>AGAP006730-PA

gnl|CDD|65178 pfam01363, FYVE, FYVE zinc finger. The FYVE zinc f...    39   0.001
gnl|CDD|66967 pfam03326, Herpes_TAF50, Herpesvirus transcription...    31   0.28 
gnl|CDD|70912 pfam07462, MSP1_C, Merozoite surface protein 1 (MS...    30   0.50 
gnl|CDD|69147 pfam05609, LAP1C, Lamina-associated polypeptide 1C...    29   0.75 
gnl|CDD|63985 pfam00097, zf-C3HC4, Zinc finger, C3HC4 type (RING...    30   0.77 


==> gnl|CDD|65178 pfam01363, FYVE, FYVE zinc finger. The FYVE zinc finger is named
          after four proteins that it has been found in: Fab1,
          YOTB/ZK632.12, Vac1, and EEA1. The FYVE finger has been
          shown to bind two Zn++ ions. The FYVE finger has eight
          potential zinc coordinating cysteine positions. Many
          members of this family also include two histidines in a
          motif R+HHC+XCG, where + represents a charged residue
          and X any residue. We have included members which do
          not conserve these histidine residues but are clearly
          related..
          Length = 65

 Score = 38.8 bits (90), Expect = 0.001
 Identities = 12/32 (37%), Positives = 17/32 (53%)

Query: 3  CEKCNVKFGIITRKKSCYECHRLFCRNCLSKR 34
          C +C   F +  R+  C  C R+FC +C SK 
Sbjct: 12 CMRCGKPFTLTKRRHHCRACGRIFCSSCSSKT 43



==> gnl|CDD|66967 pfam03326, Herpes_TAF50, Herpesvirus transcription activation
           factor (transactivator). This family includes EBV BRLF1
           and similar ORF 50 proteins from other herpesviruses..
          Length = 500

 Score = 30.8 bits (69), Expect = 0.28
 Identities = 37/196 (18%), Positives = 57/196 (29%), Gaps = 21/196 (10%)

Query: 139 QIKNTCQNLFSTFSEKINGGKCVRHAPEAGRASSGFATQEEQRHIFTQPRFGSNNVYHSY 198
                  +L    S         R       +    A+ +  R   +       +     
Sbjct: 214 HGFTPHPSLPQPQSPLKPSPSSARPQQSESFSDVWPASTQSPREETSAEPLAPASPSSRR 273

Query: 199 DSGSMERSAHFSSASSGTTGGADTSAASSSFSTPSR---------EASAPLLAEQQPSAE 249
            S + E     SS  +    G  +    SS S PS              P   ++     
Sbjct: 274 PSTAQEEQIACSSPQAEPEQGVQSYVPQSSDSRPSCFPAPSTTQPTFLPPNTNKKAKRDR 333

Query: 250 RDGAVTKQQEAGGKSE---PDVPQRSKQARRSHS------HSNLLSPVQAGPS---ADTS 297
           R   VT +QE G            R+ + R S S      +S LLS +   PS      +
Sbjct: 334 RPQMVTPKQEGGAAVSQNHDGGTVRAPRGRPSGSGQSPPSNSPLLSSLADTPSGAAHQPA 393

Query: 298 AGTPPKVVTRSQTPSS 313
           +  PP VV +    +S
Sbjct: 394 SLLPPAVVQQQLEDAS 409



==> gnl|CDD|70912 pfam07462, MSP1_C, Merozoite surface protein 1 (MSP1) C-terminus.
           This family represents the C-terminal region of
           merozoite surface protein 1 (MSP1) which are found in a
           number of Plasmodium species. MSP-1 is a 200-kDa protein
           expressed on the surface of the P. vivax merozoite.
           MSP-1 of Plasmodium species is synthesised as a
           high-molecular-weight precursor and then processed into
           several fragments. At the time of red cell invasion by
           the merozoite, only the 19-kDa C-terminal fragment
           (MSP-119), which contains two epidermal growth
           factor-like domains, remains on the surface. Antibodies
           against MSP-119 inhibit merozoite entry into red cells,
           and immunisation with MSP-119 protects monkeys from
           challenging infections. Hence, MSP-119 is considered a
           promising vaccine candidate..
          Length = 574

