MARSH LAB PUBLICATIONS
Last update = April 2004
2004
Wang, Z., Marcu, O., Berns, M.W., Marsh, J.L. (2004). In vivo FCS
Measurements of Ligand Diffusion In Intact Tissues. Journal Biomedical
Optics 9. In Press
Steffan, J.S., Agrawal, N., Pallos, J.,
Rockabrand, E., Trotman, L.C., Slepko, N., Illes, K., Lukacsovich, T., Zhu,
Y.Z., Cattaneo, E. Pandolfi, P.P., Thompson, L. M., Marsh, J. L. (2004). SUMO modification of Huntingtin and
Huntington's disease pathology. Science 304, 100-4.
Podemski, L., Sousa-Neves, R., Marsh, J.L.; Locke, J. (2004) Molecular mapping of deletion
breakpoints on chromosome 4 of D. melanogaster. Chromsoma, In Press.
Chang, Y.T., Sharma, R., Marsh, J.L.,
McPherson, J.D., Bedell, J.A., Knust, A., Brautigam, C., Hoffmann, G.F. and
Hyland, K. (2004) Levodopa-responsive aromatic L-amino acid decarboxylase
deficiency. Ann Neurol, 55,
435-8.
2003
Hockly, E., Richon, V.M., Woodman, B., Smith, D.L., Zhou, X., Rosa, E., Ghazi-Noori, S., Sathasivam, K., Mahal, A., Lowdem, P.A.S., Steffan, J.S., Marsh, J.L., Thompson,
L.M., Lewis, C.M., Marks, P.A., and Bates, G.P. (2003) Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in the R6/2 mouse
model of Huntington's Disease. PNAS 100, 2041-6.
Apostol, B. L., Kazantsev, A., Illes, K., Pallos, J., Bodai, L., Slepko, N., Hersch, S., Housman, D. E., Marsh, J. L. and Thompson, L. M. (2003) A cell based screen
for aggregation-inhibitors and validation in Drosophila for treatment of poly glutamine repeat disease. PNAS 100, 5950-5
Kao, J., Nie, Q., Teng, A., Wan, F., Lander, A. and Marsh, J.L. (2003) Can morphogen activity be enhanced by its inhibitors? Proc of 2nd MIT Conference on Computational
Fluid and Solid Mechanics, 2, 1729-1733.
Bodai, L., Pallos, J., Thompson, L. M. and Marsh, J. L. (2003). Altered protein acetylation in polyglutamine diseases. Current Medicinal Chemistry 10, 2577-2587.
Marsh, J. L., Pallos, J. and Thompson, L. M. (2003). Fly Models of Huntington's Disease. Hum Mol Genet. In Press
Thompson, L. M. and Marsh, J. L. (2003). Invertebrate models of neurologic disease: insights into pathogenesis and therapy. Curr Neurol Neurosci Rep 3, 442-8.
2002
Holcombe,
R.F., J. L. Marsh, M. L. Waterman, F. Lin, T. Milovanovic and T.Truong
(2002) Expression of Wnt ligands and Frizzled receptors in colonicmucosa and in
colon carcinoma. Molecular Pathology 55(4):220-226
Kazantsev, A., Walker, H. A.,Slepko, N.,
Bear, J. E., Preisinger, E., Steffan, J. S., Zhu, Y. Z., Gertler,F. B.,
Housman, D. E., Marsh, J. L., and Thompson, L. M. (2002). A bivalentHuntingtin
binding peptide suppresses polyglutamine aggregation and pathogenesisin
Drosophila. Nature Genetics 30, 367-76.
2001
Hovanes, K.H., J.E. Munguia, T. Truong, T.
Milovanovic, T.W.H. Li, J. L.Marsh, R.F. Holcombe and M.L. Waterman (2001)
Selective expression of ß-catenin-sensitiveforms of Lymphoid Enhancer Factor-1
in colon cancer. Nature Genetics 28,53-57.
Related summary: de Lau, W., and Clevers, H. (2001). LEF turns over anew
leaf. Nature Genetics 28, 3-4.
Vilmos, P., Gaudenz, K., Hegedus, Z.,
Marsh, J.L. (2001) The Twisted gastrulation family of proteins,
together with theIGFBP and CCN families, comprise the TIC super-family of
cysteine-rich secretedfactors. Molecular Pathology 54:317-323.
Related summaries:
Harland, R.M. (2001) Developmental biology: A twist on embryonic
signalling,Nature 410:423-424.
Ray, R. P., and Wharton, K. A. (2001). Twisted Perspective. New Insights into
Extracellular Modulation of BMP Signaling during Development. Cell 104,
801-804.
