>AGAP012068-PA

Q9VT65|CANB_DROME Calpain B (EC 3.4.22.-) (Calcium-activated neu...  1088   0.0  
Q11002|CANA_DROME Calpain A (EC 3.4.22.-) (Calcium-activated neu...   853   0.0  
O14815|CAN9_HUMAN Calpain-9 (EC 3.4.22.-) (Digestive tract-speci...   638   0.0  
Q9D805|CAN9_MOUSE Calpain-9 (EC 3.4.22.-) (Digestive tract-speci...   627   e-179
O35920|CAN9_RAT Calpain-9 (EC 3.4.22.-) (Digestive tract-specifi...   626   e-178
P00789|CANX_CHICK Calpain-1 catalytic subunit (EC 3.4.22.52) (Ca...   621   e-177
Q9GLG1|CAN2_MACFA Calpain-2 catalytic subunit precursor (EC 3.4....   614   e-175
P17655|CAN2_HUMAN Calpain-2 catalytic subunit precursor (EC 3.4....   613   e-175
Q92178|CAN2_CHICK Calpain-2 catalytic subunit precursor (EC 3.4....   612   e-174
O08529|CAN2_MOUSE Calpain-2 catalytic subunit precursor (EC 3.4....   610   e-174


==> Q9VT65|CANB_DROME Calpain B (EC 3.4.22.-) (Calcium-activated
           neutral proteinase B) (CANP B) [Contains: Calpain B
           catalytic subunit 1; Calpain B catalytic subunit 2] -
           Drosophila melanogaster (Fruit fly)
          Length = 925

 Score = 1088 bits (2813), Expect = 0.0
 Identities = 525/845 (62%), Positives = 635/845 (75%), Gaps = 36/845 (4%)

Query: 1   PAAFAQSPPASQWPTVPTPGSSGYSSLNPSISGQSLSYGFNPNVMPALPDSGAGYPPAGN 60
           P   A S PA      P PGS  Y SL PS +  SL Y   P    A   +G  YP    
Sbjct: 87  PVPEAPSAPAPYPSATPYPGSGLYPSL-PSANVSSLPY---PTAPMAPYPTGMPYPTGMP 142

Query: 61  Q--LPYPTMGFAGF--------GSPMDYT-MPNLP----------------PPVPDALLR 93
           Q  LPYP    A +        G PM Y  MP  P                PP   A  +
Sbjct: 143 QPNLPYPAAPLAPYPSAMPGLPGMPMPYAPMPTSPAPQHNIGFPALPYPTAPPPESAPTQ 202

Query: 94  GAEPAAATCEEIPFQSISIPIAEGMFSPLGDRNAGQRSSFDVQDFYQIRQQCLDNGTLFE 153
             EP+    E + F S+ +P  + MF       + +++S    DF  +R  CL NGT+FE
Sbjct: 203 EEEPSVGVAE-LSFTSVKVPENQNMFWMGRKATSARQNSVSKGDFQSLRDSCLANGTMFE 261

Query: 154 DPEFPASASSLMYSKRPDRHYEWLRPHEICDGPEFFVEGFSRFDVQQGELGDCWLLAACA 213
           DP+FPA+ +SLMYS+RPDR+YEWLRP +I D P+FFVEG+SRFDVQQGELGDCWLLAA A
Sbjct: 262 DPDFPATNASLMYSRRPDRYYEWLRPGDIADDPQFFVEGYSRFDVQQGELGDCWLLAAAA 321

Query: 214 NLTQDHKMFLRVVPEDNSFEDGYAGVFHFRFWQYGKWVDVVIDDRLPTYRGQLIYMRSSE 273
           NLTQD  +F RV+P D  F++ YAG+FHF+FWQYGKWV+VVIDDRLPTY G+LIYM S+E
Sbjct: 322 NLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHSTE 381

Query: 274 QNEFWSALLEKAYAKLHGSYESLRGGTTCEAMEDFTGGVAEMYDLKDQTPPNLFEIIEKG 333
           +NEFWSALLEKAYAKLHGSYE+L+GGTTCEAMEDFTGGV E YD+K+  PPNLF I+ K 
Sbjct: 382 KNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKE-APPNLFSIMMKA 440

Query: 334 FKRNSMFGCSIEADPHVLEAETPEGLIRGHAYSITKIQLVDIETPGRSGKIPLIRLRNPW 393
            +R SM GCS+E DPHVLEAETP+GLIRGHAYSITK+ L+DI TP R GK+P+IR+RNPW
Sbjct: 441 AERGSMMGCSLEPDPHVLEAETPQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRNPW 500

Query: 394 GNEAEWNGPWSDKSPEWRYIPDEQKQELGLNFDHDGEFWMSYRDFTRYFDRMEICNLSPD 453
           GN+AEW+GPWSD SPEWR+IP+  K+E+GLNFD DGEFWMS++DF  +FDR+EICNLSPD
Sbjct: 501 GNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPD 560

Query: 454 SLSDDEMTRGKISWEMSMFEGEWAVGTTAGGCRNYLDTFWHNPQYVIRLDDPDEDDEEGN 513
           SL++D+    +  WEMSMFEGEW  G TAGGCRN+L+TFWHNPQY+I L+DPD++D++G 
Sbjct: 561 SLTEDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISLEDPDDEDDDGK 620

Query: 514 CTVIIALLQKNRRSRRNMGVECLTIGFAVYRVTERDLAQKPLKMNFFKYNASAARSPAFI 573
           CT I+AL+QKNRRS+RN+G++CLTIGFA+Y +T+RD+  KP  +NFFKY AS ARSP FI
Sbjct: 621 CTAIVALMQKNRRSKRNVGIDCLTIGFAIYHLTDRDMQVKPQGLNFFKYRASVARSPHFI 680

Query: 574 NLREVSCRFKLPPGTYVIVPSTFEPNEEGEFIIRVFSETANSMMENDDNVGVGDLDDRIA 633
           N REV  RFKLPPG Y+IVPSTF+PNEEGEFIIRVFSET N+M ENDD VG G+ DDRIA
Sbjct: 681 NTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNMEENDDEVGFGETDDRIA 740

Query: 634 PDVPGYV---QPSPQRQAMERLFLDVAGADGEVDWVELKRILDHSFRDDNISSEGFSKDV 690
           P +P      +  PQR A+ RLF  VAG+D EVDW ELKRILDHS RD  + S+GFSKD 
Sbjct: 741 PSLPPPTPKEEDDPQRIALRRLFDSVAGSDEEVDWQELKRILDHSMRDVMVGSDGFSKDA 800