 Score = 30.0 bits (67), Expect = 0.50
 Identities = 23/143 (16%), Positives = 44/143 (30%), Gaps = 25/143 (17%)

Query: 254 VTKQQEAGGKSEPDVPQRSKQARRSHSHSNLLSPVQAGPSADTSAGTPPKVV-------- 305
           + K +   G + P+      +A     +  LL       +  T+  TPP+          
Sbjct: 229 LIKNKNYTGNTNPENNPEVNEALE--QYKELLPKGTTQEAKVTTVVTPPQADAAPSPLSV 286

Query: 306 --------TRSQTPSSSFDDLLADGEGSSSNADHAIAQDATLAATTETDALGTTVASTDD 357
                       T   +   +L  G  ++        Q+       E D+L       +D
Sbjct: 287 RPAGSSGSASGSTQIPTSGSVLGPGAAATELQQVVQLQN----YDEEDDSLVVLPIFGND 342

Query: 358 TDQWQIIN---TSEANSATHSDL 377
            D  + ++   T EA S    ++
Sbjct: 343 DDDDEDLDQVATGEAESEEMKNI 365



==> gnl|CDD|69147 pfam05609, LAP1C, Lamina-associated polypeptide 1C (LAP1C). This
           family contains rat LAP1C proteins and several
           uncharacterised highly related sequences from both mice
           and humans. LAP1s (lamina-associated polypeptide 1s) are
           type 2 integral membrane proteins with a single
           membrane-spanning region of the inner nuclear membrane.
           LAP1s bind to both A- and B-type lamins and have a
           putative role in the membrane attachment and assembly of
           the nuclear lamina..
          Length = 465

 Score = 29.4 bits (65), Expect = 0.75
 Identities = 25/125 (20%), Positives = 43/125 (34%), Gaps = 3/125 (2%)

Query: 169 RASSGFATQEEQRHIFTQPRFGSNNVYHSYDSGSMERSAHFSSASSGTTGGADTSAASSS 228
           R     AT+ + +  F +     ++ + S  + + E      S  S    G   +   SS
Sbjct: 81  RYPRYEATEVQNKQSFLEEGETEDDHHSSSSNVTKEPLRSRDSHESSDKVGRADAHLGSS 140

Query: 229 FSTPSREASAPLLAEQQPSAERDGAVTKQQE---AGGKSEPDVPQRSKQARRSHSHSNLL 285
                + AS      QQPS    G+    QE     G+    + +R      + + S   
Sbjct: 141 SWALPKSASDFTAHSQQPSVLTTGSQKAPQEWHSQAGRERTRMLRRRILKSEAGNQSPST 200

Query: 286 SPVQA 290
           S +Q 
Sbjct: 201 SKLQE 205



==> gnl|CDD|63985 pfam00097, zf-C3HC4, Zinc finger, C3HC4 type (RING finger). The
           C3HC4 type zinc-finger (RING finger) is a cysteine-rich
           domain of 40 to 60 residues that coordinates two zinc
           ions, and has the consensus sequence:
           C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C
           where X is any amino acid. Many proteins containing a
           RING finger play a key role in the ubiquitination
           pathway..
          Length = 41

 Score = 29.6 bits (66), Expect = 0.77
 Identities = 13/42 (30%), Positives = 20/42 (47%), Gaps = 8/42 (19%)

Query: 674 CKICMDAPIECV-ILECGHMTTCTAC------GKVLSECPIC 708
           C+IC++   +   IL CGH   C +C          + CP+C
Sbjct: 1   CRICLEELKDPSTILPCGH-RFCRSCLKRWLSTSGNTTCPLC 41