Skipper, M, (2001) A twisted tale of BMP antagonists. Skipper, M. NatureReviews
Genetics 2(5), 328-329.
Steffan, J. S., Bodai, L., Pallos, J.,
Poelman, M., Apostol, B. L., Kazantsev, A., Schmidt, E., Zhu, Y., Greenwald,
M., Kurokawa, R., Housman,D. E., Jackson, G. R., Marsh, J. L. and Thompson, L.
M. (2001) Histone deacetylaseinhibitors arrest polyglutamine-dependent
neurodegeneration in DrosophilaNature 413:739-743.
Related summaries:
1 - Nature News & Views Bates, G. P. (2001). Huntington's
disease.Exploiting expression. Nature 413, 691, 693-4.
2- Science Editor's Choice. Science Vol 295, 2002.
Neurodegeneration:Expanding on a Theme by Gilbert Chin
3- "Hope for Huntington's Disease" By Douglas Steinberg in The
Scientist16 [2}:34, Jan 21, 2002
4- "Researchers say Drug Halts Huntington's Disease," The Orange
CountyRegister,October 18, 2001.
5- "UCI Professor Leads Fight Against Brain Disorder," The Daily
Pilot,Oct. 18, 2001; LA Times by Diedre Newman (See Daily Pilot above)
6- Physician's Weekly by Katherine Wandersee
7- United PRess International, Oct. 22, 2001 TREATMENT FOR HUNTINGTONS DISEASE
8- Newsday, Huntington's Disease Study Offers New Hope By Robert
CookeNovember 20, 2001
9- Science's Signal Transduction Knowledge Environment (STKE,
http://www.stke.org)10/24/01
10- Trends in Neurosciences "In Brief" by Lianna Orlando2
11- Discover Magazine Special Issue "The Year in Science: Hope for
Huntington's Patients by Christine Soares January 2002, p. 54
2000
Ross, J.J., O. Shimmi, P. Vilmos, A.
Petryk, H. Kim,K. Gaudenz, S.C. Ekker, M.B. O'Connor and J. L. Marsh.
(200-) TwistedGastrulation is a conserved extracellular BMP signaling
modulator, Nature410, 479-83.
Ross et al. (2000) Nature, Supplemental
material (full text-PDF)
Marsh, J.L., Walker, H., Theisen, H. Zhu,
Y., Fielder, T., Purcell, J. and Thompson, L.M. (2000) Expanded
polyglutamine peptidesalone are intrinsically cytotoxic and cause neurodegeneration
in Drosophila. Human Molecular Genetics, 9:13-25 *cover photo
1999
Marcu, O, Stathakis, D.G. and Marsh, J.L.
(1999) The human UGDH locus encoding UDP-Glucose Dehydrogenase Maps at 4p15.1
Cytogenetics and Cell Genetics, 86: 244-245.
Marsh, J.L. and Theisen, H. (1999)
Regeneration in insects. Seminars in Cell & Developmental Biology,
10:365-375.
1998
Chang YT, Mues G, McPherson JD, Bedell J,
Marsh JL, Hyland K. (1998) Mutations in the human aromatic L-amino
acid decarboxylase gene. J Inherit Metab Dis;21:4
Lathrop, R.H., Casale, M., Tobias, D.J.,
Marsh, J.L., Thompson,L.M. (1998) Modeling Protein Homopolymeric Repeats:
Possible PolyglutamineStructural Motifs For Huntington's Disease In: Proc.
Intl. Conf. on IntelligentSystems for Molecular Biology. eds. Glasgow et. al., AAAI Press, Menlo ParkCA
Konrad, K.D., Goralski, T.J., Mahowald,
A.P., and Marsh, J.L. (1998) The gastrulation defective gene of Drosophila
melanogaster is a member of the serine protease superfamily. Proc. Natl. Acad.
Sci.95(12): 6819-6824.
Mason, E. D., and Marsh, J.L. (1998)
Changes in the pattern of twisted gastrulation gene expression among
Drosophila species. JMolec Evolution 46(2): 180-187.
1997
Haerry, T.E., Heslip, T., Marsh, J.L. and
O'Connor, M.B. (1997) Defects in glucuronate biosynthesis disrupt Wingless
signaling in Drosophila.Development 124: 3055-3064.(full
text-PDF)
Mason, E. D., Williams, S., Grotendorst, G.
R., and Marsh, J.L. (1997) Combinatorial signaling by Twisted gastrulation and
Decapentaplegic. Mech. of Devel. 64:61-75
Lewin, D.I. (1996) Double and diverge:
Building new taxa from old genes. The Journal of NIH Research. 8:37-39. (An
article about ourwork Wang et al 1996 below)
Chang, Y.T., Mues, G., Hyland, K., and
Marsh, J.L. (1997) Human hair follicles as a peripheral source of tyrosine
hydroxylase and aromatic L-amino acid decarboxylase mRNA.