Query: 691 CRAMVAMLDVDHTGKLGFEEFQQLLTDIAKWKAVFKLYDTEGSGRLSPFQLREALNSAGY 750
            R+MVAMLD D +G+LGFEEF+ LLTDIAKW+AVFKLYDT  +G +  F LR ALNSAGY
Sbjct: 801 VRSMVAMLDKDRSGRLGFEEFEALLTDIAKWRAVFKLYDTRRTGSIDGFHLRGALNSAGY 860

Query: 751 HLNNRILNALVHRYGSRSGTIPFDDFIMCAVKIKTMIEIFRERDTDGTNQATFSMDEWVE 810
           HLNNR+LNAL HRYGSR G IPFDDF+MCA+K++T IE+FRERDTD ++ A F++D+W+E
Sbjct: 861 HLNNRLLNALAHRYGSREGQIPFDDFLMCAIKVRTFIEMFRERDTDNSDTAFFNLDDWLE 920

Query: 811 KTLYS 815
           +T+YS
Sbjct: 921 RTIYS 925



==> Q11002|CANA_DROME Calpain A (EC 3.4.22.-) (Calcium-activated
           neutral proteinase A) (CANP A) [Contains: Calpain A
           catalytic subunit] - Drosophila melanogaster (Fruit fly)
          Length = 828

 Score =  853 bits (2205), Expect = 0.0
 Identities = 390/558 (69%), Positives = 462/558 (82%), Gaps = 1/558 (0%)

Query: 122 LGDRNAGQRSSFDVQDFYQIRQQCLDNGTLFEDPEFPASASSLMYSKRPDRHYEWLRPHE 181
           LG++++      +VQD+  I   CL +G+LFEDP FPAS  SL +S+RPDRH EWLRPHE
Sbjct: 59  LGEKSSSLGPYSEVQDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRHIEWLRPHE 118

Query: 182 ICDGPEFFVEGFSRFDVQQGELGDCWLLAACANLTQDHKMFLRVVPEDNSFEDGYAGVFH 241
           I + P+FFVEG+SRFDVQQGELGDCWLLAA ANLTQ+  +F RV+P + SFE+ YAG+FH
Sbjct: 119 IAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFH 178

Query: 242 FRFWQYGKWVDVVIDDRLPTYRGQLIYMRSSEQNEFWSALLEKAYAKLHGSYESLRGGTT 301
           FRFWQYGKWVDV+IDDRLPTY G+L+YM S+E+NEFWSALLEKAYAKLHGSYE+L+GG+T
Sbjct: 179 FRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGST 238

Query: 302 CEAMEDFTGGVAEMYDLKDQTPPNLFEIIEKGFKRNSMFGCSIEADPHVLEAETPEGLIR 361
           CEAMEDFTGGV+E YDLK+  P NLF I++K  +RNSM GCSIE DP+V EAETP+GLIR
Sbjct: 239 CEAMEDFTGGVSEWYDLKE-APGNLFTILQKAAERNSMMGCSIEPDPNVTEAETPQGLIR 297

Query: 362 GHAYSITKIQLVDIETPGRSGKIPLIRLRNPWGNEAEWNGPWSDKSPEWRYIPDEQKQEL 421
           GHAYSITK+ L+DI TP R GKIP+IR+RNPWGNEAEWNGPWSD SPEWRYIP+EQK E+
Sbjct: 298 GHAYSITKVCLIDIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEI 357

Query: 422 GLNFDHDGEFWMSYRDFTRYFDRMEICNLSPDSLSDDEMTRGKISWEMSMFEGEWAVGTT 481
           GL FD DGEFWMS++DF  +FDR+EICNLSPDSL++D+   GK  WEMSM+EGEW  G T
Sbjct: 358 GLTFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVT 417

Query: 482 AGGCRNYLDTFWHNPQYVIRLDDPDEDDEEGNCTVIIALLQKNRRSRRNMGVECLTIGFA 541
           AGGCRN+LDTFWHNPQY+I L DPDE+DEEG CTVI+AL+QKNRRS+RNMG+ECLTIGFA
Sbjct: 418 AGGCRNFLDTFWHNPQYIITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMGMECLTIGFA 477

Query: 542 VYRVTERDLAQKPLKMNFFKYNASAARSPAFINLREVSCRFKLPPGTYVIVPSTFEPNEE 601
           +Y + +R+L  +P  +NFF+Y +S  RSP FIN REV  RFKLPPG Y+IVPSTF+PNEE
Sbjct: 478 IYSLNDRELENRPQGLNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEE 537

Query: 602 GEFIIRVFSETANSMMENDDNVGVGDLDDRIAPDVPGYVQPSPQRQAMERLFLDVAGADG 661
           GEFIIRVFSET N+M ENDD+VG G   D I P  P      PQ++ + RLF  +AG D 
Sbjct: 538 GEFIIRVFSETQNNMEENDDHVGYGGKADTITPGFPTPKPIDPQKEGLRRLFDSIAGKDM 597

Query: 662 EVDWVELKRILDHSFRDD 679
           EVDW+ELKRILDHS RDD
Sbjct: 598 EVDWMELKRILDHSMRDD 615



 Score =  209 bits (533), Expect = 3e-053
 Identities = 96/133 (72%), Positives = 116/133 (87%)

Query: 683 SEGFSKDVCRAMVAMLDVDHTGKLGFEEFQQLLTDIAKWKAVFKLYDTEGSGRLSPFQLR 742
           + GFSKDVCR+MVAMLD D +GKLGFEEF+ LL++IAKWKA+FK+YD E +GR+S FQLR
Sbjct: 696 THGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQLR 755

Query: 743 EALNSAGYHLNNRILNALVHRYGSRSGTIPFDDFIMCAVKIKTMIEIFRERDTDGTNQAT 802
           EALNSAGYHLNNR+LN L HRYGSR G I FDDFIMCAVKIKT I+IF+ERDT+    AT
Sbjct: 756 EALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETAT 815

Query: 803 FSMDEWVEKTLYS 815
           F+++EW+E+T+YS
Sbjct: 816 FTLEEWIERTIYS 828



==> O14815|CAN9_HUMAN Calpain-9 (EC 3.4.22.-) (Digestive tract-specific
           calpain) (nCL-4) (CG36 protein) - Homo sapiens (Human)
          Length = 690

 Score =  638 bits (1645), Expect = 0.0
 Identities = 323/681 (47%), Positives = 451/681 (66%), Gaps = 22/681 (3%)

Query: 136 QDFYQIRQQCLDNGTLFEDPEFPASASSLMYSKRPDRHYEWLRPHEICDGPEFFVEGFSR 195
           Q F Q+RQ+CL  GTLFED +FPAS SSL YS+RP   + W RP EI   PEF + G +R
Sbjct: 27  QSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATR 86

