Some Genetic Functions Encoded by
Herpes Simplex Virus type 1

Dr Wagner's Home Page

Location
mu		 Kinetics Required for replication in culture? Name of
element
or protein 		Function
0 - Yes "a" cis genome cleavage, packaging signal
0--0.06 - Yes TRL Terminal Long Repeat
0.01 (RL) IE
Yes
(at low moi)
 a0 immediate-early transcription regulator (mRNA spliced)
0.02 (RL) latent No LAT ca. 600 bases in 5' region facilitates reactivation. No protein involved.
0.04 (RL) latent No LAT-intron Stable accumulation in nucleus of latently infected neurons, unknown function
0.06 early Yes gL (UL1) viral entry, associates with gH - polyadenylation usage changes with time
0.07 early No UL2 uracil DNA glycosylase, DNA repair
0.08 late No UL3 non-virion membrane associated protein
0.09 early No UL4 tegument protein, unknown function
0.1 early Yes Helicase/
Primase (UL5) 		DNA replication
0.1 late Yes UL6 capsid protein, capsid maturation, DNA packaging
0.11 ? No UL7 Unknown
0.12 early Yes Helicase/
Primase (UL8) 		DNA replication
0.13
 early
Yes
Ori binding protein (UL9)
 DNA replication
0.14
 late
No
gM (UL10)
 Glycoprotein of unknown function
0.14
 late
Yes
UL11
 tegument protein, capsid egress and envelopement
0.16
 early
Yes
Alkaline exonuclease (UL12)
 DNA packaging (?), capsid egress
0.15
 early
No
UL12.5
 C-terminal 2/3 of UL12, expressed by separate mRNA--specific function unknown
0.17
 late
No
Protein kinase (UL13)
 Tegument associated
0.18
 late
No
UL14
 Unknown
0.16/0.18
 late
Yes
UL15
 DNA packaging, cleavage of replicating DNA(?), (spliced mRNA) 
0.17
 late
No
UL16
 Unknown
0.2
 late
Yes
UL17
 cleavage and packaging of DNA
0.23
 late
Yes
Capsid (UL18)
 Triplex
0.25
 late
Yes
Capsid (UL19)
 major capsid protein, hexon
0.27
 late
Yes
UL20
 membrane associated, virion egress
0.28
 late
No
UL21
 Tegument
0.3
 late
Yes
gH (UL22)
 viral entry, functions with gL
0.32
 early
No
UL23
 Thymidine kinase
0.33
 late
No
UL24
 Unknown
0.33
 late
Yes
UL25
 tegument protein, capsid maturation, DNA packaging
0.34
 early
Yes
UL26
 Maturational protease
0.34
 early
Yes
UL26.5
 Scaffolding protein
0.36
 early
Yes
gB (UL27)
 Glycoprotein required for virus entry
0.37
 early
Yes
UL28
 capsid maturation, DNA packaging
0.4
 early
Yes
UL29
 single-stranded DNA binding protein, DNA replication
0.41
 -
No
OriL
 Origin of replication
0.42
 early
Yes
DNA pol
(UL30)
 DNA replication
0.45
 late
No
UL31
 Nuclear phosphoprotein, nuclear egress
0.45
 late
Yes
UL32
 capsid maturation, DNA packaging
0.46
 late
Yes
L33
 capsid maturation, DNA packaging
0.47
 late
No
UL34
 Membrane phosphoprotein, nuclear egress
0.47
 late
Yes
UL35
 capsid protein, capsomer tips
0.50
 ?
No
UL36
 ICP1/2, tegument protein
0.55
 late
No
UL37
 Tegument phosphoprotein
0.57
 late
Yes
UL38
 Capsid protein, triplex
0.58
 early
Yes
UL39
 Large subunit ribonucleotide reductase
0.59
 early
Yes
UL40
 Small subunit ribonucleotide reductase
0.6
 late
No
UL41
 vhs, virion-associated host shut off protein, destabilizes mRNA
0.61
 late
Yes
UL42
 Polymerase accessory protein, DNA replication
0.62
 late
No
UL43
 unknown
0.62
 -
No
UL43.5
 Anti-sense to UL43
0.63
 late
No
gC (UL44)
 Initial stages of virus-cell association
0.64
 late
No
UL45
 Membrane associated
0.65
 early
No
UL46
 Tegument associated, modulates a-TIF
0.66
early
No
UL47
 Tegument associated, modulates a-TIF
0.67
-
Yes
a-TIF
(UL48)
 virion-associated transcriptional activator, enhances immediate-early transcription through cellular Oct-1 and CTF binding at "TATGARAT" sites
0.68
early?
No
UL49
 Tegument protein
0.68
late
No
UL49.5
 Unknown
0.69
early
No
dUTPase
(UL50)
 Nucleotide pool metabolism
0.7
late
No
UL51
 Unknown
0.71
early
Yes
Helicase/primase
(UL52)
 DNA replication
0.73
late
No
gK
(UL53)
 virion egress
0.74
immediate-
early
Yes
a27
(UL54)
 Immediate-early regulatory protein, inhibits splicing
0.75
early
No
UL55
 unknown
0.76
late
No
UL56
 Tegument protein, affects pathogenesis
0.76 to 0.82
-
Yes
IRL
 Internal Long Repeat
0.82
-
Yes
RL/RS Junction
 Joint region, contains "a" sequences
0.82--0.86
-
Yes
IRS
 Internal Short Repeat
0.82--0.86 (RS)
Immediate-
early
Yes
a4
 immediate-early transcriptional activator
0.86
(RS)
-
Yes
OriS
(cis-acting)
 Origin of replication
0.86
immediate-
early
No
a22 (US1)
 immediate early protein, affects virus’ ability to replicate in certain cells
0.87
early
No
US2
 Unknown
0.89
early
No
US3
 tegument associated protein kinase, phosphorylates UL34 and US9
0.9
early
No
gG (US4)
 glycoprotein of unknown function
0.9
late
No
gJ (US5)
 glycoprotein of unknown function
0.91
late
Yes
gD (US6)
 virus entry, binds HVEM
0.92
early
No
gI (US7)
 Glycoprotein which acts with gE, binds IgG-Fc and influences cell to cell spread of virus
0.93
early
No
gE (US8)
 glycoprotein which acts gI, binds IgG-Fc and influences cell-to-cell spread of infection
0.94
early
No
US9
 Tegument associated phosphoprotein
0.95
early
No
US10
 tegument associated protein
0.95
early
No
US11
 Tegument-associated protein phosphoprotein, RNA binding, post-transcriptional regulation
0.96
immediate-
early
No
a47 (US12)
 Immediate-early protein that inhibits MHC1 antigen presentation in human and primate cells
0.96--1
-
Yes
TRS
 Terminal Short Repeat
1
-
Yes
"a"
 cis genome cleavage, packaging signal