Some Genetic Functions Encoded by
Herpes Simplex Virus type 1

Dr Wagner's Home Page


Location
mu
Kinetics Required for replication in culture? Name of
element
or protein
Function
0 - Yes "a" cis genome cleavage, packaging signal
0--0.06 - Yes TRL Terminal Long Repeat
0.01 (RL) IE
Yes
(at low moi)
a0 immediate-early transcription regulator (mRNA spliced)
0.02 (RL) latent No LAT ca. 600 bases in 5' region facilitates reactivation. No protein involved.
0.04 (RL) latent No LAT-intron Stable accumulation in nucleus of latently infected neurons, unknown function
0.06 early Yes gL (UL1) viral entry, associates with gH - polyadenylation usage changes with time
0.07 early No UL2 uracil DNA glycosylase, DNA repair
0.08 late No UL3 non-virion membrane associated protein
0.09 early No UL4 tegument protein, unknown function
0.1 early Yes Helicase/
Primase (UL5)
DNA replication
0.1 late Yes UL6 capsid protein, capsid maturation, DNA packaging
0.11 ? No UL7 Unknown
0.12 early Yes Helicase/
Primase (UL8)
DNA replication
0.13
early
Yes
Ori binding protein (UL9)
DNA replication
0.14
late
No
gM (UL10)
Glycoprotein of unknown function
0.14
late
Yes
UL11
tegument protein, capsid egress and envelopement
0.16
early
Yes
Alkaline exonuclease (UL12)
DNA packaging (?), capsid egress
0.15
early
No
UL12.5
C-terminal 2/3 of UL12, expressed by separate mRNA--specific function unknown
0.17
late
No
Protein kinase (UL13)
Tegument associated
0.18
late
No
UL14
Unknown
0.16/0.18
late
Yes
UL15
DNA packaging, cleavage of replicating DNA(?), (spliced mRNA) 
0.17
late
No
UL16
Unknown
0.2
late
Yes
UL17
cleavage and packaging of DNA
0.23
late
Yes
Capsid (UL18)
Triplex
0.25
late
Yes
Capsid (UL19)
major capsid protein, hexon
0.27
late
Yes
UL20
membrane associated, virion egress
0.28
late
No
UL21
Tegument
0.3
late
Yes
gH (UL22)
viral entry, functions with gL
0.32
early
No
UL23
Thymidine kinase
0.33
late
No
UL24
Unknown
0.33
late
Yes
UL25
tegument protein, capsid maturation, DNA packaging
0.34
early
Yes
UL26
Maturational protease
0.34
early
Yes
UL26.5
Scaffolding protein
0.36
early
Yes
gB (UL27)
Glycoprotein required for virus entry
0.37
early
Yes
UL28
capsid maturation, DNA packaging
0.4
early
Yes
UL29
single-stranded DNA binding protein, DNA replication
0.41
-
No
OriL
Origin of replication
0.42
early
Yes
DNA pol
(UL30)
DNA replication
0.45
late
No
UL31
Nuclear phosphoprotein, nuclear egress
0.45
late
Yes
UL32
capsid maturation, DNA packaging
0.46
late
Yes
L33
capsid maturation, DNA packaging
0.47
late
No
UL34
Membrane phosphoprotein, nuclear egress
0.47
late
Yes
UL35
capsid protein, capsomer tips
0.50
?
No
UL36
ICP1/2, tegument protein
0.55
late
No
UL37
Tegument phosphoprotein
0.57
late
Yes
UL38
Capsid protein, triplex
0.58
early
Yes
UL39
Large subunit ribonucleotide reductase
0.59
early
Yes
UL40
Small subunit ribonucleotide reductase
0.6
late
No
UL41
vhs, virion-associated host shut off protein, destabilizes mRNA
0.61
late
Yes
UL42
Polymerase accessory protein, DNA replication
0.62
late
No
UL43
unknown
0.62
-
No
UL43.5
Anti-sense to UL43
0.63
late
No
gC (UL44)
Initial stages of virus-cell association
0.64
late
No
UL45
Membrane associated
0.65
early
No
UL46
Tegument associated, modulates a-TIF
0.66
early
No
UL47
Tegument associated, modulates a-TIF
0.67
-
Yes
a-TIF
(UL48)
virion-associated transcriptional activator, enhances immediate-early transcription through cellular Oct-1 and CTF binding at "TATGARAT" sites
0.68
early?
No
UL49
Tegument protein
0.68
late
No
UL49.5
Unknown
0.69
early
No
dUTPase
(UL50)
Nucleotide pool metabolism
0.7
late
No
UL51
Unknown
0.71
early
Yes
Helicase/primase
(UL52)
DNA replication
0.73
late
No
gK
(UL53)
virion egress
0.74
immediate-
early
Yes
a27
(UL54)
Immediate-early regulatory protein, inhibits splicing
0.75
early
No
UL55
unknown
0.76
late
No
UL56
Tegument protein, affects pathogenesis
0.76 to 0.82
-
Yes
IRL
Internal Long Repeat
0.82
-
Yes
RL/RS Junction
Joint region, contains "a" sequences
0.82--0.86
-
Yes
IRS
Internal Short Repeat
0.82--0.86 (RS)
Immediate-
early
Yes
a4
immediate-early transcriptional activator
0.86
(RS)
-
Yes
OriS
(cis-acting)
Origin of replication
0.86
immediate-
early
No
a22 (US1)
immediate early protein, affects virus’ ability to replicate in certain cells
0.87
early
No
US2
Unknown
0.89
early
No
US3
tegument associated protein kinase, phosphorylates UL34 and US9
0.9
early
No
gG (US4)
glycoprotein of unknown function
0.9
late
No
gJ (US5)
glycoprotein of unknown function
0.91
late
Yes
gD (US6)
virus entry, binds HVEM
0.92
early
No
gI (US7)
Glycoprotein which acts with gE, binds IgG-Fc and influences cell to cell spread of virus
0.93
early
No
gE (US8)
glycoprotein which acts gI, binds IgG-Fc and influences cell-to-cell spread of infection
0.94
early
No
US9
Tegument associated phosphoprotein
0.95
early
No
US10
tegument associated protein
0.95
early
No
US11
Tegument-associated protein phosphoprotein, RNA binding, post-transcriptional regulation
0.96
immediate-
early
No
a47 (US12)
Immediate-early protein that inhibits MHC1 antigen presentation in human and primate cells
0.96--1
-
Yes
TRS
Terminal Short Repeat
1
-
Yes
"a"
cis genome cleavage, packaging signal