Query: 196 FDVQQGELGDCWLLAACANLTQDHKMFLRVVPEDNSFEDGYAGVFHFRFWQYGKWVDVVI 255
            D+ QGELGDCWLLAA A+LT + K   RV+P+D SF  GYAG+FHF+FWQ+ +W+DVVI
Sbjct: 87  TDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVVI 146

Query: 256 DDRLPTYRGQLIYMRSSEQNEFWSALLEKAYAKLHGSYESLRGGTTCEAMEDFTGGVAEM 315
           DDRLPT+R +L+++ S++ NEFWSALLEKAYAKL+GSYE+L+GG+  EAMEDFTGGVAE 
Sbjct: 147 DDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAET 206

Query: 316 YDLKDQTPPNLFEIIEKGFKRNSMFGCSIEA-DPHVLEAETPEGLIRGHAYSITKIQLVD 374
           +  K + P N +EI+EK  KR S+ GC I+       EA TP GLI+GHAYS+T I  V 
Sbjct: 207 FQTK-EAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGIDQVS 265

Query: 375 IETPGRSGKIPLIRLRNPWGNEAEWNGPWSDKSPEWRYI-PDEQKQELGLNFDHDGEFWM 433
                R  +I LIR+RNPWG + EWNG WSD SPEWR + P EQK+      D DGEFWM
Sbjct: 266 F----RGQRIELIRIRNPWG-QVEWNGSWSDSSPEWRSVGPAEQKRLCHTALD-DGEFWM 319

Query: 434 SYRDFTRYFDRMEICNLSPDSLSDDEMTRGKISWEMSMFEGEWAVGTTAGGCRNYLDTFW 493
           +++DF  +FD++EICNL+PD+L +D + +    WE+++ +G W  G+TAGGCRN+LDTFW
Sbjct: 320 AFKDFKAHFDKVEICNLTPDALEEDAIHK----WEVTVHQGSWVRGSTAGGCRNFLDTFW 375

Query: 494 HNPQYVIRLDDPDEDDEEGNCTVIIALLQKNRRSRRNMGVECLTIGFAVYRVTERDLAQK 553
            NPQ  + L + DE  EE  C+ ++AL+QK+RR  +  G   LTIG+A+Y   ++D   +
Sbjct: 376 TNPQIKLSLTEKDEGQEE--CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDKD---E 430

Query: 554 PLKMNFFKYNASAARSPAFINLREVSCRFKLPPGTYVIVPSTFEPNEEGEFIIRVFSETA 613
            L  +FF+Y+AS ARS  FINLREVS RFKLPPG Y+++PSTFEP++E +F +R+FSE  
Sbjct: 431 HLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKK 490

Query: 614 NSMMENDDNVGVGDLDDRIAPDVPGYVQPSPQRQAMERLFLDVAGADGEVDWVELKRILD 673
               + D NV + DL +   P  P   Q + + Q    LF  VAG D EV   EL+ +L+
Sbjct: 491 AITRDMDGNVDI-DLPEPPKPTPPD--QETEEEQRFRALFEQVAGEDMEVTAEELEYVLN 547

Query: 674 HSF-RDDNISSEGFSKDVCRAMVAMLDVDHTGKLGFEEFQQLLTDIAKWKAVFKLYDTEG 732
               +  +I  +  S   C+ +++++D    GKL F+EF+     + +W  +F  +D + 
Sbjct: 548 AVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADK 607

Query: 733 SGRLSPFQLREALNSAGYHLNNRILNALVHRYGSRSGTIPFDDFIMCAVKIKTMIEIFRE 792
           SG +S ++LR AL +AG+ L++ +L  +V RY      + FDDF+ C V+++    +F+ 
Sbjct: 608 SGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQA 667

Query: 793 RDTDGTNQATFSMDEWVEKTL 813
             T        +++E++  T+
Sbjct: 668 LSTKNKEFIHLNINEFIHLTM 688



==> Q9D805|CAN9_MOUSE Calpain-9 (EC 3.4.22.-) (Digestive tract-specific
           calpain) (nCL-4) - Mus musculus (Mouse)
          Length = 690

 Score =  627 bits (1616), Expect = e-179
 Identities = 316/686 (46%), Positives = 446/686 (65%), Gaps = 32/686 (4%)

Query: 136 QDFYQIRQQCLDNGTLFEDPEFPASASSLMYSKRPDRHYEWLRPHEICDGPEFFVEGFSR 195
           Q F Q+RQ CL +GTLFED +FPAS  SL YS+RP   + W RP EI + PEF + G +R
Sbjct: 27  QSFEQLRQGCLQSGTLFEDADFPASNVSLFYSERPQVPFVWKRPGEIVEKPEFILGGATR 86

Query: 196 FDVQQGELGDCWLLAACANLTQDHKMFLRVVPEDNSFEDGYAGVFHFRFWQYGKWVDVVI 255
            D+ QGELGDCWLLAA A+LT + K   RVVP+D  F  GYAG+FHF+FWQ+ +W+DVVI
Sbjct: 87  TDICQGELGDCWLLAAIASLTLNQKALTRVVPQDQGFGSGYAGIFHFQFWQHSEWLDVVI 146

Query: 256 DDRLPTYRGQLIYMRSSEQNEFWSALLEKAYAKLHGSYESLRGGTTCEAMEDFTGGVAEM 315
           DDRLPT++ +L+++ S++ NEFWSALLEKAYAKL+GSYE+L GG+  EAMEDFTGGVAE 
Sbjct: 147 DDRLPTFKDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALEGGSAIEAMEDFTGGVAEN 206

Query: 316 YDLKDQTPPNLFEIIEKGFKRNSMFGCSIEA-DPHVLEAETPEGLIRGHAYSITKIQLVD 374
           + ++ + P + FEI+EK  KR S+ GCSI+  +    EA T  GLI+GHAY++T +  V+
Sbjct: 207 FQIR-EAPEDFFEILEKALKRGSLLGCSIDTLNASESEARTSLGLIKGHAYTVTGLDQVN 265

Query: 375 IETPGRSGKIPLIRLRNPWGNEAEWNGPWSDKSPEWRYIPDEQKQELGLNFDHDGEFWMS 434
                   +I LIR+RNPWG + EWNGPWSD SPEWR +  E+++ LG     DGEFWM+
Sbjct: 266 F----HGQRIKLIRVRNPWG-QVEWNGPWSDSSPEWRSVDLEEQKRLGHTALDDGEFWMA 320

Query: 435 YRDFTRYFDRMEICNLSPDSLSDDEMTRGKISWEMSMFEGEWAVGTTAGGCRNYLDTFWH 494
           ++DF  +FD++EICNL+PD+L D  + R    WE+++ +G W  G+TAGGCRN+LDTFW 
Sbjct: 321 FKDFKIHFDKVEICNLTPDALEDSALHR----WEVTIHQGSWVRGSTAGGCRNFLDTFWT 376

