRRHNDEGKLFICSECGKSCKNSRALIGHKR 468

Query: 357 NVCTTRLFGCTTCGKQFKKRTKLKQHMTIH 386
              +  ++ C  CGK FKK   LK+HM  H
Sbjct: 469 YSHSNVIYTCEQCGKTFKKDISLKEHMAQH 498



 Score = 63.5 bits (153), Expect = 4e-010
 Identities = 37/134 (27%), Positives = 58/134 (43%), Gaps = 8/134 (5%)

Query: 146 CQLCAKKFRSRVKLVEHKDMH--ENPERFRCGV--CQ---EVHQNLEEHMQNKHQEWE-F 197
           C +C KK + +    +H  +H  E+  R +C    C+   +   NL++H++  + E + F
Sbjct: 389 CHVCGKKIKDKAVFEKHVRLHFEESGPRIKCPRPDCESWLKDEDNLKQHLRRHNDEGKLF 448

Query: 198 ACEECGKRFPFKNRLTAHMAKVHMKKDIICEECNKPFTKFSIEKHKKTVHGHGGTFICEN 257
            C ECGK       L  H    H      CE+C K F K    K     H     + C  
Sbjct: 449 ICSECGKSCKNSRALIGHKRYSHSNVIYTCEQCGKTFKKDISLKEHMAQHTGEPLYKCPF 508

Query: 258 CPKTFKTRVSLERH 271
           CP+TF +  ++  H
Sbjct: 509 CPRTFNSNANMHSH 522



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 25/95 (26%), Positives = 40/95 (42%), Gaps = 4/95 (4%)

Query: 129 LNQHMRTVHGLESGTVKCQLCAKKFRSRVKLVEHKDMHENPERFRCGVCQEVHQ---NLE 185
           L QH+R  H  E     C  C K  ++   L+ HK    +   + C  C +  +   +L+
Sbjct: 434 LKQHLRR-HNDEGKLFICSECGKSCKNSRALIGHKRYSHSNVIYTCEQCGKTFKKDISLK 492

Query: 186 EHMQNKHQEWEFACEECGKRFPFKNRLTAHMAKVH 220
           EHM     E  + C  C + F     + +H  K+H
Sbjct: 493 EHMAQHTGEPLYKCPFCPRTFNSNANMHSHKKKMH 527



==> UNIPROT|Q9HCG1 - symbol:KR18_HUMAN "KIAA1611: Zinc finger protein
           Kr18" species:9606 "Homo sapiens" [GO:0006355
           "regulation of transcription, DNA-dependent"
           evidence=NAS] [GO:0030097 "hemopoiesis" evidence=NAS]
           [GO:0005634 "nucleus" evidence=NAS] InterPro:IPR007087
           Pfam:PF00096 Prosite:PS00028 InterPro:IPR001909
           InterPro:IPR007086 UniProt:Q9HCG1 GO:GO:0005634
           GO:GO:0030097 GO:GO:0006355 SMART:SM00355
           PROSITE:PS50157 ProDom:PD000003 HSSP:P08047
           PRINTS:PR00048 Pfam:PF01352 SMART:SM00349
           PROSITE:PS50805 EMBL:AF277623 EMBL:AB046831
           EMBL:AK024442 UniGene:Hs.467236 Ensembl:ENSG00000170949
           LinkHub:Q9HCG1 ArrayExpress:Q9HCG1
           GermOnline:ENSG00000170949 RZPD-ProtExp:IOH3072
           RZPD-ProtExp:V0167
          Length = 818

 Score =  121 bits (303), Expect = 2e-027
 Identities = 74/247 (29%), Positives = 104/247 (42%), Gaps = 6/247 (2%)

Query: 145 KCQLCAKKFRSRVKLVEHKDMHENPERFRCGVCQEV---HQNLEEHMQNKHQEWEFACEE 201
           KC  C K FR    L  H+ +H   + ++C  C +    H NL  H      E  F C E
Sbjct: 314 KCHECGKVFRHNSYLATHRRIHTGEKPYKCNECGKAFRGHSNLTTHQLIHTGEKPFKCNE 373

Query: 202 CGKRFPFKNRLTAHMAKVHMKKDIICEECNKPFTKFSIEKHKKTVHGHGGTFICENCPKT 261
           CGK F   + L +H      +K   C EC K F+  S     +T+H     + C  C K 
Sbjct: 374 CGKLFTQNSHLISHWRIHTGEKPYKCNECGKAFSVRSSLAIHQTIHTGEKPYKCNECGKV 433

Query: 262 FKTRVSLERHMEGHNNGEQQQPPQQQQPQPLPLPLPQQQPSSAAT--VSCSLCNSVLKDE 319
           F+    L RH   H   +  +  +  +   +   L   Q     T    C+ C+ V    
Sbjct: 434 FRYNSYLGRHRRVHTGEKPYKCNECGKAFSMHSNLATHQVIHTGTKPFKCNECSKVFTQN 493

Query: 320 YNLKAHMKRIHAEQTPATCNTCGKTFKSKHSLNTHTANVCTTRLFGCTTCGKQFKKRTKL 379
             L  H +RIH  + P  CN CGK F  + SL TH A     + + C  CGK F +++ L
Sbjct: 494 SQLANH-RRIHTGEKPYKCNECGKAFSVRSSLTTHQAIHSGEKPYKCIECGKSFTQKSHL 552

Query: 380 KQHMTIH 386
           + H  IH
Sbjct: 553 RSHRGIH 559



 Score =  118 bits (295), Expect = 1e-026
 Identities = 100/380 (26%), Positives = 138/380 (36%), Gaps = 28/380 (7%)

Query: 13  KCPLCEKKIRTRPKLLEHKRMHQPNALLEEDSGKSGNPGGEPGPELTEEQKQTLDREIFD 72
           KC  C K  R    L  H+ +H         +G+      E G   T+         I  
Sbjct: 342 KCNECGKAFRGHSNLTTHQLIH---------TGEKPFKCNECGKLFTQNSHLISHWRIHT 392

Query: 73  FYKPIICEICDPEKVAVAVAVAGPGGDPGSVAAGAGHPEAAAAATTQEEEYRSLKQLNQH 132
             KP  C  C       A +V        ++  G    E         + +R    L +H
Sbjct: 393 GEKPYKCNECGK-----AFSVRSSLAIHQTIHTG----EKPYKCNECGKVFRYNSYLGRH 443

Query: 133 MRTVHGLESGTVKCQLCAKKFRSRVKLVEHKDMHENPERFRCGVCQEV---HQNLEEHMQ 189
            R VH  E    KC  C K F     L  H+ +H   + F+C  C +V   +  L  H +
Sbjct: 444 RR-VHTGEK-PYKCNECGKAFSMHSNLATHQVIHTGTKPFKCNECSKVFTQNSQLANHRR 501

Query: 190 NKHQEWEFACEECGKRFPFKNRLTAHMAKVHMKKDIICEECNKPFTKFSIEKHKKTVHGH 249
               E  + C ECGK F  ++ LT H A    +K   C EC K FT+ S  +  + +H  
Sbjct: 502 IHTGEKPYKCNECGKAFSVRSSLTTHQAIHSGEKPYKCIECGKSFTQKSHLRSHRGIHSG 561

Query: 250 GGTFICENCPKTFKTRVSLERHMEGHNNGEQQQPPQ---QQQPQPLPLPLPQQQPSSAAT 306
              + C  C K F     L RH   H  GE+        +       L   Q   +    
Sbjct: 562 EKPYKCNECGKVFAQTSQLARHWRVH-TGEKPYKCNDCGRAFSDRSSLTFHQAIHTGEKP 620

Query: 307 VSCSLCNSVLKDEYNLKAHMKRIHAEQTPATCNTCGKTFKSKHSLNTHTANVCTTRLFGC 366
             C  C  V +    L  H +RIH  + P  CN CGK F    +L TH       + + C
Sbjct: 621 YKCHECGKVFRHNSYLATH-RRIHTGEKPYKCNECGKAFSMHSNLTTHKVIHTGEKPYKC 679

Query: 367 TTCGKQFKKRTKLKQHMTIH 386
             CGK F + + L  H   H
Sbjct: 680 NQCGKVFTQNSHLANHQRTH 699



 Score =  117 bits (293), Expect = 2e-026
 Identities = 95/377 (25%), Positives = 138/377 (36%), Gaps = 50/377 (13%)

Query: 13  KCPLCEKKIRTRPKLLEHKRMHQPNALLEEDSGKSGNPGGEPGPELTEEQKQTLDREIFD 72
           KC  C K      +L  H+R+H         +G+      E G   +     T  + I  
Sbjct: 482 KCNECSKVFTQNSQLANHRRIH---------TGEKPYKCNECGKAFSVRSSLTTHQAIHS 532

Query: 73  FYKPIICEICDPEKVAVAVAVAGPGGDPGSVAAGAGHPEAAAAATTQEEEYRSLKQLNQH 132
             KP  C  C       +   +  G   G             A T+Q         L +H
Sbjct: 533 GEKPYKCIECGKSFTQKSHLRSHRGIHSGEKPYKCNECGKVFAQTSQ---------LARH 583

