Location mu |
Kinetics | Required for replication in culture? |
Name of element or protein |
Function |
0 | - | Yes | "a" | cis genome cleavage, packaging signal |
0--0.06 | - | Yes | TRL | Terminal Long Repeat |
0.01 (RL) | IE |
(at low moi) |
a0 | immediate-early transcription regulator (mRNA spliced) |
0.02 (RL) | latent | No | LAT | ca. 600 bases in 5' region facilitates reactivation. No protein involved. |
0.04 (RL) | latent | No | LAT-intron | Stable accumulation in nucleus of latently infected neurons, unknown function |
0.06 | early | Yes | gL (UL1) | viral entry, associates with gH - polyadenylation usage changes with time |
0.07 | early | No | UL2 | uracil DNA glycosylase, DNA repair |
0.08 | late | No | UL3 | non-virion membrane associated protein |
0.09 | early | No | UL4 | tegument protein, unknown function |
0.1 | early | Yes |
Helicase/
Primase (UL5) |
DNA replication |
0.1 | late | Yes | UL6 | capsid protein, capsid maturation, DNA packaging |
0.11 | ? | No | UL7 | Unknown |
0.12 | early | Yes |
Helicase/
Primase (UL8) |
DNA replication |
|
early |
|
|
DNA replication |
|
late |
|
|
Glycoprotein of unknown function |
|
late |
|
|
tegument protein, capsid egress and envelopement |
|
early |
|
|
DNA packaging (?), capsid egress |
|
early |
|
|
C-terminal 2/3 of UL12, expressed by separate mRNA--specific function unknown |
|
late |
|
|
Tegument associated |
|
late |
|
|
Unknown |
|
late |
|
|
DNA packaging, cleavage of replicating DNA(?), (spliced mRNA) |
|
late |
|
|
Unknown |
|
late |
|
|
cleavage and packaging of DNA |
|
late |
|
|
Triplex |
|
late |
|
|
major capsid protein, hexon |
|
late |
|
|
membrane associated, virion egress |
|
late |
|
|
Tegument |
|
late |
|
|
viral entry, functions with gL |
|
early |
|
|
Thymidine kinase |
|
late |
|
|
Unknown |
|
late |
|
|
tegument protein, capsid maturation, DNA packaging |
|
early |
|
|
Maturational protease |
|
early |
|
|
Scaffolding protein |
|
early |
|
|
Glycoprotein required for virus entry |
|
early |
|
|
capsid maturation, DNA packaging |
|
early |
|
|
single-stranded DNA binding protein, DNA replication |
|
- |
|
|
Origin of replication |
|
early |
|
(UL30) |
DNA replication |
|
late |
|
|
Nuclear phosphoprotein, nuclear egress |
|
late |
|
|
capsid maturation, DNA packaging |
|
late |
|
|
capsid maturation, DNA packaging |
|
late |
|
|
Membrane phosphoprotein, nuclear egress |
|
late |
|
|
capsid protein, capsomer tips |
|
? |
|
|
ICP1/2, tegument protein |
|
late |
|
|
Tegument phosphoprotein |
|
late |
|
|
Capsid protein, triplex |
|
early |
|
|
Large subunit ribonucleotide reductase |
|
early |
|
|
Small subunit ribonucleotide reductase |
|
late |
|
|
vhs, virion-associated host shut off protein, destabilizes mRNA |
|
late |
|
|
Polymerase accessory protein, DNA replication |
|
late |
|
|
unknown |
|
- |
|
|
Anti-sense to UL43 |
|
late |
|
|
Initial stages of virus-cell association |
|
late |
|
|
Membrane associated |
|
early |
|
|
Tegument associated, modulates a-TIF |
|
|
|
|
Tegument associated, modulates a-TIF |
|
|
|
(UL48) |
virion-associated transcriptional activator, enhances immediate-early transcription through cellular Oct-1 and CTF binding at "TATGARAT" sites |
|
|
|
|
Tegument protein |
|
|
|
|
Unknown |
|
|
|
(UL50) |
Nucleotide pool metabolism |
|
|
|
|
Unknown |
|
|
|
(UL52) |
DNA replication |
|
|
|
(UL53) |
virion egress |
|
early |
|
(UL54) |
Immediate-early regulatory protein, inhibits splicing |
|
|
|
|
unknown |
|
|
|
|
Tegument protein, affects pathogenesis |
|
|
|
|
Internal Long Repeat |
|
|
|
|
Joint region, contains "a" sequences |
|
|
|
|
Internal Short Repeat |
|
early |
|
|
immediate-early transcriptional activator |
(RS) |
|
|
(cis-acting) |
Origin of replication |
|
early |
|
|
immediate early protein, affects virus’ ability to replicate in certain cells |
|
|
|
|
Unknown |
|
|
|
|
tegument associated protein kinase, phosphorylates UL34 and US9 |
|
|
|
|
glycoprotein of unknown function |
|
|
|
|
glycoprotein of unknown function |
|
|
|
|
virus entry, binds HVEM |
|
|
|
|
Glycoprotein which acts with gE, binds IgG-Fc and influences cell to cell spread of virus |
|
|
|
|
glycoprotein which acts gI, binds IgG-Fc and influences cell-to-cell spread of infection |
|
|
|
|
Tegument associated phosphoprotein |
|
|
|
|
tegument associated protein |
|
|
|
|
Tegument-associated protein phosphoprotein, RNA binding, post-transcriptional regulation |
|
early |
|
|
Immediate-early protein that inhibits MHC1 antigen presentation in human and primate cells |
|
|
|
|
Terminal Short Repeat |
|
|
|
|
cis genome cleavage, packaging signal |