Query: 495 NPQYVIRLDDPDEDDEEGNCTVIIALLQKNRRSRRNMGVECLTIGFAVYRVTERDLAQKP 554
           NPQ  + L + DE  E   CT + AL+QK+RR  +  G   LTIG+A+Y+  ++D     
Sbjct: 377 NPQIKLSLTERDEGQE--GCTFLAALMQKDRRRLKRFGANMLTIGYAIYQCPDKD---GH 431

Query: 555 LKMNFFKYNASAARSPAFINLREVSCRFKLPPGTYVIVPSTFEPNEEGEFIIRVFSETAN 614
           L  +FF+Y+AS ARS  FINLREVS RF+LPPG Y+++PSTFEP++E +F +R+FSE   
Sbjct: 432 LSRDFFRYHASLARSKTFINLREVSERFQLPPGDYILIPSTFEPHQEADFCLRIFSE--- 488

Query: 615 SMMENDDNVGVGDLDDRIAPDVPGYVQPSPQRQAMER------LFLDVAGADGEVDWVEL 668
                       DLD+ I  D+P   +P+PQ +  E       LF  VAG D EV   EL
Sbjct: 489 ------KRAVTRDLDENIDIDLPELPKPTPQEEETEEEQQFRALFQRVAGEDMEVSAEEL 542

Query: 669 KRILDHSFRDDN-ISSEGFSKDVCRAMVAMLDVDHTGKLGFEEFQQLLTDIAKWKAVFKL 727
           + +L+   +    +  +  S   CR +++++D    GKL FEEF+     +  W  +F  
Sbjct: 543 EYVLNAVLQKKTALKFKRLSLLSCRNIISLMDTSGNGKLEFEEFRVFWDKLKHWMDLFLQ 602

Query: 728 YDTEGSGRLSPFQLREALNSAGYHLNNRILNALVHRYGSRSGTIPFDDFIMCAVKIKTMI 787
           +D + SG +S ++LR AL +AG+ L   +L  +V RY      + FDD++ C V+++   
Sbjct: 603 FDVDKSGTMSSYELRTALKAAGFQLGGHLLQLIVLRYADEDLQLDFDDYLNCLVRLENAS 662

Query: 788 EIFRERDTDGTNQATFSMDEWVEKTL 813
            +F+       +    +++E++  T+
Sbjct: 663 RVFQSLSVKNKDFIHLNINEFISLTM 688



==> O35920|CAN9_RAT Calpain-9 (EC 3.4.22.-) (Digestive tract-specific
           calpain) (nCL-4) (Fragment) - Rattus norvegicus (Rat)
          Length = 674

 Score =  626 bits (1614), Expect = e-178
 Identities = 313/686 (45%), Positives = 448/686 (65%), Gaps = 34/686 (4%)

Query: 138 FYQIRQQCLDNGTLFEDPEFPASASSLMYSKRPDRHYEWLRPHEICDGPEFFVEGFSRFD 197
           F Q+RQ CL +GTLFED +FPAS SSL YS+RP   + W RP EI + PEF + G +R D
Sbjct: 11  FEQLRQSCLQSGTLFEDADFPASNSSLFYSERPQVPFVWKRPGEIVENPEFILGGATRTD 70

Query: 198 VQQGELGDCWLLAACANLTQDHKMFLRVVPEDNSFEDGYAGVFHFRFWQYGKWVDVVIDD 257
           + QGELGDCWLLAA A+LT + K   RVVP+D  F  GYAG+FHF+FWQ+ +W+DVVIDD
Sbjct: 71  ICQGELGDCWLLAAIASLTLNQKALARVVPQDQGFGSGYAGIFHFQFWQHSEWLDVVIDD 130

Query: 258 RLPTYRGQLIYMRSSEQNEFWSALLEKAYAKLHGSYESLRGGTTCEAMEDFTGGVAEMYD 317
           RLPT+R +L+++ S++ NEFWSALLEKAYAKL+GSYE+L+GG+  EAMEDFTGGVAE + 
Sbjct: 131 RLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAENFQ 190

Query: 318 LKDQTPPNLFEIIEKGFKRNSMFGCSIEA-DPHVLEAETPEGLIRGHAYSITKIQLVDIE 376
           ++ + P + +EI+EK  +R S+ GCSI+  +    EA TP GLI+GHAY++T +  V+  
Sbjct: 191 IR-EAPEDFYEILEKALRRGSLLGCSIDTLNASESEARTPLGLIKGHAYTVTGLDQVNF- 248

Query: 377 TPGRSGKIPLIRLRNPWGNEAEWNGPWSDKSPEWRYIPDEQKQELGLNFDHDGEFWMSYR 436
                 +I LIR+RNPWG + EWNGPWSD SPEWR +  E+++ LG     DGEFWM++ 
Sbjct: 249 ---HGQRIKLIRVRNPWG-QVEWNGPWSDSSPEWRSVSLEEQKRLGHTALDDGEFWMAFE 304

Query: 437 DFTRYFDRMEICNLSPDSLSDDEMTRGKISWEMSMFEGEWAVGTTAGGCRNYLDTFWHNP 496
           DF  +FD++EICNL+PD+L D+ + +    WE+++ +G W  G+TAGGCRN+LDTFW NP
Sbjct: 305 DFKTHFDKVEICNLTPDALEDNTLHK----WEVTIHQGSWVRGSTAGGCRNFLDTFWTNP 360

Query: 497 QYVIRLDDPDEDDEEGNCTVIIALLQKNRRSRRNMGVECLTIGFAVYRVTERDLAQKPLK 556
           Q  + L + DE  E   CT + AL+QK+RR  +  G   LTIG+A+Y+  ++D     L 
Sbjct: 361 QIKLSLTERDEGQE--GCTFLAALMQKDRRRLKRFGANMLTIGYAIYQCPDKD---GHLN 415

Query: 557 MNFFKYNASAARSPAFINLREVSCRFKLPPGTYVIVPSTFEPNEEGEFIIRVFSETANSM 616
            +FF+Y+AS ARS  FINLREVS RF+LPPG Y+++PSTFEP++E +F +R+FSE     
Sbjct: 416 RDFFRYHASLARSKTFINLREVSGRFQLPPGDYILIPSTFEPHQEADFCLRIFSE----- 470

Query: 617 MENDDNVGVGDLDDRIAPDVPGYVQPSPQRQAMER------LFLDVAGADGEVDWVELKR 670
                     DLD+ I  D+P   +P+PQ +  E       LF  +AG D EV   EL+ 
Sbjct: 471 ----KKAVTQDLDENIDIDLPELPKPTPQEEETEEERQFRALFRRIAGEDMEVSAEELEY 526