Query: 133 MRTVHGLESGTVKCQLCAKKFRSRVKLVEHKDMHENPERFRCGVCQEVHQN---LEEHMQ 189
            R VH  E    KC  C + F  R  L  H+ +H   + ++C  C +V ++   L  H +
Sbjct: 584 WR-VHTGEK-PYKCNDCGRAFSDRSSLTFHQAIHTGEKPYKCHECGKVFRHNSYLATHRR 641

Query: 190 NKHQEWEFACEECGKRFPFKNRLTAHMAKVHMKKDIICEECNKPFTKFSIEKHKKTVHGH 249
               E  + C ECGK F   + LT H      +K   C +C K FT+ S   + +  H  
Sbjct: 642 IHTGEKPYKCNECGKAFSMHSNLTTHKVIHTGEKPYKCNQCGKVFTQNSHLANHQRTHTG 701

Query: 250 GGTFICENCPKTFKTRVSLERHMEGHNNGEQQQPPQQQQPQPLPLPLPQQQPSSAATVSC 309
              + C  C K F  R SL  H   H   +  +                          C
Sbjct: 702 EKPYRCNECGKAFSVRSSLTTHQAIHTGKKPYK--------------------------C 735

Query: 310 SLCNSVLKDEYNLKAHMKRIHAEQTPATCNTCGKTFKSKHSLNTHTANVCTTRLFGCTTC 369
           + C  V     +L  H +RIH  + P  C  CGK F+ + SL TH A     + + C  C
Sbjct: 736 NECGKVFTQNAHLANH-RRIHTGEKPYRCTECGKAFRVRSSLTTHMAIHTGEKRYKCNEC 794

Query: 370 GKQFKKRTKLKQHMTIH 386
           GK F++ + L  H  +H
Sbjct: 795 GKVFRQSSNLASHHRMH 811



 Score =  105 bits (261), Expect = 1e-022
 Identities = 68/247 (27%), Positives = 96/247 (38%), Gaps = 6/247 (2%)

Query: 145 KCQLCAKKFRSRVKLVEHKDMHENPERFRCGVCQE---VHQNLEEHMQNKHQEWEFACEE 201
           KC  C K F     L  H+ +H   + ++C  C +   V  NL  H      E  + C E
Sbjct: 258 KCNECGKAFTQNSNLTSHRRIHSGEKPYKCSECGKTFTVRSNLTIHQVIHTGEKPYKCHE 317

Query: 202 CGKRFPFKNRLTAHMAKVHMKKDIICEECNKPFTKFSIEKHKKTVHGHGGTFICENCPKT 261
           CGK F   + L  H      +K   C EC K F   S     + +H     F C  C K 
Sbjct: 318 CGKVFRHNSYLATHRRIHTGEKPYKCNECGKAFRGHSNLTTHQLIHTGEKPFKCNECGKL 377

Query: 262 FKTRVSLERHMEGHNNGEQQQPPQQQQPQPL--PLPLPQQQPSSAATVSCSLCNSVLKDE 319
           F     L  H   H   +  +  +  +   +   L + Q   +      C+ C  V +  
Sbjct: 378 FTQNSHLISHWRIHTGEKPYKCNECGKAFSVRSSLAIHQTIHTGEKPYKCNECGKVFRYN 437

Query: 320 YNLKAHMKRIHAEQTPATCNTCGKTFKSKHSLNTHTANVCTTRLFGCTTCGKQFKKRTKL 379
             L  H +R+H  + P  CN CGK F    +L TH      T+ F C  C K F + ++L
Sbjct: 438 SYLGRH-RRVHTGEKPYKCNECGKAFSMHSNLATHQVIHTGTKPFKCNECSKVFTQNSQL 496

Query: 380 KQHMTIH 386
             H  IH
Sbjct: 497 ANHRRIH 503



 Score = 92.0 bits (227), Expect = 1e-018
 Identities = 85/345 (24%), Positives = 125/345 (36%), Gaps = 60/345 (17%)

Query: 13  KCPLCEKKIRTRPKLLEHKRMHQPNALLEEDSGKSGNPGGEPGPELTEEQKQTLDREIFD 72
           KC  C K    R  L  H+ +H         SG+      E G   T++      R I  
Sbjct: 510 KCNECGKAFSVRSSLTTHQAIH---------SGEKPYKCIECGKSFTQKSHLRSHRGIHS 560

Query: 73  FYKPIICEICDPEKVAVAVAVAGPG------------GDPGSVAAGAGHPEAAAAATTQE 120
             KP  C  C   KV    +                  D G   +         A  T E
Sbjct: 561 GEKPYKCNECG--KVFAQTSQLARHWRVHTGEKPYKCNDCGRAFSDRSSLTFHQAIHTGE 618

Query: 121 EEYR-----SLKQLNQHMRTVHGLESGT--VKCQLCAKKFRSRVKLVEHKDMHENPERFR 173
           + Y+      + + N ++ T   + +G    KC  C K F     L  HK +H   + ++
Sbjct: 619 KPYKCHECGKVFRHNSYLATHRRIHTGEKPYKCNECGKAFSMHSNLTTHKVIHTGEKPYK 678

Query: 174 CGVCQEV---HQNLEEHMQNKHQEWEFACEECGKRFPFKNRLTAHMAKVHMKKDIICEEC 230
           C  C +V   + +L  H +    E  + C ECGK F  ++ LT H A    KK   C EC
Sbjct: 679 CNQCGKVFTQNSHLANHQRTHTGEKPYRCNECGKAFSVRSSLTTHQAIHTGKKPYKCNEC 738

Query: 231 NKPFTKFSIEKHKKTVHGHGGTFICENCPKTFKTRVSLERHMEGHNNGEQQQPPQQQQPQ 290
            K FT+ +   + + +H     + C  C K F+ R SL  HM  H  GE++         
Sbjct: 739 GKVFTQNAHLANHRRIHTGEKPYRCTECGKAFRVRSSLTTHMAIH-TGEKR--------- 788

Query: 291 PLPLPLPQQQPSSAATVSCSLCNSVLKDEYNLKAHMKRIHAEQTP 335
                             C+ C  V +   NL +H  R+H  + P
Sbjct: 789 ----------------YKCNECGKVFRQSSNLASH-HRMHTGEKP 816



 Score = 82.0 bits (201), Expect = 1e-015
 Identities = 54/190 (28%), Positives = 71/190 (37%), Gaps = 27/190 (14%)

Query: 197 FACEECGKRFPFKNRLTAHMAKVHMKKDIICEECNKPFTKFSIEKHKKTVHGHGGTFICE 256
           + C ECGK F   + LT+H      +K   C EC K FT  S     + +H     + C 
Sbjct: 257 YKCNECGKAFTQNSNLTSHRRIHSGEKPYKCSECGKTFTVRSNLTIHQVIHTGEKPYKCH 316

Query: 257 NCPKTFKTRVSLERHMEGHNNGEQQQPPQQQQPQPLPLPLPQQQPSSAATVSCSLCNSVL 316
            C K F+    L  H   H  GE+                            C+ C    
Sbjct: 317 ECGKVFRHNSYLATHRRIH-TGEK-------------------------PYKCNECGKAF 350

Query: 317 KDEYNLKAHMKRIHAEQTPATCNTCGKTFKSKHSLNTHTANVCTTRLFGCTTCGKQFKKR 376
           +   NL  H + IH  + P  CN CGK F     L +H       + + C  CGK F  R
Sbjct: 351 RGHSNLTTH-QLIHTGEKPFKCNECGKLFTQNSHLISHWRIHTGEKPYKCNECGKAFSVR 409

Query: 377 TKLKQHMTIH 386
           + L  H TIH
Sbjct: 410 SSLAIHQTIH 419



 Score = 47.4 bits (111), Expect = 3e-005
 Identities = 26/89 (29%), Positives = 41/89 (46%), Gaps = 2/89 (2%)

Query: 298 QQQPSSAATVSCSLCNSVLKDEYNLKAHMKRIHAEQTPATCNTCGKTFKSKHSLNTHTAN 357
           QQ PSS  T      + +  + ++L    ++ ++   P  CN CGK F    +L +H   
Sbjct: 221 QQIPSSVQTHRSKKYHEL--NHFSLLTQRRKANSCGKPYKCNECGKAFTQNSNLTSHRRI 278

Query: 358 VCTTRLFGCTTCGKQFKKRTKLKQHMTIH 386
               + + C+ CGK F  R+ L  H  IH
Sbjct: 279 HSGEKPYKCSECGKTFTVRSNLTIHQVIH 307



