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Herpes simplex virus Research

Animations of steps of HSV Infection and Replication

Encapsidation and Nuclear Egress

The procapsid proteins (UL18, UL19 and UL38) assemble around scaffolding proteins (UL26 and UL26.5) that are then digested away.  The empty capsid incorporates DNA by means of the action of cleavage/packaging proteins (see the DNA replication animation). The capsid migrates to the nuclear membrane and buds into the lumen between the inner and outer nuclear membrane. This enveloped virion then enters the cytoplasm through fusion with the outer nuclear membrane.

Illustration and Flash animations by
Karin Christensen
Scientific, Medical and Veterinary Illustration.

The animations are available for download for classroom teaching.