Query: 671 ILDHSFRDD---NISSEGFSKDVCRAMVAMLDVDHTGKLGFEEFQQLLTDIAKWKAVFKL 727
           +L+   +            S   CR +++++D    GK+ FEEF+     +  W  +F  
Sbjct: 527 VLNAVLQKKTALKFKRLRLSLLSCRNIISLMDTSGNGKMEFEEFRVFWDKLRYWMDLFLQ 586

Query: 728 YDTEGSGRLSPFQLREALNSAGYHLNNRILNALVHRYGSRSGTIPFDDFIMCAVKIKTMI 787
           +D + SG +S ++LR AL +AG+ L + +L  +V RY   +  + FDD++ C V+++   
Sbjct: 587 FDVDKSGTMSSYELRTALKAAGFQLGSHLLQLIVLRYADENLQLDFDDYLNCLVRLENAS 646

Query: 788 EIFRERDTDGTNQATFSMDEWVEKTL 813
            +F+       +    +++E++  T+
Sbjct: 647 RVFQCLSVKNKDFIHLNINEFINLTM 672



==> P00789|CANX_CHICK Calpain-1 catalytic subunit (EC 3.4.22.52)
           (Calpain-1 large subunit) (Calcium-activated neutral
           proteinase) (CANP) (Mu/M-type) - Gallus gallus (Chicken)
          Length = 705

 Score =  621 bits (1601), Expect = e-177
 Identities = 320/689 (46%), Positives = 441/689 (64%), Gaps = 29/689 (4%)

Query: 136 QDFYQIRQQCLDNGTLFEDPEFPASASSLMYSK-----RPDRHYEWLRPHEICDGPEFFV 190
           QD+  ++Q+C+++GTLF DP+FPA  ++L + +        R  EW RP E+ D P+F V
Sbjct: 33  QDYEALKQECIESGTLFRDPQFPAGPTALGFKELGPYSSKTRGVEWKRPSELVDDPQFIV 92

Query: 191 EGFSRFDVQQGELGDCWLLAACANLTQDHKMFLRVVPEDNSFEDGYAGVFHFRFWQYGKW 250
            G +R D+ QG LGDCWLLAA  +LT + ++  RVVP   SF++ YAG+FHF+ WQ+G+W
Sbjct: 93  GGATRTDICQGALGDCWLLAAIGSLTLNEELLHRVVPHGQSFQEDYAGIFHFQIWQFGEW 152

Query: 251 VDVVIDDRLPTYRGQLIYMRSSEQNEFWSALLEKAYAKLHGSYESLRGGTTCEAMEDFTG 310
           VDVV+DD LPT  G+L+++ S+E  EFWSALLEKAYAKL+G YESL GG+T E  EDFTG
Sbjct: 153 VDVVVDDLLPTKDGELLFVHSAECTEFWSALLEKAYAKLNGCYESLSGGSTTEGFEDFTG 212

Query: 311 GVAEMYDLKDQTPPNLFEIIEKGFKRNSMFGCSIE-ADPHVLEAETPEGLIRGHAYSITK 369
           GVAEMYDLK + P N+  II K  +R S+ GCSI+      +EA T + L++GHAYS+T 
Sbjct: 213 GVAEMYDLK-RAPRNMGHIIRKALERGSLLGCSIDITSAFDMEAVTFKKLVKGHAYSVTA 271

Query: 370 IQLVDIETPGRSGKIPLIRLRNPWGNEAEWNGPWSDKSPEWRYIPDEQKQELGLNFDHDG 429
            + V+     R  +  LIR+RNPWG + EW G WSD S EW  I    ++EL L  + DG
Sbjct: 272 FKDVNY----RGQQEQLIRIRNPWG-QVEWTGAWSDGSSEWDNIDPSDREELQLKME-DG 325

Query: 430 EFWMSYRDFTRYFDRMEICNLSPDSLSDDEMTRGKISWEMSMFEGEWAVGTTAGGCRNYL 489
           EFWMS+RDF R F R+EICNL+PD+L+ DE++R    W   +FEG W  G+TAGGCRN  
Sbjct: 326 EFWMSFRDFMREFSRLEICNLTPDALTKDELSR----WHTQVFEGTWRRGSTAGGCRNNP 381

Query: 490 DTFWHNPQYVIRL--DDPDEDDEEGNCTVIIALLQKNRRSRRNMGVECLTIGFAVYRVTE 547
            TFW NPQ+ I+L  +D D  D+E  C+ ++AL+QK+RR  R +G +  TIGFAVY V E
Sbjct: 382 ATFWINPQFKIKLLEEDDDPGDDEVACSFLVALMQKHRRRERRVGGDMHTIGFAVYEVPE 441

Query: 548 RDLAQK--PLKMNFFKYNASAARSPAFINLREVSCRFKLPPGTYVIVPSTFEPNEEGEFI 605
                +   LK +FF  N S ARS  FINLREVS + +LPPG Y++VPSTFEP++E +FI
Sbjct: 442 EAQGSQNVHLKKDFFLRNQSRARSETFINLREVSNQIRLPPGEYIVVPSTFEPHKEADFI 501

Query: 606 IRVFSETANSMMENDDNVGVGDLDDRIAPDVPGYVQPSPQRQAMERLFLDVAGADGEVDW 665
           +RVF+E  +   E D+ +     D+         +         + +F  +AG D E+  
Sbjct: 502 LRVFTEKQSDTAELDEEISADLADEE-------EITEDDIEDGFKNMFQQLAGEDMEISV 554

Query: 666 VELKRILDHSF-RDDNISSEGFSKDVCRAMVAMLDVDHTGKLGFEEFQQLLTDIAKWKAV 724
            ELK IL+    R  ++ ++GFS D CR MV ++D D + +LG  EFQ L   I  W  +
Sbjct: 555 FELKTILNRVIARHKDLKTDGFSLDSCRNMVNLMDKDGSARLGLVEFQILWNKIRSWLTI 614

Query: 725 FKLYDTEGSGRLSPFQLREALNSAGYHLNNRILNALVHRYGSRSGTIPFDDFIMCAVKIK 784
           F+ YD + SG +S +++R AL SAG+ LNN++   +V RY      + FD+F+ C VK++
Sbjct: 615 FRQYDLDKSGTMSSYEMRMALESAGFKLNNKLHQVVVARYADAETGVDFDNFVCCLVKLE 674

Query: 785 TMIEIFRERDTDGTNQATFSMDEWVEKTL 813
           TM   F   D DGT  A  ++ EW+  T+
Sbjct: 675 TMFRFFHSMDRDGTGTAVMNLAEWLLLTM 703