==> ZFIN|ZDB-GENE-991213-3 - symbol:drl "draculin" species:7955 "Danio
           rerio" [GO:0048276 "gastrulation (sensu Vertebrata)"
           evidence=IEP] [GO:0003677 "DNA binding" evidence=NAS]
           [GO:0008270 "zinc ion binding" evidence=ISS]
           InterPro:IPR007087 Pfam:PF00096 Prosite:PS00028
           ZFIN:ZDB-GENE-991213-3 GO:GO:0003677 SMART:SM00355
           PROSITE:PS50157 HSSP:P08046 ProDom:PD000003
           GO:GO:0048276 EMBL:AF157109 EMBL:BC095019
           UniGene:Dr.81311 Ensembl:ENSDARG00000035151
           Uniprot:Q9W747
          Length = 411

 Score =  114 bits (285), Expect = 2e-025
 Identities = 93/380 (24%), Positives = 148/380 (38%), Gaps = 52/380 (13%)

Query: 11  TVKCPLCEKKIRTRPKLLEHKRMHQPNALLEEDSGKSGNPGGEPGPELTEEQKQTLDREI 70
           +V C  C+K+   +  L  H R+H         +G+      + G     +Q   L  +I
Sbjct: 35  SVACSHCKKRFTHKVHLQIHMRVH---------TGEKPYRCDQCGKCFPYKQSLKLHLDI 85

Query: 71  FDFYKPIICEICDPEKVAVAVAVAGPGGDPGSVAAGAGHPEAAAAATTQ-EEEYRSLKQL 129
                P  C+ C  E     + +          +    HP+       Q E+ Y     L
Sbjct: 86  HAKGNPYTCDECG-ESFKTRLQLR---------SHMTLHPKYKPYKCDQCEKSYGREDHL 135

Query: 130 NQHMRTVHGLESGTVKCQLCAKKFRSRVKLVEHKDMHENPERFRCGVCQE---VHQNLEE 186
            +HM+   G +    KC+ C K F  R  L  H  +H   + + C  C +   + ++  E
Sbjct: 136 QRHMKLHTGEKPH--KCEHCGKSFPMRDLLRSHLMVHSEVKPYTCDQCGKGFTLKKSYNE 193

Query: 187 HMQNKHQEWEFACEECGKRFPFKNRLTAHMAKVHMKKDIICEECNKPFTKFSIEKHKKTV 246
           HM     E  + C++CGK FP++  L  HM     +K   C++C + F++         +
Sbjct: 194 HMNIHTGERPYTCDQCGKGFPYEQSLNLHMRFHREEKPFTCDQCGQSFSQKGAYNIHMKI 253

Query: 247 HGHGGTFICENCPKTFKTRVSLERHMEGHNNGEQQQPPQQQQPQPLPLPLPQQQPSSAAT 306
           H     + C+ C  +F+   SL+ HM  H+ GE+                          
Sbjct: 254 HTGEKPYTCDQCGMSFRHGYSLKLHMT-HHTGEK-------------------------P 287

Query: 307 VSCSLCNSVLKDEYNLKAHMKRIHAEQTPATCNTCGKTFKSKHSLNTHTANVCTTRLFGC 366
             C  C+        LK H+K  H +    +C TCGKTF     L  H      T+ F C
Sbjct: 288 FHCDQCDKCYSTALFLKNHIK-THDKAQIYSCLTCGKTFNQLRGLRLHEKRHSLTKPFMC 346

Query: 367 TTCGKQFKKRTKLKQHMTIH 386
             CGK +   T+LKQH+ +H
Sbjct: 347 FDCGKCYFTDTELKQHLPVH 366



 Score =  109 bits (273), Expect = 5e-024
 Identities = 63/246 (25%), Positives = 103/246 (41%), Gaps = 30/246 (12%)

Query: 146 CQLCAKKFRSRVKLVEHKDMHENPERFRCGVCQEVH---QNLEEHMQNKHQEWEFACEEC 202
           C  C + F++R++L  H  +H   + ++C  C++ +    +L+ HM+    E    CE C
Sbjct: 94  CDECGESFKTRLQLRSHMTLHPKYKPYKCDQCEKSYGREDHLQRHMKLHTGEKPHKCEHC 153

Query: 203 GKRFPFKNRLTAHMAKVHMKKDIICEECNKPFTKFSIEKHKKTVHGHGGTFICENCPKTF 262
           GK FP ++ L +H+      K   C++C K FT          +H     + C+ C K F
Sbjct: 154 GKSFPMRDLLRSHLMVHSEVKPYTCDQCGKGFTLKKSYNEHMNIHTGERPYTCDQCGKGF 213

Query: 263 KTRVSLERHMEGHNNGEQQQPPQQQQPQPLPLPLPQQQPSSAATVSCSLCNSVLKDEYNL 322
               SL  HM  H         ++++P                  +C  C      +   
Sbjct: 214 PYEQSLNLHMRFH---------REEKP-----------------FTCDQCGQSFSQKGAY 247

Query: 323 KAHMKRIHAEQTPATCNTCGKTFKSKHSLNTHTANVCTTRLFGCTTCGKQFKKRTKLKQH 382
             HMK IH  + P TC+ CG +F+  +SL  H  +    + F C  C K +     LK H
Sbjct: 248 NIHMK-IHTGEKPYTCDQCGMSFRHGYSLKLHMTHHTGEKPFHCDQCDKCYSTALFLKNH 306

Query: 383 MTIHPR 388
           +  H +
Sbjct: 307 IKTHDK 312



 Score = 93.2 bits (230), Expect = 5e-019
 Identities = 63/218 (28%), Positives = 89/218 (40%), Gaps = 35/218 (16%)

Query: 177 CQEVHQNLE---EHMQ-NKHQEWE----FACEECGKRFPFKNRLTAHMAKVHMKKDIICE 228
           C+  H N E   + M+ NK  E +     AC  C KRF  K  L  HM     +K   C+
Sbjct: 8   CRTEHHNAEGQRDRMEGNKKGETKAKKSVACSHCKKRFTHKVHLQIHMRVHTGEKPYRCD 67

Query: 229 ECNKPFTKFSIEKHKKTVHGHGGTFICENCPKTFKTRVSLERHMEGHNNGEQQQPPQQQQ 288
           +C K F      K    +H  G  + C+ C ++FKTR+ L  HM  H             
Sbjct: 68  QCGKCFPYKQSLKLHLDIHAKGNPYTCDECGESFKTRLQLRSHMTLH------------- 114

Query: 289 PQPLPLPLPQQQPSSAATVSCSLCNSVLKDEYNLKAHMKRIHAEQTPATCNTCGKTFKSK 348
                   P+ +P       C  C      E +L+ HMK +H  + P  C  CGK+F  +
Sbjct: 115 --------PKYKP-----YKCDQCEKSYGREDHLQRHMK-LHTGEKPHKCEHCGKSFPMR 160

Query: 349 HSLNTHTANVCTTRLFGCTTCGKQFKKRTKLKQHMTIH 386
             L +H       + + C  CGK F  +    +HM IH
Sbjct: 161 DLLRSHLMVHSEVKPYTCDQCGKGFTLKKSYNEHMNIH 198



 Score = 67.4 bits (163), Expect = 3e-011
 Identities = 31/83 (37%), Positives = 45/83 (54%), Gaps = 1/83 (1%)

Query: 306 TVSCSLCNSVLKDEYNLKAHMKRIHAEQTPATCNTCGKTFKSKHSLNTHTANVCTTRLFG 365
           +V+CS C      + +L+ HM R+H  + P  C+ CGK F  K SL  H         + 
Sbjct: 35  SVACSHCKKRFTHKVHLQIHM-RVHTGEKPYRCDQCGKCFPYKQSLKLHLDIHAKGNPYT 93

Query: 366 CTTCGKQFKKRTKLKQHMTIHPR 388
           C  CG+ FK R +L+ HMT+HP+
Sbjct: 94  CDECGESFKTRLQLRSHMTLHPK 116



 Score = 62.0 bits (149), Expect = 1e-009
 Identities = 40/150 (26%), Positives = 62/150 (41%), Gaps = 5/150 (3%)

Query: 130 NQHMRTVHGLESGTVKCQLCAKKFRSRVKLVEHKDMHENPERFRCGVCQEVHQN---LEE 186
           N HM+   G +  T  C  C   FR    L  H   H   + F C  C + +     L+ 
Sbjct: 248 NIHMKIHTGEKPYT--CDQCGMSFRHGYSLKLHMTHHTGEKPFHCDQCDKCYSTALFLKN 305

Query: 187 HMQNKHQEWEFACEECGKRFPFKNRLTAHMAKVHMKKDIICEECNKPFTKFSIEKHKKTV 246
           H++   +   ++C  CGK F     L  H  +  + K  +C +C K +   +  K    V
Sbjct: 306 HIKTHDKAQIYSCLTCGKTFNQLRGLRLHEKRHSLTKPFMCFDCGKCYFTDTELKQHLPV 365

Query: 247 HGHGGTFICENCPKTFKTRVSLERHMEGHN 276
           H +   ++C  C K+F    SL  H + HN
Sbjct: 366 HSNERPYMCSLCFKSFPRMGSLIVHEKTHN 395



