The Homepage of Dr. Edward K. Wagner 
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Herpes simplex virus Research

Animations of steps of HSV Infection and Replication

Envelopment and Release

Viral glycoproteins are translated from HSV RNA on the rough endoplasmic reticulum then transported to the golgi body in vesicles to continue the glycosylation process.  The glycoproteins are then transported in vesicles to the nuclear or plasma membrane.

The HSV capsid associates with tegument proteins then acquires a mature envelope by budding into an exocytotic vesicle. The enveloped infectious virion migrates to the virus modified membrane and is released outside of the cell.

Illustration and Flash animations by
Karin Christensen
Scientific, Medical and Veterinary Illustration.

The animations are available for download for classroom teaching.