==> Q9GLG1|CAN2_MACFA Calpain-2 catalytic subunit precursor (EC
           3.4.22.53) (Calpain-2 large subunit) (Calcium-activated
           neutral proteinase 2) (CANP 2) (Calpain M-type)
           (M-calpain) (Millimolar-calpain) - Macaca fascicularis
           (Crab eating macaque) (Cynomolgus monkey)
          Length = 700

 Score =  614 bits (1583), Expect = e-175
 Identities = 312/685 (45%), Positives = 444/685 (64%), Gaps = 30/685 (4%)

Query: 136 QDFYQIRQQCLDNGTLFEDPEFPASASSLMYSK-----RPDRHYEWLRPHEICDGPEFFV 190
           QD+  +R +CL+ GTLF+DP FPA  S+L + +        R  EW RP EIC  P+F +
Sbjct: 30  QDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFII 89

Query: 191 EGFSRFDVQQGELGDCWLLAACANLTQDHKMFLRVVPEDNSFEDGYAGVFHFRFWQYGKW 250
            G +R D+ QG LGDCWLLAA A+LT + ++  RVVP + SF++ YAG+FHF+FWQYG+W
Sbjct: 90  GGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEW 149

Query: 251 VDVVIDDRLPTYRGQLIYMRSSEQNEFWSALLEKAYAKLHGSYESLRGGTTCEAMEDFTG 310
           V+VV+DDRLPT  G+L+++ S+E +EFWSALLEKAYAK++G YE+L GG T E  EDFTG
Sbjct: 150 VEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTG 209

Query: 311 GVAEMYDLKDQTPPNLFEIIEKGFKRNSMFGCSIEADPHV-LEAETPEGLIRGHAYSITK 369
           G+AE Y+LK + PPNLF+II+K  ++ S+ GCSI+       EA T + L++GHAYS+T 
Sbjct: 210 GIAEWYELK-KPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITYQKLVKGHAYSVTG 268

Query: 370 IQLVDIETPGRSGKIPLIRLRNPWGNEAEWNGPWSDKSPEWRYIPDEQKQELGLNFDHDG 429
            +  ++E+ G   K  LIR+RNPWG E EW G W+D  P W  I  E+++ L    + DG
Sbjct: 269 AE--EVESSGSLQK--LIRIRNPWG-EVEWTGRWNDNCPSWNTIDPEERERLTRRHE-DG 322

Query: 430 EFWMSYRDFTRYFDRMEICNLSPDSLSDDEMTRGKISWEMSMFEGEWAVGTTAGGCRNYL 489
           EFWMS+ DF R++ R+EICNL+PD+L+ D   +    W+++  +G W  G+TAGGCRNY 
Sbjct: 323 EFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKK----WKLTKMDGNWRRGSTAGGCRNYP 378

Query: 490 DTFWHNPQYVIRLDDPDEDDEEG--NCTVIIALLQKNRRSRRNMGVECLTIGFAVYRVTE 547
           +TFW NPQY+I+L++ DED+E+G   CT ++ L+QK+RR +R MG +  TIGF +Y V E
Sbjct: 379 NTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPE 438

Query: 548 RDLAQK--PLKMNFFKYNASAARSPAFINLREVSCRFKLPPGTYVIVPSTFEPNEEGEFI 605
               Q    L  NFF  N +  RS  FINLREV  RFKLPPG Y++VPSTFEPN++G+F 
Sbjct: 439 ELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFC 498

Query: 606 IRVFSETANSMMENDDNVGVGDLDDRIAPDVPGYVQPSPQRQAMERLFLDVAGADGEVDW 665
           IRVFSE        DD +     +  I+ D               RLF  +AG D E+  
Sbjct: 499 IRVFSEKKADYQAVDDEIEANLEEFDISED--------DIDDGFRRLFAQLAGEDAEISA 550

Query: 666 VELKRILDHSF-RDDNISSEGFSKDVCRAMVAMLDVDHTGKLGFEEFQQLLTDIAKWKAV 724
            EL+ IL     +  +I S+GFS + C+ MV MLD D +GKLG +EF  L T I K++ +
Sbjct: 551 FELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKI 610

Query: 725 FKLYDTEGSGRLSPFQLREALNSAGYHLNNRILNALVHRYGSRSGTIPFDDFIMCAVKIK 784
           ++  D + SG ++ +++R+AL  AG+ +  ++   +V R+      I FD+F+ C V+++
Sbjct: 611 YREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLE 670

Query: 785 TMIEIFRERDTDGTNQATFSMDEWV 809
           T+ +IF++ D + T      +  W+
Sbjct: 671 TLFKIFKQLDPENTGTIELDLISWL 695



==> P17655|CAN2_HUMAN Calpain-2 catalytic subunit precursor (EC
           3.4.22.53) (Calpain-2 large subunit) (Calcium-activated
           neutral proteinase 2) (CANP 2) (Calpain M-type)
           (M-calpain) (Millimolar-calpain) (Calpain large
           polypeptide L2) - Homo sapiens (Human)
          Length = 700

 Score =  613 bits (1581), Expect = e-175
 Identities = 312/685 (45%), Positives = 444/685 (64%), Gaps = 30/685 (4%)

Query: 136 QDFYQIRQQCLDNGTLFEDPEFPASASSLMYSK-----RPDRHYEWLRPHEICDGPEFFV 190
           QD+  +R +CL+ GTLF+DP FPA  S+L + +        R  EW RP EIC  P+F +
Sbjct: 30  QDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFII 89

Query: 191 EGFSRFDVQQGELGDCWLLAACANLTQDHKMFLRVVPEDNSFEDGYAGVFHFRFWQYGKW 250
            G +R D+ QG LGDCWLLAA A+LT + ++  RVVP + SF++ YAG+FHF+FWQYG+W
Sbjct: 90  GGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEW 149

Query: 251 VDVVIDDRLPTYRGQLIYMRSSEQNEFWSALLEKAYAKLHGSYESLRGGTTCEAMEDFTG 310
           V+VV+DDRLPT  G+L+++ S+E +EFWSALLEKAYAK++G YE+L GG T E  EDFTG
Sbjct: 150 VEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTG 209

Query: 311 GVAEMYDLKDQTPPNLFEIIEKGFKRNSMFGCSIEADPHV-LEAETPEGLIRGHAYSITK 369
           G+AE Y+LK + PPNLF+II+K  ++ S+ GCSI+       EA T + L++GHAYS+T 
Sbjct: 210 GIAEWYELK-KPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLVKGHAYSVTG 268

Query: 370 IQLVDIETPGRSGKIPLIRLRNPWGNEAEWNGPWSDKSPEWRYIPDEQKQELGLNFDHDG 429
            +  ++E+ G   K  LIR+RNPWG E EW G W+D  P W  I  E+++ L    + DG
Sbjct: 269 AE--EVESNGSLQK--LIRIRNPWG-EVEWTGRWNDNCPSWNTIDPEERERLTRRHE-DG 322