 Score = 56.6 bits (135), Expect = 5e-008
 Identities = 43/156 (27%), Positives = 67/156 (42%), Gaps = 9/156 (5%)

Query: 127 KQLNQHMRTVHGLESGTVKCQLCAKKFRSRVKLVEHKDMHENPERFRCGVCQEVHQN--- 183
           + LN HMR     E     C  C + F  +     H  +H   + + C  C    ++   
Sbjct: 217 QSLNLHMRFHR--EEKPFTCDQCGQSFSQKGAYNIHMKIHTGEKPYTCDQCGMSFRHGYS 274

Query: 184 LEEHMQNKHQEWEFACEECGKRFPFKNRLTAHMAKVHMKKDII-CEECNKPFTKF-SIEK 241
           L+ HM +   E  F C++C K +     L  H+ K H K  I  C  C K F +   +  
Sbjct: 275 LKLHMTHHTGEKPFHCDQCDKCYSTALFLKNHI-KTHDKAQIYSCLTCGKTFNQLRGLRL 333

Query: 242 HKKTVHGHGGTFICENCPKTFKTRVSLERHMEGHNN 277
           H+K  H     F+C +C K + T   L++H+  H+N
Sbjct: 334 HEKR-HSLTKPFMCFDCGKCYFTDTELKQHLPVHSN 368



 Score = 37.7 bits (86), Expect = 0.023
 Identities = 18/52 (34%), Positives = 24/52 (46%)

Query: 338 CNTCGKTFKSKHSLNTHTANVCTTRLFGCTTCGKQFKKRTKLKQHMTIHPRG 389
           C+ C K F  K  L  H       + + C  CGK F  +  LK H+ IH +G
Sbjct: 38  CSHCKKRFTHKVHLQIHMRVHTGEKPYRCDQCGKCFPYKQSLKLHLDIHAKG 89



==> UNIPROT|P10072 - symbol:HKR1_HUMAN "HKR1: Krueppel-related zinc
           finger protein 1" species:9606 "Homo sapiens"
           [GO:0008270 "zinc ion binding" evidence=NAS] [GO:0006355
           "regulation of transcription, DNA-dependent"
           evidence=NAS] [GO:0007275 "multicellular organismal
           development" evidence=NAS] [GO:0005634 "nucleus"
           evidence=NAS] InterPro:IPR007087 Pfam:PF00096
           Prosite:PS00028 InterPro:IPR001909 UniProt:P10072
           GO:GO:0007275 GO:GO:0005634 GO:GO:0008270 GO:GO:0006355
           SMART:SM00355 PROSITE:PS50157 ProDom:PD000003
           HSSP:P08047 Pfam:PF01352 SMART:SM00349 PROSITE:PS50805
           EMBL:AB013897 EMBL:BC004513 EMBL:M20675 PIR:C31201
           UniGene:Hs.244651 Ensembl:ENSG00000181666
           KEGG:hsa:284459 HGNC:HGNC:4928 MIM:165250 LinkHub:P10072
           ArrayExpress:P10072 GermOnline:ENSG00000181666
          Length = 640

 Score =  100 bits (250), Expect = 2e-021
 Identities = 69/272 (25%), Positives = 110/272 (40%), Gaps = 10/272 (3%)

Query: 121 EEYRSLKQLNQHMRTVHGLESGTVKCQLCAKKFRSRVKLVEHKDMHENPERFRCGVCQEV 180
           + + S+  L ++ RT  G       C+ C + F  +  L+ H+  H   + + C  C   
Sbjct: 261 DSFGSMSVLIKNPRTHSG--GKPYVCRECGRGFTWKSNLITHQRTHSGEKPYVCKDCGRG 318

Query: 181 H---QNLEEHMQNKHQEWEFACEECGKRFPFKNRLTAHMAKVHMKKDIICEECNKPFTKF 237
                NL  H +       + C+ECG+ F  K+ L  H      +K  +C EC + F + 
Sbjct: 319 FTWKSNLFTHQRTHSGLKPYVCKECGQSFSLKSNLITHQRAHTGEKPYVCRECGRGFRQH 378

Query: 238 S-IEKHKKTVHGHGGTFICENCPKTFKTRVSLERHMEGHNNGEQQQPPQ--QQQPQPLPL 294
           S + +HK+T H     +IC  C + F  +  L RH+  H   +     +  +       L
Sbjct: 379 SHLVRHKRT-HSGEKPYICRECEQGFSQKSHLIRHLRTHTGEKPYVCTECGRHFSWKSNL 437

Query: 295 PLPQQQPSSAATVSCSLCNSVLKDEYNLKAHMKRIHAEQTPATCNTCGKTFKSKHSLNTH 354
              Q+  S      C  C      + NL  H +R H  + P  C  CG+ F  K +L TH
Sbjct: 438 KTHQRTHSGVKPYVCLECGQCFSLKSNLNKH-QRSHTGEKPFVCTECGRGFTRKSTLITH 496

Query: 355 TANVCTTRLFGCTTCGKQFKKRTKLKQHMTIH 386
                  + F C  CG+ F  ++ L  H   H
Sbjct: 497 QRTHSGEKPFVCAECGRGFNDKSTLISHQRTH 528



 Score = 98.2 bits (243), Expect = 1e-020
 Identities = 71/271 (26%), Positives = 109/271 (40%), Gaps = 36/271 (13%)

Query: 120 EEEYRSLKQLNQHMRTVHGLESGTVKCQLCAKKFRSRVKLVEHKDMHENPERF---RCGV 176
           E+ +     L +H+RT H  E   V C  C + F  +  L  H+  H   + +    CG 
Sbjct: 400 EQGFSQKSHLIRHLRT-HTGEKPYV-CTECGRHFSWKSNLKTHQRTHSGVKPYVCLECGQ 457

Query: 177 CQEVHQNLEEHMQNKHQEWEFACEECGKRFPFKNRLTAHMAKVHMKKDIICEECNKPFT- 235
           C  +  NL +H ++   E  F C ECG+ F  K+ L  H      +K  +C EC + F  
Sbjct: 458 CFSLKSNLNKHQRSHTGEKPFVCTECGRGFTRKSTLITHQRTHSGEKPFVCAECGRGFND 517

Query: 236 KFSIEKHKKTVHGHGGTFICENCPKTFKTRVSLERHMEGHNNGEQQQPPQQQQPQPLPLP 295
           K ++  H++T H     F+C  C + F+ + +L RH   H                    
Sbjct: 518 KSTLISHQRT-HSGEKPFMCRECGRRFRQKPNLFRHKRAH-------------------- 556

Query: 296 LPQQQPSSAATVSCSLCNSVLKDEYNLKAHMKRIHAEQTPATCNTCGKTFKSKHSLNTHT 355
                  S A V C  C      +  L  H +R HA   P  C  CG+ F  +  L  H 
Sbjct: 557 -------SGAFV-CRECGQGFCAKLTLIKH-QRAHAGGKPHVCRECGQGFSRQSHLIRHQ 607

Query: 356 ANVCTTRLFGCTTCGKQFKKRTKLKQHMTIH 386
                 + + C  CG+ F +++ L +H   H
Sbjct: 608 RTHSGEKPYICRKCGRGFSRKSNLIRHQRTH 638



 Score = 96.3 bits (238), Expect = 5e-020
 Identities = 63/259 (24%), Positives = 108/259 (41%), Gaps = 34/259 (13%)

Query: 132 HMRTVHGLESGTVKCQLCAKKFRSRVKLVEHKDMHENPERFRCGVCQE---VHQNLEEHM 188
           H RT  GL+     C+ C + F  +  L+ H+  H   + + C  C      H +L  H 
Sbjct: 328 HQRTHSGLKPYV--CKECGQSFSLKSNLITHQRAHTGEKPYVCRECGRGFRQHSHLVRHK 385

Query: 189 QNKHQEWEFACEECGKRFPFKNRLTAHMAKVHMKKDIICEECNKPFT-KFSIEKHKKTVH 247
           +    E  + C EC + F  K+ L  H+     +K  +C EC + F+ K +++ H++T H
Sbjct: 386 RTHSGEKPYICRECEQGFSQKSHLIRHLRTHTGEKPYVCTECGRHFSWKSNLKTHQRT-H 444

Query: 248 GHGGTFICENCPKTFKTRVSLERHMEGHNNGEQQQPPQQQQPQPLPLPLPQQQPSSAATV 307
                ++C  C + F  + +L +H   H  GE+                           
Sbjct: 445 SGVKPYVCLECGQCFSLKSNLNKHQRSHT-GEKP-------------------------F 478

Query: 308 SCSLCNSVLKDEYNLKAHMKRIHAEQTPATCNTCGKTFKSKHSLNTHTANVCTTRLFGCT 367
            C+ C      +  L  H +R H+ + P  C  CG+ F  K +L +H       + F C 
Sbjct: 479 VCTECGRGFTRKSTLITH-QRTHSGEKPFVCAECGRGFNDKSTLISHQRTHSGEKPFMCR 537

