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Herpes simplex virus Research

Animations of steps of HSV Infection and Replication

To view the animations the Flash plug-in is required.

HSV structure (61 Kb)
animationHSV is a nuclear replicating, icosahedral, enveloped DNA virus.

Receptor Binding (89 Kb)
animationHerpes simplex virus genome must enter the cell for the initiation of infection.

RNA Transcription in Productive Infection (154 Kb)
animationThe transcription of the HSV genome during productive infection occurs with cellular transcriptional machinery and viral promoters utilizing cellular transcription factor binding sites.....

Latent Infections (50 Kb)
animationLatent infection and reactivation by HSV takes place in sensory neurons, primarily in the trigeminal ganglia for HSV-1.....

DNA Replication (83 Kb)
animationHSV initiates rounds of DNA replication at one or all of the three origins of replication
(Ori 1, Ori 2, and Ori 3).....

Encapsidation and Nuclear Egress (136 Kb)
animationThe procapsid proteins (UL18, UL19 and UL38) assemble around scaffolding proteins (UL26 and UL26.5) that are then digested away.....

Envelopment and Release (163 Kb)
animationFinal release of the enveloped virion from the cell involves the virus being incorporated into exocytotic vesicles then released from the cell as free infectious virus.....

Illustration and Flash animations by
Karin Christensen
Scientific, Medical and Veterinary Illustration.

The animations are available for download for classroom teaching.