One of the most impressive aspect of the regeneration
process is the completeness and perfection of the replacement limb. Replacement
limbs are perfect in every way, remaining indistinguishable from ordinary
limbs. Some other vertebrates can replace part of a missing structure,
or at least begin the process but it is almost always imperfect. Lizards
for example can often replace their tails, but the replacement tails are
missing vertebrae. Another feature of the axolotl is that it can regenerate
missing structures for its entire life. Humans for example have been documented
to replace the very distal tips of their fingers. This ability is documented
to work best in children, but persists in a less perfect form throughout
life. Finger tip amputations that are sutured shut with mature skin are
inhibited from regenerating. Most animals show some regenerative ability
early in life, but lose that ability as they age. Part of the challenge
for human regeneration research then is to learn how to unlock the regenerative
potential within us.