Query: 368 TCGKQFKKRTKLKQHMTIH 386
            CG++F+++  L +H   H
Sbjct: 538 ECGRRFRQKPNLFRHKRAH 556



 Score = 64.7 bits (156), Expect = 2e-010
 Identities = 42/147 (28%), Positives = 63/147 (42%), Gaps = 5/147 (3%)

Query: 132 HMRTVHGLESGTVKCQLCAKKFRSRVKLVEHKDMHENPERFRCGVC-QEVHQNLEEHMQN 190
           H RT H  E   V C  C + F  +  L+ H+  H   + F C  C +   Q        
Sbjct: 496 HQRT-HSGEKPFV-CAECGRGFNDKSTLISHQRTHSGEKPFMCRECGRRFRQKPNLFRHK 553

Query: 191 KHQEWEFACEECGKRFPFKNRLTAHMAKVHMKKDIICEECNKPFTKFS-IEKHKKTVHGH 249
           +     F C ECG+ F  K  L  H       K  +C EC + F++ S + +H++T H  
Sbjct: 554 RAHSGAFVCRECGQGFCAKLTLIKHQRAHAGGKPHVCRECGQGFSRQSHLIRHQRT-HSG 612

Query: 250 GGTFICENCPKTFKTRVSLERHMEGHN 276
              +IC  C + F  + +L RH   H+
Sbjct: 613 EKPYICRKCGRGFSRKSNLIRHQRTHS 639



==> MGI|MGI:95457 - symbol:Evi1 "ecotropic viral integration site 1"
           species:10090 "Mus musculus" [GO:0003677 "DNA binding"
           evidence=IDA] [GO:0042127 "regulation of cell
           proliferation" evidence=IMP] [GO:0045944 "positive
           regulation of transcription from RNA polymerase II
           promoter" evidence=IDA] InterPro:IPR007087 Pfam:PF00096
           Prosite:PS00028 MGI:MGI:95457 GO:GO:0003677
           GO:GO:0045944 SMART:SM00355 PROSITE:PS50157
           GO:GO:0042127 ProDom:PD000003 HSSP:P08047 EMBL:M21829
           PIR:A31591 UniGene:Mm.56965 TRANSFAC:T00273
           Ensembl:ENSMUSG00000027684 KEGG:mmu:14013
           ArrayExpress:P14404 GermOnline:ENSMUSG00000027684
           Uniprot:P14404
          Length = 1042

 Score = 87.8 bits (216), Expect = 2e-017
 Identities = 61/216 (28%), Positives = 100/216 (46%), Gaps = 8/216 (3%)

Query: 145 KCQLCAKKFRSRVKLVEHKDMH-ENPERFRCGVCQEVHQNLEEHMQNKHQEWEFACEECG 203
           +C+ C + F S+ +L +H+      P      V +++ QNLE     +       C+EC 
Sbjct: 22  RCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDLQQNLESESDLREIHGNQDCKECD 81

Query: 204 KRFPFKNRLTAHMAKVHMKKDIICEECNKPFT-KFSIEKHKKTVHGHGGTFICENCPKTF 262
           + FP    L  HM     +++  C++C K F  K ++ +H+ + H  G  + CENC K F
Sbjct: 82  RVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMS-HDSGKHYECENCAKVF 140

Query: 263 KTRVSLERHMEGHNNGEQQQP-PQQQQPQPLPLPLPQQQ--PSSAATVSCSLCNSVLKDE 319
               +L+RH+   + G +    P+  +       L Q +   SS     C +C+      
Sbjct: 141 TDPSNLQRHIRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQF 200

Query: 320 YNLKAHMKRIHAE-QTPATCNTCGKTFKSKHSLNTH 354
            NL  H KR+HA+ +T   C  CG+ F +  SLN H
Sbjct: 201 SNLCRH-KRMHADCRTQIKCKDCGQMFSTTSSLNKH 235



 Score = 58.9 bits (141), Expect = 1e-008
 Identities = 29/96 (30%), Positives = 51/96 (53%), Gaps = 2/96 (2%)

Query: 184 LEEHMQNKHQEWEFACEECGKRFPFKNRLTAHMAKVHMKKDIICEECNKPFTKFS-IEKH 242
           L E++  K +E  + C  CGK FP    LT H+     ++   C+ C++ F+  S +++H
Sbjct: 712 LPENLLRKGKE-RYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRH 770

Query: 243 KKTVHGHGGTFICENCPKTFKTRVSLERHMEGHNNG 278
            + +H     F C  C + F  + +L+RH++ H NG
Sbjct: 771 VRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENG 806



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 24/102 (23%), Positives = 38/102 (37%), Gaps = 26/102 (25%)

Query: 253 FICENCPKTFKTRVSLERHMEGHNNGEQQQPPQQQQPQPLPLPLPQQQPSSAATVSCSLC 312
           + C  C K F    +L RH+  H  GEQ                            C  C
Sbjct: 724 YTCRYCGKIFPRSANLTRHLRTHT-GEQPY-------------------------RCKYC 757

Query: 313 NSVLKDEYNLKAHMKRIHAEQTPATCNTCGKTFKSKHSLNTH 354
           +       NL+ H++ IH ++ P  C+ C + F  + +L+ H
Sbjct: 758 DRSFSISSNLQRHVRNIHNKEKPFKCHLCDRCFGQQTNLDRH 799



==> UNIPROT|Q03112 - symbol:EVI1_HUMAN "EVI1: Ecotropic virus
           integration site 1 protein homolog" species:9606 "Homo
           sapiens" [GO:0003674 "molecular_function" evidence=ND]
           [GO:0008150 "biological_process" evidence=ND]
           [GO:0005634 "nucleus" evidence=NAS] InterPro:IPR007087
           Pfam:PF00096 Prosite:PS00028 UniProt:Q03112
           GO:GO:0005634 SMART:SM00355 PROSITE:PS50157
           ProDom:PD000003 HSSP:P08047 EMBL:X54989 EMBL:S69002
           EMBL:S82592 PIR:A60191 PIR:S41705 UniGene:Hs.554762
           TRANSFAC:T05220 Ensembl:ENSG00000085276 KEGG:hsa:2122
           HGNC:HGNC:3498 MIM:165215 ArrayExpress:Q03112
           GermOnline:ENSG00000085276
          Length = 1051

 Score = 84.0 bits (206), Expect = 3e-016
 Identities = 62/228 (27%), Positives = 100/228 (43%), Gaps = 22/228 (9%)

Query: 140 ESGTVKCQLCAKKFRSRVKLVEHKDMHENPERFRCGVCQEVHQNLEEHMQNKHQEWEFA- 198
           E    +C+ C + F S+ +L +H       ++F C         +EE  Q K +      
Sbjct: 17  EERQYRCEDCDQLFESKAELADH-------QKFPCSTPHSAFSMVEEDFQQKLESENDLQ 69

Query: 199 -------CEECGKRFPFKNRLTAHMAKVHMKKDIICEECNKPFT-KFSIEKHKKTVHGHG 250
                  C+EC + FP    L  HM     +++  C++C K F  K ++ +H+ + H  G
Sbjct: 70  EIHTIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMS-HDSG 128

Query: 251 GTFICENCPKTFKTRVSLERHMEGHNNGEQQQP-PQQQQPQPLPLPLPQQQ--PSSAATV 307
             + CENC K F    +L+RH+   + G +    P+  +       L Q +   SS    
Sbjct: 129 KHYECENCAKVFTDPSNLQRHIRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPF 188

Query: 308 SCSLCNSVLKDEYNLKAHMKRIHAE-QTPATCNTCGKTFKSKHSLNTH 354
            C +C+       NL  H KR+HA+ +T   C  CG+ F +  SLN H
Sbjct: 189 ICEVCHKSYTQFSNLCRH-KRMHADCRTQIKCKDCGQMFSTTSSLNKH 235



 Score = 58.9 bits (141), Expect = 1e-008
 Identities = 29/96 (30%), Positives = 51/96 (53%), Gaps = 2/96 (2%)

Query: 184 LEEHMQNKHQEWEFACEECGKRFPFKNRLTAHMAKVHMKKDIICEECNKPFTKFS-IEKH 242
           L E++  K +E  + C  CGK FP    LT H+     ++   C+ C++ F+  S +++H
Sbjct: 721 LPENLLRKGKE-RYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRH 779

Query: 243 KKTVHGHGGTFICENCPKTFKTRVSLERHMEGHNNG 278
            + +H     F C  C + F  + +L+RH++ H NG
Sbjct: 780 VRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENG 815



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 24/102 (23%), Positives = 38/102 (37%), Gaps = 26/102 (25%)

Query: 253 FICENCPKTFKTRVSLERHMEGHNNGEQQQPPQQQQPQPLPLPLPQQQPSSAATVSCSLC 312
           + C  C K F    +L RH+  H  GEQ                            C  C
Sbjct: 733 YTCRYCGKIFPRSANLTRHLRTHT-GEQPY-------------------------RCKYC 766

