E-mail: bardwell@uci.edu
Lab Home Page: Bardwell Lab
Abbreviated CV: Lee's CV
PubMed
search for "Bardwell L"
Note: The papers about “collective gardening” are a different L Bardwell
Listed in reverse-chronological order. Numbered in chronological order
* = These are "co-first author" papers
+ =
These are "co-corresponding author" papers
53. Bernardo,
AS, Faial, T, Gardner, L, Niakan, KK, Ortmann, D, Senner, CE, Callery, EM, Trotter,
MW, Hemberger, M, Smith, JC, Bardwell, L,
Moffett, A, Pedersen, RA (2011)
BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse
pluripotent stem cells into embryonic and extraembryonic lineages.
Cell Stem Cell, 9:144-55. Abstract
52. Hetherington AM, and Bardwell,
L (2011)
Plant signalling pathways: a comparative evolutionary overview.
Current Biology, 21:R317-9. Link
51. Bardwell,
L (2011)
Synthetic Biology: Modulating the MAP kinase module. (Review - Dispatch.)
Current Biology, 21:R249-51. Abstract
50. Compani
B, Su T, Chang I, Cheng J, Shah KH, Whisenant T, Dou Y, Bergmann A, Cheong R,
Wold B, Bardwell L, Levchenko A, Baldi
P, Mjolsness E (2010)
A Scalable and Integrative System for Pathway Bioinformatics and Systems
Biology
Adv Exp Med Biol. 680:523-534 Abstract
49. TC
Whisenant, DT Ho, RW Benz, JS Rogers, RM Kaake, EA Gordon, L Huang, P Baldi, L
Bardwell (2010)
Computational Prediction and Experimental Verification of New MAP Kinase
Docking Sites and Substrates Including Gli Transcription Factors.
PLoS Computational Biology 6:e10009084 Abstract Download
from PLoS
48. S
Haney, L Bardwell and Q Nie (2010)
Ultrasensitive responses and specificity in cell signaling.
BMC Systems Biology 4: 119. Abstract Download from BMC
47. X
Liu, L Bardwell+ and Q Nie+ (2010)
A combination of multisite phosphorylation and substrate sequestration produces
switch-like responses.
Biophysical Journal 98: 1396-407. Abstract
46. Bardwell, AJ, Frankson, E, and Bardwell, L (2009)
Selectivity of docking sites in MAPK kinases.
Journal of Biological Chemistry
284:13165-73. Abstract
45. *Hilioti, Z, *Sabbagh, W Jr., Paliwal, S, Bergmann, A,
Goncalves, M, +Bardwell, L and +Levchenko,
A (2008)
Oscillatory phosphorylation of yeast Fus3 MAP kinase
controls periodic gene expression and morphogenesis.
Current Biology, 18:1700-06. Abstract
44. Bardwell, L (2008)
Signal transduction: Turning a switch into a rheostat. (Review - Dispatch.)
Current Biology, 18:R910-12. Abstract
43. +Bardwell, L, Zou, X, Nie, Q and +Komarova, NL (2007)
Mathematical models of specificity in cell signaling.
Biophysical Journal, 92:3425-41. Abstract
42. Bardwell, L and Shah, K (2006)
Analysis of mitogen-activated protein kinase activation and interactions with
regulators and substrates.
Methods, 40:213-223. Abstract
41. Bardwell, L (2006)
Mechanisms of MAP kinase signaling specificity. (Review.)
Biochemical Society Transactions,
34:837-41. Abstract
40. Bardwell, L (2006)
G-protein signaling: A new branch in old pathway. (Review - Dispatch.)
Current Biology16:R853-55. Abstract
39. DT Ho, AJ
Bardwell, S Grewal, C Iverson and L Bardwell (2006)
Interacting JNK-docking sites in
MKK7 promote binding and activation of JNK mitogen-activated protein kinases.
Journal of Biological Chemistry 281:13169-79. Abstract
38. S Grewal,
DM Molina and L Bardwell (2006)
Mitogen-activated protein kinase
(MAPK)-docking sites in MAPK kinases function as tethers that are crucial for
MAPK regulation in vivo.
Cellular Signalling 18:123-134.
Abstract
37. DM Molina,
S Grewal and L Bardwell (2005)
Characterization of an ERK-binding
domain in MITF and differential inhibition of ERK2-mediated substrate
phosphorylation.
Journal of Biological Chemistry 280:42051-60. Abstract
36. +NL Komarova,
X Zou, Q Nie and +L Bardwell (2005)
A theoretical framework for
specificity in cell signaling.
Molecular Systems Biology doi:10.1038/msb4100031, E1-E5. Online/pdf
35. LJ
Flatauer, S Zadeh and L Bardwell (2005)
MAP Kinases With Distinct Requirements for Ste5 Scaffolding Influence Signaling
Specificity in Yeast
Molecular and Cellular Biology 25:1793-1803. Abstract
-- Get pdf
34. L
Bardwell (2005)
A walk-through of the yeast mating pheromone response pathway
Peptides 26:339-350.