Query: 430 EFWMSYRDFTRYFDRMEICNLSPDSLSDDEMTRGKISWEMSMFEGEWAVGTTAGGCRNYL 489
           EFWMS+ DF R++ R+EICNL+PD+L+ D   +    W+++  +G W  G+TAGGCRNY 
Sbjct: 323 EFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKK----WKLTKMDGNWRRGSTAGGCRNYP 378

Query: 490 DTFWHNPQYVIRLDDPDEDDEEG--NCTVIIALLQKNRRSRRNMGVECLTIGFAVYRVTE 547
           +TFW NPQY+I+L++ DED+E+G   CT ++ L+QK+RR +R MG +  TIGF +Y V E
Sbjct: 379 NTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPE 438

Query: 548 RDLAQK--PLKMNFFKYNASAARSPAFINLREVSCRFKLPPGTYVIVPSTFEPNEEGEFI 605
               Q    L  NFF  N +  RS  FINLREV  RFKLPPG Y++VPSTFEPN++G+F 
Sbjct: 439 ELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFC 498

Query: 606 IRVFSETANSMMENDDNVGVGDLDDRIAPDVPGYVQPSPQRQAMERLFLDVAGADGEVDW 665
           IRVFSE        DD +     +  I+ D               RLF  +AG D E+  
Sbjct: 499 IRVFSEKKADYQAVDDEIEANLEEFDISED--------DIDDGFRRLFAQLAGEDAEISA 550

Query: 666 VELKRILDHSF-RDDNISSEGFSKDVCRAMVAMLDVDHTGKLGFEEFQQLLTDIAKWKAV 724
            EL+ IL     +  +I S+GFS + C+ MV MLD D +GKLG +EF  L T I K++ +
Sbjct: 551 FELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKI 610

Query: 725 FKLYDTEGSGRLSPFQLREALNSAGYHLNNRILNALVHRYGSRSGTIPFDDFIMCAVKIK 784
           ++  D + SG ++ +++R+AL  AG+ +  ++   +V R+      I FD+F+ C V+++
Sbjct: 611 YREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLE 670

Query: 785 TMIEIFRERDTDGTNQATFSMDEWV 809
           T+ +IF++ D + T      +  W+
Sbjct: 671 TLFKIFKQLDPENTGTIELDLISWL 695



==> Q92178|CAN2_CHICK Calpain-2 catalytic subunit precursor (EC
           3.4.22.53) (Calpain-2 large subunit) (Calcium-activated
           neutral proteinase 2) (CANP 2) (Calpain M-type)
           (M-calpain) (Millimolar-calpain) - Gallus gallus
           (Chicken)
          Length = 700

 Score =  612 bits (1579), Expect = e-174
 Identities = 316/707 (44%), Positives = 448/707 (63%), Gaps = 30/707 (4%)

Query: 114 IAEGMFSPLGDRNAGQRSSFDVQDFYQIRQQCLDNGTLFEDPEFPASASSLMYSKRPDRH 173
           +A+   +  G    GQ   +  QDF  +R++CL  G LF DP FPA  ++L Y +     
Sbjct: 8   LAKERAAAAGAGRHGQAVPYLGQDFGALRRECLQGGRLFHDPSFPAGPAALGYRELGPNS 67

Query: 174 YE-----WLRPHEICDGPEFFVEGFSRFDVQQGELGDCWLLAACANLTQDHKMFLRVVPE 228
           Y+     W RP E+C  P F   G +R D+ QG LGDCWLLAA A+LT + ++  RVVP 
Sbjct: 68  YKTKGVVWCRPTELCSCPRFIAGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPR 127

Query: 229 DNSFEDGYAGVFHFRFWQYGKWVDVVIDDRLPTYRGQLIYMRSSEQNEFWSALLEKAYAK 288
           D SF+D YAG+FHF+FWQYG+WVDVV+DDRLPT  G+L+++ S+E +EFWSALLEKAYAK
Sbjct: 128 DQSFQDEYAGIFHFQFWQYGEWVDVVVDDRLPTKNGELLFVHSAEGSEFWSALLEKAYAK 187

Query: 289 LHGSYESLRGGTTCEAMEDFTGGVAEMYDLKDQTPPNLFEIIEKGFKRNSMFGCSIE-AD 347
           L+GSYE+L GGTT E  EDFTGG+AE Y+L+ + PPNLF+II+K  ++ S+ GCSI+   
Sbjct: 188 LNGSYEALSGGTTTEGFEDFTGGIAEWYELQ-KAPPNLFKIIQKALQKGSLLGCSIDITS 246

Query: 348 PHVLEAETPEGLIRGHAYSITKIQLVDIETPGRSGKIPLIRLRNPWGNEAEWNGPWSDKS 407
               EA T + L++GHAYS+T  + V+     R     LIR+RNPWG E EW G W+D  
Sbjct: 247 AAETEAVTSQKLVKGHAYSVTGAEEVNF----RGSIQKLIRIRNPWG-EVEWTGKWNDNC 301

Query: 408 PEWRYIPDEQKQELGLNFDHDGEFWMSYRDFTRYFDRMEICNLSPDSLSDDEMTRGKISW 467
           P W  +  E ++ L    + DGEFWM++ DF R++ R+EICNL+PD+L+ D   +    W
Sbjct: 302 PNWSGVDPEVRERLTRRHE-DGEFWMAFNDFLRHYSRLEICNLTPDTLASDRYKK----W 356

Query: 468 EMSMFEGEWAVGTTAGGCRNYLDTFWHNPQYVIRLDDPDE--DDEEGNCTVIIALLQKNR 525
            +   +G W  G TAGGCRNY +TFW NPQY+I+L++ DE  DD EG CT +I L+QK+R
Sbjct: 357 SLLKLDGNWRRGATAGGCRNYPNTFWTNPQYLIKLEEEDEDPDDPEGGCTFLIGLIQKHR 416

Query: 526 RSRRNMGVECLTIGFAVYRVTERDLAQK--PLKMNFFKYNASAARSPAFINLREVSCRFK 583
           R +R MG +  TIGFA+Y V      Q    L  NFF  N +  +S  FINLREV  RFK
Sbjct: 417 RKQRKMGEDMHTIGFAIYEVPPEFSGQTNIHLSKNFFLTNKAREKSNTFINLREVLNRFK 476

Query: 584 LPPGTYVIVPSTFEPNEEGEFIIRVFSETANSMMENDDNVGVGDLDDRIAPDVPGYVQPS 643
           LP G Y+IVPSTFEPN  G+F +RVFSE   +    DD +     +  I  D    ++PS
Sbjct: 477 LPAGEYIIVPSTFEPNLNGDFCLRVFSEKNANSTVIDDEIEANFEETEIDED---DIEPS 533