Neuroscience Letters 222:210-212.
Heslip, T., Theisen, H., Walker, H., and
Marsh, J.L. (1997) Shaggy and Dishevelled exert opposite effects on wingless
and decapentaplegic expression and on positional identity in
imaginal discs. Development124:1069-1078 (full text-PDF)
1996
Theisen, H., Haerry, T.E., O'Connor, M.B.,
and Marsh, J.L.(1996) Developmental territories created by mutual antagonism
between WGand DPP. Development 122: 3939-3948.
Wang, D, Marsh, J.L. and Ayala, F.J. (1996)
Evolutionary changes in the expression pattern of a developmentally essential
gene in threeDrosophila species. Proc. Natl. Acad. Sci. 93:7103-7107
1995
Grens, A, Mason, E., Marsh, J.L., and Bode,
H.R. (1995) Evolutionary conservation of a cell fate specification gene: The
Hydra achaete-scutehomolog has proneural activity in Drosophila. Development
121: 4027-4035.
Rothbacher, U, Blitz, I.L., Watabe, T,
Marsh, J.L. and Cho, K.W.Y. (1995) Functional conservation of the Wnt signaling
pathway revealedby ectopic expression of Drosophila dishevelled in Xenopus.
Devel.Biol. 170:717-721.
Wang, D and Marsh, J.L. (1995)
Developmental regulation of the alpha-Methyldopa Hypersensitive gene of Drosophila
melanogaster. Devel. Biol. 168:598-612.
1994
Mason, E. D., Konrad, K. D., Webb, C. D.
and Marsh, J.L. (1994) Dorsal midline fate in Drosophila embryos requires
twisted gastrulation, a gene encoding a secreted protein related to human
connective tissue growth factor. Genes & Development 8:1489-1501.
Theisen, H., Purcell, J., Bennett, M.,
Kansagara, D., Syed,A., and Marsh, J.L. (1994) dishevelled is required
during wingless signaling to establish both cell polarity and cell
identity. Development120:347-360 .(full text-PDF)
1993
Wang, Z., Crowe, R.R., and Marsh, J.L.
(1993) An SspI polymorphismfor the human Dopa Decarboxylase (DDC) gene on
chromosome 7p. Human MolecularGenetics: 2:2198.
Konrad, K.D., Wang, D. and Marsh, J.L.
(1993). Vitelline membrane biogenesis In Drosophila requires the Activity of
the a-methyldopa hypersensitive gene (l(2)amd) in both the
germline and follicle cells. Insect Molecular Biology 1: 179-187.
1992
Scherer, L.J., J. D. McPherson, J. J.
Wasmuth and J.L. Marsh (1992) Human Dopa Decarboxylase: Localization to human
chromosome 7p11and characterization of hepatic cDNAs. Genomics 13: 469-471.
-1990
Eveleth, D.D., and J.L. Marsh (1987)
Overlapping transcription units in Drosophila: Sequence and structure of the Cs
gene. Mol. Gen. Genet. 209: 290-298.
Konrad, K.D., and J.L. Marsh (1987)
Developmental expression and spatial distribution of Dopa Decarboxylase in
Drosophila. Devel. Biol. 122: 172-185.
Ngo, T.T., K.L. Brillhart, R.H. Davis, R.C.
Wong, J.H. Bovaird, J.J. Digangi, J.L. Ristow, J.L. Marsh, A.P.H. Phan, and
H.M. Lenhoff (1986) A spectrophotometric assay for ornithine decarboxylase.
Anal. Biochem. 160: 290-293.
Eveleth, D.D., R.D. Gietz, C.A. Spencer, F.
Nargang, R.B. Hodgetts, and J.L. Marsh (1986) Sequence and structure of the
dopa decarboxylase gene of Drosophila: Evidence for novel RNA splicing variants.
EMBO Journal 5: 2663-2672.
Eveleth, D.D., and J.L. Marsh (1986)
Sequence and Expression of the Cc gene, a member of the dopa decarboxylase gene
cluster of Drosophila: Possible translational regulation. Nucl. Acid Res. 14:
6169-6183.
Eveleth, D.D., and J.L. Marsh (1986)
Evidence for Evolutionary Duplication of Genes in the Dopa Decarboxylase Region
of Drosophila. Genetics 114: 469-483.
Marsh, J.L., M.P. Erfle, and C.A. Leeds (1986)
Molecular localization, developmental expression and nucleotide sequence of the
alpha methyldopa hypersensitive gene of Drosophila. Genetics 114: 453-467.