Query: 313 NSVLKDEYNLKAHMKRIHAEQTPATCNTCGKTFKSKHSLNTH 354
           +       NL+ H++ IH ++ P  C+ C + F  + +L+ H
Sbjct: 767 DRSFSISSNLQRHVRNIHNKEKPFKCHLCDRCFGQQTNLDRH 808



==> MGI|MGI:103170 - symbol:Gfi1 "growth factor independent 1"
           species:10090 "Mus musculus" [GO:0007638 "mechanosensory
           behavior" evidence=IMP] [GO:0045165 "cell fate
           commitment" evidence=IMP] [GO:0042491 "auditory receptor
           cell differentiation" evidence=IMP] [GO:0042472 "inner
           ear morphogenesis" evidence=IMP] [GO:0009996 "negative
           regulation of cell fate specification" evidence=IMP]
           [GO:0042660 "positive regulation of cell fate
           specification" evidence=IMP] InterPro:IPR007087
           InterPro:IPR001878 Pfam:PF00096 Prosite:PS00028
           MGI:MGI:103170 SMART:SM00355 PROSITE:PS50157
           SMART:SM00343 ProDom:PD000003 GO:GO:0042472 HSSP:P08047
           GO:GO:0009996 GO:GO:0042491 GO:GO:0007638 EMBL:U58973
           EMBL:U58972 EMBL:U78312 UniGene:Mm.2078
           Ensembl:ENSMUSG00000029275 KEGG:mmu:14581
           ArrayExpress:P70338 GermOnline:ENSMUSG00000029275
           GO:GO:0042660 Uniprot:P70338
          Length = 423

 Score = 82.8 bits (203), Expect = 6e-016
 Identities = 53/188 (28%), Positives = 81/188 (43%), Gaps = 30/188 (15%)

Query: 197 FACEECGKRFPFKNRLTAHMAKVHM-KKDIICEECNKPFTK-FSIEKHKKTVHGHGGTFI 254
           + C +C K F   + L  H+ + H   +   CE C K F    S+E+HK  VH    +F 
Sbjct: 256 YKCIKCSKVFSTPHGLEVHVRRSHSGTRPFACEMCGKTFGHAVSLEQHK-AVHSQERSFD 314

Query: 255 CENCPKTFKTRVSLERHMEGHNNGEQQQPPQQQQPQPLPLPLPQQQPSSAATVSCSLCNS 314
           C+ C K+FK   +L  H+  H++            +P P               C  C  
Sbjct: 315 CKICGKSFKRSSTLSTHLLIHSD-----------TRPYP---------------CQYCGK 348

Query: 315 VLKDEYNLKAHMKRIHAEQTPATCNTCGKTFKSKHSLNTHTANVCTTRLFGCTTCGKQFK 374
               + ++K H   IH  + P  C  CGK F    +L TH+      + FGC  CGK F+
Sbjct: 349 RFHQKSDMKKHTF-IHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFGCDLCGKGFQ 407

Query: 375 KRTKLKQH 382
           ++  L++H
Sbjct: 408 RKVDLRRH 415



 Score = 70.5 bits (171), Expect = 3e-012
 Identities = 47/151 (31%), Positives = 66/151 (43%), Gaps = 12/151 (7%)

Query: 135 TVHGLE-------SGT--VKCQLCAKKFRSRVKLVEHKDMHENPERFRCGVCQEVHQN-- 183
           T HGLE       SGT    C++C K F   V L +HK +H     F C +C +  +   
Sbjct: 267 TPHGLEVHVRRSHSGTRPFACEMCGKTFGHAVSLEQHKAVHSQERSFDCKICGKSFKRSS 326

Query: 184 -LEEHMQNKHQEWEFACEECGKRFPFKNRLTAHMAKVHMKKDIICEECNKPFTKFSIEKH 242
            L  H+        + C+ CGKRF  K+ +  H      +K   C+ C K F++ S    
Sbjct: 327 TLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTFIHTGEKPHKCQVCGKAFSQSSNLIT 386

Query: 243 KKTVHGHGGTFICENCPKTFKTRVSLERHME 273
               H     F C+ C K F+ +V L RH E
Sbjct: 387 HSRKHTGFKPFGCDLCGKGFQRKVDLRRHRE 417



 Score = 68.9 bits (167), Expect = 9e-012
 Identities = 37/137 (27%), Positives = 61/137 (44%), Gaps = 26/137 (18%)

Query: 250 GGTFICENCPKTFKTRVSLERHMEGHNNGEQQQPPQQQQPQPLPLPLPQQQPSSAATVSC 309
           GG++ C  C K F T   LE H+   ++G +                           +C
Sbjct: 253 GGSYKCIKCSKVFSTPHGLEVHVRRSHSGTRP-------------------------FAC 287

Query: 310 SLCNSVLKDEYNLKAHMKRIHAEQTPATCNTCGKTFKSKHSLNTHTANVCTTRLFGCTTC 369
            +C        +L+ H K +H+++    C  CGK+FK   +L+TH      TR + C  C
Sbjct: 288 EMCGKTFGHAVSLEQH-KAVHSQERSFDCKICGKSFKRSSTLSTHLLIHSDTRPYPCQYC 346

Query: 370 GKQFKKRTKLKQHMTIH 386
           GK+F +++ +K+H  IH
Sbjct: 347 GKRFHQKSDMKKHTFIH 363



 Score = 61.2 bits (147), Expect = 2e-009
 Identities = 55/200 (27%), Positives = 80/200 (40%), Gaps = 14/200 (7%)

Query: 90  AVAVAGPG--GDPGSVAAGA-GHPEAAAAATTQEEEYR-------SLKQLNQHMRTVHGL 139
           A + AG G  GD    AAG    P  AA    Q+  +         +K  ++ + T   L
Sbjct: 192 ATSAAGLGLYGDFAPAAAGLYERPSTAAGRLYQDHGHELHADKSVGVKVESELLCTRLLL 251

Query: 140 ESGTVKCQLCAKKFRSRVKLVEH-KDMHENPERFRCGVCQEVHQN---LEEHMQNKHQEW 195
             G+ KC  C+K F +   L  H +  H     F C +C +   +   LE+H     QE 
Sbjct: 252 GGGSYKCIKCSKVFSTPHGLEVHVRRSHSGTRPFACEMCGKTFGHAVSLEQHKAVHSQER 311

Query: 196 EFACEECGKRFPFKNRLTAHMAKVHMKKDIICEECNKPFTKFSIEKHKKTVHGHGGTFIC 255
            F C+ CGK F   + L+ H+      +   C+ C K F + S  K    +H       C
Sbjct: 312 SFDCKICGKSFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTFIHTGEKPHKC 371

Query: 256 ENCPKTFKTRVSLERHMEGH 275
           + C K F    +L  H   H
Sbjct: 372 QVCGKAFSQSSNLITHSRKH 391



 Score = 56.2 bits (134), Expect = 6e-008
 Identities = 37/124 (29%), Positives = 57/124 (45%), Gaps = 6/124 (4%)

Query: 129 LNQHMRTVHGLESGTVKCQLCAKKFRSRVKLVEHKDMHENPERFRCGVC-QEVHQ--NLE 185
           L QH + VH  E  +  C++C K F+    L  H  +H +   + C  C +  HQ  +++
Sbjct: 300 LEQH-KAVHSQER-SFDCKICGKSFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMK 357

Query: 186 EHMQNKHQEWEFACEECGKRFPFKNRLTAHMAKVHMKKDIICEECNKPF-TKFSIEKHKK 244
           +H      E    C+ CGK F   + L  H  K    K   C+ C K F  K  + +H++
Sbjct: 358 KHTFIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFGCDLCGKGFQRKVDLRRHRE 417

Query: 245 TVHG 248
           T HG
Sbjct: 418 TQHG 421



==> UNIPROT|Q99684 - symbol:GFI1_HUMAN "GFI1, ZNF163: Zinc finger
           protein Gfi-1" species:9606 "Homo sapiens" [GO:0003702
           "RNA polymerase II transcription factor activity"
           evidence=NR] [GO:0000083 "G1/S-specific transcription in
           mitotic cell cycle" evidence=TAS] [GO:0016032 "viral
           reproduction" evidence=TAS] InterPro:IPR007087
           InterPro:IPR001878 Pfam:PF00096 Prosite:PS00028
           UniProt:Q99684 SMART:SM00355 PROSITE:PS50157
           SMART:SM00343 ProDom:PD000003 HSSP:P08047 GO:GO:0016032
           GO:GO:0000083 EMBL:U67369 EMBL:BC032751 EMBL:BC074866
           EMBL:BC074867 UniGene:Hs.73172 Ensembl:ENSG00000162676
           KEGG:hsa:2672 HGNC:HGNC:4237 MIM:202700 MIM:600871
           MIM:607847 ArrayExpress:Q99684
           GermOnline:ENSG00000162676 InterPro:IPR011069
          Length = 422

 Score = 82.8 bits (203), Expect = 6e-016
 Identities = 53/188 (28%), Positives = 81/188 (43%), Gaps = 30/188 (15%)