Abstract
-- PDF
33. PJ Cullen,
W Sabbagh, M Irick, E Graham, E van Olden, C Neal, J Delrow, L Bardwell and GF Sprague, Jr. (2004)
Msb2 is a Signaling Mucin at the Head of the Yeast Filamentous Growth MAPK Pathway
Genes & Development 18:1695-708. Abstract
32. AB Kusari*,
DM Molina*, W Sabbagh Jr., C Lau and L Bardwell (2004)
A conserved protein interaction network involving the yeast MAP kinases Fus3
and Kss1
Journal of Cell Biology 164: 267-277. Abstract
-- Get pdf
31. AJ
Bardwell, M Abdollahi and L Bardwell
(2004)
Anthrax lethal factor-cleavage products of mitogen-activated protein kinase
(MAPK) kinases exhibit reduced binding to their cognate MAPKs
Biochemical Journal 378:569-77. Abstract
30. DT Ho, AJ
Bardwell, M Abdollahi and L Bardwell
(2003)
A docking site in MKK4 mediates high-affinity binding to JNK MAP kinases and
competes with similar docking sites in JNK substrates
Journal of Biological Chemistry 278:32662-72. Abstract
29. AJ
Bardwell, M Abdollahi and L Bardwell
(2003)
Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK
phosphatases and the Elk-1 transcription factor compete for MAPK binding and
are crucial for enzymic activity
Biochemical Journal 370:1077-1085. Abstract
28. W Sabbagh
Jr, LJ Flatauer, AJ Bardwell and L Bardwell (2001)
Specificity of MAPK signaling in yeast differentiation involves transient vs.
sustained MAPK activation.
Molecular Cell 8:683-691. Abstract
27. AJ
Bardwell, LJ Flatauer, K Matsukuma, J Thorner and L Bardwell (2001)
A conserved docking site in MEKs mediates high-affinity binding to MAP kinases
and cooperates with a scaffold protein to enhance signal transmission.
Journal of Biological Chemistry 276:10374-10386. Abstract
26. Bardwell,
L., Cook, J.G., Zhu-Shimoni, J.X., Voora, D.,
and Thorner, J. (1998) Differential regulation of transcription: Repression by
unactivated MAP kinase Kss1 requires the Dig1 and Dig2 proteins.
Proceedings National Academy of Sciences USA 95:15400-15405. Abstract
25. Bardwell,
L., Cook, J.G., Voora, D., Baggott, D.M.,
Martinez, A.R., and Thorner, J. (1998)
Repression of the yeast Ste12 transcription factor by direct binding of
unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK.
Genes & Development 12:2887-98. Abstract
24. Cook, J.G.,
Bardwell, L. *, and Thorner, J. (1997)
Inhibitory and activating functions for MAPK Kss1 in the S. cerevisiae
filamentous-growth signaling pathway.
Nature
390:85-89. Abstract
23. Cook, J.G.,
Bardwell, L., Kron, S.J. and Thorner,
J. (1996)
Two novel targets of the MAP kinase Kss1 are negative regulators of invasive
growth in the yeast Saccharomyces cerevisiae.
Genes & Development 10:2831-2848. Abstract
22. Bardwell,
L. and Thorner, J. (1996)
A conserved motif at the amino termini of MEKs might mediate high-affinity
interaction with the cognate MAPKs.
Trends in Biochemical Sciences 21:373-374.
21. Bardwell,
L., Cook, J.G., Chang, E.C., Cairns, B.R.
and Thorner, J. (1996)
Signaling in the yeast pheromone response pathway: specific and high-affinity
interaction of the MAP kinases (Kss1 and Fus3) with the upstream MAP kinase
kinase (Ste7).
Molecular and Cellular Biology 16:3637-3650. Abstract
20. Friedberg,
E.C., Bardwell, A.J., Bardwell, L.,
Feaver. W.J., Kornberg, R.D., Svejstrup, J.Q., Tomkinson, A.E. and Wang, Z.
(1995) Nucleotide excision repair in the yeast Saccharomyces cerevisiae:
its relationship to specialized mitotic recombination and RNA polymerase II
basal transcription. Phil. Trans. R. Soc. London B 347:63-68. Also in Lindahl, T.
and West, S.C. (Eds.), DNA Repair and Recombination. Chapman & Hall,
London.
19. Bardwell,
L., Cook, J.G., Inouye, C.J. and Thorner,
J. (1994)
Signal propagation and regulation in the mating pheromone response pathway of
the yeast Saccharomyces cerevisiae.
Developmental Biology 166:363-379. Abstract
18. Bardwell,
A.J., Bardwell, L.*, Tomkinson, A.E.
and Friedberg, E.C. (1994) Specific cleavage of model recombination and repair
intermediates by the yeast Rad1/Rad10 DNA endonuclease. Science 265:2082-2085. Abstract
17. Bardwell
A.J., Bardwell L., Wang Z., Siede W.,
Reagan M.S., Tomkinson A.E., Friedberg A.S., Pittenger C., Feaver W.J.,
Svejstrup J., et al. (1994) Recent insights on DNA repair. The mechanism of
damaged nucleotide excision in eukaryotes and its relationship to other
cellular processes. Annals N.Y. Academy of Science 726:281-91.