Query: 644 PQRQAMERLFLDVAGADGEVDWVELKRILDHSF-RDDNISSEGFSKDVCRAMVAMLDVDH 702
                 ++LF  +AG+D E+   EL+ IL+    +  +I S+GFS + C+ MV +LD D 
Sbjct: 534 -----FKKLFGQLAGSDAEISAFELRSILNKILAKRQDIKSDGFSIETCKIMVDLLDNDG 588

Query: 703 TGKLGFEEFQQLLTDIAKWKAVFKLYDTEGSGRLSPFQLREALNSAGYHLNNRILNALVH 762
           +GKLG +EF  L T I K++ +++  D + SG ++ +++R AL +AG+ L+ ++   +V 
Sbjct: 589 SGKLGLKEFHTLWTKIQKYQKIYREIDVDRSGTMNSYEMRRALEAAGFKLSCQLHQIIVA 648

Query: 763 RYGSRSGTIPFDDFIMCAVKIKTMIEIFRERDTDGTNQATFSMDEWV 809
           R+      I FD+ + C ++++T+ ++FR+ DT+ T     ++  W+
Sbjct: 649 RFADEDLIIDFDNCVRCLIRLETLYKMFRKLDTEKTGTIELNLINWL 695



==> O08529|CAN2_MOUSE Calpain-2 catalytic subunit precursor (EC
           3.4.22.53) (Calpain-2 large subunit) (Calcium-activated
           neutral proteinase 2) (CANP 2) (Calpain M-type)
           (M-calpain) (Millimolar-calpain) (80 kDa M-calpain
           subunit) (CALP80) - Mus musculus (Mouse)
          Length = 700

 Score =  610 bits (1573), Expect = e-174
 Identities = 310/687 (45%), Positives = 444/687 (64%), Gaps = 34/687 (4%)

Query: 136 QDFYQIRQQCLDNGTLFEDPEFPASASSLMYSK-----RPDRHYEWLRPHEICDGPEFFV 190
           QD+  +R +CL+ G LF+DP FPA  SSL Y +        R  EW RP EIC  P+F +
Sbjct: 30  QDYETLRNECLEAGALFQDPSFPALPSSLGYKELGPYSSKTRGIEWKRPTEICADPQFII 89

Query: 191 EGFSRFDVQQGELGDCWLLAACANLTQDHKMFLRVVPEDNSFEDGYAGVFHFRFWQYGKW 250
            G +R D+ QG LGDCWLLAA A+LT + ++  RVVP D SF++ YAG+FHF+FWQYG+W
Sbjct: 90  GGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPPDQSFQENYAGIFHFQFWQYGEW 149

Query: 251 VDVVIDDRLPTYRGQLIYMRSSEQNEFWSALLEKAYAKLHGSYESLRGGTTCEAMEDFTG 310
           V+VV+DDRLPT  G+L+++ S+E +EFWSALLEKAYAK++G YE+L GG T E  EDFTG
Sbjct: 150 VEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTG 209

Query: 311 GVAEMYDLKDQTPPNLFEIIEKGFKRNSMFGCSIEADPHV-LEAETPEGLIRGHAYSITK 369
           G+AE Y+L+ + PPNLF+II+K  ++ S+ GCSI+       EA T + L++GHAYS+T 
Sbjct: 210 GIAEWYELR-KPPPNLFKIIQKALEKGSLLGCSIDITSAADSEAVTYQKLVKGHAYSVTG 268

Query: 370 IQLVDIETPGRSGKIPLIRLRNPWGNEAEWNGPWSDKSPEWRYIPDEQKQELGLNFDHDG 429
            +  ++E+ G   K  LIR+RNPWG + EW G W+D  P W  +  E +  L      DG
Sbjct: 269 AE--EVESSGSLQK--LIRIRNPWG-QVEWTGKWNDNCPSWNTVDPEVRANL-TERQEDG 322

Query: 430 EFWMSYRDFTRYFDRMEICNLSPDSLSDDEMTRGKISWEMSMFEGEWAVGTTAGGCRNYL 489
           EFWMS+ DF R++ R+EICNL+PD+L+ D   +    W+++  +G W  G+TAGGCRNY 
Sbjct: 323 EFWMSFSDFLRHYSRLEICNLTPDTLTCDSYKK----WKLTKMDGNWRRGSTAGGCRNYP 378

Query: 490 DTFWHNPQYVIRLDDPDEDDEEG--NCTVIIALLQKNRRSRRNMGVECLTIGFAVYRVTE 547
           +TFW NPQY+I+L++ DED+E+G   CT ++ L+QK+RR +R MG +  TIGF +Y V E
Sbjct: 379 NTFWMNPQYLIKLEEEDEDEEDGERGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPE 438

Query: 548 RDLAQKPLKM--NFFKYNASAARSPAFINLREVSCRFKLPPGTYVIVPSTFEPNEEGEFI 605
               Q  + +  NFF    +  RS  FINLREV  RFKLPPG YV+VPSTFEP+++G+F 
Sbjct: 439 ELTGQTNIHLGKNFFLTTRARERSDTFINLREVLNRFKLPPGEYVLVPSTFEPHKDGDFC 498

Query: 606 IRVFSETANSMMENDDNV--GVGDLDDRIAPDVPGYVQPSPQRQAMERLFLDVAGADGEV 663
           IRVFSE        DD +   + ++D        G+           RLF+ +AG D E+
Sbjct: 499 IRVFSEKKADYQAVDDEIEANIEEIDANEEDIDDGF----------RRLFVQLAGEDAEI 548

Query: 664 DWVELKRILDHSF-RDDNISSEGFSKDVCRAMVAMLDVDHTGKLGFEEFQQLLTDIAKWK 722
              EL+ IL     +  +I S+GFS + C+ MV MLD D +GKLG +EF  L T I K++
Sbjct: 549 SAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDEDGSGKLGLKEFYILWTKIQKYQ 608

Query: 723 AVFKLYDTEGSGRLSPFQLREALNSAGYHLNNRILNALVHRYGSRSGTIPFDDFIMCAVK 782
            +++  D + SG ++ +++R+AL  AG+ L  ++   +V R+      I FD+F+ C V+
Sbjct: 609 KIYREIDVDRSGTMNSYEMRKALEEAGFKLPCQLHQVIVARFADDELIIDFDNFVRCLVR 668

Query: 783 IKTMIEIFRERDTDGTNQATFSMDEWV 809
           ++T+ +IF++ D + T     ++  W+
Sbjct: 669 LETLFKIFKQLDPENTGTIQLNLASWL 695