Query: 197 FACEECGKRFPFKNRLTAHMAKVHM-KKDIICEECNKPFTK-FSIEKHKKTVHGHGGTFI 254
           + C +C K F   + L  H+ + H   +   CE C K F    S+E+HK  VH    +F 
Sbjct: 255 YKCIKCSKVFSTPHGLEVHVRRSHSGTRPFACEMCGKTFGHAVSLEQHK-AVHSQERSFD 313

Query: 255 CENCPKTFKTRVSLERHMEGHNNGEQQQPPQQQQPQPLPLPLPQQQPSSAATVSCSLCNS 314
           C+ C K+FK   +L  H+  H++            +P P               C  C  
Sbjct: 314 CKICGKSFKRSSTLSTHLLIHSD-----------TRPYP---------------CQYCGK 347

Query: 315 VLKDEYNLKAHMKRIHAEQTPATCNTCGKTFKSKHSLNTHTANVCTTRLFGCTTCGKQFK 374
               + ++K H   IH  + P  C  CGK F    +L TH+      + FGC  CGK F+
Sbjct: 348 RFHQKSDMKKHTF-IHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFGCDLCGKGFQ 406

Query: 375 KRTKLKQH 382
           ++  L++H
Sbjct: 407 RKVDLRRH 414



 Score = 75.1 bits (183), Expect = 1e-013
 Identities = 67/231 (29%), Positives = 90/231 (38%), Gaps = 46/231 (19%)

Query: 88  AVAVAVAGPG----GDPGSVAAGAGHPEAAAAATTQEEE--------------------- 122
           A A A AGPG    GD GS AAG      AAA     E                      
Sbjct: 187 AGAGATAGPGLGLYGDFGSAAAGLYERPTAAAGLLYPERGHGLHADKGAGVKVESELLCT 246

Query: 123 --------YRSLKQLNQHMRTVHGLE-------SGT--VKCQLCAKKFRSRVKLVEHKDM 165
                   Y+ +K  ++   T HGLE       SGT    C++C K F   V L +HK +
Sbjct: 247 RLLLGGGSYKCIK-CSKVFSTPHGLEVHVRRSHSGTRPFACEMCGKTFGHAVSLEQHKAV 305

Query: 166 HENPERFRCGVCQEVHQN---LEEHMQNKHQEWEFACEECGKRFPFKNRLTAHMAKVHMK 222
           H     F C +C +  +    L  H+        + C+ CGKRF  K+ +  H      +
Sbjct: 306 HSQERSFDCKICGKSFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTFIHTGE 365

Query: 223 KDIICEECNKPFTKFSIEKHKKTVHGHGGTFICENCPKTFKTRVSLERHME 273
           K   C+ C K F++ S        H     F C+ C K F+ +V L RH E
Sbjct: 366 KPHKCQVCGKAFSQSSNLITHSRKHTGFKPFGCDLCGKGFQRKVDLRRHRE 416



 Score = 68.9 bits (167), Expect = 9e-012
 Identities = 37/137 (27%), Positives = 61/137 (44%), Gaps = 26/137 (18%)

Query: 250 GGTFICENCPKTFKTRVSLERHMEGHNNGEQQQPPQQQQPQPLPLPLPQQQPSSAATVSC 309
           GG++ C  C K F T   LE H+   ++G +                           +C
Sbjct: 252 GGSYKCIKCSKVFSTPHGLEVHVRRSHSGTRP-------------------------FAC 286

Query: 310 SLCNSVLKDEYNLKAHMKRIHAEQTPATCNTCGKTFKSKHSLNTHTANVCTTRLFGCTTC 369
            +C        +L+ H K +H+++    C  CGK+FK   +L+TH      TR + C  C
Sbjct: 287 EMCGKTFGHAVSLEQH-KAVHSQERSFDCKICGKSFKRSSTLSTHLLIHSDTRPYPCQYC 345

Query: 370 GKQFKKRTKLKQHMTIH 386
           GK+F +++ +K+H  IH
Sbjct: 346 GKRFHQKSDMKKHTFIH 362



==> UNIPROT|P10075 - symbol:GLI4_HUMAN "GLI4, HKR4: Zinc finger protein
           GLI4" species:9606 "Homo sapiens" [GO:0003674
           "molecular_function" evidence=ND] [GO:0008150
           "biological_process" evidence=ND] [GO:0005634 "nucleus"
           evidence=NAS] InterPro:IPR007087 Pfam:PF00096
           Prosite:PS00028 InterPro:IPR007086 UniProt:P10075
           GO:GO:0005634 SMART:SM00355 PROSITE:PS50157 HSSP:P08046
           ProDom:PD000003 PRINTS:PR00048 EMBL:BC014165 EMBL:M20678
           EMBL:M20679 PIR:F31201 UniGene:Hs.400533
           Ensembl:ENSG00000181638 KEGG:hsa:2738 HGNC:HGNC:4320
           MIM:165280 ArrayExpress:P10075
           GermOnline:ENSG00000181638 RZPD-ProtExp:IOH12330
           RZPD-ProtExp:T2616
          Length = 376

 Score = 82.0 bits (201), Expect = 1e-015
 Identities = 54/194 (27%), Positives = 81/194 (41%), Gaps = 7/194 (3%)

Query: 199 CEECGKRFPFKNRLTAHMAKVHMKKDIICEECNKPFTKFS--IEKHKKTVHGHGGTFICE 256
           CE CGK F + + L  H      +K   C EC K F  +S  I+ H+  +H     + C 
Sbjct: 185 CEACGKSFKYNSLLLKHQRIHTGEKPYACHECGKRFRGWSGFIQHHR--IHTGEKPYECG 242

Query: 257 NCPKTFKTRVSLERHMEGHNNGEQQQPPQ--QQQPQPLPLPLPQQQPSSAATVSCSLCNS 314
            C + F       +H+  HN  +  +  +  Q   Q   L   Q+  +     +CS C  
Sbjct: 243 QCGRAFSHSSHFTQHLRIHNGEKPYKCGECGQAFSQSSNLVRHQRLHTGEKPYACSQCGK 302

Query: 315 VLKDEYNLKAHMKRIHAEQTPATCNTCGKTFKSKHSLNTHTANVCTTRLFGCTTCGKQFK 374
                  L  H +RIH  + P  C+ CGK F+ +     H       + F C  CGK F 
Sbjct: 303 AFIWSSVLIEH-QRIHTGEKPYECSDCGKAFRGRSHFFRHLRTHTGEKPFACGACGKAFG 361

Query: 375 KRTKLKQHMTIHPR 388
           + ++L QH  +H R
Sbjct: 362 QSSQLIQHQRVHYR 375



 Score = 72.0 bits (175), Expect = 1e-012
 Identities = 52/202 (25%), Positives = 80/202 (39%), Gaps = 19/202 (9%)

Query: 89  VAVAVAGPGGDPGSVA------------AGAGHPEAAAAATTQEEEYRSLKQLNQHMRTV 136
           V  A AGP G P   A            +  G       A  +  +Y SL  L +H R +
Sbjct: 148 VQQAAAGPEGAPERAAELGVNFGRSRQGSARGAKPHRCEACGKSFKYNSL--LLKHQR-I 204

Query: 137 HGLESGTVKCQLCAKKFRSRVKLVEHKDMHENPERFRCGVCQEVHQN---LEEHMQNKHQ 193
           H  E     C  C K+FR     ++H  +H   + + CG C     +     +H++  + 
Sbjct: 205 HTGEK-PYACHECGKRFRGWSGFIQHHRIHTGEKPYECGQCGRAFSHSSHFTQHLRIHNG 263

Query: 194 EWEFACEECGKRFPFKNRLTAHMAKVHMKKDIICEECNKPFTKFSIEKHKKTVHGHGGTF 253
           E  + C ECG+ F   + L  H      +K   C +C K F   S+    + +H     +
Sbjct: 264 EKPYKCGECGQAFSQSSNLVRHQRLHTGEKPYACSQCGKAFIWSSVLIEHQRIHTGEKPY 323

Query: 254 ICENCPKTFKTRVSLERHMEGH 275
            C +C K F+ R    RH+  H
Sbjct: 324 ECSDCGKAFRGRSHFFRHLRTH 345



 Score = 50.8 bits (120), Expect = 3e-006
 Identities = 32/120 (26%), Positives = 50/120 (41%), Gaps = 5/120 (4%)

Query: 131 QHMRTVHGLESGTVKCQLCAKKFRSRVKLVEHKDMHENPERFRCGVCQEVH---QNLEEH 187
           QH+R  +G +    KC  C + F     LV H+ +H   + + C  C +       L EH
Sbjct: 256 QHLRIHNGEKP--YKCGECGQAFSQSSNLVRHQRLHTGEKPYACSQCGKAFIWSSVLIEH 313