16. Bardwell,
A.J., Bardwell, L.*, Iyer, N.,
Svejstrup, J.Q., Feaver, W.J., Kornberg, R.D. and Friedberg, E.C. (1994) Yeast
nucleotide excision repair proteins Rad2 and Rad4 interact with RNA polymerase
II transcription factor b (TFIIH). Molecular and Cellular Biology 14:3569-3576. Abstract
15. Bardwell,
L.*, Bardwell, A.J., Feaver, W.J.,
Svejstrup, J.Q., Kornberg, R.D. and Friedberg, E.C. (1994) Yeast RAD3 protein
binds directly to both SSL2 and SSL1 proteins: implications for the structure
and function of transcription/ repair factor b. Proc. Natl. Acad.
Sci. USA 91:3926-3930.
Abstract
14. Friedberg,
E.C., Bardwell, A.J., Bardwell, L.,
Wang, Z. and Dianov, G. (1994) Transcription and nucleotide excision repair-
reflections, considerations and recent biochemical insights. Mutation
Research 307:5-14. Abstract
13. Feaver,
W.J., Svejstrup, J.Q., Bardwell, L.,
Bardwell, A.J., Buratowski, S., Gulyas, K.D., Donahue, T.F., Friedberg, E.C.
and Kornberg, R.D. (1993) Dual roles of a multi-protein complex from S.
cerevisiae in transcription and DNA repair. Cell 75:1379-1387. Abstract
12. Bardwell,
A.J., Bardwell, L.*, Johnson, D.K. and
Friedberg, E.C. (1993) Yeast DNA recombination and repair proteins Rad1 and
Rad10 constitute a complex in vivo mediated by localized
hydrophobic domains. Molecular Microbiology 8:1177-1188. Abstract
11. Tomkinson,
A.E., Bardwell, A.J., Bardwell, L.,
Tappe, N.J. and Friedberg, E.C. (1993) Yeast DNA repair and recombination
proteins Rad1 and Rad10 constitute a single-stranded DNA endonuclease. Nature 362:860-862. Abstract
10. Naegeli, H.,
Bardwell, L. and Friedberg, E.C. (1993)
Inhibition of Rad3 DNA helicase activity by DNA adducts and abasic sites:
Implications for the role of a DNA helicase in damage-specific incision of DNA.
Biochemistry 32:613-621. Abstract
9. Bardwell,
L., Cooper, A.J. and Friedberg, E.C.
(1992) Stable and specific association between the yeast recombination and DNA
repair proteins RAD1 and RAD10 in vitro. Molecular and Cellular
Biology
12:3041-3049. Abstract
8. Friedberg,
E.C., Bardwell, L. and Naegeli, H. (1992)
What can yeast tell us about cancer pathogenesis and cancer proneness? In Bohr,
V.A., Wasserman, K., and Kraemer, K.A. (Eds.), Alfred Benzon Symposium No.
35: DNA Repair Mechanisms. Munksgaard, Denmark. pp. 80-89.
7. Naegeli,
H., Bardwell, L.. and Friedberg, E.C.
(1992) Substrate specificity of the Rad3 ATPase/DNA helicase of Saccharomyces
cerevisiae and binding of Rad3 protein to nucleic acids. Journal
of Biological Chemistry
267:7839-7844. Abstract
6. Naegeli,
H., Bardwell, L. and Friedberg, E.C.
(1991) The DNA helicase and adenosine triphosphatase activities of yeast Rad3
protein are inhibited by DNA damage: a potential mechanism for damage-specific
recognition. Journal of Biological Chemistry 267:392-398. Abstract
5. Bardwell,
L., Burtscher, H., Weiss, W.A., Nicolet,
C.M. and Friedberg, E.C. (1990) Characterization of the RAD10
gene of Saccharomyces cerevisiae and
purification of Rad10 protein. Biochemistry 29:3119-3126. Abstract
4. Bardwell,
L. (1989) The mutagenic and carcinogenic
effects of gene transfer. Mutagenesis 4:245-253. Abstract
3. Kaden,
D.A., Bardwell, L., Newmark, P.,
Anisowicz, A., Skopek, T.R. and Sager, R. (1989) High frequency of large
spontaneous deletions of DNA in tumor-derived CHEF cells. Proc.
Natl. Acad. Sci. USA
86:2306-10. Abstract
2. Kaden,
D., Gadi, I.K., Bardwell, L., Gelman,
R. and Sager, R. (1989) Spontaneous mutation rates of tumorigenic and
nontumorigenic Chinese hamster embryo fibroblast cell lines. Cancer
Research 49:3374-79.
Abstract
1. Anisowicz,
A., Bardwell, L. and Sager, R. (1987)
Constitutive overexpression of a growth-regulated gene in transformed Chinese
hamster and human cells. Proc. Natl. Acad. Sci. USA 84:7188-92. Abstract
* = These are "co-first author" papers
Last modified 12 October 2010. Back to top