Welcome to the Home Page of 

Tim Osborne 

Professor and Chairman, Department of Molecular Biology and Biochemistry at the University of California at Irvine

hawkfish flipper here

Tim Osborne
Dr. Timothy F. Osborne

(Ph.D., UCLA, 1983)

Transcriptional Regulation of Lipid Metabolism & Nutriemt Sensing in Diabetes, Obesity, & Atherosclerosis
(DOA)

  • Research Interests
  • E-mail: tfosborn@uci.edu

    • dolphins jumping

    Please click on Project Description.pdf for a downloadable text version of a four page project summary, or click on CV for more information about TO.

    Current Lab Members

    Mary Bennett
    (Staff Research Associate) 

    Chromatin Immunoprecipitation studies for SREBP regulated promoters

    mary bennett
    mkbennet@uci.edu
    Karen Matsukuma
    (MdPhD Student)

    Nuclear Receptors  & SREBPs in Regulation of Fatty  Acid Synthase
     

    Karen Matsukuma

    kmatsuku@uci.edu
    Shrimati Datta
    (Postdoctoral Scholar) 

    Functional Characterization of Specific SREBP Homo- and
    Hetero- Dimeric Pairs

    Shrimati Datta
    dattas@uci.edu
    Dong-Ju Shin
    (Postdoctoral Scholar) 

    Nutritional & Hormonal Regulation of Cholesterol & Bile Acid Metabolism

    Dong-Ju Shin
    dshin@uci.edu
    Linda Hammond
    (Postdoctoral Scholar) 

    Functional Consequences of a SREBP-1a  Specific Gene Knockout in mice

    Linda Hammond
    lhammond@uci.edu
    Maria Elizabeth Arias Moreno "Liz"
    (    UCI Undergraduate) 

    Nutritional Regulation of Cholesterol Metabolism

    Liz
    mariasmo@uci.edu
    Michelle Dragojlovic

     (UCI Undergraduate) 

    Functional Consequences of a SREBP-1a  Specific Gene Knockout in mice

    Michelle Dragojlovic
    mdragojl@uci.edu

    Selected Publications That Highlight Specific  Research Efforts

    Osborne, T.F., Sterol Regulatory Element Binding Proteins (SREBPs): Key Regulators of Nutritional Homeostasis and Insulin Action. J. Biol. Chem., 2000. 275: p. 32379-32382.(pdf link)
     
    Osborne, T.F. 2001 CREating a SCAP-less Liver Keeps SREBPs Pinned in The ER Membrane and Prevents Increased Lipid Synthesis in Response to Low Cholesterol And High Insulin. Genes and Dev. 15, p1873-1878. (pdf link)

    Shin, D.-J., and Osborne, T. F. (2003). Thyroid Hormone Regulation and Cholesterol Metabolism Are Connected through Sterol Regulatory Element-binding Protein-2 (SREBP-2). J Biol Chem 278, 34114-34118. (pdf link)

    Shin, D.-J., J. A. Campos, G. Gil, and T. F. Osborne. 2003. PGC-1{alpha} Activates CYP7A1 and Bile Acid Biosynthesis. J. Biol. Chem. 278:50047-50052. (pdf link)

    Bennett, M., J. I. Toth, and T. F. Osborne. 2004. Selective Association of Sterol Regulatory Element Binding Protein Isoforms with Target Promoters In Vivo. J. Biol. Chem 279:37360-37367. (pdf link)

    Toth, J. I., S. Datta, J. N. Athanikar, L. P. Freedman, and T. F. Osborne. 2004. Selective Co-activator Interactions in Gene Activation by SREBP-1a and -1c. Mol. Cell. Biol. 24:8288-8300. (pdf link)

    Datta, S., and T. F. Osborne. 2005. Activation domains from both monomers contribute to transcriptional stimulation by SREBP dimers. J. Biol. Chem 280:3338-3345. (pdf link)

    Zoumi, A., S. Datta, L.-L. Liaw, C. Wu, G. Manthripragada, T. F. Osborne, and V. J. LaMorte. 2005. Spatial distribution and function of SREBP-1a and SREBP-2 homo- and heterodimers by in vivo two-photon imaging and spectroscopy fluorescence resonance energy transfer. Mol. Cell. Biol 25:2946-2956.     (pdf link)
    Postdoctoral Opportunities are available.  Please send CV and 2-3 letters of reference to E-mail: tfosborn@uci.edu
    For predoctoral inquiries, we are part of the UCI Graduate Track in Mechanisms of Gene expression within the UCI graduate Program in Molecular Biology, Genetics, and Biochemistry. Applications requests or additional information about the graduate program may be obtained by electronic mail at gp-mbgb@uci.edu or by phone at (949) 824-8145. On-line applications may also be submitted through the Office of Research and Graduate Studies.

    1) Molecular Biology, Genetics, and Biochemistry

    2) Email: gp-mbgb@uci.edu or call (949) 824-8145

    3) Graduate Studies Home Page, with links to On-line applications and the Office of Research and Graduate Studies


    Click here for some of TO's under water pictures
    Pictures 1
    Pictures 2
    Pictures 3
    Pictures 4

    MB&B Departmental Retreat Lake Arrowhead Ca. 3-05
    MB&Bretreat 3-05



    Last Updated 4-05