Query: 188 MQNKHQEWEFACEECGKRFPFKNRLTAHMAKVHMKKDIICEECNKPFTKFSIEKHKKTVH 247
            +    E  + C +CGK F  ++    H+     +K   C  C K F + S     + VH
Sbjct: 314 QRIHTGEKPYECSDCGKAFRGRSHFFRHLRTHTGEKPFACGACGKAFGQSSQLIQHQRVH 373



 Score = 37.7 bits (86), Expect = 0.023
 Identities = 18/52 (34%), Positives = 24/52 (46%)

Query: 335 PATCNTCGKTFKSKHSLNTHTANVCTTRLFGCTTCGKQFKKRTKLKQHMTIH 386
           P  C  CGK+FK    L  H       + + C  CGK+F+  +   QH  IH
Sbjct: 182 PHRCEACGKSFKYNSLLLKHQRIHTGEKPYACHECGKRFRGWSGFIQHHRIH 233



==> UNIPROT|Q08705 - symbol:CTCF_CHICK "CTCF: Transcriptional repressor
           CTCF" species:9031 "Gallus gallus" [GO:0005515 "protein
           binding" evidence=IPI] InterPro:IPR007087 Pfam:PF00096
           Prosite:PS00028 UniProt:Q08705 GO:GO:0005515
           SMART:SM00355 PROSITE:PS50157 HSSP:P08046 EMBL:Z22605
           PIR:A54603 UniGene:Gga.3278 SMR:Q08705 IntAct:Q08705
           TRANSFAC:T00172 Ensembl:ENSGALG00000001817
          Length = 728

 Score = 80.1 bits (196), Expect = 4e-015
 Identities = 68/280 (24%), Positives = 110/280 (39%), Gaps = 29/280 (10%)

Query: 123 YRSLKQLNQHMRTVHGLESGTVKCQLCAKKFRSRVKLVEH---KDMHENPERFRCGVCQE 179
           +R++  L  H+ T  G      KC  C   F +  +LV H   K  HE P  F+C +C  
Sbjct: 303 FRTVTLLRNHLNTHTGTRPH--KCPDCDMAFVTSGELVRHRRYKHTHEKP--FKCSMCDY 358

Query: 180 VH---QNLEEHMQNKHQEWEFACEECGKRFPFKNRLTAHMAKVHMKKDIICEECNKPFTK 236
                  L+ H+++   E  F C  C        +L  HM     +K   C  C+  FT+
Sbjct: 359 ASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARFTQ 418

Query: 237 FS------IEKHKKTVHGHGGTFICENCPKTFKTRVSLERHMEGHNN----GEQQQPPQQ 286
                   ++KH + V      F C +C      +  L  H+   ++    G++ +    
Sbjct: 419 SGTMKMHILQKHTENV----AKFHCPHCDTVIARKSDLGVHLRKQHSYIEQGKKCRYCDA 474

Query: 287 QQPQPLPLPLPQQQPSSAATVSCSLCNSVLKDEYNLKAHMKRIHAEQTPATCNTCGKTFK 346
              +   L   Q+   +     C  C+   + E ++  H KR H  + P  C+ C KTF+
Sbjct: 475 VFHERYALIQHQKSHKNEKRFKCDQCDYACRQERHMVMH-KRTHTGEKPYACSHCDKTFR 533

Query: 347 SKHSLNTHTANV----CTTRLFGCTTCGKQFKKRTKLKQH 382
            K  L+ H             F C+ CGK F +R  + +H
Sbjct: 534 QKQLLDMHFKRYHDPNFVPAAFVCSKCGKTFTRRNTMARH 573



 Score = 75.1 bits (183), Expect = 1e-013
 Identities = 54/257 (21%), Positives = 100/257 (38%), Gaps = 17/257 (6%)

Query: 143 TVKCQLCAKKFRSRVKLVEHKDMHENPERFRCGVCQEVHQN---LEEHMQNKHQEWEFAC 199
           T +C+LC+     R  L  H   H +    +C +C    +    L  H+          C
Sbjct: 265 TFQCELCSYTCPRRSNLDRHMKSHTDERPHKCHLCGRAFRTVTLLRNHLNTHTGTRPHKC 324

Query: 200 EECGKRFPFKNRLTAHMAKVHM-KKDIICEECNKPFTKFSIEKHKKTVHGHGG--TFICE 256
            +C   F     L  H    H  +K   C  C+  +    + K K+ +  H G   F C 
Sbjct: 325 PDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCD--YASVEVSKLKRHIRSHTGERPFQCS 382

Query: 257 NCPKTFKTRVSLERHMEGHNNGEQQQ----PPQQQQPQPLPLPLPQQQPSSAATVSCSLC 312
            C    +    L+RHM  H+  +  +      +  Q   + + + Q+   + A   C  C
Sbjct: 383 LCSYASRDTYKLKRHMRTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHC 442

Query: 313 NSVLKDEYNLKAHMKRIHAE-QTPATCNTCGKTFKSKHSLNTHTANVCTTRLFGCTTCGK 371
           ++V+  + +L  H+++ H+  +    C  C   F  +++L  H  +    + F C  C  
Sbjct: 443 DTVIARKSDLGVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQCDY 502

Query: 372 QFKKRTKLKQHMTIHPR 388
             ++    ++HM +H R
Sbjct: 503 ACRQ----ERHMVMHKR 515



 Score = 72.8 bits (177), Expect = 6e-013
 Identities = 59/243 (24%), Positives = 99/243 (40%), Gaps = 40/243 (16%)

Query: 126 LKQLNQHMRTVHGLESGTVKCQLCAKKFRSRVKLVEHKDMHENPERFRCGVCQEVHQN-- 183
           + +L +H+R+  G      +C LC+   R   KL  H   H   + + C +C        
Sbjct: 363 VSKLKRHIRSHTG--ERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARFTQSG 420

Query: 184 -LEEHMQNKHQE--WEFACEECGKRFPFKNRLTAHMAKVH--MKKDIICEECNKPF-TKF 237
            ++ H+  KH E   +F C  C      K+ L  H+ K H  +++   C  C+  F  ++
Sbjct: 421 TMKMHILQKHTENVAKFHCPHCDTVIARKSDLGVHLRKQHSYIEQGKKCRYCDAVFHERY 480

Query: 238 SIEKHKKTVHGHGGTFICENCPKTFKTRVSLERHMEGHNNGEQQQPPQQQQPQPLPLPLP 297
           ++ +H+K+ H +   F C+ C    +     ERHM  H      + P             
Sbjct: 481 ALIQHQKS-HKNEKRFKCDQCDYACRQ----ERHMVMHKRTHTGEKPY------------ 523

Query: 298 QQQPSSAATVSCSLCNSVLKDEYNLKAHMKRIHAEQ-TPAT--CNTCGKTFKSKHSLNTH 354
                     +CS C+   + +  L  H KR H     PA   C+ CGKTF  ++++  H
Sbjct: 524 ----------ACSHCDKTFRQKQLLDMHFKRYHDPNFVPAAFVCSKCGKTFTRRNTMARH 573

Query: 355 TAN 357
             N
Sbjct: 574 ADN 576



 Score = 66.2 bits (160), Expect = 6e-011
 Identities = 45/168 (26%), Positives = 63/168 (37%), Gaps = 40/168 (23%)

Query: 129 LNQHMRTVHGLESGTVKCQLCAKKFRSRVKLVEHKDMHENPERFRCGVC-----QEVHQN 183
           L  H+R  H       KC+ C   F  R  L++H+  H+N +RF+C  C     QE H  
Sbjct: 452 LGVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQCDYACRQERHMV 511

Query: 184 LEEHMQNKHQEWEFACEECGKRFPFKNRLTAHMAKVHMKKDIICEECNKPFTKFSIEKHK 243
           +  H +    E  +AC  C K F  K  L  H  + H    +                  
Sbjct: 512 M--HKRTHTGEKPYACSHCDKTFRQKQLLDMHFKRYHDPNFV------------------ 551

Query: 244 KTVHGHGGTFICENCPKTFKTRVSLERHM---------EGHNNGEQQQ 282
                    F+C  C KTF  R ++ RH          EG N GE ++
Sbjct: 552 ------PAAFVCSKCGKTFTRRNTMARHADNCSGLDGGEGENGGETKK 593



 Score = 48.9 bits (115), Expect = 1e-005
 Identities = 29/94 (30%), Positives = 42/94 (44%), Gaps = 9/94 (9%)

Query: 293 PLPLPQQQPSSAATVSCSLCNSVLKDEYNLKAHMKRIHAEQTPATCNTCGKTFKS----K 348
           P P   ++     T  C LC+       NL  HMK  H ++ P  C+ CG+ F++    +
Sbjct: 252 PKPTKIKKKGVKKTFQCELCSYTCPRRSNLDRHMKS-HTDERPHKCHLCGRAFRTVTLLR 310

Query: 349 HSLNTHTANVCTTRLFGCTTCGKQFKKRTKLKQH 382
           + LNTHT     TR   C  C   F    +L +H
Sbjct: 311 NHLNTHTG----TRPHKCPDCDMAFVTSGELVRH 340