Haymer, D.S., and J.L. Marsh (1986) Germ
line and somatic instability of a white mutation in D. mauritiana due to a transposable
geneticelement. Devel. Genetics 6: 281-292.
Hodgetts, R.B., W.C. Clark, D.D. Eveleth,
R.D. Gietz, C.A.Spencer, and J.L. Marsh (1986) Hormonal Aspects of the
Regulation of DopaDecarboxylase in Drosophila melanogaster. In Progress
in DevelopmentalBiology Part A. H.C. Slavkin ed. Alan R. Liss, Inc. New York: pp. 221-234
Marsh, J.L., and T.R.F. Wright (1986)
Evidence for Regulatory variants of the Dopa Decarboxylase and alpha-methyldopa
hypersensitive lociin Drosophila. Genetics 112: 249-265.
Levinson, G., J.L. Marsh, J.T. Epplen, and
G.A. Gutman (1985) Cross-hybridizing Snake Satellite, Drosophila and Mouse DNA
Sequences May Have Arisen Independently. Molec. Biol. and Evolution 2: 494-504.
Marsh, J.L., P.D.L. Gibbs, and P.M. Timmons
(1985) Developmental Control of Transduced Dopa Decarboxylase Genes in D.
melanogaster. Mol. Gen. Genet. 198: 393-403.
Marsh, J.L., M. Erfle, and E.J. Wykes
(1984) The pIC plasmid and phage vectors with versatile cloning sites for
recombinant selection byinsertional inactivation. Gene 32: 481-485.
Wright, T.R.F., B.C. Black, C.P. Bishop,
J.L. Marsh, E.S. Pentz, R. Steward, and E.Y. Wright (1982) The Genetics of Dopa
Decarboxylase in Drosophila melanogaster. V. Ddc and l(2)amd
Alleles: Isolation, Characterization and Intragenic Complementation. Mol. Gen.
Genet. 188: 18-26.
Wright, T.R.F., W. Beerman, J.L. Marsh,
C.P. Bishop, R. Steward, B.C. Black, A.D. Tomsett, and E.Y. Wright (1981) The
Genetics andCytology of Dopa Decarboxylase in Drosophila melanogaster.
IV TheGenetics and Cytology of the 37B10-37D1 Region. Chromosoma 83: 45-58.
Marsh, J.L., and T.R.F. Wright (1980)
Developmental Relationship between Dopa Decarboxylase, Dopamine Acetyl
Transferase and Ecdysone in Drosophila.Devel. Biol. 80: 379-387.
Marsh, J.L., and T.R.F. Wright (1979)
Control of Dopa DecarboxylaseExpression During Development in Drosophila. In R.
Axel, T. Maniatis, andC. F. Fox (eds.): Eukaryotic Gene Regulation. ICN-UCLA
Symposium on Molecularand Cell Biology. New York: Acad. Press, pp. 183-194.
Marsh, J.L., and T.R.F. Wright (1979)
Evidence for Mutations Affecting the Coordinate Control of the Adjacent Genes,
Ddc and l(2)amd inDrosophila. J. Supramolecular Structure 3: 51 (Abstr.)
Marsh, J.L. (1978) Construction of a Third
Chromosome BalancerBearing a Dominant Temperature Sensitive Lethal. Drosophila
Information Service53: 155-156.
Marsh, J.L., and E. Wieschaus, (1978) Is
Sex Determination in Germ-line and Soma Controlled by Separate Genetic
Mechanisms? Nature 272:249-251.
Wieschaus, E., J.L. Marsh, and W.J.
Gehring, (1978) fs(1)K10, A Germ-line Dependent Female Sterile Mutation Causing
Abnormal Chorion Morphologyin Drosophila melanogaster. Wilhelm Roux Archiv.
184: 75-82.
Marsh, J.L., and E. Wieschaus, (1977)
Germ-line Dependence of the maroon-like Maternal Effect. Devel. Biol. 60: 396-
403.
Marsh, J.L., E. Wieschaus, and W.J.
Gehring, (1976) Transplants of Primordial Germ Cells to Distinguish Somatic
versus Germ-line Contributions to Egg Shape. Experientia 32b: 803.
Marsh, J.L., E.B. van Deusen, E. Wieschaus,
and W.J. Gehring, (1977) Germ-line Dependence of the deep orange Maternal
Effect. Devel. Biol.56:195-199.
Marsh, J.L., and B.J. McCarthy, (1973)
Analysis of DNA-RNA Hybridization Data Using the Scatchard Plot. Biochem.
Biophys. Res. Comm. 55: 805-811.
Marsh, J.L., and B.J. McCarthy, (1974) The
Effect of Nucleotide Mismatching on Rates of Reassociation. Biochemistry 33:
3382-2287.
